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Aliases for DYDC1 Gene

Aliases for DYDC1 Gene

  • DPY30 Domain Containing 1 2 3 5
  • DPY30D1 3 4
  • DPY30 Domain-Containing Protein 1 3

External Ids for DYDC1 Gene

Previous GeneCards Identifiers for DYDC1 Gene

  • GC10U900476
  • GC10M082086
  • GC10M075939

Summaries for DYDC1 Gene

Entrez Gene Summary for DYDC1 Gene

  • This gene encodes a member of a family of proteins that contains a DPY30 domain. The encoded protein is involved in acrosome formation during spermatid development. This gene locus overlaps with a closely related gene on the opposite strand. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for DYDC1 Gene

DYDC1 (DPY30 Domain Containing 1) is a Protein Coding gene. Diseases associated with DYDC1 include Arrhythmogenic Right Ventricular Cardiomyopathy. An important paralog of this gene is DYDC2.

UniProtKB/Swiss-Prot for DYDC1 Gene

  • Plays a crucial role during acrosome biogenesis.

Additional gene information for DYDC1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYDC1 Gene

Genomics for DYDC1 Gene

GeneHancer (GH) Regulatory Elements for DYDC1 Gene

Promoters and enhancers for DYDC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I080356 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 -0.5 -534 1.2 MXI1 USF1 RFX1 SMAD5 NRF1 MAX SIN3A USF2 BMI1 POLR2A DYDC2 DYDC1 FAM213A
GH10I080406 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 -55.0 -54959 10.7 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF143 FAM213A DYDC2 LOC642361 DYDC1 MBL1P PLAC9 ANXA11 PIR57963
GH10I080453 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.6 -107.6 -107580 22.7 HDGF PKNOX1 ARNT SIN3A DMAP1 IRF4 POLR2B ZNF766 ZNF207 ZNF143 TSPAN14 FAM213A LOC101929574 DYDC1 DYDC2 ANXA11 PLAC9 MBL1P SH2D4B PIR41876
GH10I080492 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10 -143.5 -143535 15 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 TSPAN14 FAM213A DYDC1 DYDC2 LOC101929574 ANXA11 PIR41876
GH10I080483 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.5 -131.1 -131074 9.5 FOXA2 MLX ARID4B ZNF48 YY1 GTF3C2 TCF12 FOS RUNX3 RXRA TSPAN14 FAM213A DYDC1 DYDC2 LOC101929574 ANXA11 PIR41876
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DYDC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DYDC1 gene promoter:

Genomic Locations for DYDC1 Gene

Genomic Locations for DYDC1 Gene
chr10:80,336,102-80,356,787
(GRCh38/hg38)
Size:
20,686 bases
Orientation:
Minus strand
chr10:82,095,861-82,116,511
(GRCh37/hg19)

Genomic View for DYDC1 Gene

Genes around DYDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYDC1 Gene

Proteins for DYDC1 Gene

  • Protein details for DYDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWB3-DYDC1_HUMAN
    Recommended name:
    DPY30 domain-containing protein 1
    Protein Accession:
    Q8WWB3
    Secondary Accessions:
    • A8K927
    • Q5QP03
    • Q5QP04
    • Q6WNP4
    • Q6ZU87

    Protein attributes for DYDC1 Gene

    Size:
    177 amino acids
    Molecular mass:
    20893 Da
    Quaternary structure:
    • Interacts with SH3GL3.
    SequenceCaution:
    • Sequence=BAC86339.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for DYDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYDC1 Gene

Post-translational modifications for DYDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DYDC1 Gene

Domains & Families for DYDC1 Gene

Gene Families for DYDC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DYDC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DYDC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WWB3

UniProtKB/Swiss-Prot:

DYDC1_HUMAN :
  • Belongs to the dpy-30 family.
Family:
  • Belongs to the dpy-30 family.
genes like me logo Genes that share domains with DYDC1: view

Function for DYDC1 Gene

Molecular function for DYDC1 Gene

UniProtKB/Swiss-Prot Function:
Plays a crucial role during acrosome biogenesis.

Phenotypes From GWAS Catalog for DYDC1 Gene

Gene Ontology (GO) - Molecular Function for DYDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042800 contributes_to histone methyltransferase activity (H3-K4 specific) IBA --
genes like me logo Genes that share ontologies with DYDC1: view

Phenotypes for DYDC1 Gene

genes like me logo Genes that share phenotypes with DYDC1: view

miRNA for DYDC1 Gene

miRTarBase miRNAs that target DYDC1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYDC1 Gene

Localization for DYDC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYDC1 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DYDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0048188 Set1C/COMPASS complex IBA --
genes like me logo Genes that share ontologies with DYDC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for DYDC1 Gene

Pathways & Interactions for DYDC1 Gene

SuperPathways for DYDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DYDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006348 chromatin silencing at telomere IBA --
GO:0051568 histone H3-K4 methylation IEA --
genes like me logo Genes that share ontologies with DYDC1: view

No data available for Pathways by source and SIGNOR curated interactions for DYDC1 Gene

Drugs & Compounds for DYDC1 Gene

No Compound Related Data Available

Transcripts for DYDC1 Gene

mRNA/cDNA for DYDC1 Gene

Unigene Clusters for DYDC1 Gene

DPY30 domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYDC1 Gene

No ASD Table

Relevant External Links for DYDC1 Gene

GeneLoc Exon Structure for
DYDC1
ECgene alternative splicing isoforms for
DYDC1

Expression for DYDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DYDC1 Gene

mRNA differential expression in normal tissues according to GTEx for DYDC1 Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for DYDC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DYDC1 Gene



Protein tissue co-expression partners for DYDC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DYDC1 Gene:

DYDC1

SOURCE GeneReport for Unigene cluster for DYDC1 Gene:

Hs.407751

mRNA Expression by UniProt/SwissProt for DYDC1 Gene:

Q8WWB3-DYDC1_HUMAN
Tissue specificity: Brain and testis. Accumulates during late stage of spermiogenesis.
genes like me logo Genes that share expression patterns with DYDC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYDC1 Gene

Orthologs for DYDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DYDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYDC1 33 34
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia DYDC1 33 34
  • 88.7 (n)
cow
(Bos Taurus)
Mammalia DYDC1 33 34
  • 84.76 (n)
rat
(Rattus norvegicus)
Mammalia Dydc1 33
  • 79.55 (n)
mouse
(Mus musculus)
Mammalia Dydc1 33 16 34
  • 73.53 (n)
oppossum
(Monodelphis domestica)
Mammalia DYDC1 34
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYDC1 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves DYDC1 33 34
  • 57.56 (n)
lizard
(Anolis carolinensis)
Reptilia DYDC1 34
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dydc2 33
  • 58.95 (n)
zebrafish
(Danio rerio)
Actinopterygii DYDC2 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
OneToMany
Species where no ortholog for DYDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DYDC1 Gene

ENSEMBL:
Gene Tree for DYDC1 (if available)
TreeFam:
Gene Tree for DYDC1 (if available)

Paralogs for DYDC1 Gene

Paralogs for DYDC1 Gene

(1) SIMAP similar genes for DYDC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DYDC1: view

Variants for DYDC1 Gene

Sequence variations from dbSNP and Humsavar for DYDC1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000073229 -- 80,356,223(-) T/C intron_variant
rs1000448044 -- 80,345,037(-) C/T intron_variant
rs1000545992 -- 80,345,784(-) A/G intron_variant
rs1000682437 -- 80,357,962(-) T/G upstream_transcript_variant
rs1000749836 -- 80,358,683(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DYDC1 Gene

Variant ID Type Subtype PubMed ID
esv3623951 CNV gain 21293372
nsv1141879 OTHER inversion 24896259
nsv520763 CNV gain 19592680
nsv551637 CNV gain 21841781
nsv825479 CNV gain 20364138
nsv831923 CNV loss 17160897

Variation tolerance for DYDC1 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DYDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYDC1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYDC1 Gene

Disorders for DYDC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DYDC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
arrhythmogenic right ventricular cardiomyopathy
  • arrhythmogenic right ventricular dysplasia
- elite association - COSMIC cancer census association via MalaCards
Search DYDC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DYDC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DYDC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DYDC1 Gene

Publications for DYDC1 Gene

  1. Interaction of SH3P13 and DYDC1 protein: a germ cell component that regulates acrosome biogenesis during spermiogenesis. (PMID: 19545932) Li S … Wang L (European journal of cell biology 2009) 3 4 58
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DYDC1 Gene

Sources for DYDC1 Gene

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