Aliases for DVL2 Gene
External Ids for DVL2 Gene
Previous GeneCards Identifiers for DVL2 Gene
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]
GeneCards Summary for DVL2 Gene
DVL2 (Dishevelled Segment Polarity Protein 2) is a Protein Coding gene. Diseases associated with DVL2 include Neural Tube Defects and Hepatocellular Carcinoma. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein self-association. An important paralog of this gene is DVL3.
UniProtKB/Swiss-Prot Summary for DVL2 Gene
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.