This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt protein... See more...

Aliases for DVL2 Gene

Aliases for DVL2 Gene

  • Dishevelled Segment Polarity Protein 2 2 3 5
  • Segment Polarity Protein Dishevelled Homolog DVL-2 3 4
  • Dishevelled 2 (Homologous To Drosophila Dsh) 2 3
  • Dishevelled, Dsh Homolog 2 (Drosophila) 2
  • Dishevelled, Dsh Homolog 2 3
  • Dishevelled-2 4
  • DSH Homolog 2 4
  • DVL2 5

External Ids for DVL2 Gene

Previous GeneCards Identifiers for DVL2 Gene

  • GC17M007526
  • GC17M007858
  • GC17M007071
  • GC17M007329
  • GC17M007069
  • GC17M007128
  • GC17M007021

Summaries for DVL2 Gene

Entrez Gene Summary for DVL2 Gene

  • This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]

GeneCards Summary for DVL2 Gene

DVL2 (Dishevelled Segment Polarity Protein 2) is a Protein Coding gene. Diseases associated with DVL2 include Neural Tube Defects and Hepatocellular Carcinoma. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein self-association. An important paralog of this gene is DVL3.

UniProtKB/Swiss-Prot Summary for DVL2 Gene

  • Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.

Gene Wiki entry for DVL2 Gene

Additional gene information for DVL2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DVL2 Gene

Genomics for DVL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DVL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DVL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DVL2

Top Transcription factor binding sites by QIAGEN in the DVL2 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2

Genomic Locations for DVL2 Gene

Genomic Locations for DVL2 Gene
chr17:7,225,341-7,234,544
(GRCh38/hg38)
Size:
9,204 bases
Orientation:
Minus strand
chr17:7,128,660-7,137,864
(GRCh37/hg19)
Size:
9,205 bases
Orientation:
Minus strand

Genomic View for DVL2 Gene

Genes around DVL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DVL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DVL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DVL2 Gene

Proteins for DVL2 Gene

  • Protein details for DVL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14641-DVL2_HUMAN
    Recommended name:
    Segment polarity protein dishevelled homolog DVL-2
    Protein Accession:
    O14641
    Secondary Accessions:
    • D3DTN3
    • Q53XM0

    Protein attributes for DVL2 Gene

    Size:
    736 amino acids
    Molecular mass:
    78948 Da
    Quaternary structure:
    • Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and the AP-2 complex (By similarity). Interacts with DACT1 and FAM105B/otulin. Interacts with DCDC2. Interacts (when phosphorylated) with FOXK1 and FOXK2; the interaction induces DVL2 nuclear translocation (PubMed:25805136). Interacts with MAPK15 (By similarity). Interacts with PKD1 (via extracellular domain) (PubMed:27214281). Interacts with LMBR1L (By similarity).

    Three dimensional structures from OCA and Proteopedia for DVL2 Gene

neXtProt entry for DVL2 Gene

Post-translational modifications for DVL2 Gene

  • Phosphorylated by CSNK1D (PubMed:21422228, PubMed:9192851). WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases (PubMed:25805136).
  • Ubiquitination at Lys343, Lys353, Lys428, Lys477, Lys484, and Lys615
  • Modification sites at PhosphoSitePlus

Other Protein References for DVL2 Gene

No data available for DME Specific Peptides for DVL2 Gene

Domains & Families for DVL2 Gene

Gene Families for DVL2 Gene

Protein Domains for DVL2 Gene

InterPro:
Blocks:
  • PDZ/DHR/GLGF domain
  • Pleckstrin putative G-protein interacting domain
  • Dishevelled protein
  • Dishevelled protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for DVL2 Gene

GenScript: Design optimal peptide antigens:
  • DSH homolog 2 (DVL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14641

UniProtKB/Swiss-Prot:

DVL2_HUMAN :
  • The DIX domain mediates homooligomerization.
  • Belongs to the DSH family.
Domain:
  • The DIX domain mediates homooligomerization.
Family:
  • Belongs to the DSH family.
genes like me logo Genes that share domains with DVL2: view

Function for DVL2 Gene

Molecular function for DVL2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
GENATLAS Biochemistry:
Drosophila dishevelled segment polarity gene homolog 2,908,95kDa,widely expressed in embryo,activated in WNT signal transduction

Phenotypes From GWAS Catalog for DVL2 Gene

Gene Ontology (GO) - Molecular Function for DVL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005109 frizzled binding IEA,TAS 25424568
GO:0005515 protein binding IEA,IPI 10644691
GO:0019901 protein kinase binding IEA --
GO:0019904 protein domain specific binding IEA --
GO:0030674 protein binding, bridging IEA --
genes like me logo Genes that share ontologies with DVL2: view
genes like me logo Genes that share phenotypes with DVL2: view

Animal Models for DVL2 Gene

MGI Knock Outs for DVL2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DVL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DVL2 Gene

Localization for DVL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DVL2 Gene

Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasm, cytosol. Cytoplasmic vesicle. Nucleus. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136). {ECO:0000250 UniProtKB:Q60838, ECO:0000269 PubMed:25805136}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DVL2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 2
cytoskeleton 2
lysosome 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DVL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 9192851
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with DVL2: view

Pathways & Interactions for DVL2 Gene

genes like me logo Genes that share pathways with DVL2: view

Pathways by source for DVL2 Gene

2 GeneGo (Thomson Reuters) pathways for DVL2 Gene
  • Transcription Androgen Receptor nuclear signaling
  • Translation Non-genomic (rapid) action of Androgen Receptor
2 R&D Systems pathways for DVL2 Gene
1 Cell Signaling Technology pathway for DVL2 Gene
1 GeneTex pathway for DVL2 Gene

SIGNOR curated interactions for DVL2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DVL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA,ISS --
GO:0001934 positive regulation of protein phosphorylation IMP 20137080
GO:0003007 heart morphogenesis IEA --
GO:0003151 outflow tract morphogenesis IEA,ISS --
GO:0006366 transcription by RNA polymerase II IDA 11742073
genes like me logo Genes that share ontologies with DVL2: view

Drugs & Compounds for DVL2 Gene

(1) Additional Compounds for DVL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DVL2: view

Transcripts for DVL2 Gene

mRNA/cDNA for DVL2 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DVL2

Alternative Splicing Database (ASD) splice patterns (SP) for DVL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: -
SP9: -
SP10:

ExUns: 13 ^ 14a · 14b · 14c ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for DVL2 Gene

GeneLoc Exon Structure for
DVL2

Expression for DVL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DVL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DVL2 Gene

This gene is overexpressed in Ovary (15.4), Fetal testis (8.4), and Fetal ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DVL2 Gene



Protein tissue co-expression partners for DVL2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DVL2

SOURCE GeneReport for Unigene cluster for DVL2 Gene:

Hs.118640

Evidence on tissue expression from TISSUES for DVL2 Gene

  • Intestine(4.5)
  • Liver(4.4)
  • Nervous system(4.3)
  • Skin(2.7)
  • Kidney(2.5)
  • Heart(2.3)
  • Muscle(2.2)
  • Lung(2.2)
  • Blood(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with DVL2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DVL2 Gene

Orthologs for DVL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DVL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DVL2 30 31
  • 99.73 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DVL2 31
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia DVL2 30 31
  • 90.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DVL2 30 31
  • 90.15 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DVL2 31
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Dvl2 30 17 31
  • 88.21 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dvl2 30
  • 87.85 (n)
Lizard
(Anolis carolinensis)
Reptilia DVL2 31
  • 88 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dvl2 30
  • 73.3 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7670 30
Zebrafish
(Danio rerio)
Actinopterygii dvl2 30 31
  • 69.98 (n)
OneToOne
Dr.5398 30
Fruit Fly
(Drosophila melanogaster)
Insecta dsh 31 32
  • 45 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea dsh-1 30 31
  • 47.43 (n)
ManyToMany
dsh-2 31
  • 30 (a)
ManyToMany
mig-5 31
  • 28 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11084 31
  • 48 (a)
OneToMany
Species where no ortholog for DVL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DVL2 Gene

ENSEMBL:
Gene Tree for DVL2 (if available)
TreeFam:
Gene Tree for DVL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DVL2: view image

Paralogs for DVL2 Gene

Paralogs for DVL2 Gene

(5) SIMAP similar genes for DVL2 Gene using alignment to 5 proteins:

  • DVL2_HUMAN
  • I3L0M7_HUMAN
  • I3L0Z8_HUMAN
  • I3L2N2_HUMAN
  • I3L2W9_HUMAN
genes like me logo Genes that share paralogs with DVL2: view

Variants for DVL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DVL2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
724111 Likely Benign: not provided 7,234,105(-) G/A MISSENSE_VARIANT
728976 Benign: not provided 7,227,523(-) C/T MISSENSE_VARIANT
775159 Benign: not provided 7,228,052(-) G/A INTRON_VARIANT
779364 Benign: not provided 7,229,141(-) A/G SYNONYMOUS_VARIANT
rs222836 Benign: not specified 7,229,843(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for DVL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for DVL2 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2665200 CNV deletion 23128226
esv3639861 CNV loss 21293372
esv3639862 CNV loss 21293372
nsv1962 CNV insertion 18451855
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for DVL2 Gene