Aliases for DVL2 Gene
External Ids for DVL2 Gene
Previous GeneCards Identifiers for DVL2 Gene
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]
GeneCards Summary for DVL2 Gene
DVL2 (Dishevelled Segment Polarity Protein 2) is a Protein Coding gene. Diseases associated with DVL2 include Neural Tube Defects and Conotruncal Heart Malformations. Among its related pathways are DNA Damage Response (only ATM dependent) and Neural Crest Differentiation. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein self-association. An important paralog of this gene is DVL3.
UniProtKB/Swiss-Prot for DVL2 Gene
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.