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Aliases for DUX4L2 Gene

Aliases for DUX4L2 Gene

  • Double Homeobox 4 Like 2 2 3 5
  • Double Homeobox Protein 4-Like Protein 2 3
  • DUX4 3

External Ids for DUX4L2 Gene

Previous GeneCards Identifiers for DUX4L2 Gene

  • GC04P191012
  • GC04P191014
  • GC04P191021
  • GC04P191026
  • GC04P191031
  • GC04P191036
  • GC04P191044

Summaries for DUX4L2 Gene

Entrez Gene Summary for DUX4L2 Gene

  • This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

GeneCards Summary for DUX4L2 Gene

DUX4L2 (Double Homeobox 4 Like 2) is a Pseudogene. An important paralog of this gene is DUX4.

UniProtKB/Swiss-Prot for DUX4L2 Gene

  • May be involved in transcriptional regulation.

Additional gene information for DUX4L2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUX4L2 Gene

Genomics for DUX4L2 Gene

GeneHancer (GH) Regulatory Elements for DUX4L2 Gene

Promoters and enhancers for DUX4L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I190111 Enhancer 0.4 Ensembl ENCODE 0.3 +20.5 20470 0.7 DUX4L2 DUX4
GH04I190122 Enhancer 0.2 ENCODE 0.3 +32.0 32006 0.2 DUX4L2 DUX4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DUX4L2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DUX4L2 Gene

Genomic Locations for DUX4L2 Gene
1,285 bases
Plus strand

Genomic View for DUX4L2 Gene

Genes around DUX4L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUX4L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUX4L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUX4L2 Gene

Proteins for DUX4L2 Gene

  • Protein details for DUX4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Double homeobox protein 4-like protein 2
    Protein Accession:

    Protein attributes for DUX4L2 Gene

    424 amino acids
    Molecular mass:
    44926 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUX4L2 Gene

Post-translational modifications for DUX4L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DUX4L2 Gene

Domains & Families for DUX4L2 Gene

Gene Families for DUX4L2 Gene

Protein Domains for DUX4L2 Gene

Suggested Antigen Peptide Sequences for DUX4L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DUX4L2: view

No data available for UniProtKB/Swiss-Prot for DUX4L2 Gene

Function for DUX4L2 Gene

Molecular function for DUX4L2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for DUX4L2 Gene

GenomeRNAi human phenotypes for DUX4L2:
genes like me logo Genes that share phenotypes with DUX4L2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUX4L2 Gene

Localization for DUX4L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUX4L2 Gene

No data available for Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DUX4L2 Gene

Pathways & Interactions for DUX4L2 Gene

SuperPathways for DUX4L2 Gene

No Data Available

Interacting Proteins for DUX4L2 Gene

Gene Ontology (GO) - Biological Process for DUX4L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for DUX4L2 Gene

Drugs & Compounds for DUX4L2 Gene

No Compound Related Data Available

Transcripts for DUX4L2 Gene

mRNA/cDNA for DUX4L2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUX4L2 Gene

No ASD Table

Relevant External Links for DUX4L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUX4L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUX4L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUX4L2 Gene:


SOURCE GeneReport for Unigene cluster for DUX4L2 Gene:

genes like me logo Genes that share expression patterns with DUX4L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUX4L2 Gene

Orthologs for DUX4L2 Gene

Evolution for DUX4L2 Gene

Gene Tree for DUX4L2 (if available)
Gene Tree for DUX4L2 (if available)

No data available for Orthologs for DUX4L2 Gene

Paralogs for DUX4L2 Gene

Paralogs for DUX4L2 Gene

(17) SIMAP similar genes for DUX4L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DUX4L2: view

Variants for DUX4L2 Gene

Additional Variant Information for DUX4L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for DUX4L2 Gene

Disorders for DUX4L2 Gene

No disorders were found for DUX4L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for DUX4L2 Gene

Publications for DUX4L2 Gene

  1. RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy. (PMID: 19359275) Snider L … Tapscott SJ (Human molecular genetics 2009) 3 58
  2. DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. (PMID: 17984056) Dixit M … Chen YW (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 58
  3. Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy. (PMID: 17668377) Clapp J … Hewitt JE (American journal of human genetics 2007) 3 58
  4. The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein. (PMID: 17588759) Kowaljow V … Rosa AL (Neuromuscular disorders : NMD 2007) 3 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58

Products for DUX4L2 Gene

Sources for DUX4L2 Gene

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