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Aliases for DUX4L1 Gene

Aliases for DUX4L1 Gene

  • Double Homeobox 4 Like 1 2 3 5
  • Double Homeobox Protein 4/10 3
  • Double Homeobox Protein 10 3
  • Double Homeobox 4 2
  • DUX10 3
  • DUX4 3

External Ids for DUX4L1 Gene

Previous HGNC Symbols for DUX4L1 Gene

  • DUX4

Summaries for DUX4L1 Gene

Entrez Gene Summary for DUX4L1 Gene

  • This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

GeneCards Summary for DUX4L1 Gene

DUX4L1 (Double Homeobox 4 Like 1) is a Pseudogene. Diseases associated with DUX4L1 include Facioscapulohumeral Muscular Dystrophy 1. An important paralog of this gene is DUX4L3.

Additional gene information for DUX4L1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUX4L1 Gene

Genomics for DUX4L1 Gene

Genomic Locations for DUX4L1 Gene

Genomic Locations for DUX4L1 Gene
1,285 bases
Plus strand

Genomic View for DUX4L1 Gene

Genes around DUX4L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUX4L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUX4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUX4L1 Gene

No data available for GeneHancer (GH) Regulatory Elements for DUX4L1 Gene

Proteins for DUX4L1 Gene

Post-translational modifications for DUX4L1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DUX4L1 Gene

Domains & Families for DUX4L1 Gene

Gene Families for DUX4L1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DUX4L1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for DUX4L1 Gene

Function for DUX4L1 Gene

genes like me logo Genes that share phenotypes with DUX4L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUX4L1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUX4L1 Gene

Localization for DUX4L1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DUX4L1 Gene

Pathways & Interactions for DUX4L1 Gene

SuperPathways for DUX4L1 Gene

No Data Available

Interacting Proteins for DUX4L1 Gene

Gene Ontology (GO) - Biological Process for DUX4L1 Gene


No data available for Pathways by source and SIGNOR curated interactions for DUX4L1 Gene

Drugs & Compounds for DUX4L1 Gene

No Compound Related Data Available

Transcripts for DUX4L1 Gene

mRNA/cDNA for DUX4L1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUX4L1

Alternative Splicing Database (ASD) splice patterns (SP) for DUX4L1 Gene

No ASD Table

Relevant External Links for DUX4L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUX4L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUX4L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUX4L1 Gene:

genes like me logo Genes that share expression patterns with DUX4L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUX4L1 Gene

Orthologs for DUX4L1 Gene

Evolution for DUX4L1 Gene

Gene Tree for DUX4L1 (if available)
Gene Tree for DUX4L1 (if available)

No data available for Orthologs for DUX4L1 Gene

Paralogs for DUX4L1 Gene

genes like me logo Genes that share paralogs with DUX4L1: view

Variants for DUX4L1 Gene

Additional Variant Information for DUX4L1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for DUX4L1 Gene

Disorders for DUX4L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUX4L1 Gene - From: Orphanet

Disorder Aliases PubMed IDs
facioscapulohumeral muscular dystrophy 1
  • fmd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DUX4L1

genes like me logo Genes that share disorders with DUX4L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUX4L1 Gene

Publications for DUX4L1 Gene

  1. DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. (PMID: 17984056) Dixit M … Chen YW (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 22 58
  2. Intracellular trafficking and dynamics of double homeodomain proteins. (PMID: 15709750) Ostlund C … Worman HJ (Biochemistry 2005) 3 22 58
  3. Dux4 induces cell cycle arrest at G1 phase through upregulation of p21 expression. (PMID: 24589735) Xu H … Yuan Y (Biochemical and biophysical research communications 2014) 3 58
  4. Myogenic enhancers regulate expression of the facioscapulohumeral muscular dystrophy-associated DUX4 gene. (PMID: 24636994) Himeda CL … Jones TI (Molecular and cellular biology 2014) 3 58
  5. Expression of DUX4 in zebrafish development recapitulates facioscapulohumeral muscular dystrophy. (PMID: 23108159) Mitsuhashi H … Kunkel LM (Human molecular genetics 2013) 3 58

Products for DUX4L1 Gene

Sources for DUX4L1 Gene

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