The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with ce... See more...

Aliases for DUSP9 Gene

Aliases for DUSP9 Gene

  • Dual Specificity Phosphatase 9 2 3 5
  • MKP-4 2 3 4
  • MKP4 2 3 4
  • Mitogen-Activated Protein Kinase Phosphatase 4 3 4
  • Dual Specificity Protein Phosphatase 9 3 4
  • Map Kinase Phosphatase 4 2 3
  • Serine/Threonine Specific Protein Phosphatase 3
  • MAP Kinase Phosphatase 4 4
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DUSP9 5

External Ids for DUSP9 Gene

Previous GeneCards Identifiers for DUSP9 Gene

  • GC0XP147045
  • GC0XP149362
  • GC0XP150493
  • GC0XP151375
  • GC0XP152428
  • GC0XP152561
  • GC0XP152907
  • GC0XP141570

Summaries for DUSP9 Gene

Entrez Gene Summary for DUSP9 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for DUSP9 Gene

DUSP9 (Dual Specificity Phosphatase 9) is a Protein Coding gene. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP6.

UniProtKB/Swiss-Prot Summary for DUSP9 Gene

Additional gene information for DUSP9 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP9 Gene

Genomics for DUSP9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DUSP9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ153643 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 604.7 +3.1 3059 4.2 CEBPG HNRNPL IKZF1 KDM1A CTCF PRDM1 ZIC2 RBFOX2 RXRB PATZ1 DUSP9 NONHSAG055552.2 SLC6A8
GH0XJ153642 Promoter 1.6 EPDnew Ensembl CraniofacialAtlas 600.7 0.0 -40 1.2 ZSCAN4 RBFOX2 RXRB PATZ1 EZH2 ZNF600 MGA KLF9 SP2 EGR1 DUSP9 lnc-CCNQ-1 CCNQ
GH0XJ153621 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.1 -17.1 -17115 7.1 HNRNPL GATAD2A TFE3 SOX13 RBFOX2 ZNF24 RXRB IRF2 SP1 CEBPA lnc-CCNQ-1 SNORA70 DUSP9 TMEM187 HCFC1 SLC10A3 EMD ZNF185 ABCD1 PDZD4
GH0XJ153609 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 4.9 -31.9 -31900 1.6 HNRNPL GATAD2A CTCF RFX1 ZIC2 ZSCAN4 RBFOX2 POLR2A RXRB PATZ1 lnc-ATP2B3-4 HCFC1 DUSP9 LOC105373384 ENSG00000260081 CCNQ
GH0XJ153507 Enhancer 1.1 Ensembl ENCODE dbSUPER 5.1 -134.6 -134641 1.2 CTCF PRDM10 ZNF692 ZIC2 ZSCAN4 PATZ1 REST RAD21 TRIM22 ZNF600 NONHSAG055547.2 DUSP9 ATP2B3 HAUS7 BGN lnc-ATP2B3-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP9

Top Transcription factor binding sites by QIAGEN in the DUSP9 gene promoter:
  • CUTL1
  • GATA-2
  • GCNF
  • GCNF-1
  • GCNF-2
  • Meis-1
  • Meis-1a
  • Meis-1b
  • NRSF form 1
  • NRSF form 2

Genomic Locations for DUSP9 Gene

Genomic Locations for DUSP9 Gene
chrX:153,642,441-153,651,326
(GRCh38/hg38)
Size:
8,886 bases
Orientation:
Plus strand
chrX:152,907,897-152,916,781
(GRCh37/hg19)
Size:
8,885 bases
Orientation:
Plus strand

Genomic View for DUSP9 Gene

Genes around DUSP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP9 Gene

Proteins for DUSP9 Gene

  • Protein details for DUSP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99956-DUS9_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 9
    Protein Accession:
    Q99956
    Secondary Accessions:
    • D3DWU5

    Protein attributes for DUSP9 Gene

    Size:
    384 amino acids
    Molecular mass:
    41868 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP9 Gene

neXtProt entry for DUSP9 Gene

Post-translational modifications for DUSP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP9 Gene

Antibody Products

  • Abcam antibodies for DUSP9
  • Santa Cruz Biotechnology (SCBT) Antibodies for DUSP9

No data available for DME Specific Peptides for DUSP9 Gene

Domains & Families for DUSP9 Gene

Gene Families for DUSP9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DUSP9 Gene

Suggested Antigen Peptide Sequences for DUSP9 Gene

GenScript: Design optimal peptide antigens:
  • Mitogen-activated protein kinase phosphatase 4 (DUS9_HUMAN)
  • Dual specificity protein phosphatase (Q6P9C2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99956

UniProtKB/Swiss-Prot:

DUS9_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP9: view

Function for DUSP9 Gene

Molecular function for DUSP9 Gene

UniProtKB/Swiss-Prot Function:
Inactivates MAP kinases. Has a specificity for the ERK family.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
GENATLAS Biochemistry:
dual specific (tyr/thr) phosphatase 9,only expressed in placenta,kidney,embryonic liver

Enzyme Numbers (IUBMB) for DUSP9 Gene

Phenotypes From GWAS Catalog for DUSP9 Gene

Gene Ontology (GO) - Molecular Function for DUSP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS,IBA 21873635
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 11988087
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA 21873635
GO:0008330 protein tyrosine/threonine phosphatase activity IBA 21873635
genes like me logo Genes that share ontologies with DUSP9: view
genes like me logo Genes that share phenotypes with DUSP9: view

Animal Models for DUSP9 Gene

MGI Knock Outs for DUSP9:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP9

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP9 Gene

Localization for DUSP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP9 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DUSP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9030581
GO:0005737 cytoplasm TAS,IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DUSP9: view

Pathways & Interactions for DUSP9 Gene

PathCards logo

SuperPathways for DUSP9 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Innate Immune System
5 Signaling by GPCR
genes like me logo Genes that share pathways with DUSP9: view

Pathways by source for DUSP9 Gene

1 GeneGo (Thomson Reuters) pathway for DUSP9 Gene
  • Signal transduction_Erk Interactions- Inhibition of Erk
1 Qiagen pathway for DUSP9 Gene
  • JNK Pathway

SIGNOR curated interactions for DUSP9 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DUSP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000188 inactivation of MAPK activity IEA --
GO:0006470 protein dephosphorylation IBA 21873635
GO:0007254 JNK cascade TAS 9030581
genes like me logo Genes that share ontologies with DUSP9: view

Drugs & Compounds for DUSP9 Gene

(2) Drugs for DUSP9 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(2) Additional Compounds for DUSP9 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with DUSP9: view

Transcripts for DUSP9 Gene

mRNA/cDNA for DUSP9 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP9

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP9 Gene

No ASD Table

Relevant External Links for DUSP9 Gene

GeneLoc Exon Structure for
DUSP9

Expression for DUSP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP9 Gene

This gene is overexpressed in Kidney - Cortex (x25.6).

Protein differential expression in normal tissues from HIPED for DUSP9 Gene

This gene is overexpressed in Fetal Liver (37.9), Fetal testis (14.2), and Fetal ovary (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP9 Gene



Protein tissue co-expression partners for DUSP9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP9

SOURCE GeneReport for Unigene cluster for DUSP9 Gene:

Hs.744909

Evidence on tissue expression from TISSUES for DUSP9 Gene

  • Liver(3.5)
  • Nervous system(2.7)
  • Heart(2.6)
  • Kidney(2.6)
  • Muscle(2.5)
  • Stomach(2.4)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with DUSP9: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP9 Gene

Orthologs for DUSP9 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DUSP9 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia DUSP9 30 31
  • 89.04 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DUSP9 30 31
  • 88.68 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dusp9 30 17 31
  • 84.71 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dusp9 30
  • 81.42 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia DUSP9 31
  • 62 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DUSP9 31
  • 58 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DUSP9 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100493388 30
  • 63.23 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-195b15.8 31
  • 15 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Mkp3 31 32
  • 33 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea lip-1 31 32
  • 28 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5162 31
  • 36 (a)
OneToMany
Species where no ortholog for DUSP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DUSP9 Gene

ENSEMBL:
Gene Tree for DUSP9 (if available)
TreeFam:
Gene Tree for DUSP9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP9: view image

Paralogs for DUSP9 Gene

(10) SIMAP similar genes for DUSP9 Gene using alignment to 2 proteins:

  • DUS9_HUMAN
  • Q6P9C2_HUMAN
genes like me logo Genes that share paralogs with DUSP9: view

Variants for DUSP9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP9 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
714973 Benign: not provided 153,649,380(+) G/A SYNONYMOUS_VARIANT
723101 Likely Benign: not provided 153,650,281(+) C/T SYNONYMOUS_VARIANT
780742 Benign: not provided 153,649,332(+) C/T SYNONYMOUS_VARIANT
787522 Benign: not provided 153,649,310(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for DUSP9 Gene

Structural Variations from Database of Genomic Variants (DGV) for DUSP9 Gene

Variant ID Type Subtype PubMed ID
esv2666278 CNV deletion 23128226
esv33199 CNV gain+loss 17666407

Variation tolerance for DUSP9 Gene

Residual Variation Intolerance Score: 40.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP9 Gene

Disorders for DUSP9 Gene

Additional Disease Information for DUSP9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for DUSP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP9 Gene

Publications for DUSP9 Gene

  1. Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4. (PMID: 9030581) Muda M … Arkinstall S (The Journal of biological chemistry 1997) 2 3 4 23
  2. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PMID: 20581827) Voight BF … GIANT Consortium (Nature genetics 2010) 3 41
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  4. Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase. (PMID: 9596579) Camps M … Arkinstall S (Science (New York, N.Y.) 1998) 3 23
  5. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. (PMID: 31980649) Kennedy SA … Kolch W (Nature communications 2020) 3

Products for DUSP9 Gene

Sources for DUSP9 Gene