The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with ce... See more...

Aliases for DUSP8 Gene

Aliases for DUSP8 Gene

  • Dual Specificity Phosphatase 8 2 3 5
  • Serine/Threonine Specific Protein Phosphatase 2 3
  • Dual Specificity Protein Phosphatase HVH-5 3 4
  • H1 Phosphatase, Vaccinia Virus Homolog 2 3
  • Dual Specificity Protein Phosphatase 8 3 4
  • C11orf81 3 4
  • HVH-5 2 3
  • HB5 2 3
  • Chromosome 11 Open Reading Frame 81 2
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • FLJ42958 2
  • DUSP8 5
  • HVH8 3
  • VH5 4

External Ids for DUSP8 Gene

Previous HGNC Symbols for DUSP8 Gene

  • C11orf81

Previous GeneCards Identifiers for DUSP8 Gene

  • GC11U990030
  • GC11M001539
  • GC11M001544
  • GC11M001533
  • GC11M001368

Summaries for DUSP8 Gene

Entrez Gene Summary for DUSP8 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP8 Gene

DUSP8 (Dual Specificity Phosphatase 8) is a Protein Coding gene. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP16.

UniProtKB/Swiss-Prot Summary for DUSP8 Gene

  • Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues.

Additional gene information for DUSP8 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP8 Gene

Genomics for DUSP8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DUSP8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J001567 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.8 1836 8 HNRNPL CREB1 CTCF ATF7 ZNF629 PRDM10 RFX1 KDM1A ZNF692 RCOR2 KRTAP5-AS1 DUSP8 KRTAP5-2 KRTAP5-5 MOB2 piR-42694-025
GH11J001565 Promoter/Enhancer 0.6 EPDnew dbSUPER 600.4 +7.0 6965 0.1 MNT DUSP8 KRTAP5-2 KRTAP5-5 KRTAP5-AS1 piR-42694-025 MOB2
GH11J001382 Promoter/Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas 10.1 +189.6 189574 1.5 CREB1 ZNF629 ZNF692 BACH1 JUND ZIC2 POLR2A PATZ1 PKNOX1 ZFX TOLLIP TOLLIP-AS1 MOB2 DUSP8 BRSK2 IFITM10 HSALNG0082101 HSALNG0082100
GH11J002131 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.4 -569.3 -569267 21.1 HNRNPL GATAD2A CTCF PRDM10 TFE3 SOX13 PRDM1 RELA ZIC2 ZSCAN4 IGF2 IGF2-AS RF00483 INS-IGF2 TSSC4 CD81 ENSG00000199550 LSP1 FAM99B LINC02708
GH11J000665 Enhancer 1 Ensembl ENCODE 11 +907.0 906989 1.5 LEF1 JUND MTA2 PKNOX1 MTA1 NR2C1 BRD9 HDAC1 SOX6 FOXJ2 ENSG00000255158 TMEM80 DEAF1 DUSP8 B4GALNT4 PHRF1 HRAS piR-57460-065 EPS8L2 DRD4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP8

Top Transcription factor binding sites by QIAGEN in the DUSP8 gene promoter:
  • c-Myb
  • Chx10
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • Pax-4a
  • USF-1
  • USF1

Genomic Locations for DUSP8 Gene

Genomic Locations for DUSP8 Gene
chr11:1,554,051-1,572,839
(GRCh38/hg38)
Size:
18,789 bases
Orientation:
Minus strand
chr11:1,575,274-1,593,150
(GRCh37/hg19)
Size:
17,877 bases
Orientation:
Minus strand

Genomic View for DUSP8 Gene

Genes around DUSP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP8 Gene

Proteins for DUSP8 Gene

  • Protein details for DUSP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13202-DUS8_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 8
    Protein Accession:
    Q13202
    Secondary Accessions:
    • Q86SS8

    Protein attributes for DUSP8 Gene

    Size:
    625 amino acids
    Molecular mass:
    65827 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for DUSP8 Gene

neXtProt entry for DUSP8 Gene

Post-translational modifications for DUSP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP8 Gene

No data available for DME Specific Peptides for DUSP8 Gene

Domains & Families for DUSP8 Gene

Gene Families for DUSP8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DUSP8 Gene

Suggested Antigen Peptide Sequences for DUSP8 Gene

GenScript: Design optimal peptide antigens:
  • Dual specificity protein phosphatase hVH-5 (DUS8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13202

UniProtKB/Swiss-Prot:

DUS8_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP8: view

Function for DUSP8 Gene

Molecular function for DUSP8 Gene

UniProtKB/Swiss-Prot Function:
Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 8,vaccinia virus VH1-like 5,murine M3/6 homolog,mainly expressed in brain,lung,tighty linked to H19 but not imprinted,involved in signal transduction

Enzyme Numbers (IUBMB) for DUSP8 Gene

Phenotypes From GWAS Catalog for DUSP8 Gene

Gene Ontology (GO) - Molecular Function for DUSP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA,IBA 21873635
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA 21873635
GO:0008330 protein tyrosine/threonine phosphatase activity IBA 21873635
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DUSP8: view
genes like me logo Genes that share phenotypes with DUSP8: view

Animal Models for DUSP8 Gene

MGI Knock Outs for DUSP8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP8

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP8 Gene

Localization for DUSP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP8 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 2
mitochondrion 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DUSP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with DUSP8: view

Pathways & Interactions for DUSP8 Gene

PathCards logo

SuperPathways for DUSP8 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Innate Immune System
5 Signaling by GPCR
genes like me logo Genes that share pathways with DUSP8: view

Pathways by source for DUSP8 Gene

SIGNOR curated interactions for DUSP8 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DUSP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IBA,ISS --
GO:0006470 protein dephosphorylation IEA,IBA 21873635
GO:0016311 dephosphorylation ISS --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA,IBA 21873635
GO:0035970 peptidyl-threonine dephosphorylation IBA 21873635
genes like me logo Genes that share ontologies with DUSP8: view

Drugs & Compounds for DUSP8 Gene

(3) Drugs for DUSP8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Calcium Nutra 6556

(1) Additional Compounds for DUSP8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with DUSP8: view

Transcripts for DUSP8 Gene

mRNA/cDNA for DUSP8 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP8

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP8 Gene

No ASD Table

Relevant External Links for DUSP8 Gene

GeneLoc Exon Structure for
DUSP8

Expression for DUSP8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUSP8 Gene

This gene is overexpressed in Platelet (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP8 Gene



Protein tissue co-expression partners for DUSP8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP8

SOURCE GeneReport for Unigene cluster for DUSP8 Gene:

Hs.41688

mRNA Expression by UniProt/SwissProt for DUSP8 Gene:

Q13202-DUS8_HUMAN
Tissue specificity: Abundant in brain, heart and skeletal muscle.

Evidence on tissue expression from TISSUES for DUSP8 Gene

  • Nervous system(4.6)
  • Skin(4.3)
  • Heart(2.3)
  • Kidney(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with DUSP8: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP8 Gene

Orthologs for DUSP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DUSP8 31
  • 97 (a)
OneToOne
LOC746336 30
  • 96.46 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia DUSP8 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia DUSP8 30 31
  • 87.8 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dusp8 30 17 31
  • 85.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dusp8 30
  • 85.02 (n)
Cow
(Bos Taurus)
Mammalia DUSP8 31
  • 85 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DUSP8 31
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DUSP8 30 31
  • 72.09 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DUSP8 31
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.18203 30
Zebrafish
(Danio rerio)
Actinopterygii dusp8a 30 31
  • 61.73 (n)
OneToMany
DUSP8 (2 of 2) 31
  • 47 (a)
OneToMany
-- 30
Worm
(Caenorhabditis elegans)
Secernentea vhp-1 31 32
  • 27 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 22 (a)
OneToMany
Species where no ortholog for DUSP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DUSP8 Gene

ENSEMBL:
Gene Tree for DUSP8 (if available)
TreeFam:
Gene Tree for DUSP8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP8: view image

Paralogs for DUSP8 Gene

(11) SIMAP similar genes for DUSP8 Gene using alignment to 1 proteins:

  • DUS8_HUMAN

Pseudogenes.org Pseudogenes for DUSP8 Gene

genes like me logo Genes that share paralogs with DUSP8: view

Variants for DUSP8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP8 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
769792 Benign: not provided 1,557,802(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for DUSP8 Gene

Structural Variations from Database of Genomic Variants (DGV) for DUSP8 Gene

Variant ID Type Subtype PubMed ID
dgv1553n54 CNV loss 21841781
nsv1069543 CNV deletion 25765185
nsv1112600 CNV deletion 24896259
nsv1112601 CNV deletion 24896259
nsv552989 CNV loss 21841781
nsv552996 CNV loss 21841781
nsv7641 CNV insertion 18451855

Variation tolerance for DUSP8 Gene

Gene Damage Index Score: 1.06; 21.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP8 Gene

Disorders for DUSP8 Gene

No disorders were found for DUSP8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP8 Gene

Publications for DUSP8 Gene

  1. Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2. (PMID: 9192849) Nesbit MA … Davies KE (Genomics 1997) 2 3 23
  2. hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. (PMID: 7561881) Martell KJ … Dixon JE (Journal of neurochemistry 1995) 2 3 4
  3. Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2. (PMID: 15899389) Berger IR … Ullrich A (Cancer genetics and cytogenetics 2005) 3 23
  4. Investigation of DUSP8 and CALCA in alcohol dependence. (PMID: 13129832) Hink RL … Sikela JM (Addiction biology 2003) 3 23
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for DUSP8 Gene

Sources for DUSP8 Gene