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Aliases for DUSP7 Gene

Aliases for DUSP7 Gene

  • Dual Specificity Phosphatase 7 2 3 5
  • Dual Specificity Protein Phosphatase PYST2 3 4
  • PYST2 3 4
  • Dual Specificity Protein Phosphatase 7 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • MKPX 3

External Ids for DUSP7 Gene

Previous GeneCards Identifiers for DUSP7 Gene

  • GC03M051176
  • GC03M051336
  • GC03M051940
  • GC03M052042
  • GC03M052059

Summaries for DUSP7 Gene

Entrez Gene Summary for DUSP7 Gene

  • Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

GeneCards Summary for DUSP7 Gene

DUSP7 (Dual Specificity Phosphatase 7) is a Protein Coding gene. Among its related pathways are Activated TLR4 signalling and Nuclear Events (kinase and transcription factor activation). Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP6.

UniProtKB/Swiss-Prot for DUSP7 Gene

  • Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.

Gene Wiki entry for DUSP7 Gene

Additional gene information for DUSP7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP7 Gene

Genomics for DUSP7 Gene

GeneHancer (GH) Regulatory Elements for DUSP7 Gene

Promoters and enhancers for DUSP7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J052044 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 661 +4.9 4928 14 HDGF PKNOX1 CLOCK ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF416 DUSP7 DCAF1 GPR62 RAD54L2 PHF7 NT5DC2 RPL29 PCBP4 WDR82 SFMBT1
GH03J052153 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.9 -97.9 -97915 2.6 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B POC1A RRP9 RAD54L2 PBRM1 RFT1 DUSP7 ABHD14A-ACY1 ABHD14B PCBP4 ACY1
GH03J052086 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13 -33.0 -33013 6.2 EGR1 SCRT2 FOS ETV6 CEBPB REST NR2F2 IKZF1 NR2C1 KDM1A GPR62 DUSP7 PCBP4 ABHD14B PPM1M GLYCTK LINC00696 POC1A
GH03J052210 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.1 -154.5 -154545 2.1 ATF1 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 SLC30A9 FOS ATF7 DCAF1 ENSG00000173366 TWF2 LOC101929054 PPM1M WDR82 MIR135A1 GLYCTK-AS1 GLYCTK POC1A
GH03J052108 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 12.9 -52.9 -52937 2.9 CTCF ATF4 RFX1 NCOR1 SCRT2 REST CHD2 NR2F2 DUSP7 ABHD14B PCBP4 ABHD14A ABHD14A-ACY1 GPR62 WDR82 GLYCTK MIR135A1 GLYCTK-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUSP7 gene promoter:
  • AP-2gamma
  • MyoD
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • Nkx2-2
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b

Genomic Locations for DUSP7 Gene

Genomic Locations for DUSP7 Gene
chr3:52,048,919-52,056,550
(GRCh38/hg38)
Size:
7,632 bases
Orientation:
Minus strand
chr3:52,082,935-52,090,566
(GRCh37/hg19)
Size:
7,632 bases
Orientation:
Minus strand

Genomic View for DUSP7 Gene

Genes around DUSP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP7 Gene

Proteins for DUSP7 Gene

  • Protein details for DUSP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16829-DUS7_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 7
    Protein Accession:
    Q16829
    Secondary Accessions:
    • Q2M3J7
    • Q8NFJ0

    Protein attributes for DUSP7 Gene

    Size:
    419 amino acids
    Molecular mass:
    44957 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP7 Gene

    Alternative splice isoforms for DUSP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP7 Gene

Post-translational modifications for DUSP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP7 Gene

Domains & Families for DUSP7 Gene

Gene Families for DUSP7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DUSP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16829

UniProtKB/Swiss-Prot:

DUS7_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP7: view

Function for DUSP7 Gene

Molecular function for DUSP7 Gene

UniProtKB/Swiss-Prot Function:
Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 7,involved in signal transduction

Enzyme Numbers (IUBMB) for DUSP7 Gene

Gene Ontology (GO) - Molecular Function for DUSP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity TAS --
GO:0005515 protein binding IPI 12907755
GO:0008138 protein tyrosine/serine/threonine phosphatase activity TAS,IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DUSP7: view
genes like me logo Genes that share phenotypes with DUSP7: view

Animal Models for DUSP7 Gene

MGI Knock Outs for DUSP7:
  • Dusp7 Dusp7<tm1(KOMP)Wtsi>

Animal Model Products

miRNA for DUSP7 Gene

miRTarBase miRNAs that target DUSP7

Clone Products

  • Addgene plasmids for DUSP7

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP7 Gene

Localization for DUSP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP7 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for DUSP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DUSP7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DUSP7 Gene

Pathways & Interactions for DUSP7 Gene

SuperPathways for DUSP7 Gene

SuperPathway Contained pathways
1 RET signaling
2 Activated TLR4 signalling
3 Nuclear Events (kinase and transcription factor activation)
4 MAPK signaling pathway
5 Developmental Biology
genes like me logo Genes that share pathways with DUSP7: view

Pathways by source for DUSP7 Gene

1 BioSystems pathway for DUSP7 Gene
1 KEGG pathway for DUSP7 Gene
1 GeneGo (Thomson Reuters) pathway for DUSP7 Gene
1 Qiagen pathway for DUSP7 Gene

SIGNOR curated interactions for DUSP7 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DUSP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000188 inactivation of MAPK activity IEA --
GO:0006470 protein dephosphorylation IEA,IBA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP7: view

Drugs & Compounds for DUSP7 Gene

(3) Drugs for DUSP7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0

(1) Additional Compounds for DUSP7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14265-44-2
genes like me logo Genes that share compounds with DUSP7: view

Transcripts for DUSP7 Gene

mRNA/cDNA for DUSP7 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUSP7 Gene

Dual specificity phosphatase 7:
Representative Sequences:

Clone Products

  • Addgene plasmids for DUSP7

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP7 Gene

No ASD Table

Relevant External Links for DUSP7 Gene

GeneLoc Exon Structure for
DUSP7
ECgene alternative splicing isoforms for
DUSP7

Expression for DUSP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUSP7 Gene

This gene is overexpressed in Platelet (31.3), Adipocyte (24.7), and Peripheral blood mononuclear cells (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP7 Gene



Protein tissue co-expression partners for DUSP7 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUSP7 Gene:

DUSP7

SOURCE GeneReport for Unigene cluster for DUSP7 Gene:

Hs.591664

mRNA Expression by UniProt/SwissProt for DUSP7 Gene:

Q16829-DUS7_HUMAN
Tissue specificity: Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells.

Evidence on tissue expression from TISSUES for DUSP7 Gene

  • Nervous system(4.5)
  • Blood(4.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with DUSP7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP7 Gene

Orthologs for DUSP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP7 34 33
  • 96.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP7 34 33
  • 93.4 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP7 34 33
  • 93.32 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp7 16 34 33
  • 92.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP7 34
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUSP7 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp7 33
  • 91.73 (n)
chicken
(Gallus gallus)
Aves DUSP7 34
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP7 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp7 33
  • 73.15 (n)
Str.14313 33
zebrafish
(Danio rerio)
Actinopterygii dusp7 34 33
  • 80.22 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012237 33
  • 54.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mkp3 34 35 33
  • 52.91 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lip-1 34 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5162 34
  • 39 (a)
OneToMany
Species where no ortholog for DUSP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP7 Gene

ENSEMBL:
Gene Tree for DUSP7 (if available)
TreeFam:
Gene Tree for DUSP7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP7: view image

Paralogs for DUSP7 Gene

Paralogs for DUSP7 Gene

(12) SIMAP similar genes for DUSP7 Gene using alignment to 2 proteins:

  • DUS7_HUMAN
  • H7C4Z0_HUMAN
genes like me logo Genes that share paralogs with DUSP7: view

Variants for DUSP7 Gene

Sequence variations from dbSNP and Humsavar for DUSP7 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000349886 -- 52,056,935(-) G/A upstream_transcript_variant
rs1000506427 -- 52,053,957(-) T/C coding_sequence_variant, missense_variant
rs1000876973 -- 52,053,754(-) A/G intron_variant
rs1001350503 -- 52,050,804(-) T/G 3_prime_UTR_variant
rs1001485135 -- 52,057,494(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP7 Gene

Variant ID Type Subtype PubMed ID
dgv8323n54 CNV loss 21841781
dgv8324n54 CNV gain 21841781
dgv8325n54 CNV loss 21841781
esv25634 CNV loss 19812545
nsv1003453 CNV gain 25217958
nsv1072692 CNV deletion 25765185
nsv1136363 CNV deletion 24896259
nsv508923 CNV insertion 20534489
nsv519445 CNV gain+loss 19592680
nsv520211 CNV gain 19592680
nsv590281 CNV loss 21841781
nsv590282 CNV gain 21841781
nsv590289 CNV gain+loss 21841781
nsv590296 CNV gain 21841781
nsv954857 CNV deletion 24416366

Variation tolerance for DUSP7 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP7 Gene

Disorders for DUSP7 Gene

Additional Disease Information for DUSP7

No disorders were found for DUSP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP7 Gene

Publications for DUSP7 Gene

  1. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PMID: 9205128) Smith A … Ashworth A (Genomics 1997) 2 3 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Characterization of the dual-specificity phosphatase PYST2 and its transcripts. (PMID: 14603440) Levy-Nissenbaum O … Witz IP (Genes, chromosomes & cancer 2004) 3 4 58
  4. cDNA microarray analysis reveals an overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia. (PMID: 14674243) Levy-Nissenbaum O … Witz IP (Methods in enzymology 2003) 3 22 58
  5. Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells. (PMID: 14576828) Levy-Nissenbaum O … Witz IP (Oncogene 2003) 3 4 58

Products for DUSP7 Gene

  • Addgene plasmids for DUSP7

Sources for DUSP7 Gene

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