DUSP6 Gene (Protein Coding)

Dual Specificity Phosphatase 6

GC12M089347
GIFtS:
48
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with c... See more...

Aliases for DUSP6 Gene

Aliases for DUSP6 Gene

  • Dual Specificity Phosphatase 6 2 3 5
  • PYST1 2 3 4
  • Mitogen-Activated Protein Kinase Phosphatase 3 3 4
  • Dual Specificity Protein Phosphatase PYST1 3 4
  • Dual Specificity Protein Phosphatase 6 3 4
  • MAP Kinase Phosphatase 3 3 4
  • MKP-3 2 4
  • MKP3 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DUSP6 5
  • HH19 3

External Ids for DUSP6 Gene

Previous GeneCards Identifiers for DUSP6 Gene

  • GC12M089159
  • GC12M090189
  • GC12M089674
  • GC12M088244
  • GC12M089741
  • GC12M086807

Summaries for DUSP6 Gene

Entrez Gene Summary for DUSP6 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]

CIViC Summary for DUSP6 Gene

GeneCards Summary for DUSP6 Gene

DUSP6 (Dual Specificity Phosphatase 6) is a Protein Coding gene. Diseases associated with DUSP6 include Hypogonadotropic Hypogonadism 19 With Or Without Anosmia and Normosmic Congenital Hypogonadotropic Hypogonadism. Among its related pathways are Transcriptional misregulation in cancer and RET signaling. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP7.

UniProtKB/Swiss-Prot Summary for DUSP6 Gene

  • Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977).

Gene Wiki entry for DUSP6 Gene

Additional gene information for DUSP6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP6 Gene

Genomics for DUSP6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for DUSP6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP6

Top Transcription factor binding sites by QIAGEN in the DUSP6 gene promoter:
  • AML1a

Genomic Locations for DUSP6 Gene

Genomic Locations for DUSP6 Gene
chr12:89,347,235-89,352,501
(GRCh38/hg38)
Size:
5,267 bases
Orientation:
Minus strand
chr12:89,741,009-89,747,048
(GRCh37/hg19)
Size:
6,040 bases
Orientation:
Minus strand

Genomic View for DUSP6 Gene

Genes around DUSP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DUSP6 Gene

Proteins for DUSP6 Gene

Products:

  1. Antibody
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  • Protein details for DUSP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16828-DUS6_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 6
    Protein Accession:
    Q16828
    Secondary Accessions:
    • O75109
    • Q53Y75
    • Q9BSH6

    Protein attributes for DUSP6 Gene

    Size:
    381 amino acids
    Molecular mass:
    42320 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP6 Gene

    Alternative splice isoforms for DUSP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP6 Gene

Protein Expression for DUSP6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DUSP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP6 Gene

Domains & Families for DUSP6 Gene

Gene Families for DUSP6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for DUSP6 Gene

InterPro:
Blocks:
  • Rhodanese-like
  • Dual specificity protein phosphatase
ProtoNet:

Suggested Antigen Peptide Sequences for DUSP6 Gene

GenScript: Design optimal peptide antigens:
  • Dual specificity protein phosphatase (B5BU29_HUMAN)
  • Mitogen-activated protein kinase phosphatase 3 (DUS6_HUMAN)
  • Dual specificity phosphatase 6 (Q689E8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16828

UniProtKB/Swiss-Prot:

DUS6_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP6: view

Function for DUSP6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for DUSP6 Gene

UniProtKB/Swiss-Prot Function:
Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 6,including two transcripts,ubiquitously expressed,involved in signal transduction altered in pancreatic ductal carcinogenesis

Enzyme Numbers (IUBMB) for DUSP6 Gene

Phenotypes From GWAS Catalog for DUSP6 Gene

Gene Ontology (GO) - Molecular Function for DUSP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA,IBA 21873635
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 12840032
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA,IBA 21873635
GO:0008330 protein tyrosine/threonine phosphatase activity IBA 21873635
genes like me logo Genes that share ontologies with DUSP6: view
genes like me logo Genes that share phenotypes with DUSP6: view

Human Phenotype Ontology for DUSP6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DUSP6 Gene

MGI Knock Outs for DUSP6:

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP6

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP6

No data available for Transcription Factor Targets and HOMER Transcription for DUSP6 Gene

Localization for DUSP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP6 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DUSP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IBA,IDA 8670865
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with DUSP6: view

Pathways & Interactions for DUSP6 Gene

PathCards logo

SuperPathways for DUSP6 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
3 Nuclear Events (kinase and transcription factor activation)
ERK/MAPK targets
.88
Nuclear Events (kinase and transcription factor activation)
.88
MAPK targets/ Nuclear events mediated by MAP kinases
.81
ERKs are inactivated
.01
4 MAPK signaling pathway
MAPK signaling pathway
.45
MAPK Signaling Pathway
.45
5 MAPK Erk Pathway
G Protein coupled Receptors Signaling
.32
MAPK Erk Pathway
.32
genes like me logo Genes that share pathways with DUSP6: view

Pathways by source for DUSP6 Gene

2 Sino Biological pathways for DUSP6 Gene
2 BioSystems pathways for DUSP6 Gene
1 GeneGo (Thomson Reuters) pathway for DUSP6 Gene
  • Signal transduction_Erk Interactions- Inhibition of Erk
1 Qiagen pathway for DUSP6 Gene
  • JNK Pathway
1 Cell Signaling Technology pathway for DUSP6 Gene

SIGNOR curated interactions for DUSP6 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DUSP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000188 inactivation of MAPK activity IEA,IDA 8670865
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0006470 protein dephosphorylation IEA,IBA 21873635
genes like me logo Genes that share ontologies with DUSP6: view

Drugs & Compounds for DUSP6 Gene

Products:

  1. Drug

(9) Drugs for DUSP6 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Calcium Nutra 6556

(7) Additional Compounds for DUSP6 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
 14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with DUSP6: view

Transcripts for DUSP6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DUSP6 Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP6

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: -
SP3:
SP4: - - -
SP5:

Relevant External Links for DUSP6 Gene

GeneLoc Exon Structure for
DUSP6

Expression for DUSP6 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP6 Gene

mRNA expression in normal human tissues for DUSP6 Gene
mRNA expression by BioGPS for DUSP6 GenemRNA expression by GTEx for DUSP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUSP6 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP6 Gene



Protein tissue co-expression partners for DUSP6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP6

SOURCE GeneReport for Unigene cluster for DUSP6 Gene:

Hs.298654

mRNA Expression by UniProt/SwissProt for DUSP6 Gene:

Q16828-DUS6_HUMAN
Tissue specificity: Expressed in keratinocytes (at protein level).

Evidence on tissue expression from TISSUES for DUSP6 Gene

  • Skin(4.7)
  • Nervous system(4.7)
  • Intestine(4.7)
  • Liver(4.7)
  • Kidney(4.6)
  • Stomach(4.4)
  • Blood(4.3)
  • Lung(4.3)
  • Spleen(3.9)
  • Bone marrow(2.8)
  • Thyroid gland(2.7)
  • Heart(2.7)
  • Muscle(2.6)
  • Lymph node(2.5)
  • Adrenal gland(2.4)
  • Eye(2.3)
  • Pancreas(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP6 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • face
  • head
  • hypothalamus
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • olfactory bulb
  • pharynx
  • pituitary gland
  • skull
  • vocal cord
Thorax:
  • breast
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • kidney
Pelvis:
  • fallopian tube
  • ovary
  • pelvis
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vas deferens
  • vulva
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with DUSP6: view

No data available for mRNA differential expression in normal tissues for DUSP6 Gene

Orthologs for DUSP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia DUSP6 30 31
  • 99.65 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia DUSP6 31
  • 95 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia DUSP6 30 31
  • 94.4 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia DUSP6 30 31
  • 93.88 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia DUSP6 31
  • 93 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Dusp6 30
  • 91.6 (n)
Mouse
(Mus musculus)
 Mammalia Dusp6 30 17 31
  • 90.64 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves MKP3 31
  • 93 (a)
 OneToOne
DUSP6 30
  • 85.21 (n)
Lizard
(Anolis carolinensis)
 Reptilia DUSP6 31
  • 79 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia dusp6 30
  • 79.37 (n)
Str.10337 30
African clawed frog
(Xenopus laevis)
 Amphibia MGC68682 30
Zebrafish
(Danio rerio)
 Actinopterygii dusp6 30 31
  • 73.77 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta Mkp3 31 32
  • 36 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea lip-1 31 32
  • 28 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.5162 31
  • 39 (a)
 OneToMany
Species where no ortholog for DUSP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DUSP6 Gene

ENSEMBL:
Gene Tree for DUSP6 (if available)
TreeFam:
Gene Tree for DUSP6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP6: view image

Paralogs for DUSP6 Gene

Paralogs for DUSP6 Gene

(13) SIMAP similar genes for DUSP6 Gene using alignment to 5 proteins:

  • DUS6_HUMAN
  • B5BU29_HUMAN
  • F8VW29_HUMAN
  • F8VZA4_HUMAN
  • Q689E8_HUMAN
genes like me logo Genes that share paralogs with DUSP6: view

Variants for DUSP6 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP6 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
710023 Benign: not provided 89,351,633(-) C/A INTRON_VARIANT
726479 Likely Benign: not provided 89,351,788(-) G/A SYNONYMOUS_VARIANT
735328 Benign: not provided 89,349,443(-) G/A SYNONYMOUS_VARIANT
741504 Likely Benign: not provided 89,349,305(-) G/A SYNONYMOUS_VARIANT
749814 Likely Benign: not provided 89,351,755(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for DUSP6 Gene

Variation tolerance for DUSP6 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.53; 97.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP6 Gene

Human Gene Mutation Database (HGMD)
DUSP6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DUSP6 Gene

Disorders for DUSP6 Gene

MalaCards: The human disease database

(9) MalaCards diseases for DUSP6 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search DUSP6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DUS6_HUMAN
  • Hypogonadotropic hypogonadism 19 with or without anosmia (HH19) [MIM:615269]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:23643382}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in DUSP6 also have a heterozygous mutation in another HH-associated gene including FGFR1 and SPRY4 (PubMed:23643382). {ECO:0000269 PubMed:23643382}.

Additional Disease Information for DUSP6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
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Publications for DUSP6 Gene

  1. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PMID: 9205128) Smith A … Ashworth A (Genomics 1997) 2 3 23
  2. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. (PMID: 8626780) Muda M … Arkinstall S (The Journal of biological chemistry 1996) 2 3 23
  3. Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells. (PMID: 20097731) Zhang Z … Halmos B (Carcinogenesis 2010) 3 23
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41

ExternalLinks

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Products for DUSP6 Gene

  • Addgene plasmids for DUSP6

Sources for DUSP6 Gene