The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated wit... See more...

Aliases for DUSP5 Gene

Aliases for DUSP5 Gene

  • Dual Specificity Phosphatase 5 2 3 5
  • Dual Specificity Protein Phosphatase HVH3 3 4
  • Dual Specificity Protein Phosphatase 5 3 4
  • HVH3 2 3
  • Serine/Threonine Specific Protein Phosphatase 3
  • VH1-Like Phosphatase 3 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DUSP5 5
  • DUSP 3
  • VH3 4

External Ids for DUSP5 Gene

Previous GeneCards Identifiers for DUSP5 Gene

  • GC10P111150
  • GC10P111491
  • GC10P112388
  • GC10P111922
  • GC10P111889
  • GC10P112247
  • GC10P105887

Summaries for DUSP5 Gene

Entrez Gene Summary for DUSP5 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP5 Gene

DUSP5 (Dual Specificity Phosphatase 5) is a Protein Coding gene. Diseases associated with DUSP5 include Lymphoma, Mucosa-Associated Lymphoid Type and Schuurs-Hoeijmakers Syndrome. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot Summary for DUSP5 Gene

  • Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.

Gene Wiki entry for DUSP5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP5 Gene

Genomics for DUSP5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DUSP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J110495 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 606.4 +2.9 2933 10.9 SP1 CREB1 TEAD4 PRDM10 ZNF629 LEF1 IKZF1 KDM1A ZNF692 POLR2A DUSP5 SMC3 XPNPEP1 MXI1 BBIP1 SHOC2 PDCD4 ENSG00000273143 lnc-SMNDC1-3 RF00017-801
GH10J110419 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18 -71.9 -71906 14 CREB1 PRDM10 ZNF512 RFX1 LEF1 IKZF1 BACH1 JUND FOXA1 RELA DUSP5 SMNDC1 SMC3 HMGB3P5 BBIP1 SHOC2 HSALNG0080579 LOC105378482 ENSG00000273143
GH10J110406 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 15.7 -86.2 -86185 9.8 SP1 CREB1 GATAD2A REST ZNF512 RCOR2 BACH1 TARDBP FOXA1 LARP7 DUSP5 SMNDC1 SMC3 HSALNG0080579 HSALNG0080577
GH10J110535 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 17.2 +38.5 38511 1.2 SP1 CTCF BACH1 JUND LARP7 ZNF143 RELA REST RAD21 TCF12 lnc-DUSP5-4 DUSP5 SHOC2 BBIP1 lnc-DUSP5-2 SMC3
GH10J110352 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 14.9 -141.8 -141825 7.2 SP1 CTCF TEAD4 KDM1A POLR2A BACH1 FOXA1 LARP7 STAT3 ZNF143 HSALNG0080572 DUSP5 SMNDC1 MXI1 piR-58297-059
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP5

Top Transcription factor binding sites by QIAGEN in the DUSP5 gene promoter:
  • Egr-2
  • p53
  • Pax-2
  • Pax-2a
  • Spz1
  • SRF
  • SRF (504 AA)
  • STAT5A

Genomic Locations for DUSP5 Gene

Genomic Locations for DUSP5 Gene
chr10:110,497,907-110,511,533
(GRCh38/hg38)
Size:
13,627 bases
Orientation:
Plus strand
chr10:112,257,596-112,271,302
(GRCh37/hg19)
Size:
13,707 bases
Orientation:
Plus strand

Genomic View for DUSP5 Gene

Genes around DUSP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP5 Gene

Proteins for DUSP5 Gene

  • Protein details for DUSP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16690-DUS5_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 5
    Protein Accession:
    Q16690
    Secondary Accessions:
    • Q12997
    • Q5T603

    Protein attributes for DUSP5 Gene

    Size:
    384 amino acids
    Molecular mass:
    42047 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP5 Gene

neXtProt entry for DUSP5 Gene

Post-translational modifications for DUSP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP5 Gene

Domains & Families for DUSP5 Gene

Gene Families for DUSP5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DUSP5 Gene

Suggested Antigen Peptide Sequences for DUSP5 Gene

GenScript: Design optimal peptide antigens:
  • Dual specificity protein phosphatase hVH3 (DUS5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16690

UniProtKB/Swiss-Prot:

DUS5_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP5: view

Function for DUSP5 Gene

Molecular function for DUSP5 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000269|PubMed:7961985};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:7961985};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:7961985};.
GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 5,non receptor,involved in signal transduction

Enzyme Numbers (IUBMB) for DUSP5 Gene

Phenotypes From GWAS Catalog for DUSP5 Gene

Gene Ontology (GO) - Molecular Function for DUSP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA,IBA 21873635
GO:0004725 protein tyrosine phosphatase activity TAS 7961985
GO:0005515 protein binding IPI 15713638
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA,IDA 7961985
GO:0008330 protein tyrosine/threonine phosphatase activity IBA 21873635
genes like me logo Genes that share ontologies with DUSP5: view
genes like me logo Genes that share phenotypes with DUSP5: view

Animal Models for DUSP5 Gene

MGI Knock Outs for DUSP5:
  • Dusp5 Dusp5<tm1.1Achn>
  • Dusp5 Dusp5<tm1a(KOMP)Wtsi>
  • Dusp5 Dusp5<tm1d(KOMP)Wtsi>
  • Dusp5 Dusp5<tm1.1Skey>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP5 Gene

Localization for DUSP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP5 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DUSP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with DUSP5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DUSP5 Gene

Pathways & Interactions for DUSP5 Gene

PathCards logo

SuperPathways for DUSP5 Gene

SuperPathway Contained pathways
1 RET signaling
2 MAPK signaling pathway
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 Innate Immune System
genes like me logo Genes that share pathways with DUSP5: view

SIGNOR curated interactions for DUSP5 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DUSP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000188 inactivation of MAPK activity IBA 21873635
GO:0001706 endoderm formation IBA 21873635
GO:0006470 protein dephosphorylation TAS,IBA 21873635
genes like me logo Genes that share ontologies with DUSP5: view

Drugs & Compounds for DUSP5 Gene

(5) Drugs for DUSP5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Calcium Nutra 6556

(2) Additional Compounds for DUSP5 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with DUSP5: view

Transcripts for DUSP5 Gene

mRNA/cDNA for DUSP5 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP5

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for DUSP5 Gene

GeneLoc Exon Structure for
DUSP5

Expression for DUSP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP5 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.9).

Protein differential expression in normal tissues from HIPED for DUSP5 Gene

This gene is overexpressed in Plasma (52.4) and Urine (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP5 Gene



Protein tissue co-expression partners for DUSP5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP5

SOURCE GeneReport for Unigene cluster for DUSP5 Gene:

Hs.2128

Evidence on tissue expression from TISSUES for DUSP5 Gene

  • Nervous system(3.3)
  • Skin(3.1)
  • Lymph node(3)
  • Spleen(2.9)
  • Blood(2.8)
  • Bone marrow(2.8)
  • Heart(2.7)
  • Intestine(2.7)
  • Liver(2.6)
  • Lung(2.4)
  • Kidney(2.4)
  • Muscle(2.3)
  • Thyroid gland(2.1)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with DUSP5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP5 Gene

Orthologs for DUSP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DUSP5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DUSP5 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia DUSP5 30 31
  • 93.02 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DUSP5 30 31
  • 91.58 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dusp5 30 17 31
  • 90.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dusp5 30
  • 90.36 (n)
Oppossum
(Monodelphis domestica)
Mammalia DUSP5 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DUSP5 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DUSP5 30 31
  • 73.88 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DUSP5 31
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dusp5 30
  • 66.22 (n)
Str.4744 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15374 30
Zebrafish
(Danio rerio)
Actinopterygii dusp5 30 31
  • 61.6 (n)
OneToOne
wufc86e02 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 32 (a)
OneToMany
Species where no ortholog for DUSP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DUSP5 Gene

ENSEMBL:
Gene Tree for DUSP5 (if available)
TreeFam:
Gene Tree for DUSP5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP5: view image

Paralogs for DUSP5 Gene

(6) SIMAP similar genes for DUSP5 Gene using alignment to 1 proteins:

  • DUS5_HUMAN

Pseudogenes.org Pseudogenes for DUSP5 Gene

genes like me logo Genes that share paralogs with DUSP5: view

Variants for DUSP5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP5 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
735161 Benign: not provided 110,510,234(+) G/C SYNONYMOUS_VARIANT
780891 Benign: not provided 110,498,284(+) G/T MISSENSE_VARIANT
rs1889565 - p.Ala220Val
rs1889566 - p.Ala220Thr
rs2282238 - p.Glu154Asp

Additional dbSNP identifiers (rs#s) for DUSP5 Gene

Structural Variations from Database of Genomic Variants (DGV) for DUSP5 Gene

Variant ID Type Subtype PubMed ID
nsv1069964 CNV deletion 25765185
nsv1143515 CNV deletion 24896259
nsv467454 CNV gain 19166990
nsv526452 CNV gain 19592680
nsv552171 CNV gain 21841781
nsv7211 OTHER inversion 18451855

Variation tolerance for DUSP5 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP5 Gene

Disorders for DUSP5 Gene

MalaCards: The human disease database

(5) MalaCards diseases for DUSP5 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search DUSP5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DUSP5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with DUSP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP5 Gene

Publications for DUSP5 Gene

  1. Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines. (PMID: 7836374) Kwak SP … Dixon JE (The Journal of biological chemistry 1995) 3 4 23
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 41
  4. Crystal structure of the catalytic domain of human DUSP5, a dual specificity MAP kinase protein phosphatase. (PMID: 17078075) Jeong DG … Kim SJ (Proteins 2007) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41

Products for DUSP5 Gene

Sources for DUSP5 Gene