The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with c... See more...

Aliases for DUSP3 Gene

Aliases for DUSP3 Gene

  • Dual Specificity Phosphatase 3 2 3 5
  • Dual Specificity Protein Phosphatase VHR 3 4
  • Vaccinia Virus Phosphatase VH1-Related 2 3
  • Dual Specificity Protein Phosphatase 3 3 4
  • Vaccinia H1-Related Phosphatase 3 4
  • VHR 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DUSP3 5

External Ids for DUSP3 Gene

Previous HGNC Symbols for DUSP3 Gene

  • VHR

Previous GeneCards Identifiers for DUSP3 Gene

  • GC17M041587
  • GC17M044020
  • GC17M041856
  • GC17M042320
  • GC17M042318
  • GC17M039199
  • GC17M037607
  • GC17M041843

Summaries for DUSP3 Gene

Entrez Gene Summary for DUSP3 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP3 Gene

DUSP3 (Dual Specificity Phosphatase 3) is a Protein Coding gene. Diseases associated with DUSP3 include Vaccinia and Cervix Carcinoma. Among its related pathways are Activated TLR4 signalling and Nuclear Events (kinase and transcription factor activation). Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is STYXL2.

UniProtKB/Swiss-Prot Summary for DUSP3 Gene

  • Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

Gene Wiki entry for DUSP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP3 Gene

Genomics for DUSP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DUSP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J043777 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 257.5 +0.3 321 2.7 EZH2 SP1 MYC ZNF600 JUND ATF2 POLR2A ATF3 BRCA1 ZIC2 DUSP3 CFAP97D1 lnc-SOST-1 piR-54942 ASB16-AS1 UBTF TMUB2 ENSG00000267681 DHX8 ENSG00000267340
GH17J043780 Promoter 0.3 EPDnew 250.7 -1.4 -1439 0.1 CFAP97D1 DUSP3 piR-54942
GH17J043832 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 -53.5 -53524 2.6 ZNF223 ZIC2 NFIC NONO SMAD5 ZNF341 KLF7 MAX THAP11 KLF9 MPP3 LOC107984979 CFAP97D1 DUSP3 ENSG00000267405 HSALNG0116684
GH17J043846 Enhancer 0.8 ENCODE 11 -67.6 -67612 0.8 ZNF654 ZNF600 CEBPA CTCF REST TRIM22 HOMEZ KMT2B THAP11 SMAD4 CD300LG CFAP97D1 DUSP3 SOST ENSG00000221044 LOC107984979 MPP3
GH17J043558 Enhancer 0.9 Ensembl 10.3 +219.3 219276 1.8 IKZF1 SSRP1 ZMYM3 KLF9 CEBPA CHD4 MXD4 KLF11 ZFP64 FOXA2 ETV4 DHX8 ENSG00000267681 ASB16-AS1 LINC00910 MEOX1 UBTF VPS25 PLEKHH3 TMUB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP3

Top Transcription factor binding sites by QIAGEN in the DUSP3 gene promoter:
  • aMEF-2
  • CBF(2)
  • MEF-2
  • MEF-2A
  • MyoD
  • NF-AT
  • NF-AT4
  • NF-Y
  • p53
  • Sp1

Genomic Locations for DUSP3 Gene

Latest Assembly
chr17:43,766,125-43,778,977
(GRCh38/hg38)
Size:
12,853 bases
Orientation:
Minus strand

Previous Assembly
chr17:41,843,493-41,856,345
(GRCh37/hg19 by Entrez Gene)
Size:
12,853 bases
Orientation:
Minus strand

chr17:41,843,489-41,856,356
(GRCh37/hg19 by Ensembl)
Size:
12,868 bases
Orientation:
Minus strand

Genomic View for DUSP3 Gene

Genes around DUSP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP3 Gene

Proteins for DUSP3 Gene

  • Protein details for DUSP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51452-DUS3_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 3
    Protein Accession:
    P51452
    Secondary Accessions:
    • D3DX45
    • Q5U0J1
    • Q8IYJ9

    Protein attributes for DUSP3 Gene

    Size:
    185 amino acids
    Molecular mass:
    20478 Da
    Quaternary structure:
    • Interacts with VRK3, which seems to activate it's phosphatase activity.

    Three dimensional structures from OCA and Proteopedia for DUSP3 Gene

    Alternative splice isoforms for DUSP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP3 Gene

Post-translational modifications for DUSP3 Gene

  • Ubiquitination at Lys53 and Lys116
  • Modification sites at PhosphoSitePlus

Other Protein References for DUSP3 Gene

No data available for DME Specific Peptides for DUSP3 Gene

Domains & Families for DUSP3 Gene

Gene Families for DUSP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DUSP3 Gene

GenScript: Design optimal peptide antigens:
  • Dual specificity phosphatase 3 (B5BUI8_HUMAN)
  • Vaccinia H1-related phosphatase (DUS3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51452

UniProtKB/Swiss-Prot:

DUS3_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP3: view

Function for DUSP3 Gene

Molecular function for DUSP3 Gene

UniProtKB/Swiss-Prot Function:
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 3,vaccinia virus phosphatase VH1 related,expressed in breast and ovary,involved in signal transduction

Enzyme Numbers (IUBMB) for DUSP3 Gene

Phenotypes From GWAS Catalog for DUSP3 Gene

Gene Ontology (GO) - Molecular Function for DUSP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,IMP 28759036
GO:0005515 protein binding IPI 32296183
GO:0008092 cytoskeletal protein binding IPI 28759036
genes like me logo Genes that share ontologies with DUSP3: view
genes like me logo Genes that share phenotypes with DUSP3: view

Animal Models for DUSP3 Gene

MGI Knock Outs for DUSP3:
  • Dusp3 Dusp3<tm1a(KOMP)Wtsi>
  • Dusp3 Dusp3<tm1b(KOMP)Wtsi>
  • Dusp3 Dusp3<tm1Srah>

Animal Models for research

  • Taconic Biosciences Mouse Models for DUSP3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP3 Gene

Localization for DUSP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP3 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DUSP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 12447358
GO:0005634 nucleus IEA,IDA 16604064
GO:0005654 nucleoplasm IDA,TAS --
GO:0005829 cytosol IDA 12447358
genes like me logo Genes that share ontologies with DUSP3: view

Pathways & Interactions for DUSP3 Gene

genes like me logo Genes that share pathways with DUSP3: view

Pathways by source for DUSP3 Gene

1 KEGG pathway for DUSP3 Gene
1 GeneGo (Thomson Reuters) pathway for DUSP3 Gene
  • Signal transduction_Erk Interactions- Inhibition of Erk
2 Qiagen pathways for DUSP3 Gene
  • ERK Signaling
  • TCR Signaling
1 Cell Signaling Technology pathway for DUSP3 Gene

SIGNOR curated interactions for DUSP3 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for DUSP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IMP 16604064
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA,IDA 24531476
GO:0030336 negative regulation of cell migration IMP 28759036
GO:0035335 peptidyl-tyrosine dephosphorylation IEA,IMP 28759036
genes like me logo Genes that share ontologies with DUSP3: view

Drugs & Compounds for DUSP3 Gene

(8) Drugs for DUSP3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0
Calcium Nutra 6959

(4) Additional Compounds for DUSP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DUSP3: view

Transcripts for DUSP3 Gene

mRNA/cDNA for DUSP3 Gene

1 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP3

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - - - - - - -
SP7: - - - - - - - -

Relevant External Links for DUSP3 Gene

GeneLoc Exon Structure for
DUSP3

Expression for DUSP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for DUSP3 Gene

This gene is overexpressed in Cardia (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP3 Gene



Protein tissue co-expression partners for DUSP3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP3

SOURCE GeneReport for Unigene cluster for DUSP3 Gene:

Hs.181046

Evidence on tissue expression from TISSUES for DUSP3 Gene

  • Nervous system(4.8)
  • Intestine(4.4)
  • Skin(3.9)
  • Lung(3.9)
  • Heart(3.3)
  • Muscle(3.3)
  • Liver(3)
  • Kidney(2.7)
  • Eye(2.2)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with DUSP3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP3 Gene

Orthologs for DUSP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DUSP3 29 30
  • 99.82 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DUSP3 29 30
  • 93.96 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DUSP3 29 30
  • 92.21 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dusp3 29 16 30
  • 90.4 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dusp3 29
  • 89.86 (n)
Oppossum
(Monodelphis domestica)
Mammalia DUSP3 30
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DUSP3 29 30
  • 72.55 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DUSP3 30
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100498529 29
  • 65.39 (n)
Zebrafish
(Danio rerio)
Actinopterygii dusp3a 29 30
  • 70.39 (n)
OneToMany
dusp3b 30
  • 59 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG7378 30
  • 31 (a)
OneToMany
Species where no ortholog for DUSP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DUSP3 Gene

ENSEMBL:
Gene Tree for DUSP3 (if available)
TreeFam:
Gene Tree for DUSP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP3: view image
Alliance of Genome Resources:
Additional Orthologs for DUSP3

Paralogs for DUSP3 Gene

(32) SIMAP similar genes for DUSP3 Gene using alignment to 6 proteins:

  • DUS3_HUMAN
  • B5BUI8_HUMAN
  • K7ELG5_HUMAN
  • K7EPK5_HUMAN
  • K7ES89_HUMAN
  • Q8IYJ9_HUMAN

Pseudogenes.org Pseudogenes for DUSP3 Gene

genes like me logo Genes that share paralogs with DUSP3: view

Variants for DUSP3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DUSP3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DUSP3 Gene

Variant ID Type Subtype PubMed ID
esv2660851 CNV deletion 23128226
esv3640636 CNV loss 21293372
nsv1060861 CNV gain 25217958
nsv1146669 OTHER inversion 26484159

Variation tolerance for DUSP3 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP3 Gene

Human Gene Mutation Database (HGMD)
DUSP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP3
Leiden Open Variation Database (LOVD)
DUSP3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP3 Gene

Disorders for DUSP3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for DUSP3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
vaccinia
cervix carcinoma
  • cancer of cervix
variola major
  • smallpox
myoclonic epilepsy of lafora
  • melf
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search DUSP3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DUSP3

genes like me logo Genes that share disorders with DUSP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP3 Gene

Publications for DUSP3 Gene

  1. Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase. (PMID: 11863439) Schumacher MA … Denu JM (Biochemistry 2002) 3 4 22
  2. Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. (PMID: 10224087) Todd JL … Denu JM (The Journal of biological chemistry 1999) 3 4 22
  3. Crystal structure of the dual specificity protein phosphatase VHR. (PMID: 8650541) Yuvaniyama J … Saper MA (Science (New York, N.Y.) 1996) 3 4 22
  4. Expression cloning of a human dual-specificity phosphatase. (PMID: 1281549) Ishibashi T … Aaronson SA (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 22
  5. Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR. (PMID: 18505570) Henkens R … Rahmouni S (BMC cancer 2008) 3 22

Products for DUSP3 Gene

Sources for DUSP3 Gene