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The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with c... See more...
Aliases for DUSP3 Gene
Aliases for DUSP3 Gene
External Ids for DUSP3 Gene
- HGNC: 3069
- NCBI Entrez Gene: 1845
- Ensembl: ENSG00000108861
- OMIM®: 600183
- UniProtKB/Swiss-Prot: P51452
Previous HGNC Symbols for DUSP3 Gene
- VHR
Previous GeneCards Identifiers for DUSP3 Gene
- GC17M041587
- GC17M044020
- GC17M041856
- GC17M042320
- GC17M042318
- GC17M039199
- GC17M037607
- GC17M041843
Summaries for DUSP3 Gene
-
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
GeneCards Summary for DUSP3 Gene
DUSP3 (Dual Specificity Phosphatase 3) is a Protein Coding gene. Diseases associated with DUSP3 include Vaccinia and Cervix Carcinoma. Among its related pathways are ERK Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is STYXL2.
UniProtKB/Swiss-Prot Summary for DUSP3 Gene
-
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
Additional gene information for DUSP3 Gene
- HGNC (3069)
- NCBI Entrez Gene (1845)
- Ensembl (ENSG00000108861)
- OMIM® (600183)
- UniProtKB/Swiss-Prot (P51452)
- Open Targets Platform(ENSG00000108861)
- Monarch Initiative
- Search for DUSP3 at DataMed
- Search for DUSP3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP3 Gene
Genomics for DUSP3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DUSP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DUSP3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP3
- Top Transcription factor binding sites by QIAGEN in the DUSP3 gene promoter:
-
- aMEF-2
- CBF(2)
- MEF-2
- MEF-2A
- MyoD
- NF-AT
- NF-AT4
- NF-Y
- p53
- Sp1
Genomic Locations for DUSP3 Gene
Latest Assembly
- chr17:43,766,125-43,778,977
- (GRCh38/hg38)
- Size:
- 12,853 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:41,843,493-41,856,345
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 12,853 bases
- Orientation:
- Minus strand
- chr17:41,843,489-41,856,356
- (GRCh37/hg19 by Ensembl)
- Size:
- 12,868 bases
- Orientation:
- Minus strand
Genomic View for DUSP3 Gene
Genes around DUSP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.31 by HGNC
- 17q21.31 by Entrez Gene
- 17q21.31 by Ensembl
DUSP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DUSP3 Gene
Proteins for DUSP3 Gene
-
Protein details for DUSP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P51452-DUS3_HUMAN
- Recommended name:
- Dual specificity protein phosphatase 3
- Protein Accession:
- P51452
- D3DX45
- Q5U0J1
- Q8IYJ9
Protein attributes for DUSP3 Gene
- Size:
- 185 amino acids
- Molecular mass:
- 20478 Da
- Quaternary structure:
-
- Interacts with VRK3, which seems to activate it's phosphatase activity.
Protein Expression for DUSP3 Gene
Post-translational modifications for DUSP3 Gene
Other Protein References for DUSP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ DUSP3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for DUSP3
- Novus Biologicals Antibodies for DUSP3
-
Abcam antibodies for DUSP3
- Invitrogen Antibodies for DUSP3 (AFLGC-Dusp3)
-
Custom Antibody ServicesProSci Antibodies for DUSP3
- Sino Biological Antibodies for DUSP3
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for DUSP3
- Origene Custom Protein Services for DUSP3
- Sino Biological Recombinant Proteins for DUSP3
- Sino Biological Cell Lysates for DUSP3
- ProSpec Recombinant Proteins for DUSP3
-
ProSci Proteins for DUSP3
-
Abcam proteins for DUSP3
Assay products for research
- RayBiotech Custom Human VHR ELISA
- antibodies-online: Show 7 available DUSP3 Elisa Kits ranked by validation data
- Compare Top DUSP3 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for DUSP3 Gene
Domains & Families for DUSP3 Gene
Gene Families for DUSP3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for DUSP3 Gene
- InterPro:
- Blocks:
-
- Dual specificity protein phosphatase
- ProtoNet:
Suggested Antigen Peptide Sequences for DUSP3 Gene
- GenScript: Design optimal peptide antigens:
-
- Dual specificity phosphatase 3 (B5BUI8_HUMAN)
- Vaccinia H1-related phosphatase (DUS3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P51452UniProtKB/Swiss-Prot:
DUS3_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Function for DUSP3 Gene
Molecular function for DUSP3 Gene
- UniProtKB/Swiss-Prot Function:
- Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
- GENATLAS Biochemistry:
- dual specificity (tyr/thr) phosphatase 3,vaccinia virus phosphatase VH1 related,expressed in breast and ovary,involved in signal transduction
Enzyme Numbers (IUBMB) for DUSP3 Gene
Phenotypes From GWAS Catalog for DUSP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004722 | protein serine/threonine phosphatase activity | IEA | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IEA,IMP | 28759036 |
| GO:0005515 | protein binding | IPI | 32296183 |
| GO:0008092 | cytoskeletal protein binding | IPI | 28759036 |
Phenotypes for DUSP3 Gene
- MGI mutant phenotypes for DUSP3:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for DUSP3:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Increased cell death HMECs cells
- Increased ionizing radiation sensitivity
- Decreased G3BP1 protein expression and assembly in stress granules after arsenite stimulation
- Decreased viability in esophageal squamous lineage; decreased viability in glioblastoma multiforme (GBM) lineage; decreased viability in ovarian lineage
Animal Models for DUSP3 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for DUSP3
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for DUSP3 - Starting at $85 >
- * DUSP3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for DUSP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP3
miRNA for DUSP3 Gene
- miRTarBase miRNAs that target DUSP3
-
- mmu-miR-362-5p (MIRT008966)
- hsa-miR-361-5p (MIRT020096)
- hsa-miR-125a-5p (MIRT021310)
- hsa-miR-10a-5p (MIRT025606)
- hsa-miR-421 (MIRT039365)
- hsa-miR-513a-3p (MIRT345078)
- hsa-miR-513c-3p (MIRT345080)
- hsa-miR-3606-3p (MIRT345081)
- hsa-miR-374a-3p (MIRT552237)
- hsa-miR-6814-5p (MIRT552238)
- hsa-miR-7157-5p (MIRT552239)
- hsa-miR-186-3p (MIRT552240)
- hsa-miR-4310 (MIRT552241)
- hsa-miR-4733-5p (MIRT552242)
- hsa-miR-3617-3p (MIRT552243)
- hsa-miR-101-5p (MIRT552244)
- hsa-miR-2114-5p (MIRT552245)
- hsa-miR-5588-3p (MIRT552246)
- hsa-miR-605-5p (MIRT552247)
- hsa-miR-548t-5p (MIRT552248)
- hsa-miR-548az-5p (MIRT552249)
- hsa-miR-548n (MIRT552250)
- hsa-miR-7152-5p (MIRT564504)
- hsa-miR-3074-5p (MIRT564505)
- hsa-miR-6847-3p (MIRT564506)
- hsa-miR-4679 (MIRT564507)
- hsa-miR-4677-3p (MIRT564508)
- hsa-miR-6068 (MIRT564509)
- hsa-miR-3193 (MIRT564510)
- hsa-miR-1539 (MIRT564511)
- hsa-miR-4277 (MIRT564512)
- hsa-miR-6874-3p (MIRT564513)
- hsa-miR-148b-5p (MIRT564514)
- hsa-miR-4282 (MIRT564515)
- mmu-miR-5101 (MIRT590222)
- mmu-miR-706 (MIRT592756)
- mmu-miR-665-3p (MIRT592757)
- mmu-miR-339-5p (MIRT592758)
- mmu-miR-10a-5p (MIRT592759)
- mmu-miR-10b-5p (MIRT592760)
- mmu-miR-3108-5p (MIRT602449)
- mmu-miR-5135 (MIRT602450)
- mmu-miR-292a-5p (MIRT602451)
- mmu-miR-290a-5p (MIRT602452)
- mmu-miR-139-5p (MIRT606462)
- mmu-miR-3082-5p (MIRT606463)
- hsa-miR-6807-5p (MIRT715186)
- hsa-miR-143-5p (MIRT715187)
- hsa-miR-3944-5p (MIRT715188)
- hsa-miR-6872-3p (MIRT715189)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP3
- Browse OriGene Inhibitory RNA Products For DUSP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP3
Clone products for research
- Applied Biological Materials (abm): Clones for DUSP3 - Starting at $45 >
- * DUSP3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for DUSP3
- Addgene plasmids for DUSP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP3
Cell Lines for research
-
Horizon Cell Lines for DUSP3
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP3 Gene
Localization for DUSP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DUSP3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Nucleoplasm (3)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001772 | immunological synapse | IDA | 12447358 |
| GO:0005634 | nucleus | IEA,IDA | 16604064 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005829 | cytosol | IDA | 12447358 |
Pathways & Interactions for DUSP3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Nuclear Events (kinase and transcription factor activation) |
.88
|
|
| 3 | Innate Immune System |
.61
|
|
| 4 | RET signaling | ||
| 5 | MAP Kinase Signaling | ||
Pathways by source for DUSP3 Gene
27 Reactome pathways for DUSP3 Gene
1 KEGG pathway for DUSP3 Gene
1 GeneGo (Thomson Reuters) pathway for DUSP3 Gene
- Signal transduction_Erk Interactions- Inhibition of Erk
2 Qiagen pathways for DUSP3 Gene
- ERK Signaling
- TCR Signaling
1 Cell Signaling Technology pathway for DUSP3 Gene
Interacting Proteins for DUSP3 Gene
Selected Interacting proteins:
P51452-DUS3_HUMAN
ENSP00000226004
for DUSP3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for DUSP3
SIGNOR curated interactions for DUSP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000188 | inactivation of MAPK activity | IMP | 16604064 |
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0016311 | dephosphorylation | IEA,IDA | 24531476 |
| GO:0030336 | negative regulation of cell migration | IMP | 28759036 |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IEA,IMP | 28759036 |
Transcripts for DUSP3 Gene
mRNA/cDNA for DUSP3 Gene
- 1 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000226004 4095 nts (view in UCSC)
- ENST00000590342 2077 nts (view in UCSC)
- ENST00000590753 1019 nts (view in UCSC)
- ENST00000590935 3666 nts (view in UCSC)
- ENST00000591618 538 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for DUSP3 - Starting at $85 >
- * DUSP3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for DUSP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP3
- Browse OriGene Inhibitory RNA Products For DUSP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP3
Clone products for research
- Applied Biological Materials (abm): Clones for DUSP3 - Starting at $45 >
- * DUSP3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for DUSP3
- Addgene plasmids for DUSP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP3
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - |
Relevant External Links for DUSP3 Gene
- GeneLoc Exon Structure for
- DUSP3
Expression for DUSP3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Skeletal Muscle (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for DUSP3 Gene
This gene is overexpressed in Muscle - Skeletal (x4.1).
This gene is overexpressed in Cardia (10.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP3
SOURCE GeneReport for Unigene cluster for DUSP3 Gene:
Hs.181046Evidence on tissue expression from TISSUES for DUSP3 Gene
- Nervous system(4.8)
- Intestine(4.4)
- Skin(3.9)
- Lung(3.9)
- Heart(3.3)
- Muscle(3.3)
- Liver(3)
- Kidney(2.7)
- Eye(2.2)
- Blood(2.2)
Primer products for research
-
OriGene qPCR primer pairs for DUSP3
-
OriGene qPCR primer pairs and template standards for DUSP3
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP3 Gene
Orthologs for DUSP3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DUSP3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DUSP3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DUSP3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Dusp3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dusp3 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | DUSP3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | DUSP3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DUSP3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100498529 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | dusp3a 30 31 |
|
OneToMany | |
| dusp3b 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG7378 31 |
|
OneToMany |
- Species where no ortholog for DUSP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for DUSP3 Gene
- ENSEMBL:
- Gene Tree for DUSP3 (if available)
- TreeFam:
- Gene Tree for DUSP3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DUSP3: view image
Paralogs for DUSP3 Gene
Paralogs for DUSP3 Gene
(32) SIMAP similar genes for DUSP3 Gene using alignment to 6 proteins:
- DUS3_HUMAN
- B5BUI8_HUMAN
- K7ELG5_HUMAN
- K7EPK5_HUMAN
- K7ES89_HUMAN
- Q8IYJ9_HUMAN
Pseudogenes.org Pseudogenes for DUSP3 Gene
Variants for DUSP3 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2660851 | CNV | deletion | 23128226 |
| esv3640636 | CNV | loss | 21293372 |
| nsv1060861 | CNV | gain | 25217958 |
| nsv1146669 | OTHER | inversion | 26484159 |
Residual Variation Intolerance Score:
38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.62;
13.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DUSP3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP3 Gene
Disorders for DUSP3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| vaccinia |
|
|
| cervix carcinoma |
|
|
| variola major |
|
|
| myoclonic epilepsy of lafora |
|
|
| breast cancer |
|
|
Search DUSP3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DUSP3
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP3 Gene
Publications for DUSP3 Gene
- Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase. (PMID: 11863439) Schumacher MA … Denu JM (Biochemistry 2002) 3 4 23
- Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. (PMID: 10224087) Todd JL … Denu JM (The Journal of biological chemistry 1999) 3 4 23
- Crystal structure of the dual specificity protein phosphatase VHR. (PMID: 8650541) Yuvaniyama J … Saper MA (Science (New York, N.Y.) 1996) 3 4 23
- Expression cloning of a human dual-specificity phosphatase. (PMID: 1281549) Ishibashi T … Aaronson SA (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 23
- High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells. (PMID: 18311544) Wong PF … Abubakar S (Cellular & molecular biology letters 2008) 3 23
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Sources for DUSP3 Gene
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