Aliases for DUSP3 Gene
Aliases for DUSP3 Gene
External Ids for DUSP3 Gene
- HGNC: 3069
- Entrez Gene: 1845
- Ensembl: ENSG00000108861
- OMIM: 600183
- UniProtKB: P51452
Previous HGNC Symbols for DUSP3 Gene
- VHR
Previous GeneCards Identifiers for DUSP3 Gene
- GC17M041587
- GC17M044020
- GC17M041856
- GC17M042320
- GC17M042318
- GC17M039199
- GC17M037607
- GC17M041843
Summaries for DUSP3 Gene
-
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
GeneCards Summary for DUSP3 Gene
DUSP3 (Dual Specificity Phosphatase 3) is a Protein Coding gene. Diseases associated with DUSP3 include Vaccinia and Byssinosis. Among its related pathways are Innate Immune System and RET signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is DUPD1.
UniProtKB/Swiss-Prot for DUSP3 Gene
-
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
Additional gene information for DUSP3 Gene
- Monarch Initiative
- Search for DUSP3 at DataMed
- Search for DUSP3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP3 Gene
Genomics for DUSP3 Gene
GeneHancer (GH) Regulatory Elements for DUSP3 Gene
Promoters and enhancers for DUSP3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17I043777 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 557.6 | +0.3 | 344 | 2.7 | HDGF PKNOX1 MLX ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 YY1 | DUSP3 CFAP97D1 PIR48941 ASB16-AS1 UBTF HMGN1P29 TMUB2 DHX8 ENSG00000267340 LINC00910 | |
| GH17I043780 | Promoter | 0.5 | EPDnew | 550.8 | -1.4 | -1416 | 0.1 | PIR48941 DUSP3 CFAP97D1 | ||
| GH17I043839 | Enhancer | 1 | Ensembl ENCODE | 10.9 | -61.1 | -61146 | 1.6 | NFIB RAD21 YY1 ZNF335 ZNF366 SCRT2 RCOR1 ZNF391 ELK4 SMARCC1 | DUSP3 CFAP97D1 MPP2 MPP3 MEOX1 CD300LG | |
| GH17I043841 | Enhancer | 0.9 | Ensembl ENCODE | 10.7 | -63.5 | -63524 | 1.2 | HDAC1 MEIS2 KLF1 PKNOX1 KLF17 ZFHX2 EGR1 KLF8 KLF13 EGR2 | MPP2 DUSP3 CFAP97D1 MPP3 CD300LG | |
| GH17I043846 | Enhancer | 0.8 | ENCODE | 10.9 | -67.6 | -67589 | 0.8 | RB1 ARID4B ZNF2 ZNF48 RAD21 ZNF335 ARID2 SCRT2 ZNF143 THAP11 | CD300LG CFAP97D1 DUSP3 SOST ENSG00000221044 MPP3 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DUSP3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for DUSP3 Gene
Genomic Locations for DUSP3 Gene
- chr17:43,766,121-43,779,000
- (GRCh38/hg38)
- Size:
- 12,880 bases
- Orientation:
- Minus strand
- chr17:41,843,489-41,856,368
- (GRCh37/hg19)
Genomic View for DUSP3 Gene
Genes around DUSP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.31 by Ensembl
- 17q21.31 by Entrez Gene
- 17q21.31 by HGNC
DUSP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DUSP3 Gene
Proteins for DUSP3 Gene
-
Protein details for DUSP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P51452-DUS3_HUMAN
- Recommended name:
- Dual specificity protein phosphatase 3
- Protein Accession:
- P51452
- D3DX45
- Q5U0J1
- Q8IYJ9
Protein attributes for DUSP3 Gene
- Size:
- 185 amino acids
- Molecular mass:
- 20478 Da
- Quaternary structure:
-
- Interacts with VRK3, which seems to activate its phosphatase activity.
Protein Expression for DUSP3 Gene
Post-translational modifications for DUSP3 Gene
Other Protein References for DUSP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for DUSP3 (VHR)
-
Custom Antibody ServicesOriGene Antibodies for DUSP3
- Novus Biologicals Antibodies for DUSP3
-
Abcam antibodies for DUSP3
-
Cloud-Clone Corp. Antibodies for DUSP3
- Invitrogen Antibodies for DUSP3
- GeneTex DUSP3 antibody for DUSP3
- Sino Biological Antibodies for DUSP3
Protein Products
- R&D Systems Proteins and Enzymes for DUSP3 (VHR)
-
OriGene Purified Proteins for DUSP3
- Search Origene for MassSpec and Protein Over-expression Lysates for DUSP3
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- Sino Biological Recombinant Proteins for DUSP3
- Sino Biological Cell Lysates for DUSP3
- ProSpec Recombinant Proteins for DUSP3
-
Cloud-Clone Corp. Proteins for DUSP3
- GeneTex Proteins for DUSP3
-
ProSci Proteins for DUSP3
-
Abcam proteins for DUSP3
Assay Products
No data available for DME Specific Peptides for DUSP3 Gene
Domains & Families for DUSP3 Gene
Gene Families for DUSP3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for DUSP3 Gene
Suggested Antigen Peptide Sequences for DUSP3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P51452UniProtKB/Swiss-Prot:
DUS3_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Function for DUSP3 Gene
Molecular function for DUSP3 Gene
- GENATLAS Biochemistry:
- dual specificity (tyr/thr) phosphatase 3,vaccinia virus phosphatase VH1 related,expressed in breast and ovary,involved in signal transduction
- UniProtKB/Swiss-Prot CatalyticActivity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
- UniProtKB/Swiss-Prot Function:
- Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
Enzyme Numbers (IUBMB) for DUSP3 Gene
Phenotypes From GWAS Catalog for DUSP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IEA,TAS | -- |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IMP,IEA | 7961745 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016791 | phosphatase activity | IEA,IDA | 24531476 |
Phenotypes for DUSP3 Gene
- MGI mutant phenotypes for DUSP3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for DUSP3:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Increased cell death HMECs cells
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
Animal Model Products
-
Taconic Biosciences Mouse Models for DUSP3
- Cyagen custom Knockout/knockin (KOKI) mouse models for DUSP3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for DUSP3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DUSP3 gene
- Search ViGene Biosciences for DUSP3
CRISPR Products
-
OriGene CRISPR knockouts for DUSP3
- genomics-online: gRNA clones - Search results for available DUSP3 gene related products
- Applied Biological Materials CRISPR for DUSP3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP3
- GenScript: Design CRISPR guide RNA sequences for DUSP3
miRNA for DUSP3 Gene
- miRTarBase miRNAs that target DUSP3
-
- hsa-mir-361-5p (MIRT020096)
- hsa-mir-125a-5p (MIRT021310)
- hsa-mir-10a-5p (MIRT025606)
- hsa-mir-421 (MIRT039365)
- hsa-mir-513a-3p (MIRT345078)
- hsa-mir-513c-3p (MIRT345080)
- hsa-mir-3606-3p (MIRT345081)
- hsa-mir-374a-3p (MIRT552237)
- hsa-mir-6814-5p (MIRT552238)
- hsa-mir-7157-5p (MIRT552239)
- hsa-mir-186-3p (MIRT552240)
- hsa-mir-4310 (MIRT552241)
- hsa-mir-4733-5p (MIRT552242)
- hsa-mir-3617-3p (MIRT552243)
- hsa-mir-101-5p (MIRT552244)
- hsa-mir-2114-5p (MIRT552245)
- hsa-mir-5588-3p (MIRT552246)
- hsa-mir-605-5p (MIRT552247)
- hsa-mir-548t-5p (MIRT552248)
- hsa-mir-548az-5p (MIRT552249)
- hsa-mir-548n (MIRT552250)
- hsa-mir-7152-5p (MIRT564504)
- hsa-mir-3074-5p (MIRT564505)
- hsa-mir-6847-3p (MIRT564506)
- hsa-mir-4679 (MIRT564507)
- hsa-mir-4677-3p (MIRT564508)
- hsa-mir-6068 (MIRT564509)
- hsa-mir-3193 (MIRT564510)
- hsa-mir-1539 (MIRT564511)
- hsa-mir-4277 (MIRT564512)
- hsa-mir-6874-3p (MIRT564513)
- hsa-mir-148b-5p (MIRT564514)
- hsa-mir-4282 (MIRT564515)
- hsa-mir-6807-5p (MIRT715186)
- hsa-mir-143-5p (MIRT715187)
- hsa-mir-3944-5p (MIRT715188)
- hsa-mir-6872-3p (MIRT715189)
miRNA Products
- Search ViGene Biosciences for DUSP3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DUSP3
- Browse OriGene Inhibitory RNA Products For DUSP3
- genomics-online: shRNA clones - Search results for available DUSP3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DUSP3 gene
Clone Products
- Sino Biological Human cDNA Clone for DUSP3
- VectorBuilder custom plasmid, inducible vectors for DUSP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DUSP3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DUSP3
- genomics-online: cdna clones - Search results for available DUSP3 gene related products
- orf clones - Search results for available DUSP3 gene related products
- Applied Biological Materials Clones for DUSP3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DUSP3
-
ViGene Biosciences adenoviral particle packaged cDNA for DUSP3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DUSP3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DUSP3 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP3 Gene
Localization for DUSP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DUSP3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
- Nucleoplasm (3)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001772 | immunological synapse | IDA | 12447358 |
| GO:0005634 | nucleus | IEA,IDA | 16604064 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005829 | cytosol | IDA | 12447358 |
| GO:0070062 | extracellular exosome | IDA,HDA | 23376485 |
Pathways & Interactions for DUSP3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Nuclear Events (kinase and transcription factor activation) |
.88
|
|
| 3 | Innate Immune System |
.61
|
|
| 4 | RET signaling | ||
| 5 | MAPK signaling pathway | ||
Pathways by source for DUSP3 Gene
27 Reactome pathways for DUSP3 Gene
1 KEGG pathway for DUSP3 Gene
1 GeneGo (Thomson Reuters) pathway for DUSP3 Gene
2 Qiagen pathways for DUSP3 Gene
1 Cell Signaling Technology pathway for DUSP3 Gene
Interacting Proteins for DUSP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000188 | inactivation of MAPK activity | IMP | 16604064 |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0016311 | dephosphorylation | IDA,IEA | 24531476 |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IEA,IDA | 7876121 |
Drugs & Compounds for DUSP3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14265-44-2 |
|
Transcripts for DUSP3 Gene
mRNA/cDNA for DUSP3 Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (470) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DUSP3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DUSP3
- genomics-online: gRNA clones - Search results for available DUSP3 gene related products
- Applied Biological Materials CRISPR for DUSP3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP3
- GenScript: Design CRISPR guide RNA sequences for DUSP3
miRNA Products
- Search ViGene Biosciences for DUSP3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DUSP3
- Browse OriGene Inhibitory RNA Products For DUSP3
- genomics-online: shRNA clones - Search results for available DUSP3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DUSP3 gene
Clone Products
- Sino Biological Human cDNA Clone for DUSP3
- VectorBuilder custom plasmid, inducible vectors for DUSP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DUSP3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DUSP3
- genomics-online: cdna clones - Search results for available DUSP3 gene related products
- orf clones - Search results for available DUSP3 gene related products
- Applied Biological Materials Clones for DUSP3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - |
Expression for DUSP3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Monocytes Peripheral Blood
-
Skeletal Muscle (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for DUSP3 Gene
This gene is overexpressed in Muscle - Skeletal (x4.1).
This gene is overexpressed in Cardia (10.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DUSP3 Gene:
DUSP3SOURCE GeneReport for Unigene cluster for DUSP3 Gene:
Hs.181046Evidence on tissue expression from TISSUES for DUSP3 Gene
- Nervous system(4.8)
- Intestine(4.3)
- Lung(3.6)
- Skin(3.5)
- Heart(3.2)
- Muscle(3)
- Liver(2.3)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for DUSP3
-
OriGene qPCR primer pairs and template standards for DUSP3
- genomics-online: primer clones - Search results for available DUSP3 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP3 Gene
Orthologs for DUSP3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DUSP3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | DUSP3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DUSP3 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Dusp3 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dusp3 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DUSP3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DUSP3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | DUSP3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100498529 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dusp3a 33 34 |
|
||
| dusp3b 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7378 34 |
|
OneToMany |
- Species where no ortholog for DUSP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for DUSP3 Gene
Paralogs for DUSP3 Gene
(32) SIMAP similar genes for DUSP3 Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for DUSP3 Gene
Variants for DUSP3 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000405652 | -- | 43,770,940(-) | T/G | intron_variant | |
| rs1000566559 | -- | 43,776,038(-) | G/C | intron_variant | |
| rs1000602014 | -- | 43,778,777(-) | C/T | intron_variant | |
| rs1000737382 | -- | 43,772,896(-) | AAAAAAA/AAAAAAAA | intron_variant | |
| rs1000887209 | -- | 43,767,059(-) | G/A/T | 3_prime_UTR_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2660851 | CNV | deletion | 23128226 |
| esv3640636 | CNV | loss | 21293372 |
| nsv1060861 | CNV | gain | 25217958 |
| nsv1146669 | OTHER | inversion | 26484159 |
Residual Variation Intolerance Score:
38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.62;
13.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DUSP3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP3 Gene
Disorders for DUSP3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| vaccinia |
|
|
| byssinosis |
|
|
| cervix carcinoma |
|
|
Search DUSP3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DUSP3
No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP3 Gene
Publications for DUSP3 Gene
- Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase. (PMID: 11863439) Schumacher MA … Denu JM (Biochemistry 2002) 3 4 22 58
- Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. (PMID: 10224087) Todd JL … Denu JM (The Journal of biological chemistry 1999) 3 4 22 58
- Crystal structure of the dual specificity protein phosphatase VHR. (PMID: 8650541) Yuvaniyama J … Saper MA (Science (New York, N.Y.) 1996) 3 4 22 58
- Expression cloning of a human dual-specificity phosphatase. (PMID: 1281549) Ishibashi T … Aaronson SA (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 22 58
- High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells. (PMID: 18311544) Wong PF … Abubakar S (Cellular & molecular biology letters 2008) 3 22 58
Products for DUSP3 Gene
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP3
- Browse OriGene Inhibitory RNA Products For DUSP3
- OriGene qPCR primer pairs and template standards for DUSP3
- OriGene qPCR primer pairs for DUSP3
- OriGene CRISPR knockouts for DUSP3
- OriGene ORF clones in human for DUSP3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DUSP3
- GenScript: Next-day shipping of latest version cDNA ORF clones for DUSP3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for DUSP3
- GenScript Custom Assay Services for DUSP3
- GenScript Custom overexpressing Cell Line Services for DUSP3
- GenScript: Design CRISPR guide RNA sequences for DUSP3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DUSP3
- Sino Biological Human cDNA Clone for DUSP3
- Sino Biological Cell Lysates for DUSP3
- Sino Biological Recombinant Proteins for DUSP3
- Sino Biological Antibodies for DUSP3
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for DUSP3
- Novus Biologicals lysates and proteins for DUSP3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for DUSP3
- Abcam proteins for DUSP3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for DUSP3
- Cloud-Clone Corp. Antibodies for DUSP3
- Cloud-Clone Corp. Proteins for DUSP3
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for DUSP3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for DUSP3
- Cyagen custom Knockout/knockin (KOKI) mouse models for DUSP3
- VectorBuilder custom plasmid, inducible vectors for DUSP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DUSP3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DUSP3
- antibodies-online: Search results for 84 available DUSP3 Antibodies ranked by validation data
- Compare Top DUSP3 Antibodies
- antibodies-online: Search results for 4 available DUSP3 Elisa Kits ranked by validation data
- Compare Top DUSP3 Elisa Kits
- Recommended
- antibodies-online: Search results for 15 available DUSP3 Proteins ranked by validation data
- Compare Top DUSP3 Proteins
- GeneTex DUSP3 antibody for DUSP3
- GeneTex Proteins for DUSP3
- ViGene Biosciences adenoviral particle packaged cDNA for DUSP3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for DUSP3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for DUSP3 gene
- Search ViGene Biosciences for DUSP3
- Search Santa Cruz Biotechnology (SCBT) for DUSP3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DUSP3
- Search for DUSP3 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for DUSP3
- Horizon Cell Lines for DUSP3
- genomics-online: cdna clones - Search results for available DUSP3 gene related products
- orf clones - Search results for available DUSP3 gene related products
- genomics-online: gRNA clones - Search results for available DUSP3 gene related products
- genomics-online: primer clones - Search results for available DUSP3 gene related products
- genomics-online: shRNA clones - Search results for available DUSP3 gene related products
Sources for DUSP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems