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The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
DUSP3 (Dual Specificity Phosphatase 3) is a Protein Coding gene. Diseases associated with DUSP3 include Vaccinia and Cervix Carcinoma. Among its related pathways are ERK Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is STYXL2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
GO:0004722 | protein serine/threonine phosphatase activity | IEA | -- |
GO:0004725 | protein tyrosine phosphatase activity | IEA,IMP | 28759036 |
GO:0005515 | protein binding | IPI | 32296183 |
GO:0008092 | cytoskeletal protein binding | IPI | 28759036 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001772 | immunological synapse | IDA | 12447358 |
GO:0005634 | nucleus | IEA,IDA | 16604064 |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
GO:0005829 | cytosol | IDA | 12447358 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Nuclear Events (kinase and transcription factor activation) |
.88
|
|
3 | Innate Immune System |
.61
|
|
4 | RET signaling | ||
5 | MAP Kinase Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000188 | inactivation of MAPK activity | IMP | 16604064 |
GO:0006470 | protein dephosphorylation | IEA | -- |
GO:0016311 | dephosphorylation | IEA,IDA | 24531476 |
GO:0030336 | negative regulation of cell migration | IMP | 28759036 |
GO:0035335 | peptidyl-tyrosine dephosphorylation | IEA,IMP | 28759036 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7a | · | 7b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DUSP3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DUSP3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DUSP3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dusp3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dusp3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | DUSP3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DUSP3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DUSP3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100498529 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dusp3a 30 31 |
|
OneToMany | |
dusp3b 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG7378 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2660851 | CNV | deletion | 23128226 |
esv3640636 | CNV | loss | 21293372 |
nsv1060861 | CNV | gain | 25217958 |
nsv1146669 | OTHER | inversion | 26484159 |
Disorder | Aliases | PubMed IDs |
---|---|---|
vaccinia |
|
|
cervix carcinoma |
|
|
variola major |
|
|
myoclonic epilepsy of lafora |
|
|
breast cancer |
|
|