Aliases for DUSP3 Gene
External Ids for DUSP3 Gene
Previous HGNC Symbols for DUSP3 Gene
Previous GeneCards Identifiers for DUSP3 Gene
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
GeneCards Summary for DUSP3 Gene
DUSP3 (Dual Specificity Phosphatase 3) is a Protein Coding gene. Diseases associated with DUSP3 include Vaccinia and Byssinosis. Among its related pathways are Activated TLR4 signalling and Nuclear Events (kinase and transcription factor activation). Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP13.
UniProtKB/Swiss-Prot for DUSP3 Gene
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.