Aliases for DUSP29 Gene

Aliases for DUSP29 Gene

  • Dual Specificity Phosphatase 29 2 3
  • Dual Specificity Phosphatase And Pro Isomerase Domain Containing 1 2 3 5
  • DUSP27 2 3 4
  • Dual Specificity Phosphatase DUPD1 3 4
  • Dual Specificity Phosphatase 27 3 4
  • DUPD1 3 5
  • Atypical Dual-Specific Protein Phosphatase 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • FMDSP 3

External Ids for DUSP29 Gene

Previous HGNC Symbols for DUSP29 Gene

  • DUPD1

Summaries for DUSP29 Gene

GeneCards Summary for DUSP29 Gene

DUSP29 (Dual Specificity Phosphatase 29) is a Protein Coding gene. Diseases associated with DUSP29 include Genitopatellar Syndrome and Variola Major. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot Summary for DUSP29 Gene

  • Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP29 Gene

Genomics for DUSP29 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DUSP29 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J075058 Promoter/Enhancer 0.9 EPDnew Ensembl 600.4 +15.3 15273 1.7 SIX5 ZNF143 GABPA ZNF341 DEAF1 NFIC HCFC1 GABPB1 ETS1 THAP11 DUSP29 DUSP13 ZNF503 lnc-DUSP13-1 LOC101929165 KAT6B
GH10J075073 Promoter 0.3 EPDnew 609.6 +0.2 167 0.1 DUSP29 lnc-SAMD8-2 lnc-DUSP13-1 LOC101929165 KAT6B
GH10J075135 Enhancer 1.2 Ensembl ENCODE dbSUPER 11 -63.8 -63801 3.7 ZNF512 IKZF1 JUND MTA2 PKNOX1 ZNF24 DPF2 HDAC1 SOX6 GATAD2B ZNF503-AS1 DUSP29 PPIAP13 RPS26P42 piR-37404 lnc-VDAC2-3 DUSP13 SAMD8 VDAC2 LOC101929165
GH10J075222 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 10 -151.3 -151264 5.3 TEAD4 PRDM10 RFX1 RBFOX2 SP1 SCRT2 SOX13 KLF9 ETS1 POLR2A ZNF503-AS1 DUSP29 COMTD1 VDAC2 PPIAP13 lnc-COMTD1-6
GH10J074921 Enhancer 1.1 Ensembl ENCODE 10.1 +148.3 148326 9.8 PRDM10 ZNF629 IKZF1 ZNF692 JUND FOXA1 PRDM1 ZIC2 HDAC1 ZNF600 RF00017-708 KAT6B ENSG00000227186 ENSG00000234149 DUSP29 ADK LOC101929165
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP29 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP29

Genomic Locations for DUSP29 Gene

Genomic Locations for DUSP29 Gene
chr10:75,026,427-75,073,827
(GRCh38/hg38)
Size:
47,401 bases
Orientation:
Minus strand
chr10:76,797,594-76,818,272
(GRCh37/hg19)
Size:
20,679 bases
Orientation:
Minus strand

Genomic View for DUSP29 Gene

Genes around DUSP29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP29 Gene

Proteins for DUSP29 Gene

  • Protein details for DUSP29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68J44-DUPD1_HUMAN
    Recommended name:
    Dual specificity phosphatase DUPD1
    Protein Accession:
    Q68J44
    Secondary Accessions:
    • B2RP93

    Protein attributes for DUSP29 Gene

    Size:
    220 amino acids
    Molecular mass:
    25336 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DUSP29 Gene

neXtProt entry for DUSP29 Gene

Post-translational modifications for DUSP29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP29 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP29 Gene

Domains & Families for DUSP29 Gene

Gene Families for DUSP29 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DUSP29 Gene

Suggested Antigen Peptide Sequences for DUSP29 Gene

GenScript: Design optimal peptide antigens:
  • Dual specificity phosphatase 27 (DUPD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q68J44

UniProtKB/Swiss-Prot:

DUPD1_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP29: view

Function for DUSP29 Gene

Molecular function for DUSP29 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000269|PubMed:17498703};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:17498703};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:17498703};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.02 mM for para-nitrophenylphosphate (at pH 5.5) {ECO:0000269|PubMed:17498703}; Note=kcat is 0.330 sec(-1) for para-nitrophenylphosphate. {ECO:0000269|PubMed:17498703};

Enzyme Numbers (IUBMB) for DUSP29 Gene

Phenotypes From GWAS Catalog for DUSP29 Gene

Gene Ontology (GO) - Molecular Function for DUSP29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IDA 17498703
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP29: view
genes like me logo Genes that share phenotypes with DUSP29: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP29

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUSP29 Gene

Localization for DUSP29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP29 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP29 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DUSP29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0032991 protein-containing complex IDA 21543850
genes like me logo Genes that share ontologies with DUSP29: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DUSP29 Gene

Pathways & Interactions for DUSP29 Gene

PathCards logo

SuperPathways for DUSP29 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IDA 17498703
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP29: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP29 Gene

Drugs & Compounds for DUSP29 Gene

(2) Drugs for DUSP29 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with DUSP29: view

Transcripts for DUSP29 Gene

mRNA/cDNA for DUSP29 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP29

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP29 Gene

No ASD Table

Relevant External Links for DUSP29 Gene

GeneLoc Exon Structure for
DUSP29

Expression for DUSP29 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP29

SOURCE GeneReport for Unigene cluster for DUSP29 Gene:

Hs.535090
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP29 Gene

Orthologs for DUSP29 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP29 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DUPD1 30 31
  • 99.09 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dupd1 30 17 31
  • 86.33 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dupd1 30
  • 85.69 (n)
Cow
(Bos Taurus)
Mammalia DUPD1 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DUPD1 31
  • 70 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DUPD1 31
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DUPD1 30 31
  • 71.53 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DUPD1 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dupd1 30
  • 68.06 (n)
Zebrafish
(Danio rerio)
Actinopterygii zgc:136906 30
  • 67.06 (n)
DUPD1 (5 of 12) 31
  • 55 (a)
OneToMany
DUPD1 (10 of 12) 31
  • 40 (a)
OneToMany
DUPD1 (7 of 12) 31
  • 36 (a)
OneToMany
DUPD1 (2 of 12) 31
  • 35 (a)
OneToMany
DUPD1 (6 of 12) 31
  • 31 (a)
OneToMany
DUPD1 (4 of 12) 31
  • 26 (a)
OneToMany
DUPD1 (9 of 12) 31
  • 22 (a)
OneToMany
DUPD1 (11 of 12) 31
  • 22 (a)
OneToMany
DUPD1 (8 of 12) 31
  • 20 (a)
OneToMany
DUPD1 (12 of 12) 31
  • 20 (a)
OneToMany
DUPD1 (1 of 12) 31
  • 19 (a)
OneToMany
DUPD1 (3 of 12) 31
  • 16 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG7378 31
  • 37 (a)
OneToMany
Species where no ortholog for DUSP29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DUSP29 Gene

ENSEMBL:
Gene Tree for DUSP29 (if available)
TreeFam:
Gene Tree for DUSP29 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP29: view image

Paralogs for DUSP29 Gene

Variants for DUSP29 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP29 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
637031 Pathogenic: Blepharophimosis - intellectual disability syndrome, SBBYS type 75,029,988(-) A/AC FRAMESHIFT_VARIANT
642582 Uncertain Significance: Genitopatellar syndrome 75,028,786(-) A/T MISSENSE_VARIANT
647581 Pathogenic: Genitopatellar syndrome 75,030,325(-) AC/A NONSENSE
802590 Likely Pathogenic: Genitopatellar syndrome 75,028,896(-) G/T NONSENSE
802591 Pathogenic: Genitopatellar syndrome 75,029,684(-) TG/T FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for DUSP29 Gene

Structural Variations from Database of Genomic Variants (DGV) for DUSP29 Gene

Variant ID Type Subtype PubMed ID
dgv926n100 CNV gain 25217958
dgv927n100 CNV gain 25217958
nsv7188 CNV insertion 18451855

Variation tolerance for DUSP29 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.71; 78.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP29 Gene

Disorders for DUSP29 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DUSP29 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
genitopatellar syndrome
  • gps
variola major
  • smallpox
blepharophimosis
clubfoot
  • congenital clubfoot
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with DUSP29: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP29 Gene

Publications for DUSP29 Gene

  1. Identification and characterization of DUSP27, a novel dual-specific protein phosphatase. (PMID: 17498703) Friedberg I … Mustelin T (FEBS letters 2007) 3 4 23
  2. Structure of human dual-specificity phosphatase 27 at 2.38 Å resolution. (PMID: 21543850) Lountos GT … Waugh DS (Acta crystallographica. Section D, Biological crystallography 2011) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling. (PMID: 28675297) Kumar P … Maddika S (Journal of proteome research 2017) 3
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3

Products for DUSP29 Gene

Sources for DUSP29 Gene