Aliases for DUSP28 Gene

Aliases for DUSP28 Gene

  • Dual Specificity Phosphatase 28 2 3 4 5
  • DUSP26 2 3
  • VHP 2 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DUSP28 5

External Ids for DUSP28 Gene

Previous GeneCards Identifiers for DUSP28 Gene

  • GC02P241149
  • GC02P241499
  • GC02P233255

Summaries for DUSP28 Gene

GeneCards Summary for DUSP28 Gene

DUSP28 (Dual Specificity Phosphatase 28) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is SSH2.

UniProtKB/Swiss-Prot Summary for DUSP28 Gene

  • Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro) (PubMed:24531476, PubMed:29121083). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine (PubMed:29121083). The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site (PubMed:29121083).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP28 Gene

Genomics for DUSP28 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DUSP28 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP28 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP28

Top Transcription factor binding sites by QIAGEN in the DUSP28 gene promoter:
  • Cart-1
  • E47
  • GR
  • GR-alpha
  • GR-beta
  • Hand1
  • Msx-1

Genomic Locations for DUSP28 Gene

Latest Assembly
chr2:240,559,239-240,565,256
(GRCh38/hg38)
Size:
6,018 bases
Orientation:
Plus strand

Previous Assembly
chr2:241,499,471-241,504,673
(GRCh37/hg19 by Entrez Gene)
Size:
5,203 bases
Orientation:
Plus strand

chr2:241,499,471-241,503,431
(GRCh37/hg19 by Ensembl)
Size:
3,961 bases
Orientation:
Plus strand

Genomic View for DUSP28 Gene

Genes around DUSP28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP28 Gene

Proteins for DUSP28 Gene

  • Protein details for DUSP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0W2-DUS28_HUMAN
    Recommended name:
    Dual specificity phosphatase 28
    Protein Accession:
    Q4G0W2

    Protein attributes for DUSP28 Gene

    Size:
    176 amino acids
    Molecular mass:
    18324 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for DUSP28 Gene

neXtProt entry for DUSP28 Gene

Post-translational modifications for DUSP28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP28 Gene

No data available for DME Specific Peptides for DUSP28 Gene

Domains & Families for DUSP28 Gene

Gene Families for DUSP28 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DUSP28 Gene

InterPro:
Blocks:
  • Dual specificity protein phosphatase
ProtoNet:

Suggested Antigen Peptide Sequences for DUSP28 Gene

GenScript: Design optimal peptide antigens:
  • Dual specificity phosphatase 28 (DUS28_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q4G0W2

UniProtKB/Swiss-Prot:

DUS28_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP28: view

Function for DUSP28 Gene

Molecular function for DUSP28 Gene

UniProtKB/Swiss-Prot Function:
Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro) (PubMed:24531476, PubMed:29121083). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine (PubMed:29121083). The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site (PubMed:29121083).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.0. {ECO:0000269|PubMed:29121083};

Enzyme Numbers (IUBMB) for DUSP28 Gene

Phenotypes From GWAS Catalog for DUSP28 Gene

Gene Ontology (GO) - Molecular Function for DUSP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DUSP28: view
genes like me logo Genes that share phenotypes with DUSP28: view

miRNA for DUSP28 Gene

miRTarBase miRNAs that target DUSP28

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP28

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP28 Gene

Localization for DUSP28 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP28 gene
Compartment Confidence
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nuclear speckles (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUSP28 Gene

Pathways & Interactions for DUSP28 Gene

PathCards logo

SuperPathways for DUSP28 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA,IDA 24531476
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP28: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP28 Gene

Drugs & Compounds for DUSP28 Gene

(2) Drugs for DUSP28 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DUSP28: view

Transcripts for DUSP28 Gene

mRNA/cDNA for DUSP28 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP28

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP28 Gene

No ASD Table

Relevant External Links for DUSP28 Gene

GeneLoc Exon Structure for
DUSP28

Expression for DUSP28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP28 Gene

Protein differential expression in normal tissues from HIPED for DUSP28 Gene

This gene is overexpressed in Heart (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP28 Gene



Protein tissue co-expression partners for DUSP28 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP28

SOURCE GeneReport for Unigene cluster for DUSP28 Gene:

Hs.369297
genes like me logo Genes that share expression patterns with DUSP28: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP28 Gene

Orthologs for DUSP28 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP28 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DUSP28 30 31
  • 99.43 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dusp28 30
  • 83.76 (n)
Mouse
(Mus musculus)
Mammalia Dusp28 30 17 31
  • 83.54 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DUSP28 31
  • 62 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DUSP28 31
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DUSP28 30 31
  • 66.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DUSP28 31
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dusp28 30
  • 54.2 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100005205 30
  • 57.49 (n)
DUSP28 31
  • 44 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG15528 31
  • 26 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea F13D11.3 31
  • 26 (a)
ManyToMany
F26A3.4 31
  • 20 (a)
ManyToMany
C04F12.8 31
  • 17 (a)
ManyToMany
ZK757.2 31
  • 15 (a)
ManyToMany
Species where no ortholog for DUSP28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DUSP28 Gene

ENSEMBL:
Gene Tree for DUSP28 (if available)
TreeFam:
Gene Tree for DUSP28 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP28: view image

Paralogs for DUSP28 Gene

(6) SIMAP similar genes for DUSP28 Gene using alignment to 2 proteins:

  • DUS28_HUMAN
  • H7C234_HUMAN
genes like me logo Genes that share paralogs with DUSP28: view

Variants for DUSP28 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DUSP28 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DUSP28 Gene

Variant ID Type Subtype PubMed ID
esv2759119 CNV gain 17122850
esv3575343 CNV gain 25503493
esv3594802 CNV gain 21293372
nsv1001262 CNV gain 25217958
nsv10226 CNV gain 18304495
nsv821937 CNV gain 20364138
nsv821938 CNV gain 20364138
nsv834586 CNV loss 17160897
nsv955290 CNV deletion 24416366
nsv999050 CNV gain 25217958

Variation tolerance for DUSP28 Gene

Gene Damage Index Score: 2.99; 49.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP28

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP28 Gene

Disorders for DUSP28 Gene

Additional Disease Information for DUSP28

No disorders were found for DUSP28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP28 Gene

Publications for DUSP28 Gene

  1. Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28. (PMID: 29121083) Ku B … Ryu SE (PloS one 2017) 3 4
  2. The family-wide structure and function of human dual-specificity protein phosphatases. (PMID: 24531476) Jeong DG … Ryu SE (Acta crystallographica. Section D, Biological crystallography 2014) 3 4
  3. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3
  4. The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer. (PMID: 30737378) Tang W … Wang J (Nature communications 2019) 3
  5. Scattered DUSP28 is a novel biomarker responsible for aggravating malignancy via the autocrine and paracrine signaling in metastatic pancreatic cancer. (PMID: 30902562) Lee J … Kim JH (Cancer letters 2019) 3

Products for DUSP28 Gene

Sources for DUSP28 Gene