Aliases for DUSP28 Gene
External Ids for DUSP28 Gene
Previous GeneCards Identifiers for DUSP28 Gene
GeneCards Summary for DUSP28 Gene
DUSP28 (Dual Specificity Phosphatase 28) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is SSH2.
UniProtKB/Swiss-Prot Summary for DUSP28 Gene
Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro) (PubMed:24531476, PubMed:29121083). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine (PubMed:29121083). The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site (PubMed:29121083).