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Aliases for DUSP28 Gene

Aliases for DUSP28 Gene

  • Dual Specificity Phosphatase 28 2 3 5
  • EC 4
  • EC 4
  • DUSP26 3
  • VHP 3

External Ids for DUSP28 Gene

Previous GeneCards Identifiers for DUSP28 Gene

  • GC02P241149
  • GC02P241499
  • GC02P233255

Summaries for DUSP28 Gene

GeneCards Summary for DUSP28 Gene

DUSP28 (Dual Specificity Phosphatase 28) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP12.

UniProtKB/Swiss-Prot for DUSP28 Gene

  • Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro).

Additional gene information for DUSP28 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP28 Gene

Genomics for DUSP28 Gene

GeneHancer (GH) Regulatory Elements for DUSP28 Gene

Promoters and enhancers for DUSP28 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I240558 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.3 1267 4.8 HDGF CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 DUSP28 ANKMY1 RNPEPL1
GH02I240620 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 10.2 +63.9 63939 7.2 PKNOX1 MLX ARID4B DMAP1 IRF4 ZNF48 ZNF121 ZNF143 ATF7 RUNX3 GPR35 DUSP28 CAPN10 LOC285191 PASK AQP12B AQP12A MTERF4 RNPEPL1 LOC100420500
GH02I240556 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 5.8 -2.4 -2386 1.7 CTCF PKNOX1 MAX ARID4B BACH1 SIN3A BMI1 IRF4 RAD21 POLR2A ANKMY1 PIR41651 DUSP28 PIR62560
GH02I240646 Enhancer 0.9 FANTOM5 ENCODE 2.2 +86.5 86480 0.5 PKNOX1 ATF1 NCOA1 GABPA MTA3 TARDBP GABPB1 CREB1 CREM LOC285191 DUSP28 GPR35 CAPN10 MTERF4 LOC100420500
GH02I240965 Enhancer 1 FANTOM5 Ensembl 1.3 +407.3 407273 4.7 ARID4B DMAP1 ZBTB40 THRB ZNF48 RAD21 THAP11 RXRA SP5 ZBTB11 LOC200772 GC02M240925 C2orf54 AGXT DUSP28 CROCC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DUSP28 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUSP28 gene promoter:

Genomic Locations for DUSP28 Gene

Genomic Locations for DUSP28 Gene
3,961 bases
Plus strand

Genomic View for DUSP28 Gene

Genes around DUSP28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP28 Gene

Proteins for DUSP28 Gene

  • Protein details for DUSP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity phosphatase 28
    Protein Accession:

    Protein attributes for DUSP28 Gene

    176 amino acids
    Molecular mass:
    18324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUSP28 Gene

Post-translational modifications for DUSP28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP28 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP28 Gene

Domains & Families for DUSP28 Gene

Gene Families for DUSP28 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DUSP28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP28: view

Function for DUSP28 Gene

Molecular function for DUSP28 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro).

Enzyme Numbers (IUBMB) for DUSP28 Gene

Phenotypes From GWAS Catalog for DUSP28 Gene

Gene Ontology (GO) - Molecular Function for DUSP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IDA 24531476
genes like me logo Genes that share ontologies with DUSP28: view
genes like me logo Genes that share phenotypes with DUSP28: view

miRNA for DUSP28 Gene

miRTarBase miRNAs that target DUSP28

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP28 Gene

Localization for DUSP28 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP28 gene
Compartment Confidence
extracellular 2
cytosol 2
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nuclear speckles (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUSP28 Gene

Pathways & Interactions for DUSP28 Gene

SuperPathways for DUSP28 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IDA 24531476
GO:0035335 peptidyl-tyrosine dephosphorylation IBA --
genes like me logo Genes that share ontologies with DUSP28: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP28 Gene

Drugs & Compounds for DUSP28 Gene

(2) Drugs for DUSP28 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for DUSP28 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with DUSP28: view

Transcripts for DUSP28 Gene

mRNA/cDNA for DUSP28 Gene

Unigene Clusters for DUSP28 Gene

Dual specificity phosphatase 28:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP28 Gene

No ASD Table

Relevant External Links for DUSP28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP28 Gene

Protein differential expression in normal tissues from HIPED for DUSP28 Gene

This gene is overexpressed in Heart (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP28 Gene

Protein tissue co-expression partners for DUSP28 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUSP28 Gene:


SOURCE GeneReport for Unigene cluster for DUSP28 Gene:

genes like me logo Genes that share expression patterns with DUSP28: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP28 Gene

Orthologs for DUSP28 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP28 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DUSP28 33 34
  • 99.43 (n)
(Rattus norvegicus)
Mammalia Dusp28 33
  • 83.76 (n)
(Mus musculus)
Mammalia Dusp28 33 16 34
  • 83.54 (n)
(Ornithorhynchus anatinus)
Mammalia DUSP28 34
  • 62 (a)
(Monodelphis domestica)
Mammalia DUSP28 34
  • 58 (a)
(Gallus gallus)
Aves DUSP28 33 34
  • 66.67 (n)
(Anolis carolinensis)
Reptilia DUSP28 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp28 33
  • 54.2 (n)
(Danio rerio)
Actinopterygii LOC100005205 33
  • 57.49 (n)
DUSP28 34
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15528 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea F13D11.3 34
  • 26 (a)
F26A3.4 34
  • 20 (a)
C04F12.8 34
  • 17 (a)
ZK757.2 34
  • 15 (a)
Species where no ortholog for DUSP28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP28 Gene

Gene Tree for DUSP28 (if available)
Gene Tree for DUSP28 (if available)

Paralogs for DUSP28 Gene

(6) SIMAP similar genes for DUSP28 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP28: view

Variants for DUSP28 Gene

Sequence variations from dbSNP and Humsavar for DUSP28 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000260964 -- 240,560,054(+) T/C 5_prime_UTR_variant
rs1000758029 -- 240,560,312(+) G/A 5_prime_UTR_variant
rs1000992931 -- 240,560,310(+) G/A 5_prime_UTR_variant
rs1001213276 -- 240,559,380(+) CTGCT/CT upstream_transcript_variant
rs1001277949 -- 240,560,398(+) G/A 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP28 Gene

Variant ID Type Subtype PubMed ID
esv2759119 CNV gain 17122850
esv3575343 CNV gain 25503493
esv3594802 CNV gain 21293372
nsv1001262 CNV gain 25217958
nsv10226 CNV gain 18304495
nsv821937 CNV gain 20364138
nsv821938 CNV gain 20364138
nsv834586 CNV loss 17160897
nsv955290 CNV deletion 24416366
nsv999050 CNV gain 25217958

Variation tolerance for DUSP28 Gene

Gene Damage Index Score: 2.99; 49.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP28 Gene

Disorders for DUSP28 Gene

Additional Disease Information for DUSP28

No disorders were found for DUSP28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP28 Gene

Publications for DUSP28 Gene

  1. The family-wide structure and function of human dual-specificity protein phosphatases. (PMID: 24531476) Jeong DG … Ryu SE (Acta crystallographica. Section D, Biological crystallography 2014) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28. (PMID: 29121083) Ku B … Ryu SE (PloS one 2017) 3 58
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  5. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58

Products for DUSP28 Gene

Sources for DUSP28 Gene

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