Aliases for DUSP27 Gene

Aliases for DUSP27 Gene

  • Dual Specificity Phosphatase 27, Atypical 2 3 5
  • Dual Specificity Phosphatase 27 (Putative) 2 3
  • Inactive Dual Specificity Phosphatase 27 3 4

External Ids for DUSP27 Gene

Previous GeneCards Identifiers for DUSP27 Gene

  • GC01P163796
  • GC01P165329
  • GC01P167063
  • GC01P138310

Summaries for DUSP27 Gene

GeneCards Summary for DUSP27 Gene

DUSP27 (Dual Specificity Phosphatase 27, Atypical) is a Protein Coding gene. Diseases associated with DUSP27 include Variola Major. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is SSH2.

UniProtKB/Swiss-Prot Summary for DUSP27 Gene

Additional gene information for DUSP27 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP27 Gene

Genomics for DUSP27 Gene

GeneHancer (GH) Regulatory Elements for DUSP27 Gene

Promoters and enhancers for DUSP27 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J167092 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.1 148 3.6 RFX1 NFIC FOS IKZF3 POLR2A NFIB PRDM6 ZNF18 MEIS2 ZNF366 DUSP27 GPA33 ENSG00000213068
GH01J167066 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas dbSUPER 12.1 -27.4 -27366 0.3 CTCF ZBTB26 REST MYC RAD21 TRIM22 SMC3 MXI1 KDM4B MYNN DUSP27 GPA33 POU2F1 ILDR2 RF00017-383 LOC105371600 LOC105371598
GH01J167165 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 10.7 +72.4 72418 2.3 ZSCAN5C TEAD4 ZNF423 TRIM28 RFX1 KLF7 ZNF341 POLR2A OSR2 WT1 GPA33 HSALNG0008213 LOC105371601 LINC01363 DUSP27
GH01J167134 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 +43.2 43222 4.6 EP300 SMC3 FOS NR3C1 NFE2 SMARCA4 TRIM28 MAX SETDB1 DACH1 GPA33 DUSP27 LINC01363 ENSG00000213068
GH01J167121 Promoter/Enhancer 1 ENCODE CraniofacialAtlas dbSUPER 11.4 +27.7 27684 1.6 GABPA POLR2A NFIC FOXP2 TBP CTBP2 CTCF EZH2 BACH1 RBBP5 DUSP27 GPA33 ENSG00000227907 ENSG00000213068
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP27 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP27

Top Transcription factor binding sites by QIAGEN in the DUSP27 gene promoter:
  • c-Myb
  • c-Rel
  • C/EBPalpha
  • Cart-1
  • HNF-4alpha1
  • HNF-4alpha2
  • Nkx2-5
  • Pbx1a
  • RFX1
  • RSRFC4

Genomic Locations for DUSP27 Gene

Genomic Locations for DUSP27 Gene
35,823 bases
Plus strand
35,121 bases
Plus strand

Genomic View for DUSP27 Gene

Genes around DUSP27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP27 Gene

Proteins for DUSP27 Gene

  • Protein details for DUSP27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive dual specificity phosphatase 27
    Protein Accession:
    Secondary Accessions:
    • A0AUM4
    • Q9C074

    Protein attributes for DUSP27 Gene

    1158 amino acids
    Molecular mass:
    130176 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK02011.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for DUSP27 Gene

Post-translational modifications for DUSP27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP27 Gene

No data available for DME Specific Peptides for DUSP27 Gene

Domains & Families for DUSP27 Gene

Gene Families for DUSP27 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DUSP27 Gene

Suggested Antigen Peptide Sequences for DUSP27 Gene

GenScript: Design optimal peptide antigens:
  • Inactive dual specificity phosphatase 27 (DUS27_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP27: view

Function for DUSP27 Gene

Molecular function for DUSP27 Gene

UniProtKB/Swiss-Prot Function:
May be required for myofiber maturation.

Gene Ontology (GO) - Molecular Function for DUSP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP27: view
genes like me logo Genes that share phenotypes with DUSP27: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP27

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUSP27 Gene

Localization for DUSP27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP27 Gene

Cytoplasm, myofibril, sarcomere.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP27 gene
Compartment Confidence
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DUSP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030017 sarcomere IEA --
genes like me logo Genes that share ontologies with DUSP27: view

Pathways & Interactions for DUSP27 Gene

PathCards logo

SuperPathways for DUSP27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP27: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP27 Gene

Drugs & Compounds for DUSP27 Gene

No Compound Related Data Available

Transcripts for DUSP27 Gene

mRNA/cDNA for DUSP27 Gene

3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP27 Gene

No ASD Table

Relevant External Links for DUSP27 Gene

GeneLoc Exon Structure for

Expression for DUSP27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP27 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP27 Gene

This gene is overexpressed in Muscle - Skeletal (x22.2), Heart - Left Ventricle (x16.4), and Heart - Atrial Appendage (x11.0).

Protein differential expression in normal tissues from HIPED for DUSP27 Gene

This gene is overexpressed in NK cells (23.6), Fetal heart (15.4), Peripheral blood mononuclear cells (8.7), Fetal testis (7.3), Fetal Liver (6.8), and Heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP27 Gene

Protein tissue co-expression partners for DUSP27 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP27

SOURCE GeneReport for Unigene cluster for DUSP27 Gene:


Evidence on tissue expression from TISSUES for DUSP27 Gene

  • Muscle(2.8)
  • Heart(2.3)
genes like me logo Genes that share expression patterns with DUSP27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP27 Gene

Orthologs for DUSP27 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DUSP27 31 30
  • 99.05 (n)
(Bos Taurus)
Mammalia DUSP27 31 30
  • 85.87 (n)
(Canis familiaris)
Mammalia DUSP27 31 30
  • 84.9 (n)
(Mus musculus)
Mammalia Dusp27 17 31 30
  • 83.1 (n)
(Rattus norvegicus)
Mammalia Dusp27 30
  • 83.05 (n)
(Monodelphis domestica)
Mammalia DUSP27 31
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia DUSP27 31
  • 68 (a)
(Gallus gallus)
Aves DUSP27 31 30
  • 63.94 (n)
(Anolis carolinensis)
Reptilia DUSP27 31
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp27 30
  • 58.78 (n)
(Danio rerio)
Actinopterygii LOC792623 30
  • 59.51 (n)
DUSP27 31
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7378 31
  • 37 (a)
Species where no ortholog for DUSP27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP27 Gene

Gene Tree for DUSP27 (if available)
Gene Tree for DUSP27 (if available)
Evolutionary constrained regions (ECRs) for DUSP27: view image

Paralogs for DUSP27 Gene

(4) SIMAP similar genes for DUSP27 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP27: view

Variants for DUSP27 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP27 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
715851 Benign: not provided 167,117,353(+) A/T SYNONYMOUS_VARIANT
769541 Benign: not provided 167,127,158(+) C/T MISSENSE_VARIANT
769542 Benign: not provided 167,127,609(+) C/T SYNONYMOUS_VARIANT
775621 Benign: not provided 167,119,239(+) C/T INTRON_VARIANT
783013 Benign: not provided 167,119,270(+) G/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for DUSP27 Gene

Structural Variations from Database of Genomic Variants (DGV) for DUSP27 Gene

Variant ID Type Subtype PubMed ID
esv2719184 CNV deletion 23290073
esv2750815 CNV gain 17911159
esv3542134 CNV deletion 23714750
nsv1008831 CNV gain 25217958
nsv1078878 OTHER inversion 25765185
nsv1113190 CNV deletion 24896259

Variation tolerance for DUSP27 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.48; 85.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP27 Gene

Disorders for DUSP27 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUSP27 Gene - From: DISEASES

Disorder Aliases PubMed IDs
variola major
  • smallpox
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DUSP27

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DUSP27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP27 Gene

Publications for DUSP27 Gene

  1. Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. (PMID: 26302245) Zhao BM … Ulrich RG (PloS one 2015) 2 3 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. (PMID: 20520587) Nielsen DA … Kreek MJ (Psychiatric genetics 2010) 3 41 54
  4. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 41 54
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 54

Products for DUSP27 Gene

Sources for DUSP27 Gene