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Aliases for DUSP27 Gene

Aliases for DUSP27 Gene

  • Dual Specificity Phosphatase 27, Atypical 2 3 5
  • Dual Specificity Phosphatase 27 (Putative) 2

External Ids for DUSP27 Gene

Previous GeneCards Identifiers for DUSP27 Gene

  • GC01P163796
  • GC01P165329
  • GC01P167063
  • GC01P138310

Summaries for DUSP27 Gene

GeneCards Summary for DUSP27 Gene

DUSP27 (Dual Specificity Phosphatase 27, Atypical) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUPD1.

UniProtKB/Swiss-Prot for DUSP27 Gene

  • May be required for myofiber maturation.

Additional gene information for DUSP27 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP27 Gene

Genomics for DUSP27 Gene

GeneHancer (GH) Regulatory Elements for DUSP27 Gene

Promoters and enhancers for DUSP27 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I167092 Enhancer 1.1 Ensembl ENCODE dbSUPER 550.8 +0.2 178 3.6 MEIS2 PKNOX1 NFIB BMI1 ZNF121 ZNF366 RFX1 ZNF362 ZNF501 ZEB2 DUSP27 GPA33 GC01P167158
GH01I167066 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.1 -27.2 -27202 0.7 RB1 ZFP64 ZBTB40 ZNF2 ZNF48 RAD21 ZNF335 ARID2 ZNF143 SMARCA5 GPA33 DUSP27 POU2F1 ILDR2 MAEL LOC105371600 LOC105371598
GH01I167059 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.5 -34.6 -34608 0.9 RB1 MZF1 ZNF76 SIN3A ZNF2 RAD21 CHAMP1 ZNF213 ZNF143 BCLAF1 GPA33 TADA1 DUSP27 LOC105371600 LOC105371598
GH01I167134 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.7 +42.8 42754 3.6 POLR2A DACH1 MAX FOS SETDB1 GPA33 DUSP27 LINC01363 GC01P167158
GH01I167121 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.4 +27.7 27732 1.6 NFIC BACH1 FOXP2 EZH2 DUSP27 GPA33 LOC105371600 GC01P167158
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DUSP27 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUSP27 gene promoter:

Genomic Locations for DUSP27 Gene

Genomic Locations for DUSP27 Gene
chr1:167,094,045-167,129,897
(GRCh38/hg38)
Size:
35,853 bases
Orientation:
Plus strand
chr1:167,063,282-167,098,402
(GRCh37/hg19)

Genomic View for DUSP27 Gene

Genes around DUSP27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP27 Gene

Proteins for DUSP27 Gene

  • Protein details for DUSP27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZP5-DUS27_HUMAN
    Recommended name:
    Inactive dual specificity phosphatase 27
    Protein Accession:
    Q5VZP5
    Secondary Accessions:
    • A0AUM4
    • Q9C074

    Protein attributes for DUSP27 Gene

    Size:
    1158 amino acids
    Molecular mass:
    130176 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK02011.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for DUSP27 Gene

Post-translational modifications for DUSP27 Gene

No Post-translational modifications

Other Protein References for DUSP27 Gene

No data available for DME Specific Peptides for DUSP27 Gene

Domains & Families for DUSP27 Gene

Gene Families for DUSP27 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DUSP27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VZP5

UniProtKB/Swiss-Prot:

DUS27_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP27: view

Function for DUSP27 Gene

Molecular function for DUSP27 Gene

UniProtKB/Swiss-Prot Function:
May be required for myofiber maturation.

Gene Ontology (GO) - Molecular Function for DUSP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP27: view
genes like me logo Genes that share phenotypes with DUSP27: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUSP27 Gene

Localization for DUSP27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP27 Gene

Cytoplasm, myofibril, sarcomere.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP27 gene
Compartment Confidence
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DUSP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030017 sarcomere IEA --
genes like me logo Genes that share ontologies with DUSP27: view

Pathways & Interactions for DUSP27 Gene

SuperPathways for DUSP27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP27: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP27 Gene

Drugs & Compounds for DUSP27 Gene

No Compound Related Data Available

Transcripts for DUSP27 Gene

Unigene Clusters for DUSP27 Gene

Dual specificity phosphatase 27 (putative):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP27 Gene

No ASD Table

Relevant External Links for DUSP27 Gene

GeneLoc Exon Structure for
DUSP27
ECgene alternative splicing isoforms for
DUSP27

Expression for DUSP27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP27 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP27 Gene

This gene is overexpressed in Muscle - Skeletal (x22.2), Heart - Left Ventricle (x16.4), and Heart - Atrial Appendage (x11.0).

Protein differential expression in normal tissues from HIPED for DUSP27 Gene

This gene is overexpressed in NK cells (23.6), Fetal heart (15.4), Peripheral blood mononuclear cells (8.7), Fetal testis (7.3), Fetal Liver (6.8), and Heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DUSP27 Gene



Protein tissue co-expression partners for DUSP27 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUSP27 Gene:

DUSP27

SOURCE GeneReport for Unigene cluster for DUSP27 Gene:

Hs.632462

Evidence on tissue expression from TISSUES for DUSP27 Gene

  • Muscle(2.8)
  • Heart(2.3)
genes like me logo Genes that share expression patterns with DUSP27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP27 Gene

Orthologs for DUSP27 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP27 33 34
  • 99.05 (n)
cow
(Bos Taurus)
Mammalia DUSP27 33 34
  • 85.87 (n)
dog
(Canis familiaris)
Mammalia DUSP27 33 34
  • 84.9 (n)
mouse
(Mus musculus)
Mammalia Dusp27 33 16 34
  • 83.1 (n)
rat
(Rattus norvegicus)
Mammalia Dusp27 33
  • 83.05 (n)
oppossum
(Monodelphis domestica)
Mammalia DUSP27 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP27 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP27 33 34
  • 63.94 (n)
lizard
(Anolis carolinensis)
Reptilia DUSP27 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp27 33
  • 58.78 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC792623 33
  • 59.51 (n)
DUSP27 34
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7378 34
  • 37 (a)
OneToMany
Species where no ortholog for DUSP27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP27 Gene

ENSEMBL:
Gene Tree for DUSP27 (if available)
TreeFam:
Gene Tree for DUSP27 (if available)

Paralogs for DUSP27 Gene

(4) SIMAP similar genes for DUSP27 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP27: view

Variants for DUSP27 Gene

Sequence variations from dbSNP and Humsavar for DUSP27 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000070127 -- 167,095,668(+) T/C intron_variant
rs1000173439 -- 167,095,570(+) A/T intron_variant
rs1000268630 -- 167,123,924(+) T/G intron_variant
rs1000335294 -- 167,128,983(+) A/G 3_prime_UTR_variant
rs1000336861 -- 167,122,900(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP27 Gene

Variant ID Type Subtype PubMed ID
nsv1113190 CNV deletion 24896259
nsv1078878 OTHER inversion 25765185
nsv1008831 CNV gain 25217958
esv3542134 CNV deletion 23714750
esv2750815 CNV gain 17911159
esv2719184 CNV deletion 23290073

Variation tolerance for DUSP27 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.48; 85.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP27 Gene

Disorders for DUSP27 Gene

Additional Disease Information for DUSP27

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DUSP27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP27 Gene

Publications for DUSP27 Gene

  1. Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. (PMID: 26302245) Zhao BM … Ulrich RG (PloS one 2015) 2 3 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. (PMID: 20520587) Nielsen DA … Kreek MJ (Psychiatric genetics 2010) 3 44 58
  4. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 44 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for DUSP27 Gene

Sources for DUSP27 Gene

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