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Aliases for DUSP26 Gene

Aliases for DUSP26 Gene

  • Dual Specificity Phosphatase 26 2 3 5
  • Low-Molecular-Mass Dual-Specificity Phosphatase 4 3 4
  • Novel Amplified Gene In Thyroid Anaplastic Cancer 3 4
  • Mitogen-Activated Protein Kinase Phosphatase 8 3 4
  • Dual Specificity Phosphatase 26 (Putative) 2 3
  • Dual Specificity Phosphatase SKRP3 3 4
  • MAP Kinase Phosphatase 8 3 4
  • DUSP24 3 4
  • DSP-4 3 4
  • LDP-4 3 4
  • MKP-8 3 4
  • NATA1 3 4
  • SKRP3 3 4
  • MKP8 3 4
  • Dual Specificity Protein Phosphatase 26 3
  • Neuroendocrine-Associated Phosphatase 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • NEAP 3
  • LDP4 4

External Ids for DUSP26 Gene

Previous GeneCards Identifiers for DUSP26 Gene

  • GC08M033569
  • GC08M033448
  • GC08M031980

Summaries for DUSP26 Gene

Entrez Gene Summary for DUSP26 Gene

  • This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for DUSP26 Gene

DUSP26 (Dual Specificity Phosphatase 26) is a Protein Coding gene. Diseases associated with DUSP26 include Thyroid Cancer and Neuroblastoma. Gene Ontology (GO) annotations related to this gene include phosphatase activity and p53 binding. An important paralog of this gene is DUPD1.

UniProtKB/Swiss-Prot for DUSP26 Gene

  • Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).

Additional gene information for DUSP26 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP26 Gene

Genomics for DUSP26 Gene

GeneHancer (GH) Regulatory Elements for DUSP26 Gene

Promoters and enhancers for DUSP26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I033597 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 553.9 +1.3 1322 3.4 ZSCAN4 KLF17 SIN3A ZNF2 ZNF335 GLIS2 SCRT2 MEF2D NFIC GLIS1 DUSP26 FUT10 GC08P033581
GH08I033580 Enhancer 0.8 ENCODE 0.4 +18.6 18589 1.6 DRAP1 ELF3 SOX13 SAP130 ARID4B DMAP1 ZNF48 ZSCAN9 TEAD3 GATAD1 GC08P033581 RN7SL621P FUT10 LOC100630919 SNORD13 TTI2 ENSG00000252505 RPL10P18 MAK16 RNF122
GH08I033591 Enhancer 0.7 ENCODE 0.4 +9.0 8998 0.2 ELF3 CTCF ARID4B KLF17 ZNF2 RAD21 SCRT2 SMC3 ZNF143 ZNF654 DUSP26 GC08P033581
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DUSP26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUSP26 gene promoter:

Genomic Locations for DUSP26 Gene

Genomic Locations for DUSP26 Gene
chr8:33,591,330-33,600,106
(GRCh38/hg38)
Size:
8,777 bases
Orientation:
Minus strand
chr8:33,448,851-33,457,624
(GRCh37/hg19)

Genomic View for DUSP26 Gene

Genes around DUSP26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP26 Gene

Proteins for DUSP26 Gene

  • Protein details for DUSP26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV47-DUS26_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 26
    Protein Accession:
    Q9BV47
    Secondary Accessions:
    • D3DSV8
    • Q9BTW0

    Protein attributes for DUSP26 Gene

    Size:
    211 amino acids
    Molecular mass:
    23946 Da
    Quaternary structure:
    • Interacts with HSF4.

    Three dimensional structures from OCA and Proteopedia for DUSP26 Gene

    Alternative splice isoforms for DUSP26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP26 Gene

Post-translational modifications for DUSP26 Gene

No Post-translational modifications

Other Protein References for DUSP26 Gene

No data available for DME Specific Peptides for DUSP26 Gene

Domains & Families for DUSP26 Gene

Gene Families for DUSP26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DUSP26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV47

UniProtKB/Swiss-Prot:

DUS26_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP26: view

Function for DUSP26 Gene

Molecular function for DUSP26 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).

Enzyme Numbers (IUBMB) for DUSP26 Gene

Phenotypes From GWAS Catalog for DUSP26 Gene

Gene Ontology (GO) - Molecular Function for DUSP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001102 RNA polymerase II activating transcription factor binding IPI 16581800
GO:0002039 p53 binding IPI 20562916
GO:0004647 phosphoserine phosphatase activity IMP 15796912
GO:0004721 phosphoprotein phosphatase activity IEA,IDA 19043453
GO:0004725 protein tyrosine phosphatase activity IMP 15796912
genes like me logo Genes that share ontologies with DUSP26: view
genes like me logo Genes that share phenotypes with DUSP26: view

Animal Models for DUSP26 Gene

MGI Knock Outs for DUSP26:

miRNA for DUSP26 Gene

miRTarBase miRNAs that target DUSP26

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP26 Gene

Localization for DUSP26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP26 Gene

Cytoplasm. Nucleus. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP26 gene
Compartment Confidence
extracellular 5
nucleus 5
golgi apparatus 5
mitochondrion 4
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DUSP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15796912
GO:0005737 cytoplasm IEA,IDA 15796912
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IEA,IDA 19043453
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with DUSP26: view

Pathways & Interactions for DUSP26 Gene

SuperPathways for DUSP26 Gene

No Data Available

SIGNOR curated interactions for DUSP26 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DUSP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 16581800
GO:0006470 protein dephosphorylation IEA,IDA 15796912
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation IMP 15796912
genes like me logo Genes that share ontologies with DUSP26: view

No data available for Pathways by source for DUSP26 Gene

Drugs & Compounds for DUSP26 Gene

(2) Drugs for DUSP26 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with DUSP26: view

Transcripts for DUSP26 Gene

Unigene Clusters for DUSP26 Gene

Dual specificity phosphatase 26 (putative):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP26 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for DUSP26 Gene

GeneLoc Exon Structure for
DUSP26
ECgene alternative splicing isoforms for
DUSP26

Expression for DUSP26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP26 Gene

This gene is overexpressed in Muscle - Skeletal (x10.6).

NURSA nuclear receptor signaling pathways regulating expression of DUSP26 Gene:

DUSP26

SOURCE GeneReport for Unigene cluster for DUSP26 Gene:

Hs.8719

mRNA Expression by UniProt/SwissProt for DUSP26 Gene:

Q9BV47-DUS26_HUMAN
Tissue specificity: Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.

Evidence on tissue expression from TISSUES for DUSP26 Gene

  • Nervous system(4.9)
  • Lung(4.2)
  • Muscle(2.6)
genes like me logo Genes that share expression patterns with DUSP26: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP26 Gene

Orthologs for DUSP26 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP26 34 33
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP26 33 34
  • 93.36 (n)
rat
(Rattus norvegicus)
Mammalia Dusp26 33
  • 91.15 (n)
mouse
(Mus musculus)
Mammalia Dusp26 33 16 34
  • 90.68 (n)
oppossum
(Monodelphis domestica)
Mammalia DUSP26 34
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP26 33 34
  • 88.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP26 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP26 34 33
  • 76.91 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP26 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493443 33
  • 63.05 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC570815 33
  • 69.48 (n)
DUSP26 34
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7378 33 34
  • 56.35 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008228 33
  • 55 (n)
Species where no ortholog for DUSP26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP26 Gene

ENSEMBL:
Gene Tree for DUSP26 (if available)
TreeFam:
Gene Tree for DUSP26 (if available)

Paralogs for DUSP26 Gene

(6) SIMAP similar genes for DUSP26 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP26: view

Variants for DUSP26 Gene

Sequence variations from dbSNP and Humsavar for DUSP26 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000179301 -- 33,592,883(-) A/G intron_variant
rs1000508202 -- 33,599,361(-) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000585245 -- 33,599,138(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000739511 -- 33,593,299(-) A/C intron_variant
rs1000964617 -- 33,598,988(-) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP26 Gene

Variant ID Type Subtype PubMed ID
esv2752251 CNV loss 17911159
nsv478822 CNV novel sequence insertion 20440878

Variation tolerance for DUSP26 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP26 Gene

Disorders for DUSP26 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DUSP26 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
thyroid cancer
  • malignant neoplasm of thyroid gland
neuroblastoma
  • neuroblastoma, susceptibility to
drug-induced mental disorder
drug psychosis
  • drug-induced psychosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DUSP26

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DUSP26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP26 Gene

Publications for DUSP26 Gene

  1. MKP-8, a novel MAPK phosphatase that inhibits p38 kinase. (PMID: 15796912) Vasudevan SA … Yang J (Biochemical and biophysical research communications 2005) 2 3 4 22 58
  2. A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity. (PMID: 16924234) Yu W … Inazawa J (Oncogene 2007) 3 4 22 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. (PMID: 20562916) Shang X … Yang J (Oncogene 2010) 2 3 58
  5. Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain. (PMID: 17001450) Takagaki K … Kikuchi K (Molecular and cellular biochemistry 2007) 3 4 58

Products for DUSP26 Gene

Sources for DUSP26 Gene

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