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Aliases for DUSP23 Gene

Aliases for DUSP23 Gene

  • Dual Specificity Phosphatase 23 2 3 5
  • VH1-Like Phosphatase Z 3 4
  • LDP-3 3 4
  • VHZ 3 4
  • Low-Molecular-Mass Dual-Specificity Phosphatase 3 3
  • Low Molecular Mass Dual Specificity Phosphatase 3 4
  • Dual Specificity Protein Phosphatase 23 3
  • Testicular Tissue Protein Li 59 3
  • VH1-Like Member Z 3
  • EC 4
  • EC 4
  • DUSP25 3
  • MOSP 3
  • LDP3 4

External Ids for DUSP23 Gene

Previous GeneCards Identifiers for DUSP23 Gene

  • GC01P156968
  • GC01P156563
  • GC01P158017
  • GC01P131107

Summaries for DUSP23 Gene

GeneCards Summary for DUSP23 Gene

DUSP23 (Dual Specificity Phosphatase 23) is a Protein Coding gene. Diseases associated with DUSP23 include Neuronal Intestinal Dysplasia. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is CDC14A.

UniProtKB/Swiss-Prot for DUSP23 Gene

  • Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).

Gene Wiki entry for DUSP23 Gene

Additional gene information for DUSP23 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP23 Gene

Genomics for DUSP23 Gene

GeneHancer (GH) Regulatory Elements for DUSP23 Gene

Promoters and enhancers for DUSP23 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J159778 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 655.4 -0.6 -551 3.3 HDGF FOXA2 PKNOX1 ATF1 SIN3A YY1 ZNF143 ATF7 RXRA NCOA1 DUSP23 LOC101928264 FCRL6 RPL27P2
GH01J159888 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +109.6 109551 3 HDGF ATF1 SIN3A ZNF2 IRF4 GLIS2 ARID2 ZNF207 ZNF143 ATF7 ENSG00000272668 SLAMF8 SNHG28 FCRL6 VSIG8 ENSG00000212161 IGSF9 DUSP23 PIGM SLAMF9
GH01J159751 Enhancer 1 Ensembl ENCODE 10.1 -28.3 -28319 3.2 FOXA2 RAD21 YY1 EGR1 RCOR1 SMARCC1 RXRA USF2 CEBPB REST CRP FCRL6 DUSP23 ENSG00000212161 AIM2 RPL27P2
GH01J159211 Enhancer 0.7 Ensembl 9.2 -569.5 -569531 0.4 CTCF ARNT CEBPG RAD21 CC2D1A ARID2 SCRT2 SMC3 ZNF143 SCRT1 CADM3 AIM2 OR10J2P FCER1A OR10J3 DUSP23 ACKR1 CADM3-AS1 MPTX1
GH01J159959 Enhancer 0.6 ENCODE 9.6 +178.6 178558 0.9 ZNF687 IRF4 ATF2 ZNF592 ZNF217 GATA3 CTBP1 SCRT2 IKZF1 CREB1 LINC01133 ENSG00000212161 ENSG00000225279 DUSP23 FCRL6 SLAMF9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DUSP23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUSP23 gene promoter:

Genomic Locations for DUSP23 Gene

Genomic Locations for DUSP23 Gene
1,612 bases
Plus strand

Genomic View for DUSP23 Gene

Genes around DUSP23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP23 Gene

Proteins for DUSP23 Gene

  • Protein details for DUSP23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 23
    Protein Accession:
    Secondary Accessions:
    • Q9NX48

    Protein attributes for DUSP23 Gene

    150 amino acids
    Molecular mass:
    16588 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP23 Gene

neXtProt entry for DUSP23 Gene

Post-translational modifications for DUSP23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP23 Gene

No data available for DME Specific Peptides for DUSP23 Gene

Domains & Families for DUSP23 Gene

Gene Families for DUSP23 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DUSP23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP23: view

Function for DUSP23 Gene

Molecular function for DUSP23 Gene

UniProtKB/Swiss-Prot Function:
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.498 mM for p-nitrophenylphosphate {ECO:0000269 PubMed:15201283};

Enzyme Numbers (IUBMB) for DUSP23 Gene

Phenotypes From GWAS Catalog for DUSP23 Gene

Gene Ontology (GO) - Molecular Function for DUSP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity IBA --
GO:0004725 protein tyrosine phosphatase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA,IDA 17498703
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DUSP23: view
genes like me logo Genes that share phenotypes with DUSP23: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP23

miRNA for DUSP23 Gene

miRTarBase miRNAs that target DUSP23

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP23 Gene

Localization for DUSP23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP23 Gene

Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP23 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DUSP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IEA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with DUSP23: view

Pathways & Interactions for DUSP23 Gene

SuperPathways for DUSP23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IDA 24531476
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP23: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP23 Gene

Drugs & Compounds for DUSP23 Gene

(3) Drugs for DUSP23 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
4-Nitrophenyl phosphate Experimental Pharma Target 0
genes like me logo Genes that share compounds with DUSP23: view

Transcripts for DUSP23 Gene

mRNA/cDNA for DUSP23 Gene

Unigene Clusters for DUSP23 Gene

Dual specificity phosphatase 23:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP23 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c
SP2: -

Relevant External Links for DUSP23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP23 Gene

This gene is overexpressed in Kidney - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for DUSP23 Gene

This gene is overexpressed in Bone (31.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP23 Gene

Protein tissue co-expression partners for DUSP23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DUSP23 Gene:


SOURCE GeneReport for Unigene cluster for DUSP23 Gene:


mRNA Expression by UniProt/SwissProt for DUSP23 Gene:

Tissue specificity: Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach.

Evidence on tissue expression from TISSUES for DUSP23 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with DUSP23: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP23 Gene

Orthologs for DUSP23 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUSP23 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DUSP23 34 33
  • 99.78 (n)
(Bos Taurus)
Mammalia DUSP23 34 33
  • 91.56 (n)
(Rattus norvegicus)
Mammalia Dusp23 33
  • 90.22 (n)
(Mus musculus)
Mammalia Dusp23 16 34 33
  • 89.33 (n)
(Canis familiaris)
Mammalia DUSP23 34 33
  • 86.46 (n)
(Monodelphis domestica)
Mammalia DUSP23 34
  • 86 (a)
(Gallus gallus)
Aves DUSP23 34 33
  • 70.55 (n)
(Anolis carolinensis)
Reptilia DUSP23 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp23 33
  • 67.42 (n)
Str.11103 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15941 33
(Danio rerio)
Actinopterygii zgc:92902 33
  • 67.11 (n)
DUSP23 (2 of 2) 34
  • 64 (a)
DUSP23 (1 of 2) 34
  • 54 (a)
Dr.8008 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.620 33
fruit fly
(Drosophila melanogaster)
Insecta cdc14 34
  • 4 (a)
(Caenorhabditis elegans)
Secernentea cdc-14 34
  • 4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC14 34
  • 7 (a)
Species where no ortholog for DUSP23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP23 Gene

Gene Tree for DUSP23 (if available)
Gene Tree for DUSP23 (if available)
Evolutionary constrained regions (ECRs) for DUSP23: view image

Paralogs for DUSP23 Gene

Paralogs for DUSP23 Gene

(3) SIMAP similar genes for DUSP23 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP23: view

Variants for DUSP23 Gene

Sequence variations from dbSNP and Humsavar for DUSP23 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000747334 -- 159,781,044(+) A/G 5_prime_UTR_variant, intron_variant
rs1000833009 -- 159,780,481(+) A/C upstream_transcript_variant
rs1001201071 -- 159,781,311(+) C/A coding_sequence_variant, missense_variant
rs1002125415 -- 159,781,870(+) A/G intron_variant
rs1002200377 -- 159,781,565(+) ACTG/ intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP23 Gene

Variant ID Type Subtype PubMed ID
nsv1005195 CNV gain 25217958

Variation tolerance for DUSP23 Gene

Gene Damage Index Score: 5.60; 72.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP23 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP23 Gene

Disorders for DUSP23 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUSP23 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
neuronal intestinal dysplasia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DUSP23

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DUSP23: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP23 Gene

Publications for DUSP23 Gene

  1. Molecular cloning and characterization of a novel dual-specificity phosphatase 23 gene from human fetal brain. (PMID: 15147733) Wu Q … Mao Y (The international journal of biochemistry & cell biology 2004) 2 3 4 22 58
  2. The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ. (PMID: 15201283) Alonso A … Mustelin T (The Journal of biological chemistry 2004) 3 4 22 58
  3. Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer: genome-wide analysis of genetic data. (PMID: 21787189) Nyberg F … Kamatani N (Pharmacogenomics 2011) 3 44 58
  4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for DUSP23 Gene

Sources for DUSP23 Gene

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