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This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues.[provided by RefSeq, Mar 2009]
DUSP21 (Dual Specificity Phosphatase 21) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP18.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
GO:0004722 | protein serine/threonine phosphatase activity | IEA | -- |
GO:0004725 | protein tyrosine phosphatase activity | IDA | 12408986 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 12408986 |
GO:0005737 | cytoplasm | IEA,IDA | 12408986 |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005743 | mitochondrial inner membrane | IEA | -- |
GO:0005759 | mitochondrial matrix | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000188 | inactivation of MAPK activity | IEA | -- |
GO:0006470 | protein dephosphorylation | IEA | -- |
GO:0016311 | dephosphorylation | IEA | -- |
GO:0035335 | peptidyl-tyrosine dephosphorylation | IDA | 12408986 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DUSP21 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DUSP21 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dusp21 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | DUSP21 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | DUSP18 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG15528 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | F13D11.3 31 |
|
ManyToMany | |
F26A3.4 31 |
|
ManyToMany | |||
C04F12.8 31 |
|
ManyToMany | |||
ZK757.2 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10229 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1372839121 | A colorectal cancer sample |
p.Arg167Cys |
|||
rs1045031 | - |
p.Met186Thr |
No disorders were found for DUSP21 Gene.