Aliases for DUSP21 Gene
Aliases for DUSP21 Gene
External Ids for DUSP21 Gene
- HGNC: 20476
- Entrez Gene: 63904
- Ensembl: ENSG00000189037
- OMIM: 300678
- UniProtKB: Q9H596
Previous GeneCards Identifiers for DUSP21 Gene
- GC0XP042963
- GC0XP043529
- GC0XP043749
- GC0XP044459
- GC0XP044588
- GC0XP044703
- GC0XP042424
Summaries for DUSP21 Gene
-
This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues.[provided by RefSeq, Mar 2009]
GeneCards Summary for DUSP21 Gene
DUSP21 (Dual Specificity Phosphatase 21) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP18.
UniProtKB/Swiss-Prot for DUSP21 Gene
-
Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.
Additional gene information for DUSP21 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP21 Gene
Genomics for DUSP21 Gene
GeneHancer (GH) Regulatory Elements for DUSP21 Gene
Promoters and enhancers for DUSP21 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XJ044708 | Enhancer | 0.7 | ENCODE | 12.3 | -135.3 | -135333 | 0.2 | LEF1 TEAD4 TAL1 CCNT2 CC2D1A TCF12 MTA3 POLR2A GATA2 NCOR1 | DUSP21 RPSAP61 PIR53424 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around DUSP21 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DUSP21 gene promoter:
-
- Pax-5
- NF-E2 p45
- NF-E2
- Pax-4a
- POU2F1
- POU2F1a
- POU2F1b
- POU2F1c
- CUTL1
- AP-1
Regulatory Element Products
Genomic Locations for DUSP21 Gene
Genomic Locations for DUSP21 Gene
- chrX:44,844,003-44,844,888
- (GRCh38/hg38)
- Size:
- 886 bases
- Orientation:
- Plus strand
- chrX:44,703,249-44,704,134
- (GRCh37/hg19)
- Size:
- 886 bases
- Orientation:
- Plus strand
Genomic View for DUSP21 Gene
Genes around DUSP21 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.3 by Entrez Gene
- Xp11.3 by HGNC
- Xp11.3 by Ensembl
DUSP21 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DUSP21 Gene
Proteins for DUSP21 Gene
-
Protein details for DUSP21 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H596-DUS21_HUMAN
- Recommended name:
- Dual specificity protein phosphatase 21
- Protein Accession:
- Q9H596
- Q0VDA6
- Q6IAJ6
- Q6YDQ8
Protein attributes for DUSP21 Gene
- Size:
- 190 amino acids
- Molecular mass:
- 21529 Da
- Quaternary structure:
- No Data Available
Protein Expression for DUSP21 Gene
Post-translational modifications for DUSP21 Gene
Other Protein References for DUSP21 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for DUSP21
- antibodies-online: Search results for 4 available DUSP21 Antibodies ranked by validation data
- Compare Top DUSP21 Antibodies
-
Quality Products:
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Protein Products
-
OriGene Purified Proteins for DUSP21
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- ProSpec Recombinant Proteins for DUSP21
- antibodies-online: Search results for 6 available DUSP21 Proteins ranked by validation data
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-
Quality Products:
- GeneTex Proteins for DUSP21
-
Abcam proteins for DUSP21
Assay Products
No data available for DME Specific Peptides for DUSP21 Gene
Domains & Families for DUSP21 Gene
Gene Families for DUSP21 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for DUSP21 Gene
Suggested Antigen Peptide Sequences for DUSP21 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H596UniProtKB/Swiss-Prot:
DUS21_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Function for DUSP21 Gene
Molecular function for DUSP21 Gene
- UniProtKB/Swiss-Prot Function:
- Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Enzyme Numbers (IUBMB) for DUSP21 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IDA | 12408986 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IEA,IBA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for DUSP21 Gene
Animal Model Products
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-
CRISPR Products
-
OriGene CRISPR knockouts for DUSP21
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- Overview of 99 available DUSP21 gene related products
- Applied Biological Materials CRISPR for DUSP21
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP21
- GenScript: Design CRISPR guide RNA sequences for DUSP21
miRNA for DUSP21 Gene
- miRTarBase miRNAs that target DUSP21
miRNA Products
Inhibitory RNA Products
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- Overview of 99 available DUSP21 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DUSP21
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP21
- Applied Biological Materials Clones for DUSP21
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DUSP21
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP21 Gene
Localization for DUSP21 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DUSP21 Gene
- Cytoplasm. Nucleus. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 3 |
| cytosol | 3 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 12408986 |
| GO:0005737 | cytoplasm | IEA,IDA | 12408986 |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005743 | mitochondrial inner membrane | IEA | -- |
| GO:0005759 | mitochondrial matrix | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for DUSP21 Gene
Pathways & Interactions for DUSP21 Gene
No Data Available
Interacting Proteins for DUSP21 Gene
Selected Interacting proteins:
ENSP00000343244
Q9H596-DUS21_HUMAN
for DUSP21 Gene via
STRING
MINT
UniProtKB
IID
GPS-Prot Interaction Network for DUSP21
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000188 | inactivation of MAPK activity | IEA | -- |
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0016311 | dephosphorylation | IEA | -- |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IDA | 12408986 |
No data available for Pathways by source and SIGNOR curated interactions for DUSP21 Gene
Drugs & Compounds for DUSP21 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14265-44-2 |
|
Drug Products
Transcripts for DUSP21 Gene
mRNA/cDNA for DUSP21 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (14) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000339042 885 bps (uc004dgd.4)
Unigene Clusters for DUSP21 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DUSP21
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP21
- genomics-online: gRNA clones - Search results for 99 available DUSP21 gene related products
- Overview of 99 available DUSP21 gene related products
- Applied Biological Materials CRISPR for DUSP21
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP21
- GenScript: Design CRISPR guide RNA sequences for DUSP21
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP21
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- Overview of 99 available DUSP21 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DUSP21
- VectorBuilder custom plasmid, inducible vectors for DUSP21
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DUSP21
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP21
- Applied Biological Materials Clones for DUSP21
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for DUSP21 Gene
mRNA differential expression in normal tissues according to GTEx for DUSP21 Gene
This gene is overexpressed in Testis (x51.9).
This gene is overexpressed in Peripheral blood mononuclear cells (42.7) and Blymphocyte (26.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP21 Gene
NURSA nuclear receptor signaling pathways regulating expression of DUSP21 Gene:
DUSP21SOURCE GeneReport for Unigene cluster for DUSP21 Gene:
Hs.534478mRNA Expression by UniProt/SwissProt for DUSP21 Gene:
Q9H596-DUS21_HUMAN
Tissue specificity:
Expressed in testis.
Evidence on tissue expression from TISSUES for DUSP21 Gene
- Liver(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for DUSP21
-
OriGene qPCR primer pairs for DUSP21
- genomics-online: primer clones - Search results for 99 available DUSP21 gene related products
- Overview of 99 available DUSP21 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP21 Gene
Orthologs for DUSP21 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DUSP21 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DUSP21 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Dusp21 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | DUSP21 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | DUSP18 34 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG15528 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | F13D11.3 34 |
|
ManyToMany | |
| F26A3.4 34 |
|
ManyToMany | |||
| C04F12.8 34 |
|
ManyToMany | |||
| ZK757.2 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10229 34 |
|
OneToMany |
- Species where no ortholog for DUSP21 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for DUSP21 Gene
- ENSEMBL:
- Gene Tree for DUSP21 (if available)
- TreeFam:
- Gene Tree for DUSP21 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DUSP21: view image
Paralogs for DUSP21 Gene
Paralogs for DUSP21 Gene
(9) SIMAP similar genes for DUSP21 Gene using alignment to 1 proteins:
- DUS21_HUMAN
Variants for DUSP21 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035644 | A colorectal cancer sample | p.Arg167Cys | |||
| rs1000001311 | -- | 44,843,082(+) | G/A | upstream_transcript_variant | |
| rs1002040084 | -- | 44,843,184(+) | C/T | upstream_transcript_variant | |
| rs1003595529 | -- | 44,845,377(+) | TTT/T | downstream_transcript_variant | |
| rs1007060580 | -- | 44,842,583(+) | A/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.51;
10.97% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DUSP21 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DUSP21
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DUSP21 Gene
Disorders for DUSP21 Gene
Additional Disease Information for DUSP21
No disorders were found for DUSP21 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP21 Gene
Publications for DUSP21 Gene
- Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. (PMID: 12408986) Hood KL … Yoon C (Biochemical and biophysical research communications 2002) 2 3 4 58
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for DUSP21 Gene
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- ProSpec Recombinant Proteins for DUSP21
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 4 available DUSP21 Antibodies ranked by validation data
- Compare Top DUSP21 Antibodies
- Quality Products:
- antibodies-online: Search results for available DUSP21 related products ranked by validation data
- antibodies-online: Search results for 6 available DUSP21 Proteins ranked by validation data
- Compare Top DUSP21 Proteins
- Quality Products:
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- genomics-online: cdna clones - Search results for 99 available DUSP21 gene related products
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Sources for DUSP21 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
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