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Aliases for DUSP21 Gene

Aliases for DUSP21 Gene

  • Dual Specificity Phosphatase 21 2 3 5
  • Low Molecular Weight Dual Specificity Phosphatase 21 3 4
  • LMW-DSP21 3 4
  • LMWDSP21 3 4
  • Dual Specificity Protein Phosphatase 21 3
  • BJ-HCC-26 Tumor Antigen 3
  • EC 4
  • EC 4

External Ids for DUSP21 Gene

Previous GeneCards Identifiers for DUSP21 Gene

  • GC0XP042963
  • GC0XP043529
  • GC0XP043749
  • GC0XP044459
  • GC0XP044588
  • GC0XP044703
  • GC0XP042424

Summaries for DUSP21 Gene

Entrez Gene Summary for DUSP21 Gene

  • This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues.[provided by RefSeq, Mar 2009]

GeneCards Summary for DUSP21 Gene

DUSP21 (Dual Specificity Phosphatase 21) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP18.

UniProtKB/Swiss-Prot for DUSP21 Gene

  • Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.

Additional gene information for DUSP21 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP21 Gene

Genomics for DUSP21 Gene

GeneHancer (GH) Regulatory Elements for DUSP21 Gene

Promoters and enhancers for DUSP21 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ044708 Enhancer 0.7 ENCODE 12.3 -135.3 -135333 0.2 LEF1 TEAD4 TAL1 CCNT2 CC2D1A TCF12 MTA3 POLR2A GATA2 NCOR1 DUSP21 RPSAP61 PIR53424
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUSP21 gene promoter:
  • Pax-5
  • NF-E2 p45
  • NF-E2
  • Pax-4a
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • CUTL1
  • AP-1

Genomic Locations for DUSP21 Gene

Genomic Locations for DUSP21 Gene
886 bases
Plus strand
886 bases
Plus strand

Genomic View for DUSP21 Gene

Genes around DUSP21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP21 Gene

Proteins for DUSP21 Gene

  • Protein details for DUSP21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 21
    Protein Accession:
    Secondary Accessions:
    • Q0VDA6
    • Q6IAJ6
    • Q6YDQ8

    Protein attributes for DUSP21 Gene

    190 amino acids
    Molecular mass:
    21529 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUSP21 Gene

Post-translational modifications for DUSP21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP21 Gene

Domains & Families for DUSP21 Gene

Gene Families for DUSP21 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DUSP21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP21: view

Function for DUSP21 Gene

Molecular function for DUSP21 Gene

UniProtKB/Swiss-Prot Function:
Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for DUSP21 Gene

Gene Ontology (GO) - Molecular Function for DUSP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IDA 12408986
GO:0005515 protein binding IPI 25416956
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA,IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DUSP21: view
genes like me logo Genes that share phenotypes with DUSP21: view

Animal Model Products

miRNA for DUSP21 Gene

miRTarBase miRNAs that target DUSP21

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP21 Gene

Localization for DUSP21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP21 Gene

Cytoplasm. Nucleus. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP21 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for DUSP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12408986
GO:0005737 cytoplasm IEA,IDA 12408986
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with DUSP21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DUSP21 Gene

Pathways & Interactions for DUSP21 Gene

SuperPathways for DUSP21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IEA --
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IDA 12408986
genes like me logo Genes that share ontologies with DUSP21: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP21 Gene

Drugs & Compounds for DUSP21 Gene

(3) Drugs for DUSP21 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0

(1) Additional Compounds for DUSP21 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
genes like me logo Genes that share compounds with DUSP21: view

Transcripts for DUSP21 Gene

mRNA/cDNA for DUSP21 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUSP21 Gene

Dual specificity phosphatase 21:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP21 Gene

No ASD Table

Relevant External Links for DUSP21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP21 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP21 Gene

This gene is overexpressed in Testis (x51.9).

Protein differential expression in normal tissues from HIPED for DUSP21 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (42.7) and Blymphocyte (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP21 Gene

Protein tissue co-expression partners for DUSP21 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUSP21 Gene:


SOURCE GeneReport for Unigene cluster for DUSP21 Gene:


mRNA Expression by UniProt/SwissProt for DUSP21 Gene:

Tissue specificity: Expressed in testis.

Evidence on tissue expression from TISSUES for DUSP21 Gene

  • Liver(4)
genes like me logo Genes that share expression patterns with DUSP21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP21 Gene

Orthologs for DUSP21 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DUSP21 34 33
  • 98.94 (n)
(Canis familiaris)
Mammalia DUSP21 34
  • 71 (a)
(Mus musculus)
Mammalia Dusp21 34
  • 70 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
(Bos Taurus)
Mammalia DUSP21 34
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
(Gallus gallus)
Aves -- 34
  • 45 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 58 (a)
(Danio rerio)
Actinopterygii DUSP18 34
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15528 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea F13D11.3 34
  • 32 (a)
F26A3.4 34
  • 31 (a)
C04F12.8 34
  • 26 (a)
ZK757.2 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10229 34
  • 43 (a)
Species where no ortholog for DUSP21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DUSP21 Gene

Gene Tree for DUSP21 (if available)
Gene Tree for DUSP21 (if available)
Evolutionary constrained regions (ECRs) for DUSP21: view image

Paralogs for DUSP21 Gene

(9) SIMAP similar genes for DUSP21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP21: view

Variants for DUSP21 Gene

Sequence variations from dbSNP and Humsavar for DUSP21 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
VAR_035644 A colorectal cancer sample p.Arg167Cys
rs1000001311 -- 44,843,082(+) G/A upstream_transcript_variant
rs1002040084 -- 44,843,184(+) C/T upstream_transcript_variant
rs1003595529 -- 44,845,377(+) TTT/T downstream_transcript_variant
rs1007060580 -- 44,842,583(+) A/G upstream_transcript_variant

Variation tolerance for DUSP21 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 10.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DUSP21 Gene

Disorders for DUSP21 Gene

Additional Disease Information for DUSP21

No disorders were found for DUSP21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP21 Gene

Publications for DUSP21 Gene

  1. Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. (PMID: 12408986) Hood KL … Yoon C (Biochemical and biophysical research communications 2002) 2 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for DUSP21 Gene

Sources for DUSP21 Gene

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