Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated wit... See more...
Aliases for DUSP2 Gene
Aliases for DUSP2 Gene
External Ids for DUSP2 Gene
- HGNC: 3068
- Entrez Gene: 1844
- Ensembl: ENSG00000158050
- OMIM: 603068
- UniProtKB: Q05923
Previous GeneCards Identifiers for DUSP2 Gene
- GC02M094680
- GC02M095263
- GC02M096276
- GC02M096293
- GC02M096230
- GC02M096173
- GC02M096808
- GC02M090770
- GC02M096147
- GC02M096148
- GC02M096162
- GC02M096163
- GC02M096164
- GC02M096166
- GC02M096149
- GC02M096150
- GC02M096151
- GC02M096156
- GC02M096157
- GC02M096158
- GC02M096159
- GC02M096160
Summaries for DUSP2 Gene
-
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]
GeneCards Summary for DUSP2 Gene
DUSP2 (Dual Specificity Phosphatase 2) is a Protein Coding gene. Diseases associated with DUSP2 include Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP1.
UniProtKB/Swiss-Prot Summary for DUSP2 Gene
-
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
Additional gene information for DUSP2 Gene
- HGNC(3068)
- Entrez Gene(1844)
- Ensembl(ENSG00000158050)
- OMIM(603068)
- UniProtKB(Q05923)
- Open Targets Platform(ENSG00000158050)
- Search for DUSP2 at DataMed
- Search for DUSP2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP2 Gene
Genomics for DUSP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DUSP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DUSP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP2
- Top Transcription factor binding sites by QIAGEN in the DUSP2 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- HEN1
- HNF-4alpha1
- HNF-4alpha2
- p53
Genomic Locations for DUSP2 Gene
Genomic Locations for DUSP2 Gene
- chr2:96,143,166-96,145,468
- (GRCh38/hg38)
- Size:
- 2,303 bases
- Orientation:
- Minus strand
- chr2:96,808,905-96,811,179
- (GRCh37/hg19)
- Size:
- 2,275 bases
- Orientation:
- Minus strand
Genomic View for DUSP2 Gene
Genes around DUSP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q11.2 by HGNC
- 2q11.2 by Entrez Gene
- 2q11.2 by Ensembl
DUSP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DUSP2 Gene
Proteins for DUSP2 Gene
-
Protein details for DUSP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q05923-DUS2_HUMAN
- Recommended name:
- Dual specificity protein phosphatase 2
- Protein Accession:
- Q05923
- Q53T45
Protein attributes for DUSP2 Gene
- Size:
- 314 amino acids
- Molecular mass:
- 34400 Da
- Quaternary structure:
- No Data Available
Protein Expression for DUSP2 Gene
Post-translational modifications for DUSP2 Gene
Other Protein References for DUSP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences DUSP2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for DUSP2
- Novus Biologicals Antibodies for DUSP2
-
Abcam antibodies for DUSP2
- Invitrogen Antibodies for DUSP2 (AFLGC-DUSP2)
-
Biorbyt antibodies for DUSP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for DUSP2
Protein Products
-
OriGene Purified Proteins for DUSP2
- Search Origene for MassSpec and Protein Over-expression Lysates for DUSP2
- Origene Custom Protein Services for DUSP2
-
Signalway Proteins for DUSP2
Assay Products
- antibodies-online: Show 4 available DUSP2 Elisa Kits ranked by validation data
- Compare Top DUSP2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for DUSP2 Gene
Domains & Families for DUSP2 Gene
Gene Families for DUSP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for DUSP2 Gene
- InterPro:
- Blocks:
-
- Rhodanese-like
- Dual specificity protein phosphatase
- ProtoNet:
Suggested Antigen Peptide Sequences for DUSP2 Gene
- GenScript: Design optimal peptide antigens:
-
- Dual specificity protein phosphatase PAC-1 (DUS2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q05923UniProtKB/Swiss-Prot:
DUS2_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Function for DUSP2 Gene
Molecular function for DUSP2 Gene
- UniProtKB/Swiss-Prot Function:
- Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
- UniProtKB/Swiss-Prot Induction:
- By mitogens.
- GENATLAS Biochemistry:
- dual specificity (tyr/thr) phosphatase 2,expressed in hematopoietic tissues,involved in signal transduction
Enzyme Numbers (IUBMB) for DUSP2 Gene
Phenotypes From GWAS Catalog for DUSP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA,IBA | 21873635 |
| GO:0004725 | protein tyrosine phosphatase activity | TAS | 7681221 |
| GO:0005515 | protein binding | IPI | 21784977 |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IBA | -- |
| GO:0008330 | protein tyrosine/threonine phosphatase activity | TAS,IBA | 21873635 |
Phenotypes for DUSP2 Gene
- MGI mutant phenotypes for DUSP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DUSP2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Synthetic lethal with Ras
- Increased epidermal growth factor (EGF) endocytosis
- shRNA abundance <= 25%
- Increased NF-kappaB reporter expression
- Increased cell death in HCC-1954 cells
- Fragmented cis-Golgi, fragmented medial Golgi, fragmented trans-Golgi
- Increased focal adhesion (FA) area, decreased number of small and round FAs
Animal Models for DUSP2 Gene
- MGI Knock Outs for DUSP2:
-
- Dusp2 Dusp2<tm1Cmac>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DUSP2 - Select products 50% OFF >
- * DUSP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DUSP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP2
miRNA for DUSP2 Gene
- miRTarBase miRNAs that target DUSP2
-
- hsa-miR-122-5p (MIRT003094)
- mmu-miR-29b-3p (MIRT004918)
- hsa-miR-29b-3p (MIRT007102)
- hsa-miR-124-3p (MIRT023093)
- hsa-miR-20a-5p (MIRT053023)
- hsa-miR-4726-5p (MIRT477909)
- hsa-miR-4640-5p (MIRT477910)
- hsa-miR-3194-5p (MIRT477911)
- hsa-miR-298 (MIRT477912)
- hsa-miR-4264 (MIRT477913)
- hsa-miR-361-3p (MIRT477914)
- hsa-miR-6849-3p (MIRT477915)
- hsa-miR-4530 (MIRT477916)
- hsa-miR-1910-5p (MIRT477917)
- hsa-miR-455-3p (MIRT477918)
- hsa-miR-922 (MIRT477919)
- hsa-miR-4733-3p (MIRT477920)
- hsa-miR-6895-5p (MIRT477921)
- hsa-miR-5197-3p (MIRT477922)
- hsa-miR-634 (MIRT477923)
- hsa-miR-29c-3p (MIRT477924)
- hsa-miR-29a-3p (MIRT477925)
- hsa-miR-6793-3p (MIRT494063)
- hsa-miR-568 (MIRT494064)
- hsa-miR-4639-5p (MIRT494065)
- hsa-miR-3686 (MIRT494066)
- hsa-miR-4742-3p (MIRT494067)
- hsa-miR-4796-3p (MIRT494068)
- hsa-miR-548ah-5p (MIRT494069)
- hsa-miR-3609 (MIRT494070)
- hsa-miR-340-5p (MIRT494071)
- hsa-miR-142-5p (MIRT494072)
- hsa-miR-5590-3p (MIRT494073)
- hsa-miR-20b-5p (MIRT494074)
- hsa-miR-93-5p (MIRT494075)
- hsa-miR-526b-3p (MIRT494076)
- hsa-miR-519d-3p (MIRT494077)
- hsa-miR-17-5p (MIRT494078)
- hsa-miR-106b-5p (MIRT494079)
- hsa-miR-106a-5p (MIRT494080)
- hsa-miR-302b-3p (MIRT494081)
- hsa-miR-520e (MIRT494082)
- hsa-miR-520d-3p (MIRT494083)
- hsa-miR-520c-3p (MIRT494084)
- hsa-miR-520b (MIRT494085)
- hsa-miR-520a-3p (MIRT494086)
- hsa-miR-372-3p (MIRT494087)
- hsa-miR-302e (MIRT494088)
- hsa-miR-302a-3p (MIRT494089)
- hsa-miR-302d-3p (MIRT494090)
- hsa-miR-302c-3p (MIRT494091)
- hsa-miR-373-3p (MIRT494092)
- mmu-miR-702-3p (MIRT583877)
- mmu-miR-1942 (MIRT583878)
- hsa-miR-623 (MIRT688410)
- hsa-miR-4662a-5p (MIRT688411)
- hsa-miR-6780b-3p (MIRT688412)
- hsa-miR-4780 (MIRT688413)
- hsa-miR-6866-3p (MIRT688414)
- hsa-miR-188-5p (MIRT688415)
- hsa-miR-575 (MIRT688416)
- hsa-miR-4676-5p (MIRT688417)
- hsa-miR-6858-3p (MIRT688418)
- hsa-miR-605-5p (MIRT688419)
- hsa-miR-548c-3p (MIRT688420)
- hsa-miR-1292-5p (MIRT762325)
- hsa-miR-1324 (MIRT762543)
- hsa-miR-194-3p (MIRT763455)
- hsa-miR-4471 (MIRT769472)
- hsa-miR-4519 (MIRT769941)
- hsa-miR-6784-3p (MIRT779085)
- hsa-miR-6802-3p (MIRT779501)
- hsa-miR-6862-3p (MIRT780595)
- hsa-miR-8059 (MIRT782332)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP2
- Browse OriGene Inhibitory RNA Products For DUSP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP2
Clone Products
- Applied Biological Materials (abm): Clones for DUSP2 - Select products 50% OFF >
- * DUSP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DUSP2
- Addgene plasmids for DUSP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP2
Cell Line Products
-
Horizon Cell Lines for DUSP2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP2 Gene
Localization for DUSP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DUSP2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Nuclear membrane (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IBA | 21873635 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0031965 | nuclear membrane | IDA | -- |
Pathways & Interactions for DUSP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Developmental Biology |
.51
|
|
| 3 | Cytokine Signaling in Immune system | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | Signaling by GPCR | ||
Pathways by source for DUSP2 Gene
1 BioSystems pathway for DUSP2 Gene
48 Reactome pathways for DUSP2 Gene
1 KEGG pathway for DUSP2 Gene
Interacting Proteins for DUSP2 Gene
GPS-Prot Interaction Network for DUSP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000188 | inactivation of MAPK activity | TAS,IBA | 21873635 |
| GO:0001706 | endoderm formation | IBA | 21873635 |
| GO:0006470 | protein dephosphorylation | TAS,IBA | 21873635 |
| GO:0016311 | dephosphorylation | IEA | -- |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IEA,IBA | 21873635 |
Drugs & Compounds for DUSP2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14066-19-4, 14265-44-2 |
|
Transcripts for DUSP2 Gene
mRNA/cDNA for DUSP2 Gene
- 1 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000288943 1685 nts (view in UCSC)
- ENST00000488952 773 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DUSP2 - Select products 50% OFF >
- * DUSP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DUSP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP2
- Browse OriGene Inhibitory RNA Products For DUSP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP2
Clone Products
- Applied Biological Materials (abm): Clones for DUSP2 - Select products 50% OFF >
- * DUSP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DUSP2
- Addgene plasmids for DUSP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP2
Relevant External Links for DUSP2 Gene
- GeneLoc Exon Structure for
- DUSP2
Expression for DUSP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Adipose (Muscoskeletal System)
- Umbilical Cord (Extraembryonic Tissues)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for DUSP2 Gene
This gene is overexpressed in Whole Blood (x9.5).
This gene is overexpressed in Breast (43.3) and Platelet (25.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP2
SOURCE GeneReport for Unigene cluster for DUSP2 Gene:
Hs.1183mRNA Expression by UniProt/SwissProt for DUSP2 Gene:
Q05923-DUS2_HUMAN
Tissue specificity:
Expressed in hematopoietic tissues.
Evidence on tissue expression from TISSUES for DUSP2 Gene
- Bone marrow(2.7)
- Lymph node(2.5)
- Spleen(2.3)
- Intestine(2.2)
- Blood(2.1)
Primer Products
-
OriGene qPCR primer pairs for DUSP2
-
OriGene qPCR primer pairs and template standards for DUSP2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP2 Gene
Orthologs for DUSP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | DUSP2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DUSP2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Dusp2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dusp2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | DUSP2 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DUSP2 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | dusp2 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for DUSP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for DUSP2 Gene
- ENSEMBL:
- Gene Tree for DUSP2 (if available)
- TreeFam:
- Gene Tree for DUSP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DUSP2: view image
Paralogs for DUSP2 Gene
Paralogs for DUSP2 Gene
(8) SIMAP similar genes for DUSP2 Gene using alignment to 1 proteins:
- DUS2_HUMAN
Variants for DUSP2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP2 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 788774 | Benign: not provided | 96,144,788(-) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4009n100 | CNV | gain | 25217958 |
| dgv607e201 | CNV | deletion | 23290073 |
| esv3425717 | CNV | duplication | 20981092 |
| esv3591652 | OTHER | inversion | 21293372 |
| esv5003 | OTHER | complex | 18987735 |
| nsv1135873 | CNV | deletion | 24896259 |
Gene Damage Index Score:
1.25;
24.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DUSP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DUSP2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP2 Gene
Disorders for DUSP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diabetes mellitus, noninsulin-dependent |
|
Search DUSP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DUSP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP2 Gene
Publications for DUSP2 Gene
- Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11. (PMID: 7590752) Yi H … Kelly K (Genomics 1995) 2 3 4 23
- PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. (PMID: 12673251) Yin Y … Barrett JC (Nature 2003) 2 3 23
- PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. (PMID: 7681221) Rohan PJ … Kelly K (Science (New York, N.Y.) 1993) 3 4 23
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- PAC1 is a direct transcription target of E2F-1 in apoptotic signaling. (PMID: 17471234) Wu J … Yin Y (Oncogene 2007) 3 23
ExternalLinks
Products for DUSP2 Gene
- Custom Antibody ServicesOriGene Antibodies for DUSP2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for DUSP2
- Search Origene for MassSpec and Protein Over-expression Lysates for DUSP2
- Origene Custom Protein Services for DUSP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP2
- Browse OriGene Inhibitory RNA Products For DUSP2
- OriGene qPCR primer pairs for DUSP2
- OriGene qPCR primer pairs and template standards for DUSP2
- OriGene CRISPR knockouts for DUSP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DUSP2
- Sino Biological Human cDNA Clone for DUSP2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for DUSP2
- Novus Biologicals proteins and lysates for DUSP2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for DUSP2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for DUSP2 (AFLGC-DUSP2)
- VectorBuilder Custom and pre-made DNA vectors for DUSP2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for DUSP2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for DUSP2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DUSP2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DUSP2
- Addgene plasmids for DUSP2
- antibodies-online: Show 37 available DUSP2 Antibodies ranked by validation data
- Compare Top DUSP2 Antibodies
- Quality Products:
- antibodies-online: Show 4 available DUSP2 Elisa Kits ranked by validation data
- Compare Top DUSP2 Elisa Kits
- Quality Products:
- antibodies-online: Search results for available DUSP2 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for DUSP2
- Search Santa Cruz Biotechnology (SCBT) for DUSP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DUSP2
- Horizon Cell Lines for DUSP2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DUSP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP2
- Biorbyt antibodies for DUSP2
- Signalway Proteins for DUSP2
Sources for DUSP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB