The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated wit... See more...

Aliases for DUSP2 Gene

Aliases for DUSP2 Gene

  • Dual Specificity Phosphatase 2 2 3 5
  • Dual Specificity Protein Phosphatase PAC-1 3 4
  • Dual Specificity Protein Phosphatase 2 3 4
  • PAC-1 2 3
  • PAC1 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DUSP2 5

External Ids for DUSP2 Gene

Previous GeneCards Identifiers for DUSP2 Gene

  • GC02M094680
  • GC02M095263
  • GC02M096276
  • GC02M096293
  • GC02M096230
  • GC02M096173
  • GC02M096808
  • GC02M090770
  • GC02M096147
  • GC02M096148
  • GC02M096162
  • GC02M096163
  • GC02M096164
  • GC02M096166
  • GC02M096149
  • GC02M096150
  • GC02M096151
  • GC02M096156
  • GC02M096157
  • GC02M096158
  • GC02M096159
  • GC02M096160

Summaries for DUSP2 Gene

Entrez Gene Summary for DUSP2 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP2 Gene

DUSP2 (Dual Specificity Phosphatase 2) is a Protein Coding gene. Diseases associated with DUSP2 include Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP1.

UniProtKB/Swiss-Prot Summary for DUSP2 Gene

  • Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.

Gene Wiki entry for DUSP2 Gene

Additional gene information for DUSP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP2 Gene

Genomics for DUSP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DUSP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP2

Top Transcription factor binding sites by QIAGEN in the DUSP2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • HEN1
  • HNF-4alpha1
  • HNF-4alpha2
  • p53

Genomic Locations for DUSP2 Gene

Genomic Locations for DUSP2 Gene
chr2:96,143,166-96,145,468
(GRCh38/hg38)
Size:
2,303 bases
Orientation:
Minus strand
chr2:96,808,905-96,811,179
(GRCh37/hg19)
Size:
2,275 bases
Orientation:
Minus strand

Genomic View for DUSP2 Gene

Genes around DUSP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP2 Gene

Proteins for DUSP2 Gene

  • Protein details for DUSP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05923-DUS2_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 2
    Protein Accession:
    Q05923
    Secondary Accessions:
    • Q53T45

    Protein attributes for DUSP2 Gene

    Size:
    314 amino acids
    Molecular mass:
    34400 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP2 Gene

neXtProt entry for DUSP2 Gene

Post-translational modifications for DUSP2 Gene

  • Ubiquitination at Lys157 and Lys288
  • Modification sites at PhosphoSitePlus

Other Protein References for DUSP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP2 Gene

Domains & Families for DUSP2 Gene

Gene Families for DUSP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DUSP2 Gene

Suggested Antigen Peptide Sequences for DUSP2 Gene

GenScript: Design optimal peptide antigens:
  • Dual specificity protein phosphatase PAC-1 (DUS2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q05923

UniProtKB/Swiss-Prot:

DUS2_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP2: view

Function for DUSP2 Gene

Molecular function for DUSP2 Gene

UniProtKB/Swiss-Prot Function:
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
UniProtKB/Swiss-Prot Induction:
By mitogens.
GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 2,expressed in hematopoietic tissues,involved in signal transduction

Enzyme Numbers (IUBMB) for DUSP2 Gene

Phenotypes From GWAS Catalog for DUSP2 Gene

Gene Ontology (GO) - Molecular Function for DUSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA,IBA 21873635
GO:0004725 protein tyrosine phosphatase activity TAS 7681221
GO:0005515 protein binding IPI 21784977
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0008330 protein tyrosine/threonine phosphatase activity TAS,IBA 21873635
genes like me logo Genes that share ontologies with DUSP2: view
genes like me logo Genes that share phenotypes with DUSP2: view

Animal Models for DUSP2 Gene

MGI Knock Outs for DUSP2:

Animal Model Products

CRISPR Products

miRNA for DUSP2 Gene

miRTarBase miRNAs that target DUSP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP2 Gene

Localization for DUSP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP2 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DUSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with DUSP2: view

Pathways & Interactions for DUSP2 Gene

PathCards logo

SuperPathways for DUSP2 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Innate Immune System
5 Signaling by GPCR
genes like me logo Genes that share pathways with DUSP2: view

Pathways by source for DUSP2 Gene

1 KEGG pathway for DUSP2 Gene

SIGNOR curated interactions for DUSP2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DUSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS,IBA 21873635
GO:0001706 endoderm formation IBA 21873635
GO:0006470 protein dephosphorylation TAS,IBA 21873635
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA,IBA 21873635
genes like me logo Genes that share ontologies with DUSP2: view

Drugs & Compounds for DUSP2 Gene

(7) Drugs for DUSP2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Calcium Nutra 6556

(11) Additional Compounds for DUSP2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with DUSP2: view

Transcripts for DUSP2 Gene

mRNA/cDNA for DUSP2 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP2

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP2 Gene

No ASD Table

Relevant External Links for DUSP2 Gene

GeneLoc Exon Structure for
DUSP2

Expression for DUSP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP2 Gene

This gene is overexpressed in Whole Blood (x9.5).

Protein differential expression in normal tissues from HIPED for DUSP2 Gene

This gene is overexpressed in Breast (43.3) and Platelet (25.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP2 Gene



Protein tissue co-expression partners for DUSP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP2

SOURCE GeneReport for Unigene cluster for DUSP2 Gene:

Hs.1183

mRNA Expression by UniProt/SwissProt for DUSP2 Gene:

Q05923-DUS2_HUMAN
Tissue specificity: Expressed in hematopoietic tissues.

Evidence on tissue expression from TISSUES for DUSP2 Gene

  • Bone marrow(2.7)
  • Lymph node(2.5)
  • Spleen(2.3)
  • Intestine(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with DUSP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP2 Gene

Orthologs for DUSP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DUSP2 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia DUSP2 30 31
  • 89.07 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DUSP2 30 31
  • 88.32 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dusp2 30 17 31
  • 85.24 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dusp2 30
  • 84.82 (n)
Oppossum
(Monodelphis domestica)
Mammalia DUSP2 31
  • 76 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DUSP2 31
  • 73 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dusp2 30 31
  • 59.06 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
OneToMany
Species where no ortholog for DUSP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DUSP2 Gene

ENSEMBL:
Gene Tree for DUSP2 (if available)
TreeFam:
Gene Tree for DUSP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP2: view image

Paralogs for DUSP2 Gene

(8) SIMAP similar genes for DUSP2 Gene using alignment to 1 proteins:

  • DUS2_HUMAN
genes like me logo Genes that share paralogs with DUSP2: view

Variants for DUSP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
788774 Benign: not provided 96,144,788(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for DUSP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for DUSP2 Gene

Variant ID Type Subtype PubMed ID
dgv4009n100 CNV gain 25217958
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv3591652 OTHER inversion 21293372
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259

Variation tolerance for DUSP2 Gene

Gene Damage Index Score: 1.25; 24.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP2 Gene

Disorders for DUSP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUSP2 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • niddm
- elite association - COSMIC cancer census association via MalaCards
Search DUSP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DUSP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with DUSP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP2 Gene

Publications for DUSP2 Gene

  1. Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11. (PMID: 7590752) Yi H … Kelly K (Genomics 1995) 2 3 4 23
  2. PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. (PMID: 12673251) Yin Y … Barrett JC (Nature 2003) 2 3 23
  3. PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. (PMID: 7681221) Rohan PJ … Kelly K (Science (New York, N.Y.) 1993) 3 4 23
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. PAC1 is a direct transcription target of E2F-1 in apoptotic signaling. (PMID: 17471234) Wu J … Yin Y (Oncogene 2007) 3 23

Products for DUSP2 Gene

  • Signalway Proteins for DUSP2

Sources for DUSP2 Gene