Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal ... See more...

Aliases for DUSP18 Gene

Aliases for DUSP18 Gene

  • Dual Specificity Phosphatase 18 2 3 5
  • Low Molecular Weight Dual Specificity Phosphatase 20 3 4
  • Dual Specificity Protein Phosphatase 18 3 4
  • LMWDSP20 3 4
  • DUSP20 2 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • LMW-DSP20 4
  • DUSP18 5
  • DSP18 3

External Ids for DUSP18 Gene

Previous GeneCards Identifiers for DUSP18 Gene

  • GC22M027744
  • GC22M029372
  • GC22M029382
  • GC22M031048
  • GC22M014021

Summaries for DUSP18 Gene

Entrez Gene Summary for DUSP18 Gene

  • Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

GeneCards Summary for DUSP18 Gene

DUSP18 (Dual Specificity Phosphatase 18) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP21.

UniProtKB/Swiss-Prot Summary for DUSP18 Gene

  • Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).

Gene Wiki entry for DUSP18 Gene

Additional gene information for DUSP18 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP18 Gene

Genomics for DUSP18 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DUSP18 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP18 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP18

Top Transcription factor binding sites by QIAGEN in the DUSP18 gene promoter:
  • C/EBPalpha
  • CP2
  • Evi-1
  • NF-1
  • NF-1/L
  • Pax-5
  • Roaz
  • SEF-1 (1)
  • SRF
  • SRF (504 AA)

Genomic Locations for DUSP18 Gene

Genomic Locations for DUSP18 Gene
chr22:30,652,051-30,667,890
(GRCh38/hg38)
Size:
15,840 bases
Orientation:
Minus strand
chr22:31,048,038-31,063,877
(GRCh37/hg19)
Size:
15,840 bases
Orientation:
Minus strand

Genomic View for DUSP18 Gene

Genes around DUSP18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP18 Gene

Proteins for DUSP18 Gene

  • Protein details for DUSP18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEJ0-DUS18_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 18
    Protein Accession:
    Q8NEJ0
    Secondary Accessions:
    • B3KPA4

    Protein attributes for DUSP18 Gene

    Size:
    188 amino acids
    Molecular mass:
    21066 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP18 Gene

neXtProt entry for DUSP18 Gene

Post-translational modifications for DUSP18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DUSP18 Gene

Domains & Families for DUSP18 Gene

Gene Families for DUSP18 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DUSP18 Gene

Suggested Antigen Peptide Sequences for DUSP18 Gene

GenScript: Design optimal peptide antigens:
  • Low molecular weight dual specificity phosphatase 20 (DUS18_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NEJ0

UniProtKB/Swiss-Prot:

DUS18_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP18: view

Function for DUSP18 Gene

Molecular function for DUSP18 Gene

UniProtKB/Swiss-Prot Function:
Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000269|PubMed:12408986, ECO:0000269|PubMed:12591617};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:12408986, ECO:0000269|PubMed:12591617};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:12408986, ECO:0000269|PubMed:12591617};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.0. {ECO:0000269|PubMed:12591617}; Temperature dependence: Optimum temperature is 55 degrees Celsius. {ECO:0000269|PubMed:12591617};
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by manganese ions, inhibited by iodoaretic acid.

Enzyme Numbers (IUBMB) for DUSP18 Gene

Phenotypes From GWAS Catalog for DUSP18 Gene

Gene Ontology (GO) - Molecular Function for DUSP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,IDA 12408986
GO:0005515 protein binding IPI 28065597
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA,IDA 12591617
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DUSP18: view
genes like me logo Genes that share phenotypes with DUSP18: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP18

CRISPR Products

miRNA for DUSP18 Gene

miRTarBase miRNAs that target DUSP18

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP18

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP18 Gene

Localization for DUSP18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP18 Gene

Cytoplasm. Nucleus. Mitochondrion inner membrane. Peripheral membrane protein. Intermembrane side. Note=Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment. {ECO:0000250 UniProtKB:Q8VE01}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP18 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 2
cytoskeleton 1
peroxisome 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DUSP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12408986
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 12408986
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with DUSP18: view

Pathways & Interactions for DUSP18 Gene

PathCards logo

SuperPathways for DUSP18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IEA --
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA,IDA 24531476
GO:0035335 peptidyl-tyrosine dephosphorylation IEA,IDA 12408986
GO:0035970 peptidyl-threonine dephosphorylation IDA 12591617
genes like me logo Genes that share ontologies with DUSP18: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP18 Gene

Drugs & Compounds for DUSP18 Gene

(4) Drugs for DUSP18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 56
Calcium Nutra 6556

(1) Additional Compounds for DUSP18 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with DUSP18: view

Transcripts for DUSP18 Gene

mRNA/cDNA for DUSP18 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP18

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP18 Gene

No ASD Table

Relevant External Links for DUSP18 Gene

GeneLoc Exon Structure for
DUSP18

Expression for DUSP18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP18 Gene

This gene is overexpressed in Testis (x6.6) and Whole Blood (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP18 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP18

SOURCE GeneReport for Unigene cluster for DUSP18 Gene:

Hs.517544

mRNA Expression by UniProt/SwissProt for DUSP18 Gene:

Q8NEJ0-DUS18_HUMAN
Tissue specificity: Widely expressed with highest levels in liver, brain, ovary and testis.

Evidence on tissue expression from TISSUES for DUSP18 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with DUSP18: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP18 Gene

Orthologs for DUSP18 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP18 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DUSP18 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DUSP18 30 31
  • 89.01 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DUSP18 30 31
  • 87.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dusp18 30
  • 84.22 (n)
Mouse
(Mus musculus)
Mammalia Dusp18 30 17 31
  • 82.45 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 80 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 75 (a)
OneToMany
Chicken
(Gallus gallus)
Aves DUSP18 30
  • 68.46 (n)
-- 31
  • 52 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 63 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dusp18 30
  • 57.36 (n)
Zebrafish
(Danio rerio)
Actinopterygii DUSP18 31
  • 47 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG15528 31
  • 36 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea F26A3.4 31
  • 29 (a)
ManyToMany
F13D11.3 31
  • 29 (a)
ManyToMany
C04F12.8 31
  • 25 (a)
ManyToMany
ZK757.2 31
  • 19 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10229 31
  • 45 (a)
OneToMany
Species where no ortholog for DUSP18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DUSP18 Gene

ENSEMBL:
Gene Tree for DUSP18 (if available)
TreeFam:
Gene Tree for DUSP18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP18: view image

Paralogs for DUSP18 Gene

(12) SIMAP similar genes for DUSP18 Gene using alignment to 5 proteins:

  • DUS18_HUMAN
  • C9JEE9_HUMAN
  • F2Z2P2_HUMAN
  • F8VX42_HUMAN
  • H7C401_HUMAN
genes like me logo Genes that share paralogs with DUSP18: view

Variants for DUSP18 Gene

Additional dbSNP identifiers (rs#s) for DUSP18 Gene

Structural Variations from Database of Genomic Variants (DGV) for DUSP18 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv834175 CNV gain 17160897

Variation tolerance for DUSP18 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP18 Gene

Disorders for DUSP18 Gene

Additional Disease Information for DUSP18

No disorders were found for DUSP18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP18 Gene

Publications for DUSP18 Gene

  1. Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family. (PMID: 16699184) Jeong DG … Kim SJ (Acta crystallographica. Section D, Biological crystallography 2006) 3 4 23
  2. Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. (PMID: 12408986) Hood KL … Yoon C (Biochemical and biophysical research communications 2002) 2 3 4
  3. Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo. (PMID: 16720344) Wu Q … Mao Y (Frontiers in bioscience : a journal and virtual library 2006) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for DUSP18 Gene

Sources for DUSP18 Gene