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Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
DUSP18 (Dual Specificity Phosphatase 18) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP21.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
GO:0004725 | protein tyrosine phosphatase activity | IEA,IDA | 12408986 |
GO:0005515 | protein binding | IPI | 28065597 |
GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IEA,IDA | 12591617 |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 12408986 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 12408986 |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005743 | mitochondrial inner membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000188 | inactivation of MAPK activity | IEA | -- |
GO:0006470 | protein dephosphorylation | IEA | -- |
GO:0016311 | dephosphorylation | IEA,IDA | 24531476 |
GO:0035335 | peptidyl-tyrosine dephosphorylation | IEA,IDA | 12408986 |
GO:0035970 | peptidyl-threonine dephosphorylation | IDA | 12591617 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Phosphate |
|
14066-19-4, 14265-44-2 |
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DUSP18 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DUSP18 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DUSP18 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dusp18 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Dusp18 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | DUSP18 30 |
|
||
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dusp18 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | DUSP18 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG15528 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | F26A3.4 31 |
|
ManyToMany | |
F13D11.3 31 |
|
ManyToMany | |||
C04F12.8 31 |
|
ManyToMany | |||
ZK757.2 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10229 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1110864 | OTHER | inversion | 24896259 |
nsv834175 | CNV | gain | 17160897 |
No disorders were found for DUSP18 Gene.