Free for academic non-profit institutions. Other users need a Commercial license
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal ... See more...
Aliases for DUSP18 Gene
Aliases for DUSP18 Gene
External Ids for DUSP18 Gene
- HGNC: 18484
- Entrez Gene: 150290
- Ensembl: ENSG00000167065
- OMIM: 611446
- UniProtKB: Q8NEJ0
Previous GeneCards Identifiers for DUSP18 Gene
- GC22M027744
- GC22M029372
- GC22M029382
- GC22M031048
- GC22M014021
Summaries for DUSP18 Gene
-
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
GeneCards Summary for DUSP18 Gene
DUSP18 (Dual Specificity Phosphatase 18) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP21.
UniProtKB/Swiss-Prot Summary for DUSP18 Gene
-
Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
Additional gene information for DUSP18 Gene
- HGNC(18484)
- Entrez Gene(150290)
- Ensembl(ENSG00000167065)
- OMIM(611446)
- UniProtKB(Q8NEJ0)
- Open Targets Platform(ENSG00000167065)
- Search for DUSP18 at DataMed
- Search for DUSP18 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP18 Gene
Genomics for DUSP18 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DUSP18 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DUSP18 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP18
- Top Transcription factor binding sites by QIAGEN in the DUSP18 gene promoter:
-
- C/EBPalpha
- CP2
- Evi-1
- NF-1
- NF-1/L
- Pax-5
- Roaz
- SEF-1 (1)
- SRF
- SRF (504 AA)
Genomic Locations for DUSP18 Gene
Genomic Locations for DUSP18 Gene
- chr22:30,652,051-30,667,890
- (GRCh38/hg38)
- Size:
- 15,840 bases
- Orientation:
- Minus strand
- chr22:31,048,038-31,063,877
- (GRCh37/hg19)
- Size:
- 15,840 bases
- Orientation:
- Minus strand
Genomic View for DUSP18 Gene
Genes around DUSP18 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.2 by HGNC
- 22q12.2 by Entrez Gene
- 22q12.2 by Ensembl
DUSP18 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DUSP18 Gene
Proteins for DUSP18 Gene
-
Protein details for DUSP18 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NEJ0-DUS18_HUMAN
- Recommended name:
- Dual specificity protein phosphatase 18
- Protein Accession:
- Q8NEJ0
- B3KPA4
Protein attributes for DUSP18 Gene
- Size:
- 188 amino acids
- Molecular mass:
- 21066 Da
- Quaternary structure:
- No Data Available
Protein Expression for DUSP18 Gene
Post-translational modifications for DUSP18 Gene
Other Protein References for DUSP18 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-DUSP18 monoclonal antibody
- Novus Biologicals Antibodies for DUSP18
- Invitrogen Antibodies for DUSP18 (AFLGC-DUSP18)
-
Santa Cruz Biotechnology (SCBT) Antibodies for DUSP18
Protein Products
- Creative Biomart Recombinant Human Dual Specificity Phosphatase 18, His-tagged
-
OriGene Purified Proteins for DUSP18
- Search Origene for MassSpec and Protein Over-expression Lysates for DUSP18
- Origene Custom Protein Services for DUSP18
- ProSpec Recombinant Proteins for DUSP18
- antibodies-online: Show 11 available DUSP18 Proteins ranked by validation data
- Compare Top DUSP18 Proteins
-
Quality Products:
-
Abcam proteins for DUSP18
No data available for DME Specific Peptides for DUSP18 Gene
Domains & Families for DUSP18 Gene
Gene Families for DUSP18 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for DUSP18 Gene
- InterPro:
- Blocks:
-
- Dual specificity protein phosphatase
- ProtoNet:
Suggested Antigen Peptide Sequences for DUSP18 Gene
- GenScript: Design optimal peptide antigens:
-
- Low molecular weight dual specificity phosphatase 20 (DUS18_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8NEJ0UniProtKB/Swiss-Prot:
DUS18_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Function for DUSP18 Gene
Molecular function for DUSP18 Gene
- UniProtKB/Swiss-Prot Function:
- Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000269|PubMed:12408986, ECO:0000269|PubMed:12591617};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:12408986, ECO:0000269|PubMed:12591617};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:12408986, ECO:0000269|PubMed:12591617};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- pH dependence: Optimum pH is 6.0. {ECO:0000269|PubMed:12591617}; Temperature dependence: Optimum temperature is 55 degrees Celsius. {ECO:0000269|PubMed:12591617};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by manganese ions, inhibited by iodoaretic acid.
Enzyme Numbers (IUBMB) for DUSP18 Gene
Phenotypes From GWAS Catalog for DUSP18 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IEA,IDA | 12408986 |
| GO:0005515 | protein binding | IPI | 28065597 |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IEA,IDA | 12591617 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for DUSP18 Gene
- MGI mutant phenotypes for DUSP18:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DUSP18:
-
- no effect
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Weakly decreased NFAT1-GFP nuclear translocation
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Elongated cells
- Increased caspase activity
- Decreased epidermal growth factor (EGF) endocytosis
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Increased cell migration
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, decreased FA abundance
Animal Model Products
-
Taconic Biosciences Mouse Models for DUSP18
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DUSP18 - Select products 50% OFF >
- * DUSP18 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DUSP18
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP18
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP18
miRNA for DUSP18 Gene
- miRTarBase miRNAs that target DUSP18
-
- mmu-miR-7b-5p (MIRT009092)
- hsa-miR-218-5p (MIRT024249)
- hsa-miR-744-5p (MIRT037689)
- hsa-miR-20a-5p (MIRT440767)
- hsa-miR-106b-5p (MIRT440768)
- hsa-miR-6857-5p (MIRT453887)
- hsa-miR-3115 (MIRT453888)
- hsa-miR-6867-5p (MIRT453889)
- hsa-miR-4450 (MIRT453890)
- hsa-miR-4764-5p (MIRT453891)
- hsa-miR-539-5p (MIRT453892)
- hsa-miR-6890-5p (MIRT453893)
- hsa-miR-3675-5p (MIRT453894)
- hsa-miR-5680 (MIRT453895)
- hsa-miR-4428 (MIRT453896)
- hsa-miR-4480 (MIRT496682)
- hsa-miR-4258 (MIRT496683)
- hsa-miR-449b-3p (MIRT496684)
- hsa-miR-338-5p (MIRT496685)
- hsa-miR-6848-3p (MIRT497186)
- hsa-miR-6843-3p (MIRT497187)
- hsa-miR-215-5p (MIRT497188)
- hsa-miR-192-5p (MIRT497189)
- hsa-miR-6131 (MIRT497190)
- hsa-miR-6821-3p (MIRT497191)
- hsa-miR-6790-3p (MIRT497192)
- hsa-miR-3663-5p (MIRT497193)
- mmu-miR-743b-3p (MIRT583879)
- mmu-miR-743a-3p (MIRT583880)
- mmu-miR-466f-3p (MIRT583881)
- mmu-miR-362-3p (MIRT583882)
- mmu-miR-329-3p (MIRT583883)
- mmu-miR-466i-3p (MIRT583884)
- mmu-miR-3082-5p (MIRT583885)
- mmu-miR-145a-5p (MIRT583886)
- mmu-miR-199a-5p (MIRT583887)
- mmu-miR-466m-3p (MIRT583888)
- mmu-miR-466o-3p (MIRT583889)
- mmu-miR-224-5p (MIRT604085)
- mmu-miR-3059-5p (MIRT604086)
- hsa-miR-2681-5p (MIRT613639)
- hsa-miR-466 (MIRT613640)
- hsa-miR-4672 (MIRT613641)
- hsa-miR-3941 (MIRT613642)
- hsa-miR-153-5p (MIRT613643)
- hsa-miR-6768-5p (MIRT613644)
- hsa-miR-603 (MIRT613645)
- hsa-miR-362-3p (MIRT613646)
- hsa-miR-329-3p (MIRT613647)
- hsa-miR-8485 (MIRT613648)
- hsa-miR-497-3p (MIRT618166)
- hsa-miR-744-3p (MIRT632988)
- hsa-miR-106a-3p (MIRT632989)
- hsa-miR-4423-5p (MIRT632990)
- hsa-miR-6501-5p (MIRT632991)
- hsa-miR-4430 (MIRT632992)
- hsa-miR-3652 (MIRT632993)
- hsa-miR-122-5p (MIRT632994)
- hsa-miR-504-3p (MIRT632995)
- hsa-miR-3135b (MIRT632996)
- hsa-miR-367-5p (MIRT632997)
- hsa-miR-1267 (MIRT632998)
- hsa-miR-454-3p (MIRT632999)
- hsa-miR-4295 (MIRT633000)
- hsa-miR-3666 (MIRT633001)
- hsa-miR-301b-3p (MIRT633002)
- hsa-miR-301a-3p (MIRT633003)
- hsa-miR-130b-3p (MIRT633004)
- hsa-miR-130a-3p (MIRT633005)
- hsa-miR-4638-5p (MIRT644053)
- hsa-miR-99b-3p (MIRT644054)
- hsa-miR-99a-3p (MIRT644055)
- hsa-miR-519d-3p (MIRT727839)
- hsa-miR-20b-5p (MIRT727840)
- hsa-miR-93-5p (MIRT727841)
- hsa-miR-17-5p (MIRT727842)
- hsa-miR-4269 (MIRT768236)
- hsa-miR-4422 (MIRT768846)
- hsa-miR-4438 (MIRT769128)
- hsa-miR-500b-3p (MIRT772984)
- hsa-miR-5089-5p (MIRT773239)
- hsa-miR-5095 (MIRT773279)
- hsa-miR-548e-5p (MIRT774379)
- hsa-miR-582-3p (MIRT775312)
- hsa-miR-619-5p (MIRT776051)
- hsa-miR-6504-3p (MIRT776575)
- hsa-miR-6506-5p (MIRT776600)
- hsa-miR-6715b-5p (MIRT777690)
- hsa-miR-7151-3p (MIRT781508)
- hsa-miR-194-5p (MIRT784055)
- hsa-miR-6077 (MIRT787992)
- hsa-miR-6079 (MIRT787997)
- hsa-miR-7-5p (MIRT789507)
- hsa-miR-7850-5p (MIRT789568)
- hsa-miR-95-5p (MIRT790019)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP18
- Browse OriGene Inhibitory RNA Products For DUSP18
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP18
Clone Products
- Applied Biological Materials (abm): Clones for DUSP18 - Select products 50% OFF >
- * DUSP18 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DUSP18
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP18
Cell Line Products
-
Horizon Cell Lines for DUSP18
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP18 Gene
Localization for DUSP18 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DUSP18 Gene
- Cytoplasm. Nucleus. Mitochondrion inner membrane. Peripheral membrane protein. Intermembrane side. Note=Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment. {ECO:0000250 UniProtKB:Q8VE01}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 4 |
| cytosol | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| extracellular | 0 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 12408986 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 12408986 |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005743 | mitochondrial inner membrane | IEA | -- |
Pathways & Interactions for DUSP18 Gene
Interacting Proteins for DUSP18 Gene
Selected Interacting proteins:
Q8NEJ0-DUS18_HUMAN
ENSP00000333917
for DUSP18 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for DUSP18
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000188 | inactivation of MAPK activity | IEA | -- |
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0016311 | dephosphorylation | IEA,IDA | 24531476 |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IEA,IDA | 12408986 |
| GO:0035970 | peptidyl-threonine dephosphorylation | IDA | 12591617 |
No data available for Pathways by source and SIGNOR curated interactions for DUSP18 Gene
Drugs & Compounds for DUSP18 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14066-19-4, 14265-44-2 |
|
Drug Products
- Creative Biomart Recombinant Human Dual Specificity Phosphatase 18, His-tagged
Transcripts for DUSP18 Gene
mRNA/cDNA for DUSP18 Gene
- 4 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000430175 598 nts (view in UCSC)
- ENST00000404885 1306 nts (view in UCSC)
- ENST00000407308 1978 nts (view in UCSC)
- ENST00000461301 760 nts (view in UCSC)
- ENST00000377087 1732 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DUSP18 - Select products 50% OFF >
- * DUSP18 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DUSP18
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP18
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP18
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP18
- Browse OriGene Inhibitory RNA Products For DUSP18
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP18
Clone Products
- Applied Biological Materials (abm): Clones for DUSP18 - Select products 50% OFF >
- * DUSP18 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DUSP18
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP18
Relevant External Links for DUSP18 Gene
- GeneLoc Exon Structure for
- DUSP18
Expression for DUSP18 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for DUSP18 Gene
This gene is overexpressed in Testis (x6.6) and Whole Blood (x4.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP18 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP18
SOURCE GeneReport for Unigene cluster for DUSP18 Gene:
Hs.517544mRNA Expression by UniProt/SwissProt for DUSP18 Gene:
Q8NEJ0-DUS18_HUMAN
Tissue specificity:
Widely expressed with highest levels in liver, brain, ovary and testis.
Evidence on tissue expression from TISSUES for DUSP18 Gene
- Nervous system(4.4)
Primer Products
-
OriGene qPCR primer pairs for DUSP18
-
OriGene qPCR primer pairs and template standards for DUSP18
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP18 Gene
Orthologs for DUSP18 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DUSP18 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DUSP18 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DUSP18 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dusp18 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Dusp18 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | DUSP18 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dusp18 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | DUSP18 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG15528 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | F26A3.4 31 |
|
ManyToMany | |
| F13D11.3 31 |
|
ManyToMany | |||
| C04F12.8 31 |
|
ManyToMany | |||
| ZK757.2 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10229 31 |
|
OneToMany |
- Species where no ortholog for DUSP18 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for DUSP18 Gene
- ENSEMBL:
- Gene Tree for DUSP18 (if available)
- TreeFam:
- Gene Tree for DUSP18 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DUSP18: view image
Paralogs for DUSP18 Gene
Paralogs for DUSP18 Gene
(12) SIMAP similar genes for DUSP18 Gene using alignment to 5 proteins:
- DUS18_HUMAN
- C9JEE9_HUMAN
- F2Z2P2_HUMAN
- F8VX42_HUMAN
- H7C401_HUMAN
Variants for DUSP18 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1110864 | OTHER | inversion | 24896259 |
| nsv834175 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.89;
18.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DUSP18 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DUSP18
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP18 Gene
Disorders for DUSP18 Gene
Additional Disease Information for DUSP18
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for DUSP18 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP18 Gene
Publications for DUSP18 Gene
- Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family. (PMID: 16699184) Jeong DG … Kim SJ (Acta crystallographica. Section D, Biological crystallography 2006) 3 4 23
- Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. (PMID: 12408986) Hood KL … Yoon C (Biochemical and biophysical research communications 2002) 2 3 4
- Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo. (PMID: 16720344) Wu Q … Mao Y (Frontiers in bioscience : a journal and virtual library 2006) 3 23
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for DUSP18 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for DUSP18
- Search Origene for MassSpec and Protein Over-expression Lysates for DUSP18
- Origene Custom Protein Services for DUSP18
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP18
- Browse OriGene Inhibitory RNA Products For DUSP18
- OriGene qPCR primer pairs for DUSP18
- OriGene qPCR primer pairs and template standards for DUSP18
- OriGene CRISPR knockouts for DUSP18
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DUSP18
- Sino Biological Human cDNA Clone for DUSP18
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for DUSP18
- Novus Biologicals proteins and lysates for DUSP18
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for DUSP18
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for DUSP18
- Taconic Biosciences Mouse Models for DUSP18
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for DUSP18 (AFLGC-DUSP18)
- VectorBuilder Custom and pre-made DNA vectors for DUSP18 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for DUSP18 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for DUSP18 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DUSP18 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DUSP18
- antibodies-online: Show 12 available DUSP18 Antibodies ranked by validation data
- Compare Top DUSP18 Antibodies
- antibodies-online: Search results for available DUSP18 related products ranked by validation data
- antibodies-online: Show 11 available DUSP18 Proteins ranked by validation data
- Compare Top DUSP18 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for DUSP18
- Search Santa Cruz Biotechnology (SCBT) for DUSP18 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DUSP18
- Horizon Cell Lines for DUSP18
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP18
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP18
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DUSP18
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP18
Sources for DUSP18 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB