Aliases for DUSP18 Gene
Aliases for DUSP18 Gene
External Ids for DUSP18 Gene
- HGNC: 18484
- Entrez Gene: 150290
- Ensembl: ENSG00000167065
- OMIM: 611446
- UniProtKB: Q8NEJ0
Previous GeneCards Identifiers for DUSP18 Gene
- GC22M027744
- GC22M029372
- GC22M029382
- GC22M031048
- GC22M014021
Summaries for DUSP18 Gene
-
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
GeneCards Summary for DUSP18 Gene
DUSP18 (Dual Specificity Phosphatase 18) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP21.
UniProtKB/Swiss-Prot for DUSP18 Gene
-
Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
Additional gene information for DUSP18 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP18 Gene
Genomics for DUSP18 Gene
GeneHancer (GH) Regulatory Elements for DUSP18 Gene
Promoters and enhancers for DUSP18 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around DUSP18 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DUSP18 gene promoter:
-
- SRF (504 AA)
- SRF
- Evi-1
- C/EBPalpha
- CP2
- NF-1/L
- NF-1
- Roaz
- Pax-5
- SEF-1 (1)
Regulatory Element Products
Genomic Locations for DUSP18 Gene
Genomic Locations for DUSP18 Gene
- chr22:30,652,051-30,667,890
- (GRCh38/hg38)
- Size:
- 15,840 bases
- Orientation:
- Minus strand
- chr22:31,048,038-31,063,877
- (GRCh37/hg19)
- Size:
- 15,840 bases
- Orientation:
- Minus strand
Genomic View for DUSP18 Gene
Genes around DUSP18 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.2 by Entrez Gene
- 22q12.2 by HGNC
- 22q12.2 by Ensembl
DUSP18 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DUSP18 Gene
Proteins for DUSP18 Gene
-
Protein details for DUSP18 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NEJ0-DUS18_HUMAN
- Recommended name:
- Dual specificity protein phosphatase 18
- Protein Accession:
- Q8NEJ0
- B3KPA4
Protein attributes for DUSP18 Gene
- Size:
- 188 amino acids
- Molecular mass:
- 21066 Da
- Quaternary structure:
- No Data Available
Protein Expression for DUSP18 Gene
Post-translational modifications for DUSP18 Gene
Other Protein References for DUSP18 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for DUSP18
- Invitrogen Antibodies for DUSP18 (AFLGC-DUSP18)
- Search GeneTex for Antibodies for DUSP18
-
Santa Cruz Biotechnology (SCBT) Antibodies for DUSP18
Protein Products
-
OriGene Purified Proteins for DUSP18
- Search Origene for MassSpec and Protein Over-expression Lysates for DUSP18
- Origene Custom Protein Services for DUSP18
- ProSpec Recombinant Proteins for DUSP18
- Search GeneTex for Proteins for DUSP18
-
Abcam proteins for DUSP18
Assay Products
No data available for DME Specific Peptides for DUSP18 Gene
Domains & Families for DUSP18 Gene
Gene Families for DUSP18 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for DUSP18 Gene
Suggested Antigen Peptide Sequences for DUSP18 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NEJ0UniProtKB/Swiss-Prot:
DUS18_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Function for DUSP18 Gene
Molecular function for DUSP18 Gene
- UniProtKB/Swiss-Prot Function:
- Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by manganese ions, inhibited by iodoaretic acid.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- pH dependence: Optimum pH is 6.0. {ECO:0000269 PubMed:12591617}; Temperature dependence: Optimum temperature is 55 degrees Celsius. {ECO:0000269 PubMed:12591617};
Enzyme Numbers (IUBMB) for DUSP18 Gene
Phenotypes From GWAS Catalog for DUSP18 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IDA,IEA | 12408986 |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IEA,IDA | 12591617 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016791 | phosphatase activity | IDA,IEA | 24531476 |
Phenotypes for DUSP18 Gene
- GenomeRNAi human phenotypes for DUSP18:
-
- Moderately decreased NFAT1-GFP nuclear translocation
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Increased cell migration
- Decreased cell migration
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- no effect
- Increased caspase activity
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased transferrin (TF) endocytosis
- Lamellipodia cells
Animal Model Products
-
Taconic Biosciences Mouse Models for DUSP18
- Cyagen custom Knockout/knockin (KOKI) mouse models for DUSP18
-
CRISPR Products
-
OriGene CRISPR knockouts for DUSP18
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP18
- genomics-online: gRNA clones - Search results for 90 available DUSP18 gene related products
- Overview of 90 available DUSP18 gene related products
- Applied Biological Materials CRISPR for DUSP18
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP18
- GenScript: Design CRISPR guide RNA sequences for DUSP18
miRNA for DUSP18 Gene
- miRTarBase miRNAs that target DUSP18
-
- hsa-mir-218-5p (MIRT024249)
- hsa-mir-744-5p (MIRT037689)
- hsa-mir-20a-5p (MIRT440767)
- hsa-mir-106b-5p (MIRT440768)
- hsa-mir-6857-5p (MIRT453887)
- hsa-mir-3115 (MIRT453888)
- hsa-mir-6867-5p (MIRT453889)
- hsa-mir-4450 (MIRT453890)
- hsa-mir-4764-5p (MIRT453891)
- hsa-mir-539-5p (MIRT453892)
- hsa-mir-6890-5p (MIRT453893)
- hsa-mir-3675-5p (MIRT453894)
- hsa-mir-5680 (MIRT453895)
- hsa-mir-4428 (MIRT453896)
- hsa-mir-4480 (MIRT496682)
- hsa-mir-4258 (MIRT496683)
- hsa-mir-449b-3p (MIRT496684)
- hsa-mir-338-5p (MIRT496685)
- hsa-mir-6848-3p (MIRT497186)
- hsa-mir-6843-3p (MIRT497187)
- hsa-mir-215-5p (MIRT497188)
- hsa-mir-192-5p (MIRT497189)
- hsa-mir-6131 (MIRT497190)
- hsa-mir-6821-3p (MIRT497191)
- hsa-mir-6790-3p (MIRT497192)
- hsa-mir-3663-5p (MIRT497193)
- hsa-mir-2681-5p (MIRT613639)
- hsa-mir-466 (MIRT613640)
- hsa-mir-4672 (MIRT613641)
- hsa-mir-3941 (MIRT613642)
- hsa-mir-153-5p (MIRT613643)
- hsa-mir-6768-5p (MIRT613644)
- hsa-mir-603 (MIRT613645)
- hsa-mir-362-3p (MIRT613646)
- hsa-mir-329-3p (MIRT613647)
- hsa-mir-8485 (MIRT613648)
- hsa-mir-497-3p (MIRT618166)
- hsa-mir-744-3p (MIRT632988)
- hsa-mir-106a-3p (MIRT632989)
- hsa-mir-4423-5p (MIRT632990)
- hsa-mir-6501-5p (MIRT632991)
- hsa-mir-4430 (MIRT632992)
- hsa-mir-3652 (MIRT632993)
- hsa-mir-122-5p (MIRT632994)
- hsa-mir-504-3p (MIRT632995)
- hsa-mir-3135b (MIRT632996)
- hsa-mir-367-5p (MIRT632997)
- hsa-mir-1267 (MIRT632998)
- hsa-mir-454-3p (MIRT632999)
- hsa-mir-4295 (MIRT633000)
- hsa-mir-3666 (MIRT633001)
- hsa-mir-301b-3p (MIRT633002)
- hsa-mir-301a-3p (MIRT633003)
- hsa-mir-130b-3p (MIRT633004)
- hsa-mir-130a-3p (MIRT633005)
- hsa-mir-4638-5p (MIRT644053)
- hsa-mir-99b-3p (MIRT644054)
- hsa-mir-99a-3p (MIRT644055)
- hsa-mir-519d-3p (MIRT727839)
- hsa-mir-20b-5p (MIRT727840)
- hsa-mir-93-5p (MIRT727841)
- hsa-mir-17-5p (MIRT727842)
- hsa-mir-4269 (MIRT768236)
- hsa-mir-4422 (MIRT768846)
- hsa-mir-4438 (MIRT769128)
- hsa-mir-500b-3p (MIRT772984)
- hsa-mir-5089-5p (MIRT773239)
- hsa-mir-5095 (MIRT773279)
- hsa-mir-548e-5p (MIRT774379)
- hsa-mir-582-3p (MIRT775312)
- hsa-mir-619-5p (MIRT776051)
- hsa-mir-6504-3p (MIRT776575)
- hsa-mir-6506-5p (MIRT776600)
- hsa-mir-6715b-5p (MIRT777690)
- hsa-mir-7151-3p (MIRT781508)
- hsa-mir-194-5p (MIRT784055)
- hsa-mir-6077 (MIRT787992)
- hsa-mir-6079 (MIRT787997)
- hsa-mir-7-5p (MIRT789507)
- hsa-mir-7850-5p (MIRT789568)
- hsa-mir-95-5p (MIRT790019)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP18
- Browse OriGene Inhibitory RNA Products For DUSP18
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP18
- genomics-online: shRNA clones - Search results for 90 available DUSP18 gene related products
- Overview of 90 available DUSP18 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DUSP18
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP18
- Applied Biological Materials Clones for DUSP18
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DUSP18
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP18 Gene
Localization for DUSP18 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DUSP18 Gene
- Cytoplasm. Nucleus. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment. {ECO:0000250 UniProtKB:Q8VE01}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 4 |
| cytosol | 3 |
| extracellular | 1 |
| peroxisome | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 12408986 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 12408986 |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005743 | mitochondrial inner membrane | IEA | -- |
Pathways & Interactions for DUSP18 Gene
No Data Available
Interacting Proteins for DUSP18 Gene
GPS-Prot Interaction Network for DUSP18
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000188 | inactivation of MAPK activity | IEA | -- |
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0016311 | dephosphorylation | IEA,IDA | 24531476 |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IDA,IEA | 12408986 |
| GO:0035970 | peptidyl-threonine dephosphorylation | IDA | 12591617 |
No data available for Pathways by source and SIGNOR curated interactions for DUSP18 Gene
Drugs & Compounds for DUSP18 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14265-44-2 |
|
Drug Products
Transcripts for DUSP18 Gene
mRNA/cDNA for DUSP18 Gene
- (10) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (83) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000430175 598 bps (uc062dfg.1)
- ENST00000404885 1306 bps (uc003aiu.4)
- ENST00000407308 1978 bps (uc021wnv.2)
- ENST00000461301 760 bps (uc062dfh.1)
- ENST00000377087 1732 bps (uc062dfi.1)
Unigene Clusters for DUSP18 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DUSP18
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP18
- genomics-online: gRNA clones - Search results for 90 available DUSP18 gene related products
- Overview of 90 available DUSP18 gene related products
- Applied Biological Materials CRISPR for DUSP18
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP18
- GenScript: Design CRISPR guide RNA sequences for DUSP18
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP18
- Browse OriGene Inhibitory RNA Products For DUSP18
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP18
- genomics-online: shRNA clones - Search results for 90 available DUSP18 gene related products
- Overview of 90 available DUSP18 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DUSP18
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP18
- Applied Biological Materials Clones for DUSP18
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for DUSP18 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for DUSP18 Gene
This gene is overexpressed in Testis (x6.6) and Whole Blood (x4.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP18 Gene
NURSA nuclear receptor signaling pathways regulating expression of DUSP18 Gene:
DUSP18SOURCE GeneReport for Unigene cluster for DUSP18 Gene:
Hs.517544mRNA Expression by UniProt/SwissProt for DUSP18 Gene:
Q8NEJ0-DUS18_HUMAN
Tissue specificity:
Widely expressed with highest levels in liver, brain, ovary and testis.
Evidence on tissue expression from TISSUES for DUSP18 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for DUSP18
-
OriGene qPCR primer pairs and template standards for DUSP18
- genomics-online: primer clones - Search results for 90 available DUSP18 gene related products
- Overview of 90 available DUSP18 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP18 Gene
Orthologs for DUSP18 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DUSP18 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DUSP18 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DUSP18 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Dusp18 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Dusp18 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | DUSP18 33 |
|
||
| -- 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dusp18 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | DUSP18 34 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG15528 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | F26A3.4 34 |
|
ManyToMany | |
| F13D11.3 34 |
|
ManyToMany | |||
| C04F12.8 34 |
|
ManyToMany | |||
| ZK757.2 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10229 34 |
|
OneToMany |
- Species where no ortholog for DUSP18 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for DUSP18 Gene
- ENSEMBL:
- Gene Tree for DUSP18 (if available)
- TreeFam:
- Gene Tree for DUSP18 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DUSP18: view image
Paralogs for DUSP18 Gene
Paralogs for DUSP18 Gene
(12) SIMAP similar genes for DUSP18 Gene using alignment to 5 proteins:
- DUS18_HUMAN
- C9JEE9_HUMAN
- F2Z2P2_HUMAN
- F8VX42_HUMAN
- H7C401_HUMAN
Variants for DUSP18 Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000095639 | -- | 30,652,366(-) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000148986 | -- | 30,660,115(-) | T/C | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant | |
| rs1000354461 | -- | 30,666,697(-) | A/G | intron_variant | |
| rs1000356204 | -- | 30,661,694(-) | G/A | 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant | |
| rs1000447800 | -- | 30,652,679(-) | G/A | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1110864 | OTHER | inversion | 24896259 |
| nsv834175 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.89;
18.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DUSP18 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DUSP18
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP18 Gene
Disorders for DUSP18 Gene
Additional Disease Information for DUSP18
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for DUSP18 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP18 Gene
Publications for DUSP18 Gene
- Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family. (PMID: 16699184) Jeong DG … Kim SJ (Acta crystallographica. Section D, Biological crystallography 2006) 3 4 22 58
- Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. (PMID: 12408986) Hood KL … Yoon C (Biochemical and biophysical research communications 2002) 2 3 4 58
- Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo. (PMID: 16720344) Wu Q … Mao Y (Frontiers in bioscience : a journal and virtual library 2006) 3 22 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
Products for DUSP18 Gene
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- Custom Antibody Services
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- OriGene Purified Proteins for DUSP18
- Search Origene for MassSpec and Protein Over-expression Lysates for DUSP18
- Origene Custom Protein Services for DUSP18
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP18
- Browse OriGene Inhibitory RNA Products For DUSP18
- OriGene qPCR primer pairs for DUSP18
- OriGene qPCR primer pairs and template standards for DUSP18
- OriGene CRISPR knockouts for DUSP18
- OriGene ORF clones in human for DUSP18
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DUSP18
- GenScript: Next-day shipping of latest version cDNA ORF clones for DUSP18 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for DUSP18
- GenScript Custom Assay Services for DUSP18
- GenScript Custom overexpressing Cell Line Services for DUSP18
- GenScript: Design CRISPR guide RNA sequences for DUSP18
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DUSP18
- Sino Biological Human cDNA Clone for DUSP18
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
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- Browse Sino Biological Assays
- Browse cDNA Clones
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for DUSP18
- Novus Biologicals lysates and proteins for DUSP18
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Abcam proteins for DUSP18
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- ProSpec Recombinant Proteins for DUSP18
- Taconic Biosciences Mouse Models for DUSP18
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for DUSP18 (AFLGC-DUSP18)
- Cyagen custom Knockout/knockin (KOKI) mouse models for DUSP18
- antibodies-online: Search results for 13 available DUSP18 Antibodies ranked by validation data
- Compare Top DUSP18 Antibodies
- antibodies-online: Search results for available DUSP18 related products ranked by validation data
- antibodies-online: Search results for 10 available DUSP18 Proteins ranked by validation data
- Compare Top DUSP18 Proteins
- Search GeneTex for Antibodies for DUSP18
- Search GeneTex for Proteins for DUSP18
- Santa Cruz Biotechnology (SCBT) Antibodies for DUSP18
- Search Santa Cruz Biotechnology (SCBT) for DUSP18 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DUSP18
- Horizon Cell Lines for DUSP18
- genomics-online: cdna clones - Search results for 90 available DUSP18 gene related products
- Overview of 90 available DUSP18 gene related products
- orf clones - Search results for 90 available DUSP18 gene related products
- Overview of 90 available DUSP18 gene related products
- genomics-online: gRNA clones - Search results for 90 available DUSP18 gene related products
- Overview of 90 available DUSP18 gene related products
- genomics-online: primer clones - Search results for 90 available DUSP18 gene related products
- Overview of 90 available DUSP18 gene related products
- genomics-online: shRNA clones - Search results for 90 available DUSP18 gene related products
- Overview of 90 available DUSP18 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP18
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP18
- GeneCopoeia miRNA 3'UTR Target clone products for DUSP18
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP18
Sources for DUSP18 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (120) Genetics Home Reference
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- (123) CDC
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- (125) NCBI Bookshelf
- (126) ClinVar
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- (128) ViGene Biosciences
- (129) HPO
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt