Aliases for DUSP16 Gene
External Ids for DUSP16 Gene
Previous GeneCards Identifiers for DUSP16 Gene
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
GeneCards Summary for DUSP16 Gene
DUSP16 (Dual Specificity Phosphatase 16) is a Protein Coding gene. Diseases associated with DUSP16 include Obstructive Hydrocephalus. Among its related pathways are RET signaling and Signal transduction_Erk Interactions- Inhibition of Erk. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP8.
UniProtKB/Swiss-Prot Summary for DUSP16 Gene
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.