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Aliases for DUSP16 Gene

Aliases for DUSP16 Gene

  • Dual Specificity Phosphatase 16 2 3 5
  • Mitogen-Activated Protein Kinase Phosphatase 7 3 4
  • MAP Kinase Phosphatase 7 3 4
  • MAPK Phosphatase-7 2 3
  • MKP-7 3 4
  • MKP7 3 4
  • Dual Specificity Protein Phosphatase 16 3
  • EC 4
  • EC 4
  • KIAA1700 4

External Ids for DUSP16 Gene

Previous GeneCards Identifiers for DUSP16 Gene

  • GC12M012354
  • GC12M012771
  • GC12M012527
  • GC12M012518
  • GC12M012520
  • GC12M012628

Summaries for DUSP16 Gene

Entrez Gene Summary for DUSP16 Gene

  • This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]

GeneCards Summary for DUSP16 Gene

DUSP16 (Dual Specificity Phosphatase 16) is a Protein Coding gene. Among its related pathways are RET signaling and Regulation of p38-alpha and p38-beta. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP8.

UniProtKB/Swiss-Prot for DUSP16 Gene

  • Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.

Gene Wiki entry for DUSP16 Gene

Additional gene information for DUSP16 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP16 Gene

Genomics for DUSP16 Gene

GeneHancer (GH) Regulatory Elements for DUSP16 Gene

Promoters and enhancers for DUSP16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J012557 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 653.7 +1.7 1724 7 PKNOX1 FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 DUSP16 DDX47 CREBL2 GPR19 CDKN1B ENSG00000255670 BCL2L14 GC12M012561 PIR41199
GH12J012610 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.9 -49.4 -49434 3.2 FEZF1 DMAP1 YY1 ZNF143 SP3 ZNF610 GLIS1 NBN KDM1A WT1 CREBL2 DUSP16 RPL21P136
GH12J012379 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 19.6 +182.3 182295 2.7 PKNOX1 FOXA2 MLX RAD21 RARA YY1 ZNF766 ATF7 CREM RUNX3 GC12M012376 CDKN1B DUSP16 MANSC1 ENSG00000240424 BORCS5 APOLD1 BCL2L14 GC12M012364 GC12P012364
GH12J012439 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.2 +120.9 120861 5.9 PKNOX1 FOXA2 ARID4B YY1 SLC30A9 TCF12 ZNF207 FOS RUNX3 RXRA BORCS5 DUSP16 DDX47 ENSG00000240424 CDKN1B CREBL2 APOLD1 BCL2L14 GPR19 GC12P012450
GH12J012448 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.7 +112.5 112538 3 PKNOX1 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 SLC30A9 ATF7 NFKBIZ GC12P012450 DUSP16 CREBL2 ENSG00000240424 GPR19 BORCS5 BCL2L14 ENSG00000271370
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUSP16 gene promoter:
  • c-Jun
  • ATF-2
  • AP-1
  • HOXA5
  • POU2F1a
  • POU2F1
  • COUP
  • COUP-TF1
  • HNF-4alpha1

Genomic Locations for DUSP16 Gene

Genomic Locations for DUSP16 Gene
89,558 bases
Minus strand
89,233 bases
Minus strand

Genomic View for DUSP16 Gene

Genes around DUSP16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP16 Gene

Proteins for DUSP16 Gene

  • Protein details for DUSP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 16
    Protein Accession:
    Secondary Accessions:
    • Q547C7
    • Q96QS2
    • Q9C0G3

    Protein attributes for DUSP16 Gene

    665 amino acids
    Molecular mass:
    73102 Da
    Quaternary structure:
    • Interacts with ARRB2.
    • Sequence=BAB21791.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DUSP16 Gene

    Alternative splice isoforms for DUSP16 Gene


neXtProt entry for DUSP16 Gene

Post-translational modifications for DUSP16 Gene

  • Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity.
  • (Microbial infection) Acetylated at Lys-55 by the M.tuberculosis Eis protein; this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP16 Gene

No data available for DME Specific Peptides for DUSP16 Gene

Domains & Families for DUSP16 Gene

Gene Families for DUSP16 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DUSP16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP16: view

Function for DUSP16 Gene

Molecular function for DUSP16 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for DUSP16 Gene

Phenotypes From GWAS Catalog for DUSP16 Gene

Gene Ontology (GO) - Molecular Function for DUSP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS 11489891
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA,IEA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IDA 24531476
genes like me logo Genes that share ontologies with DUSP16: view
genes like me logo Genes that share phenotypes with DUSP16: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP16 Gene

Localization for DUSP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP16 Gene

Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP16 gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DUSP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 11489891
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 11489891
GO:0005829 cytosol IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with DUSP16: view

Pathways & Interactions for DUSP16 Gene

SuperPathways for DUSP16 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Innate Immune System
5 Signaling by GPCR
genes like me logo Genes that share pathways with DUSP16: view

Pathways by source for DUSP16 Gene

1 BioSystems pathway for DUSP16 Gene
1 KEGG pathway for DUSP16 Gene
1 Qiagen pathway for DUSP16 Gene
1 Cell Signaling Technology pathway for DUSP16 Gene

SIGNOR curated interactions for DUSP16 Gene

Other effect:

Gene Ontology (GO) - Biological Process for DUSP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 11489891
GO:0006470 protein dephosphorylation IEA,IBA --
GO:0016311 dephosphorylation TAS 11489891
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0043409 negative regulation of MAPK cascade IEA --
genes like me logo Genes that share ontologies with DUSP16: view

Drugs & Compounds for DUSP16 Gene

(3) Drugs for DUSP16 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0

(1) Additional Compounds for DUSP16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
genes like me logo Genes that share compounds with DUSP16: view

Transcripts for DUSP16 Gene

Unigene Clusters for DUSP16 Gene

Dual specificity phosphatase 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP16 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP4: -

Relevant External Links for DUSP16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUSP16 Gene

This gene is overexpressed in Plasma (57.5) and Adrenal (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP16 Gene

Protein tissue co-expression partners for DUSP16 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUSP16 Gene:


SOURCE GeneReport for Unigene cluster for DUSP16 Gene:


Evidence on tissue expression from TISSUES for DUSP16 Gene

  • Nervous system(4.6)
  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with DUSP16: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP16 Gene

Orthologs for DUSP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DUSP16 34 33
  • 99.45 (n)
(Canis familiaris)
Mammalia DUSP16 34 33
  • 91.29 (n)
(Mus musculus)
Mammalia Dusp16 16 34 33
  • 88.64 (n)
(Rattus norvegicus)
Mammalia Dusp16 33
  • 88.08 (n)
(Monodelphis domestica)
Mammalia DUSP16 34
  • 87 (a)
(Bos Taurus)
Mammalia DUSP16 34 33
  • 82.91 (n)
(Ornithorhynchus anatinus)
Mammalia DUSP16 34
  • 69 (a)
(Gallus gallus)
Aves DUSP16 34 33
  • 78.69 (n)
(Anolis carolinensis)
Reptilia DUSP16 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp16 33
  • 68.22 (n)
(Danio rerio)
Actinopterygii dusp16 34 33
  • 64.48 (n)
(Caenorhabditis elegans)
Secernentea vhp-1 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
Species where no ortholog for DUSP16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP16 Gene

Gene Tree for DUSP16 (if available)
Gene Tree for DUSP16 (if available)
Evolutionary constrained regions (ECRs) for DUSP16: view image

Paralogs for DUSP16 Gene

Paralogs for DUSP16 Gene

(11) SIMAP similar genes for DUSP16 Gene using alignment to 4 proteins:

  • F5H5X4_HUMAN
  • Q32MA0_HUMAN
genes like me logo Genes that share paralogs with DUSP16: view

Variants for DUSP16 Gene

Sequence variations from dbSNP and Humsavar for DUSP16 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000000850 -- 12,556,661(-) C/A/T intron_variant
rs1000002329 -- 12,539,854(-) C/A intron_variant
rs1000020873 -- 12,558,941(-) C/A intron_variant
rs1000070796 -- 12,489,428(-) T/C intron_variant
rs1000095362 -- 12,556,566(-) CCCC/CCCCC intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP16 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV deletion 23290073
esv2759880 CNV gain 17122850
esv33583 CNV loss 17666407
esv3628615 CNV loss 21293372
esv3628616 CNV loss 21293372
nsv1046355 CNV loss 25217958
nsv1070096 CNV deletion 25765185
nsv1112617 CNV deletion 24896259
nsv1143559 CNV deletion 24896259
nsv523022 CNV loss 19592680
nsv523366 CNV gain 19592680
nsv8922 CNV gain 18304495

Variation tolerance for DUSP16 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.60; 82.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP16 Gene

Disorders for DUSP16 Gene

Additional Disease Information for DUSP16

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DUSP16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP16 Gene

Publications for DUSP16 Gene

  1. MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein. (PMID: 11489891) Masuda K … Kikuchi K (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2. (PMID: 15888437) Willoughby EA … Collins MK (The Journal of biological chemistry 2005) 2 3 4 58
  3. MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation. (PMID: 14586399) Hoornaert I … Baens M (Oncogene 2003) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm. (PMID: 20122898) Masuda K … Shima H (Biochemical and biophysical research communications 2010) 3 22 58

Products for DUSP16 Gene

Sources for DUSP16 Gene

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