The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] See more...

Aliases for DUSP15 Gene

Aliases for DUSP15 Gene

  • Dual Specificity Phosphatase 15 2 3 5
  • VHY 2 3 4
  • Vaccinia Virus VH1-Related Dual-Specific Protein Phosphatase Y 3 4
  • Dual Specificity Protein Phosphatase 15 3 4
  • Dual Specificity Phosphatase-Like 15 2 3
  • VH1-Related Member Y 3 4
  • C20orf57 3 4
  • Chromosome 20 Open Reading Frame 57 2
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • BA243J16.6 2
  • BA243J16.5 2
  • FLJ20645 2
  • DUSP15 5

External Ids for DUSP15 Gene

Previous HGNC Symbols for DUSP15 Gene

  • C20orf57

Previous GeneCards Identifiers for DUSP15 Gene

  • GC20M030237
  • GC20M030183
  • GC20M031133
  • GC20M031180
  • GC20M031181
  • GC20M029899
  • GC20M029912
  • GC20M030437
  • GC20M030439
  • GC20M030443
  • GC20M030446

Summaries for DUSP15 Gene

Entrez Gene Summary for DUSP15 Gene

  • The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for DUSP15 Gene

DUSP15 (Dual Specificity Phosphatase 15) is a Protein Coding gene. Diseases associated with DUSP15 include Nanophthalmos. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP22.

UniProtKB/Swiss-Prot Summary for DUSP15 Gene

  • May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (PubMed:22792334).
  • [Isoform 3]: May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity).

Gene Wiki entry for DUSP15 Gene

Additional gene information for DUSP15 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP15 Gene

Genomics for DUSP15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DUSP15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J031869 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 609.6 +0.2 156 1.6 PRDM10 ZNF692 ZNF174 LARP7 ZIC2 PKNOX1 POLR2A PATZ1 REST IRF2 DUSP15 TTLL9 ASXL1 TM9SF4 PLAGL2 BAK1P1 FOXS1
GH20J031868 Promoter/Enhancer 0.8 Ensembl CraniofacialAtlas 606.3 +1.5 1549 0.8 ZNF792 ZNF335 IKZF5 EZH2 DUSP15 TTLL9 MYLK2 XKR7 FOXS1
GH20J031871 Promoter 0.6 Ensembl 600.7 -0.8 -754 0.2 PRDM10 NR2C1 NR2F1 ZNF664 ZNF548 EZH2 DUSP15 TTLL9 ASXL1 piR-46079-002 PDRG1
GH20J031950 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 19 -80.8 -80758 2.4 BRCA1 ARHGAP35 SP1 CREB1 GATAD2A CTCF ATF7 PRDM10 ZNF629 REST PDRG1 lnc-DUSP15-2 XKR7 DUSP15 TTLL9 RF00017-3547
GH20J031967 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 -97.7 -97653 2.4 HNRNPL GATAD2A TEAD4 ZNF629 REST TFE3 NFKBIZ RFX5 KDM1A ZNF692 ENSG00000278012 XKR7 PDRG1 TTLL9 RSL24D1P6 DUSP15 RNA5SP481 CCM2L FOXS1 MYLK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP15

Top Transcription factor binding sites by QIAGEN in the DUSP15 gene promoter:
  • AREB6
  • GATA-2
  • Nkx2-5
  • POU3F2

Genomic Locations for DUSP15 Gene

Genomic Locations for DUSP15 Gene
chr20:31,845,578-31,870,747
(GRCh38/hg38)
Size:
25,170 bases
Orientation:
Minus strand
chr20:30,435,440-30,458,550
(GRCh37/hg19)
Size:
23,111 bases
Orientation:
Minus strand

Genomic View for DUSP15 Gene

Genes around DUSP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP15 Gene

Proteins for DUSP15 Gene

  • Protein details for DUSP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1R2-DUS15_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 15
    Protein Accession:
    Q9H1R2
    Secondary Accessions:
    • A6NH79
    • A8MVC8
    • Q5QP62
    • Q5QP63
    • Q5QP65
    • Q6PGN7
    • Q8N826
    • Q9BX24

    Protein attributes for DUSP15 Gene

    Size:
    295 amino acids
    Molecular mass:
    31882 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP15 Gene

    Alternative splice isoforms for DUSP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP15 Gene

Post-translational modifications for DUSP15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DUSP15 Gene

Domains & Families for DUSP15 Gene

Gene Families for DUSP15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DUSP15 Gene

Suggested Antigen Peptide Sequences for DUSP15 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ34641 fis, clone KIDNE2016570, highly similar to Homo sapiens dual specificity phosphatase 15 (DUSP15), transcript variant 2, mRNA (A8MVC8_HUMAN)
  • Vaccinia virus VH1-related dual-specific protein phosphatase Y (DUS15_HUMAN)
  • Dual specificity phosphatase 15 (Q5QP66_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H1R2

UniProtKB/Swiss-Prot:

DUS15_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP15: view

Function for DUSP15 Gene

Molecular function for DUSP15 Gene

UniProtKB/Swiss-Prot Function:
May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (PubMed:22792334).
UniProtKB/Swiss-Prot Function:
[Isoform 3]: May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000269|PubMed:22792334};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.

Enzyme Numbers (IUBMB) for DUSP15 Gene

Phenotypes From GWAS Catalog for DUSP15 Gene

Gene Ontology (GO) - Molecular Function for DUSP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IDA 22792334
GO:0005515 protein binding IPI 17474147
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IDA 17498703
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DUSP15: view
genes like me logo Genes that share phenotypes with DUSP15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP15

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP15

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUSP15 Gene

Localization for DUSP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP15 Gene

Cytoplasm.
[Isoform 3]: Cell membrane. Lipid-anchor. Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP15 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DUSP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA,IDA --
GO:0005886 plasma membrane IEA,IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DUSP15: view

Pathways & Interactions for DUSP15 Gene

PathCards logo

SuperPathways for DUSP15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway IBA 21873635
GO:0016311 dephosphorylation IDA 24531476
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0042127 regulation of cell proliferation IBA 21873635
genes like me logo Genes that share ontologies with DUSP15: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP15 Gene

Drugs & Compounds for DUSP15 Gene

(3) Drugs for DUSP15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Calcium Nutra 6556

(1) Additional Compounds for DUSP15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with DUSP15: view

Transcripts for DUSP15 Gene

mRNA/cDNA for DUSP15 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP15

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3:

Relevant External Links for DUSP15 Gene

GeneLoc Exon Structure for
DUSP15

Expression for DUSP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP15 Gene

This gene is overexpressed in Testis (x19.6) and Kidney - Cortex (x7.2).

Protein differential expression in normal tissues from HIPED for DUSP15 Gene

This gene is overexpressed in Spinal cord (37.8) and Frontal cortex (30.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP15 Gene



Protein tissue co-expression partners for DUSP15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP15

SOURCE GeneReport for Unigene cluster for DUSP15 Gene:

Hs.585017

mRNA Expression by UniProt/SwissProt for DUSP15 Gene:

Q9H1R2-DUS15_HUMAN
Tissue specificity: Highly expressed in testis (PubMed:15138252). Expressed in brain; up-regulated in patients with multiple sclerosis gray matter lesions (PubMed:22792334).

Evidence on tissue expression from TISSUES for DUSP15 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with DUSP15: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP15 Gene

Orthologs for DUSP15 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DUSP15 30 31
  • 99.01 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DUSP15 30 31
  • 92.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DUSP15 30 31
  • 91.49 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dusp15 30 17 31
  • 87.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dusp15 30
  • 86.95 (n)
Oppossum
(Monodelphis domestica)
Mammalia DUSP15 31
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DUSP15 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DUSP15 30 31
  • 69.63 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DUSP15 31
  • 70 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dusp22a 31
  • 45 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG10089 31
  • 23 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C16A3.2 31
  • 22 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9033 31
  • 37 (a)
OneToMany
Species where no ortholog for DUSP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for DUSP15 Gene

ENSEMBL:
Gene Tree for DUSP15 (if available)
TreeFam:
Gene Tree for DUSP15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP15: view image

Paralogs for DUSP15 Gene

(4) SIMAP similar genes for DUSP15 Gene using alignment to 3 proteins:

  • DUS15_HUMAN
  • H0Y5A2_HUMAN
  • Q5QP64_HUMAN
genes like me logo Genes that share paralogs with DUSP15: view

Variants for DUSP15 Gene

Additional dbSNP identifiers (rs#s) for DUSP15 Gene

Structural Variations from Database of Genomic Variants (DGV) for DUSP15 Gene

Variant ID Type Subtype PubMed ID
dgv4300n100 CNV gain 25217958
nsv833952 CNV gain 17160897

Variation tolerance for DUSP15 Gene

Gene Damage Index Score: 3.52; 55.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP15 Gene

Human Gene Mutation Database (HGMD)
DUSP15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP15 Gene

Disorders for DUSP15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUSP15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nanophthalmos
  • nanophthalmia
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with DUSP15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP15 Gene

Publications for DUSP15 Gene

  1. VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. (PMID: 15138252) Alonso A … Mustelin T (The Journal of biological chemistry 2004) 2 3 4
  2. Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach. (PMID: 22792334) Schmidt F … Hooft van Huijsduijnen R (PloS one 2012) 3 4
  3. Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase. (PMID: 16170801) Yoon TS … Kim SJ (Proteins 2005) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for DUSP15 Gene

Sources for DUSP15 Gene