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Aliases for DUSP15 Gene

Aliases for DUSP15 Gene

  • Dual Specificity Phosphatase 15 2 3 5
  • Vaccinia Virus VH1-Related Dual-Specific Protein Phosphatase Y 3 4
  • Dual Specificity Phosphatase-Like 15 2 3
  • VH1-Related Member Y 3 4
  • C20orf57 3 4
  • VHY 3 4
  • Dual Specificity Protein Phosphatase 15 3
  • Chromosome 20 Open Reading Frame 57 2
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for DUSP15 Gene

Previous HGNC Symbols for DUSP15 Gene

  • C20orf57

Previous GeneCards Identifiers for DUSP15 Gene

  • GC20M030237
  • GC20M030183
  • GC20M031133
  • GC20M031180
  • GC20M031181
  • GC20M029899
  • GC20M029912
  • GC20M030437
  • GC20M030439
  • GC20M030443
  • GC20M030446

Summaries for DUSP15 Gene

Entrez Gene Summary for DUSP15 Gene

  • The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for DUSP15 Gene

DUSP15 (Dual Specificity Phosphatase 15) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP22.

UniProtKB/Swiss-Prot for DUSP15 Gene

  • May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (PubMed:22792334).

  • Isoform 3: May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity).

Gene Wiki entry for DUSP15 Gene

Additional gene information for DUSP15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP15 Gene

Genomics for DUSP15 Gene

GeneHancer (GH) Regulatory Elements for DUSP15 Gene

Promoters and enhancers for DUSP15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J031869 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 659.7 +0.1 128 1.5 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF48 ZNF121 GLIS2 ZNF548 MXD4 DUSP15 TTLL9 ASXL1 PLAGL2 TM9SF4 FOXS1
GH20J031950 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 19 -80.8 -80758 2.4 PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 PDRG1 XKR7 DUSP15 TTLL9 PIR49802
GH20J031879 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 -9.2 -9153 1.4 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 E2F8 TTLL9 ASXL1 BAK1P1 TM9SF4 PLAGL2 DUSP15 FOXS1 MYLK2 RNU1-94P
GH20J031840 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.9 +26.7 26712 6.6 HDGF PKNOX1 SIN3A YBX1 ZNF48 TCF12 GLIS2 ZNF207 ZNF143 ATF7 GC20M031845 FOXS1 ASXL1 MYLK2 POFUT1 TSPY26P TTLL9 TM9SF4 BAK1P1 PLAGL2
GH20J031835 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.6 +33.5 33542 3.8 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 TCF12 GLIS2 CBX5 FOS TM9SF4 ASXL1 DUSP15 TTLL9 XKR7 HM13 GC20M031845 MYLK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DUSP15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUSP15 gene promoter:

Genomic Locations for DUSP15 Gene

Genomic Locations for DUSP15 Gene
chr20:31,847,637-31,870,747
(GRCh38/hg38)
Size:
23,111 bases
Orientation:
Minus strand
chr20:30,435,440-30,458,550
(GRCh37/hg19)

Genomic View for DUSP15 Gene

Genes around DUSP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP15 Gene

Proteins for DUSP15 Gene

  • Protein details for DUSP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1R2-DUS15_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 15
    Protein Accession:
    Q9H1R2
    Secondary Accessions:
    • A6NH79
    • A8MVC8
    • Q5QP62
    • Q5QP63
    • Q5QP65
    • Q6PGN7
    • Q8N826
    • Q9BX24

    Protein attributes for DUSP15 Gene

    Size:
    295 amino acids
    Molecular mass:
    31882 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP15 Gene

    Alternative splice isoforms for DUSP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP15 Gene

Post-translational modifications for DUSP15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DUSP15 Gene

Domains & Families for DUSP15 Gene

Gene Families for DUSP15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9H1R2

UniProtKB/Swiss-Prot:

DUS15_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP15: view

Function for DUSP15 Gene

Molecular function for DUSP15 Gene

UniProtKB/Swiss-Prot Function:
May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (PubMed:22792334).
UniProtKB/Swiss-Prot Function:
Isoform 3: May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for DUSP15 Gene

Phenotypes From GWAS Catalog for DUSP15 Gene

Gene Ontology (GO) - Molecular Function for DUSP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IDA 22792334
GO:0005515 protein binding IPI 17474147
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IDA 17498703
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IDA 24531476
genes like me logo Genes that share ontologies with DUSP15: view
genes like me logo Genes that share phenotypes with DUSP15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP15

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUSP15 Gene

Localization for DUSP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP15 Gene

Cytoplasm.
Isoform 3: Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP15 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DUSP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA,IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DUSP15: view

Pathways & Interactions for DUSP15 Gene

SuperPathways for DUSP15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway IBA --
GO:0016311 dephosphorylation IDA 24531476
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0042127 regulation of cell proliferation IBA --
genes like me logo Genes that share ontologies with DUSP15: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP15 Gene

Drugs & Compounds for DUSP15 Gene

(3) Drugs for DUSP15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0

(1) Additional Compounds for DUSP15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14265-44-2
genes like me logo Genes that share compounds with DUSP15: view

Transcripts for DUSP15 Gene

mRNA/cDNA for DUSP15 Gene

Unigene Clusters for DUSP15 Gene

Dual specificity phosphatase 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3:

Relevant External Links for DUSP15 Gene

GeneLoc Exon Structure for
DUSP15
ECgene alternative splicing isoforms for
DUSP15

Expression for DUSP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP15 Gene

This gene is overexpressed in Testis (x19.6) and Kidney - Cortex (x7.2).

Protein differential expression in normal tissues from HIPED for DUSP15 Gene

This gene is overexpressed in Spinal cord (37.8) and Frontal cortex (30.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP15 Gene



Protein tissue co-expression partners for DUSP15 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUSP15 Gene:

DUSP15

SOURCE GeneReport for Unigene cluster for DUSP15 Gene:

Hs.585017

mRNA Expression by UniProt/SwissProt for DUSP15 Gene:

Q9H1R2-DUS15_HUMAN
Tissue specificity: Highly expressed in testis (PubMed:15138252). Expressed in brain; up-regulated in patients with multiple sclerosis gray matter lesions (PubMed:22792334).

Evidence on tissue expression from TISSUES for DUSP15 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with DUSP15: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP15 Gene

Orthologs for DUSP15 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP15 34 33
  • 99.01 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP15 34 33
  • 92.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP15 34 33
  • 91.49 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp15 16 34 33
  • 87.09 (n)
rat
(Rattus norvegicus)
Mammalia Dusp15 33
  • 86.95 (n)
oppossum
(Monodelphis domestica)
Mammalia DUSP15 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP15 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP15 34 33
  • 69.63 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP15 34
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dusp22a 34
  • 45 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10089 34
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C16A3.2 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9033 34
  • 37 (a)
OneToMany
Species where no ortholog for DUSP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DUSP15 Gene

ENSEMBL:
Gene Tree for DUSP15 (if available)
TreeFam:
Gene Tree for DUSP15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP15: view image

Paralogs for DUSP15 Gene

(4) SIMAP similar genes for DUSP15 Gene using alignment to 3 proteins:

  • DUS15_HUMAN
  • H0Y5A2_HUMAN
  • Q5QP64_HUMAN
genes like me logo Genes that share paralogs with DUSP15: view

Variants for DUSP15 Gene

Sequence variations from dbSNP and Humsavar for DUSP15 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000036719 -- 31,849,056(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000192116 -- 31,855,069(-) A/C genic_downstream_transcript_variant, intron_variant
rs1000249644 -- 31,852,053(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000340713 -- 31,861,845(-) T/C intron_variant
rs1000645861 -- 31,851,562(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP15 Gene

Variant ID Type Subtype PubMed ID
dgv4300n100 CNV gain 25217958
nsv833952 CNV gain 17160897

Variation tolerance for DUSP15 Gene

Gene Damage Index Score: 3.52; 55.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP15 Gene

Human Gene Mutation Database (HGMD)
DUSP15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP15 Gene

Disorders for DUSP15 Gene

No disorders were found for DUSP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP15 Gene

Publications for DUSP15 Gene

  1. VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. (PMID: 15138252) Alonso A … Mustelin T (The Journal of biological chemistry 2004) 2 3 4 58
  2. Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach. (PMID: 22792334) Schmidt F … Hooft van Huijsduijnen R (PloS one 2012) 3 4 58
  3. Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase. (PMID: 16170801) Yoon TS … Kim SJ (Proteins 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for DUSP15 Gene

Sources for DUSP15 Gene

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