Aliases for DUSP14 Gene
External Ids for DUSP14 Gene
Previous GeneCards Identifiers for DUSP14 Gene
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
GeneCards Summary for DUSP14 Gene
DUSP14 (Dual Specificity Phosphatase 14) is a Protein Coding gene. Diseases associated with DUSP14 include Variola Major and Frontometaphyseal Dysplasia. Among its related pathways are Hypertrophy Model and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is DUSP18.
UniProtKB/Swiss-Prot Summary for DUSP14 Gene
Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.