Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal ... See more...

Aliases for DUSP14 Gene

Aliases for DUSP14 Gene

  • Dual Specificity Phosphatase 14 2 3 5
  • MKP-L 2 3 4
  • MKP6 2 3 4
  • Mitogen-Activated Protein Kinase Phosphatase 6 3 4
  • Dual Specificity Protein Phosphatase 14 3 4
  • MKP-1-Like Protein Tyrosine Phosphatase 3 4
  • MAP Kinase Phosphatase 6 3 4
  • MKP-6 3 4
  • MKP-1 Like Protein Tyrosine Phosphatase 2
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DUSP14 5

External Ids for DUSP14 Gene

Previous GeneCards Identifiers for DUSP14 Gene

  • GC17P035255
  • GC17P037802
  • GC17P035580
  • GC17P036045
  • GC17P032924
  • GC17P035850
  • GC17P031787

Summaries for DUSP14 Gene

Entrez Gene Summary for DUSP14 Gene

  • Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

GeneCards Summary for DUSP14 Gene

DUSP14 (Dual Specificity Phosphatase 14) is a Protein Coding gene. Diseases associated with DUSP14 include Variola Major and Frontometaphyseal Dysplasia. Among its related pathways are Hypertrophy Model and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is DUSP18.

UniProtKB/Swiss-Prot Summary for DUSP14 Gene

  • Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP14 Gene

Genomics for DUSP14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DUSP14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP14

Top Transcription factor binding sites by QIAGEN in the DUSP14 gene promoter:
  • CUTL1
  • E47
  • FOXF2
  • FOXO4
  • Hand1
  • IRF-7A
  • POU3F2
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for DUSP14 Gene

Genomic Locations for DUSP14 Gene
chr17:37,488,561-37,513,501
(GRCh38/hg38)
Size:
24,941 bases
Orientation:
Plus strand
chr17:35,849,937-35,873,603
(GRCh37/hg19)
Size:
23,667 bases
Orientation:
Plus strand

Genomic View for DUSP14 Gene

Genes around DUSP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP14 Gene

Proteins for DUSP14 Gene

  • Protein details for DUSP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95147-DUS14_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 14
    Protein Accession:
    O95147

    Protein attributes for DUSP14 Gene

    Size:
    198 amino acids
    Molecular mass:
    22255 Da
    Quaternary structure:
    • Interacts with CD28.

    Three dimensional structures from OCA and Proteopedia for DUSP14 Gene

neXtProt entry for DUSP14 Gene

Post-translational modifications for DUSP14 Gene

  • Ubiquitination at Lys187
  • Modification sites at PhosphoSitePlus

Other Protein References for DUSP14 Gene

Antibody Products

  • Abcam antibodies for DUSP14
  • Boster Bio Antibodies for DUSP14

No data available for DME Specific Peptides for DUSP14 Gene

Domains & Families for DUSP14 Gene

Gene Families for DUSP14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DUSP14 Gene

Suggested Antigen Peptide Sequences for DUSP14 Gene

GenScript: Design optimal peptide antigens:
  • Mitogen-activated protein kinase phosphatase 6 (DUS14_HUMAN)
  • cDNA, FLJ95796, Homo sapiens dual specificity phosphatase 14 (DUSP14), mRNA (Q6FI36_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95147

UniProtKB/Swiss-Prot:

DUS14_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP14: view

Function for DUSP14 Gene

Molecular function for DUSP14 Gene

UniProtKB/Swiss-Prot Function:
Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.

Enzyme Numbers (IUBMB) for DUSP14 Gene

Phenotypes From GWAS Catalog for DUSP14 Gene

Gene Ontology (GO) - Molecular Function for DUSP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP14: view
genes like me logo Genes that share phenotypes with DUSP14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP14

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP14

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP14 Gene

Localization for DUSP14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP14 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUSP14 Gene

Pathways & Interactions for DUSP14 Gene

PathCards logo

SuperPathways for DUSP14 Gene

SuperPathway Contained pathways
1 TGF-Beta Pathway
.51
2 Hypertrophy Model
genes like me logo Genes that share pathways with DUSP14: view

Pathways by source for DUSP14 Gene

1 BioSystems pathway for DUSP14 Gene
1 Qiagen pathway for DUSP14 Gene
  • JNK Pathway

Gene Ontology (GO) - Biological Process for DUSP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IEA --
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP14: view

No data available for SIGNOR curated interactions for DUSP14 Gene

Drugs & Compounds for DUSP14 Gene

(3) Drugs for DUSP14 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Calcium Nutra 6556

(1) Additional Compounds for DUSP14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with DUSP14: view

Transcripts for DUSP14 Gene

mRNA/cDNA for DUSP14 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP14

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP14 Gene

No ASD Table

Relevant External Links for DUSP14 Gene

GeneLoc Exon Structure for
DUSP14

Expression for DUSP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP14 Gene

Protein differential expression in normal tissues from HIPED for DUSP14 Gene

This gene is overexpressed in Cervix (30.0), Hair follicle (17.8), and Urine (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP14 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP14

SOURCE GeneReport for Unigene cluster for DUSP14 Gene:

Hs.91448

Evidence on tissue expression from TISSUES for DUSP14 Gene

  • Lung(4.2)
  • Nervous system(2.8)
  • Skin(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with DUSP14: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP14 Gene

Orthologs for DUSP14 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP14 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DUSP14 30
  • 100 (n)
Dog
(Canis familiaris)
Mammalia DUSP14 30
  • 92.76 (n)
Cow
(Bos Taurus)
Mammalia DUSP14 30
  • 91.25 (n)
Mouse
(Mus musculus)
Mammalia Dusp14 30 17
  • 90.74 (n)
Rat
(Rattus norvegicus)
Mammalia Dusp14 30
  • 90.74 (n)
Chicken
(Gallus gallus)
Aves DUSP14 30
  • 79.63 (n)
Zebrafish
(Danio rerio)
Actinopterygii dusp14 30
  • 70.7 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006593 30
  • 54.56 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG15528 30
  • 48.43 (n)
Worm
(Caenorhabditis elegans)
Secernentea C04F12.8 30 32
  • 49.9 (n)
Species where no ortholog for DUSP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for DUSP14 Gene

ENSEMBL:
Gene Tree for DUSP14 (if available)
TreeFam:
Gene Tree for DUSP14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP14: view image

Paralogs for DUSP14 Gene

(13) SIMAP similar genes for DUSP14 Gene using alignment to 2 proteins:

  • DUS14_HUMAN
  • Q6FI36_HUMAN
genes like me logo Genes that share paralogs with DUSP14: view

Variants for DUSP14 Gene

Additional dbSNP identifiers (rs#s) for DUSP14 Gene

Structural Variations from Database of Genomic Variants (DGV) for DUSP14 Gene

Variant ID Type Subtype PubMed ID
esv3305513 CNV mobile element insertion 20981092
esv3376555 CNV insertion 20981092
esv3640494 CNV gain 21293372
nsv1070826 CNV deletion 25765185
nsv1136235 CNV deletion 24896259

Variation tolerance for DUSP14 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP14 Gene

Human Gene Mutation Database (HGMD)
DUSP14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP14 Gene

Disorders for DUSP14 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DUSP14 Gene - From: DISEASES

Disorder Aliases PubMed IDs
variola major
  • smallpox
frontometaphyseal dysplasia
  • fmd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DUSP14

genes like me logo Genes that share disorders with DUSP14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP14 Gene

Publications for DUSP14 Gene

  1. Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6. (PMID: 11123293) Marti F … King PD (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4 23
  2. Overproduction, purification and structure determination of human dual-specificity phosphatase 14. (PMID: 19770498) Lountos GT … Waugh DS (Acta crystallographica. Section D, Biological crystallography 2009) 3 4 23
  3. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. (PMID: 20694014) Thye T … Hill AVS (Nature genetics 2010) 3 41
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection. (PMID: 31594818) Yeung ATY … Dougan G (mBio 2019) 3

Products for DUSP14 Gene

Sources for DUSP14 Gene