Aliases for DUSP14 Gene
Aliases for DUSP14 Gene
External Ids for DUSP14 Gene
- HGNC: 17007
- Entrez Gene: 11072
- Ensembl: ENSG00000276023
- OMIM: 606618
- UniProtKB: O95147
Previous GeneCards Identifiers for DUSP14 Gene
- GC17P035255
- GC17P037802
- GC17P035580
- GC17P036045
- GC17P032924
- GC17P035850
- GC17P031787
Summaries for DUSP14 Gene
-
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
GeneCards Summary for DUSP14 Gene
DUSP14 (Dual Specificity Phosphatase 14) is a Protein Coding gene. Diseases associated with DUSP14 include Chromosome 17Q12 Deletion Syndrome. Among its related pathways are Hypertrophy Model and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is DUSP18.
UniProtKB/Swiss-Prot for DUSP14 Gene
-
Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.
Additional gene information for DUSP14 Gene
- Monarch Initiative
- Search for DUSP14 at DataMed
- Search for DUSP14 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP14 Gene
Genomics for DUSP14 Gene
GeneHancer (GH) Regulatory Elements for DUSP14 Gene
Promoters and enhancers for DUSP14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DUSP14 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DUSP14 gene promoter:
Regulatory Element Products
Genomic Locations for DUSP14 Gene
Genomic Locations for DUSP14 Gene
- chr17:37,488,561-37,513,501
- (GRCh38/hg38)
- Size:
- 24,941 bases
- Orientation:
- Plus strand
- chr17:35,849,937-35,873,603
- (GRCh37/hg19)
Genomic View for DUSP14 Gene
Genes around DUSP14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Entrez Gene
- 17q12 by HGNC
- 17q12 by Ensembl
DUSP14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DUSP14 Gene
Proteins for DUSP14 Gene
-
Protein details for DUSP14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95147-DUS14_HUMAN
- Recommended name:
- Dual specificity protein phosphatase 14
- Protein Accession:
- O95147
Protein attributes for DUSP14 Gene
- Size:
- 198 amino acids
- Molecular mass:
- 22255 Da
- Quaternary structure:
-
- Interacts with CD28.
Protein Expression for DUSP14 Gene
Post-translational modifications for DUSP14 Gene
Other Protein References for DUSP14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DUSP14
- Novus Biologicals Antibodies for DUSP14
- Invitrogen Antibodies for DUSP14
- GeneTex DUSP14 Antibody for DUSP14
-
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Protein Products
-
OriGene Purified Proteins for DUSP14
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- Browse Sino Biological Cell Lysates
- antibodies-online: Search results for 10 available DUSP14 Proteins ranked by validation data
- Compare Top DUSP14 Proteins
-
Quality Products:
- GeneTex Proteins for DUSP14
Assay Products
No data available for DME Specific Peptides for DUSP14 Gene
Domains & Families for DUSP14 Gene
Gene Families for DUSP14 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for DUSP14 Gene
Suggested Antigen Peptide Sequences for DUSP14 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O95147UniProtKB/Swiss-Prot:
DUS14_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Function for DUSP14 Gene
Molecular function for DUSP14 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Enzyme Numbers (IUBMB) for DUSP14 Gene
Phenotypes From GWAS Catalog for DUSP14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22681889 |
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IEA,IBA | -- |
Phenotypes for DUSP14 Gene
- GenomeRNAi human phenotypes for DUSP14:
-
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased viability
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Apoptosis resistance
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
Animal Model Products
-
Taconic Biosciences Mouse Models for DUSP14
- Cyagen custom Knockout/knockin (KOKI) mouse models for DUSP14
-
CRISPR Products
-
OriGene CRISPR knockouts for DUSP14
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- Applied Biological Materials CRISPR for DUSP14
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP14
- GenScript: Design CRISPR guide RNA sequences for DUSP14
miRNA for DUSP14 Gene
- miRTarBase miRNAs that target DUSP14
-
- hsa-mir-26b-5p (MIRT030025)
- hsa-mir-16-5p (MIRT031948)
- hsa-mir-922 (MIRT234263)
- hsa-mir-3680-3p (MIRT558299)
- hsa-mir-557 (MIRT558300)
- hsa-mir-507 (MIRT558301)
- hsa-mir-450b-5p (MIRT558302)
- hsa-mir-5047 (MIRT558303)
- hsa-mir-6516-5p (MIRT558304)
- hsa-mir-7156-3p (MIRT558305)
- hsa-mir-1301-3p (MIRT558306)
- hsa-mir-107 (MIRT558307)
- hsa-mir-4528 (MIRT558308)
- hsa-mir-103a-3p (MIRT558309)
- hsa-mir-1343-5p (MIRT737458)
- hsa-mir-1908-5p (MIRT738319)
- hsa-mir-4419a (MIRT744172)
- hsa-mir-4468 (MIRT744916)
- hsa-mir-4510 (MIRT745611)
- hsa-mir-4706 (MIRT747328)
- hsa-mir-4749-5p (MIRT748309)
- hsa-mir-6081 (MIRT751755)
- hsa-mir-6127 (MIRT752086)
- hsa-mir-6129 (MIRT752158)
- hsa-mir-6130 (MIRT752247)
- hsa-mir-6133 (MIRT752351)
- hsa-mir-663a (MIRT753579)
- hsa-mir-6777-5p (MIRT755385)
- hsa-mir-6787-5p (MIRT755940)
- hsa-mir-6873-5p (MIRT758061)
- hsa-mir-6889-5p (MIRT758634)
- hsa-mir-939-5p (MIRT760749)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP14
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Clone Products
- Sino Biological Human cDNA Clone for DUSP14
- VectorBuilder custom plasmid, inducible vectors for DUSP14
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP14
- genomics-online: cdna clones - Search results for available DUSP14 gene related products
- orf clones - Search results for available DUSP14 gene related products
- Applied Biological Materials Clones for DUSP14
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DUSP14
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP14 Gene
Localization for DUSP14 Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 3 |
| nucleus | 3 |
| cytosol | 3 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for DUSP14 Gene
Pathways & Interactions for DUSP14 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | TGF-Beta Pathway |
.51
|
|
| 2 | Hypertrophy Model | ||
Pathways by source for DUSP14 Gene
1 BioSystems pathway for DUSP14 Gene
1 Qiagen pathway for DUSP14 Gene
Interacting Proteins for DUSP14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000188 | inactivation of MAPK activity | IEA | -- |
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0016311 | dephosphorylation | IEA | -- |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IBA | -- |
No data available for SIGNOR curated interactions for DUSP14 Gene
Drugs & Compounds for DUSP14 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14265-44-2 |
|
Transcripts for DUSP14 Gene
mRNA/cDNA for DUSP14 Gene
- (183) Selected AceView cDNA sequences:
- (9) Additional mRNA sequences :
- (3) REFSEQ mRNAs :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000613659 1559 bps (uc060ekm.1)
- ENST00000614411 2207 bps (uc002hnz.3)
- ENST00000617516 1537 bps (uc002hnx.3)
Unigene Clusters for DUSP14 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DUSP14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP14
- genomics-online: gRNA clones - Search results for available DUSP14 gene related products
- Applied Biological Materials CRISPR for DUSP14
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP14
- GenScript: Design CRISPR guide RNA sequences for DUSP14
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP14
- Browse OriGene Inhibitory RNA Products For DUSP14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP14
- genomics-online: shRNA clones - Search results for available DUSP14 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DUSP14
- VectorBuilder custom plasmid, inducible vectors for DUSP14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DUSP14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP14
- genomics-online: cdna clones - Search results for available DUSP14 gene related products
- orf clones - Search results for available DUSP14 gene related products
- Applied Biological Materials Clones for DUSP14
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for DUSP14 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
This gene is overexpressed in Cervix (30.0), Hair follicle (17.8), and Urine (11.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP14 Gene
NURSA nuclear receptor signaling pathways regulating expression of DUSP14 Gene:
DUSP14SOURCE GeneReport for Unigene cluster for DUSP14 Gene:
Hs.91448Evidence on tissue expression from TISSUES for DUSP14 Gene
- Lung(4.2)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for DUSP14
-
OriGene qPCR primer pairs for DUSP14
- genomics-online: primer clones - Search results for available DUSP14 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP14 Gene
Orthologs for DUSP14 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DUSP14 33 |
|
||
| dog (Canis familiaris) |
Mammalia | DUSP14 33 |
|
||
| cow (Bos Taurus) |
Mammalia | DUSP14 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Dusp14 16 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dusp14 33 |
|
||
| chicken (Gallus gallus) |
Aves | DUSP14 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dusp14 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006593 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG15528 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | C04F12.8 35 33 |
|
- Species where no ortholog for DUSP14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for DUSP14 Gene
- ENSEMBL:
- Gene Tree for DUSP14 (if available)
- TreeFam:
- Gene Tree for DUSP14 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DUSP14: view image
Paralogs for DUSP14 Gene
Paralogs for DUSP14 Gene
(13) SIMAP similar genes for DUSP14 Gene using alignment to 2 proteins:
- DUS14_HUMAN
- Q6FI36_HUMAN
Variants for DUSP14 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000213439 | -- | 37,508,664(+) | G/A | intron_variant | |
| rs1000255279 | -- | 37,507,747(+) | C/G | intron_variant | |
| rs1000268801 | -- | 37,501,971(+) | T/C | intron_variant | |
| rs1000324181 | -- | 37,502,322(+) | C/T | intron_variant | |
| rs1000465719 | -- | 37,496,128(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3305513 | CNV | mobile element insertion | 20981092 |
| esv3376555 | CNV | insertion | 20981092 |
| esv3640494 | CNV | gain | 21293372 |
| nsv1070826 | CNV | deletion | 25765185 |
| nsv1136235 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.03;
21.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DUSP14 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP14 Gene
Disorders for DUSP14 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 17q12 deletion syndrome |
|
|
Search DUSP14 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DUSP14
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP14 Gene
Publications for DUSP14 Gene
- Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6. (PMID: 11123293) Marti F … King PD (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4 22 58
- Overproduction, purification and structure determination of human dual-specificity phosphatase 14. (PMID: 19770498) Lountos GT … Waugh DS (Acta crystallographica. Section D, Biological crystallography 2009) 3 4 22 58
- Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. (PMID: 20694014) Thye T … Hill AVS (Nature genetics 2010) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for DUSP14 Gene
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- Taconic Biosciences Mouse Models for DUSP14
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- Humanized Mice
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 104 available DUSP14 Antibodies ranked by validation data
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- antibodies-online: Search results for 10 available DUSP14 Proteins ranked by validation data
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- genomics-online: cdna clones - Search results for available DUSP14 gene related products
- orf clones - Search results for available DUSP14 gene related products
- genomics-online: gRNA clones - Search results for available DUSP14 gene related products
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Sources for DUSP14 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
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