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Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
DUSP14 (Dual Specificity Phosphatase 14) is a Protein Coding gene. Diseases associated with DUSP14 include Variola Major and Frontometaphyseal Dysplasia. Among its related pathways are Hypertrophy Model and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is DUSP18.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22681889 |
GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
GO:0004725 | protein tyrosine phosphatase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | TGF-Beta Pathway |
JNK Pathway
.51
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2 | Hypertrophy Model |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000188 | inactivation of MAPK activity | IEA | -- |
GO:0006470 | protein dephosphorylation | IEA | -- |
GO:0016311 | dephosphorylation | IEA | -- |
GO:0035335 | peptidyl-tyrosine dephosphorylation | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Phosphate |
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14066-19-4, 14265-44-2 |
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This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DUSP14 30 |
|
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Dog (Canis familiaris) |
Mammalia | DUSP14 30 |
|
||
Cow (Bos Taurus) |
Mammalia | DUSP14 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Dusp14 30 17 |
|
||
Rat (Rattus norvegicus) |
Mammalia | Dusp14 30 |
|
||
Chicken (Gallus gallus) |
Aves | DUSP14 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dusp14 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006593 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG15528 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | C04F12.8 30 32 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3305513 | CNV | mobile element insertion | 20981092 |
esv3376555 | CNV | insertion | 20981092 |
esv3640494 | CNV | gain | 21293372 |
nsv1070826 | CNV | deletion | 25765185 |
nsv1136235 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
variola major |
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frontometaphyseal dysplasia |
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