Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes diffe... See more...

Aliases for DUSP13 Gene

Aliases for DUSP13 Gene

  • Dual Specificity Phosphatase 13 2 3 5
  • DUSP13A 2 3 4
  • DUSP13B 2 3 4
  • BEDP 2 3 4
  • TMDP 2 3 4
  • Testis- And Skeletal-Muscle-Specific DSP 3 4
  • Branching-Enzyme Interacting DSP 3 4
  • Muscle-Restricted DSP 3 4
  • EC 3.1.3.16 4 4
  • EC 3.1.3.48 4 4
  • MDSP 3 4
  • Branching-Enzyme Interacting Dual-Specificity Protein Phosphatase 3
  • Dual Specificity Protein Phosphatase 13 Isoform A 4
  • Dual Specificity Protein Phosphatase 13 Isoform B 4
  • Dual Specificity Protein Phosphatase 13 3
  • Dual Specificity Phosphatase SKRP4 4
  • FLJ32450 2
  • DUSP13 5
  • SKRP4 3

External Ids for DUSP13 Gene

Previous GeneCards Identifiers for DUSP13 Gene

  • GC10M075808
  • GC10M075957
  • GC10M076746
  • GC10M076198
  • GC10M076524
  • GC10M076854
  • GC10M070852

Summaries for DUSP13 Gene

Entrez Gene Summary for DUSP13 Gene

  • Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP13 Gene

DUSP13 (Dual Specificity Phosphatase 13) is a Protein Coding gene. Diseases associated with DUSP13 include Ruvalcaba Syndrome and Myoclonic Epilepsy Of Lafora. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP29.

UniProtKB/Swiss-Prot Summary for DUSP13 Gene

  • Probable protein tyrosine phosphatase. Has phosphatase activity with synthetic substrates (PubMed:15252030, PubMed:29106959). Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.
  • Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.

Gene Wiki entry for DUSP13 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP13 Gene

Genomics for DUSP13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DUSP13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP13

Top Transcription factor binding sites by QIAGEN in the DUSP13 gene promoter:
  • AREB6
  • FOXF2
  • GR
  • GR-alpha
  • GR-beta
  • HOXA5
  • NF-1
  • NF-1/L

Genomic Locations for DUSP13 Gene

Genomic Locations for DUSP13 Gene
chr10:75,094,432-75,109,221
(GRCh38/hg38)
Size:
14,790 bases
Orientation:
Minus strand
chr10:76,854,190-76,868,979
(GRCh37/hg19)
Size:
14,790 bases
Orientation:
Minus strand

Genomic View for DUSP13 Gene

Genes around DUSP13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP13 Gene

Proteins for DUSP13 Gene

  • Protein details for DUSP13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6B8I1-DS13A_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 13 isoform A
    Protein Accession:
    Q6B8I1
    Secondary Accessions:
    • Q96J67

    Protein attributes for DUSP13 Gene

    Size:
    188 amino acids
    Molecular mass:
    20658 Da
    Quaternary structure:
    • Monomer (PubMed:29106959). Interacts with MAP3K5/ASK1; may compete with AKT1 preventing MAP3K5/ASK1 phosphorylation by AKT1.
    SequenceCaution:
    • Sequence=AAH09778.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAF84580.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAF84586.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG51843.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG54592.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG62362.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=BAG62362.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 5]: Produced by alternative promoter usage.
    • [Isoform 2]: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 6]: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 7]: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 8]: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for DUSP13 Gene

    Alternative splice isoforms for DUSP13 Gene

  • Protein details for DUSP13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UII6-DS13B_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 13 isoform B
    Protein Accession:
    Q9UII6
    Secondary Accessions:
    • A0A024QZR6
    • A8K776
    • A8K782
    • B3KPY1
    • B3KXT0
    • B4DUK0
    • Q5JSC6
    • Q6IAR0
    • Q96GC2

    Protein attributes for DUSP13 Gene

    Size:
    198 amino acids
    Molecular mass:
    22149 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 1]: Produced by alternative promoter usage.
    • [Isoform 4]: Produced by alternative promoter usage and alternative splicing.

    Three dimensional structures from OCA and Proteopedia for DUSP13 Gene

    Alternative splice isoforms for DUSP13 Gene

neXtProt entry for DUSP13 Gene

Post-translational modifications for DUSP13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for DUSP13
  • Boster Bio Antibodies for DUSP13
  • Santa Cruz Biotechnology (SCBT) Antibodies for DUSP13

No data available for DME Specific Peptides for DUSP13 Gene

Domains & Families for DUSP13 Gene

Gene Families for DUSP13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for DUSP13 Gene

GenScript: Design optimal peptide antigens:
  • Testis- and skeletal-muscle-specific DSP (DUS13_HUMAN)
  • Muscle-restricted DSP (MDSP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6B8I1

UniProtKB/Swiss-Prot:

DS13B_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP13: view

Function for DUSP13 Gene

Molecular function for DUSP13 Gene

UniProtKB/Swiss-Prot Function:
Probable protein tyrosine phosphatase. Has phosphatase activity with synthetic substrates (PubMed:15252030, PubMed:29106959). Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000305|PubMed:15252030, ECO:0000305|PubMed:29106959};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7.5 mM for p-nitrophenol phosphate (at pH 6.0) {ECO:0000269|PubMed:15252030};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by vanadate.
UniProtKB/Swiss-Prot Function:
Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.

Enzyme Numbers (IUBMB) for DUSP13 Gene

Phenotypes From GWAS Catalog for DUSP13 Gene

Gene Ontology (GO) - Molecular Function for DUSP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008138 protein tyrosine/serine/threonine phosphatase activity TAS,IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DUSP13: view
genes like me logo Genes that share phenotypes with DUSP13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP13

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUSP13 Gene

Localization for DUSP13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP13 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP13 gene
Compartment Confidence
extracellular 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DUSP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DUSP13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DUSP13 Gene

Pathways & Interactions for DUSP13 Gene

PathCards logo

SuperPathways for DUSP13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 10585869
GO:0007283 spermatogenesis TAS 10585869
GO:0016311 dephosphorylation IDA 24531476
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0051321 meiotic cell cycle TAS 10585869
genes like me logo Genes that share ontologies with DUSP13: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP13 Gene

Drugs & Compounds for DUSP13 Gene

(10) Drugs for DUSP13 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Calcium Nutra 6556

(8) Additional Compounds for DUSP13 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with DUSP13: view

Transcripts for DUSP13 Gene

mRNA/cDNA for DUSP13 Gene

9 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP13

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - -
SP2: - - -
SP3: - - - - - - -
SP4:
SP5: -
SP6: - - - -
SP7: - - - - - - - -
SP8: -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: -

Relevant External Links for DUSP13 Gene

GeneLoc Exon Structure for
DUSP13

Expression for DUSP13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP13 Gene

This gene is overexpressed in Muscle - Skeletal (x38.7) and Testis (x6.2).

Protein differential expression in normal tissues from HIPED for DUSP13 Gene

This gene is overexpressed in Spleen (54.3) and Liver (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP13 Gene



Protein tissue co-expression partners for DUSP13 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP13

SOURCE GeneReport for Unigene cluster for DUSP13 Gene:

Hs.178170

mRNA Expression by UniProt/SwissProt for DUSP13 Gene:

Q6B8I1-DS13A_HUMAN
Tissue specificity: Skeletal muscle specific.

Evidence on tissue expression from TISSUES for DUSP13 Gene

  • Muscle(4.6)
  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with DUSP13: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP13 Gene

Orthologs for DUSP13 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DUSP13 30 31
  • 98.74 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DUSP13 30
  • 91.08 (n)
-- 31
  • 22 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia DUSP13 30
  • 89.56 (n)
-- 31
  • 22 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Dusp13 30 17 31
  • 83.41 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100909469 30
  • 80.71 (n)
Oppossum
(Monodelphis domestica)
Mammalia DUSP13 31
  • 70 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DUSP13 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DUSP13 30 31
  • 65.97 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DUSP13 31
  • 56 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii zgc:172281 30
  • 60 (n)
DUSP13 (3 of 3) 31
  • 60 (a)
OneToMany
DUSP13 (1 of 3) 31
  • 52 (a)
OneToMany
DUSP13 (2 of 3) 31
  • 49 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG7378 31
  • 39 (a)
OneToMany
Species where no ortholog for DUSP13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DUSP13 Gene

ENSEMBL:
Gene Tree for DUSP13 (if available)
TreeFam:
Gene Tree for DUSP13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP13: view image

Paralogs for DUSP13 Gene

(10) SIMAP similar genes for DUSP13 Gene using alignment to 9 proteins:

  • DS13A_HUMAN
  • DS13B_HUMAN
  • E9PSD4_HUMAN
  • F2Z2C4_HUMAN
  • U3KQ82_HUMAN
  • U3KQA1_HUMAN
  • U3KQB7_HUMAN
  • U3KQE1_HUMAN
  • U3KQG1_HUMAN
genes like me logo Genes that share paralogs with DUSP13: view

Variants for DUSP13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP13 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
734156 Benign: not provided 75,094,704(-) C/T MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
780869 Benign: not provided 75,094,705(-) G/C MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
780870 Benign: not provided 75,103,972(-) G/A SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
786165 Benign: not provided 75,103,934(-) G/A MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
rs16931996 - p.Arg190Gly

Additional dbSNP identifiers (rs#s) for DUSP13 Gene

Structural Variations from Database of Genomic Variants (DGV) for DUSP13 Gene

Variant ID Type Subtype PubMed ID
dgv927n100 CNV gain 25217958
nsv516793 CNV gain 19592680
nsv518639 CNV loss 19592680
nsv7199 CNV insertion 18451855
nsv831913 CNV loss 17160897

Variation tolerance for DUSP13 Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.71; 96.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP13 Gene

Disorders for DUSP13 Gene

MalaCards: The human disease database

(7) MalaCards diseases for DUSP13 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DUSP13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with DUSP13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP13 Gene

Publications for DUSP13 Gene

  1. Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. (PMID: 10585869) Nakamura K … Kikuchi K (The Biochemical journal 1999) 2 3 4 23
  2. Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity. (PMID: 17044055) Kim SJ … Kim JH (Proteins 2007) 3 4 23
  3. Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2. (PMID: 15252030) Chen HH … Tonks NK (The Journal of biological chemistry 2004) 3 4 23
  4. DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression. (PMID: 21360282) Katagiri C … Shima H (Molecular and cellular biochemistry 2011) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41

Products for DUSP13 Gene

Sources for DUSP13 Gene