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Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate spe... See more...
Aliases for DUSP10 Gene
Aliases for DUSP10 Gene
External Ids for DUSP10 Gene
- HGNC: 3065
- Entrez Gene: 11221
- Ensembl: ENSG00000143507
- OMIM: 608867
- UniProtKB: Q9Y6W6
Previous GeneCards Identifiers for DUSP10 Gene
- GC01M220468
- GC01M217790
- GC01M218406
- GC01M218931
- GC01M218263
- GC01M219941
- GC01M221874
- GC01M192550
Summaries for DUSP10 Gene
-
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
GeneCards Summary for DUSP10 Gene
DUSP10 (Dual Specificity Phosphatase 10) is a Protein Coding gene. Diseases associated with DUSP10 include Shwartzman Phenomenon. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP7.
UniProtKB/Swiss-Prot Summary for DUSP10 Gene
-
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
Additional gene information for DUSP10 Gene
- HGNC(3065)
- Entrez Gene(11221)
- Ensembl(ENSG00000143507)
- OMIM(608867)
- UniProtKB(Q9Y6W6)
- Open Targets Platform(ENSG00000143507)
- Search for DUSP10 at DataMed
- Search for DUSP10 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP10 Gene
Genomics for DUSP10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DUSP10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DUSP10 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP10
- Top Transcription factor binding sites by QIAGEN in the DUSP10 gene promoter:
-
- FOXJ2
- LUN-1
- MZF-1
- PPAR-gamma1
- PPAR-gamma2
- RFX1
Genomic Locations for DUSP10 Gene
Genomic Locations for DUSP10 Gene
- chr1:221,701,420-221,742,176
- (GRCh38/hg38)
- Size:
- 40,757 bases
- Orientation:
- Minus strand
- chr1:221,874,764-221,915,518
- (GRCh37/hg19)
- Size:
- 40,755 bases
- Orientation:
- Minus strand
Genomic View for DUSP10 Gene
Genes around DUSP10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q41 by HGNC
- 1q41 by Entrez Gene
- 1q41 by Ensembl
DUSP10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DUSP10 Gene
Proteins for DUSP10 Gene
-
Protein details for DUSP10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6W6-DUS10_HUMAN
- Recommended name:
- Dual specificity protein phosphatase 10
- Protein Accession:
- Q9Y6W6
- D3DTB4
- Q6GSI4
- Q9H9Z5
Protein attributes for DUSP10 Gene
- Size:
- 482 amino acids
- Molecular mass:
- 52642 Da
- Quaternary structure:
-
- Monomer. Interacts with MAPK14.
Three dimensional structures from OCA and Proteopedia for DUSP10 Gene
Protein Expression for DUSP10 Gene
Post-translational modifications for DUSP10 Gene
Other Protein References for DUSP10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ DUSP10 Antibody
- Novus Biologicals Antibodies for DUSP10
-
Abcam antibodies for DUSP10
- Invitrogen Antibodies for DUSP10 (AFLGC-DUSP10)
-
Boster Bio Antibodies for DUSP10
-
Santa Cruz Biotechnology (SCBT) Antibodies for DUSP10
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for DUSP10
- Origene Custom Protein Services for DUSP10
- ProSpec Recombinant Proteins for DUSP10
- antibodies-online: Show 8 available DUSP10 Proteins ranked by validation data
- Compare Top DUSP10 Proteins
-
Quality Products:
-
Signalway Proteins for DUSP10
-
Abcam proteins for DUSP10
No data available for DME Specific Peptides for DUSP10 Gene
Domains & Families for DUSP10 Gene
Gene Families for DUSP10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for DUSP10 Gene
- InterPro:
- Blocks:
-
- Disintegrin
- Rhodanese-like
- Dual specificity protein phosphatase
- ProtoNet:
Suggested Antigen Peptide Sequences for DUSP10 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ52863, highly similar to Dual specificity protein phosphatase 10 (EC 3.1.3.48) (B4DDQ0_HUMAN)
- Mitogen-activated protein kinase phosphatase 5 (DUS10_HUMAN)
- DUSP10 protein (Q6IAR2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y6W6UniProtKB/Swiss-Prot:
DUS10_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Function for DUSP10 Gene
Molecular function for DUSP10 Gene
- UniProtKB/Swiss-Prot Function:
- Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000269|PubMed:16806267, ECO:0000269|PubMed:22375048};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:16806267, ECO:0000269|PubMed:22375048};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:16806267, ECO:0000269|PubMed:22375048};.
- GENATLAS Biochemistry:
- dual specificity (tyr/thr) phosphatase 10,expressed in various tissues and organs,located evently in nucleus and cytoplasm and inactivating p38 and SAPK/SNK kinases
Enzyme Numbers (IUBMB) for DUSP10 Gene
Phenotypes From GWAS Catalog for DUSP10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA,IBA | 21873635 |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16288922 |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IBA | -- |
| GO:0008330 | protein tyrosine/threonine phosphatase activity | IDA | 10391943 |
Phenotypes for DUSP10 Gene
- MGI mutant phenotypes for DUSP10:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DUSP10:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability
- Increased IL-8 secretion
- Decreased cell migration
- Increased Nanog expression
- Increased apoptosis
- Decreased nuclei size in G2M
- Decreased telomerase activity
- Increased Erk phosphorylation after EGF stimulation
- Increased transferrin (TF) endocytosis
- Increased viability
Animal Models for DUSP10 Gene
- MGI Knock Outs for DUSP10:
-
- Dusp10 Dusp10<tm1Flv>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DUSP10 - Select products 50% OFF >
- * DUSP10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DUSP10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP10
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP10
miRNA for DUSP10 Gene
- miRTarBase miRNAs that target DUSP10
-
- hsa-miR-21-5p (MIRT006323)
- hsa-miR-98-5p (MIRT027621)
- hsa-miR-92a-3p (MIRT438170)
- mmu-miR-495-3p (MIRT590223)
- mmu-miR-1192 (MIRT590224)
- mmu-miR-129-5p (MIRT595150)
- mmu-miR-450a-5p (MIRT595151)
- hsa-miR-129-5p (MIRT615028)
- hsa-miR-450a-5p (MIRT615029)
- hsa-miR-4446-5p (MIRT646194)
- hsa-miR-4755-5p (MIRT646195)
- hsa-miR-4753-3p (MIRT646196)
- hsa-miR-6873-3p (MIRT646197)
- hsa-miR-211-5p (MIRT646198)
- hsa-miR-204-5p (MIRT646199)
- hsa-miR-623 (MIRT646200)
- hsa-miR-6883-3p (MIRT646201)
- hsa-miR-642b-5p (MIRT646202)
- hsa-miR-4791 (MIRT646203)
- hsa-miR-3201 (MIRT646204)
- hsa-miR-190b (MIRT646205)
- hsa-miR-190a-5p (MIRT646206)
- hsa-miR-3124-3p (MIRT646207)
- hsa-miR-130b-5p (MIRT646208)
- hsa-miR-6817-3p (MIRT646209)
- hsa-miR-7110-3p (MIRT646210)
- hsa-miR-5088-3p (MIRT646211)
- hsa-miR-454-5p (MIRT646212)
- hsa-miR-410-3p (MIRT646213)
- hsa-miR-3163 (MIRT646214)
- hsa-miR-670-3p (MIRT646215)
- hsa-miR-6818-3p (MIRT646216)
- hsa-miR-3667-3p (MIRT646217)
- hsa-miR-6734-3p (MIRT646218)
- hsa-miR-660-3p (MIRT646219)
- hsa-miR-5193 (MIRT646220)
- hsa-miR-6891-3p (MIRT646221)
- hsa-miR-6072 (MIRT646222)
- hsa-miR-4289 (MIRT646223)
- hsa-miR-5196-3p (MIRT646224)
- hsa-miR-7151-5p (MIRT646225)
- hsa-miR-32-5p (MIRT727843)
- hsa-miR-92b-3p (MIRT727844)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP10
- Browse OriGene Inhibitory RNA Products For DUSP10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP10
Clone Products
- Applied Biological Materials (abm): Clones for DUSP10 - Select products 50% OFF >
- * DUSP10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DUSP10
- Addgene plasmids for DUSP10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP10
Cell Line Products
-
Horizon Cell Lines for DUSP10
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP10 Gene
Localization for DUSP10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DUSP10 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (3)
- Nucleoplasm (3)
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 10391943 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA,IDA | 10391943 |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for DUSP10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | MAPK signaling pathway | ||
| 3 | Developmental Biology |
.51
|
|
| 4 | Cytokine Signaling in Immune system | ||
| 5 | Innate Immune System |
.61
|
|
Pathways by source for DUSP10 Gene
3 BioSystems pathways for DUSP10 Gene
48 Reactome pathways for DUSP10 Gene
1 KEGG pathway for DUSP10 Gene
1 Qiagen pathway for DUSP10 Gene
- JNK Pathway
1 Cell Signaling Technology pathway for DUSP10 Gene
Interacting Proteins for DUSP10 Gene
Selected Interacting proteins:
Q9Y6W6-DUS10_HUMAN
ENSP00000355866
for DUSP10 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for DUSP10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000188 | inactivation of MAPK activity | IBA,IDA | 22375048 |
| GO:0002819 | regulation of adaptive immune response | IEA | -- |
| GO:0006470 | protein dephosphorylation | IDA | 22375048 |
| GO:0010033 | response to organic substance | IEA | -- |
| GO:0010633 | negative regulation of epithelial cell migration | IEA,ISS | -- |
Drugs & Compounds for DUSP10 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14066-19-4, 14265-44-2 |
|
Transcripts for DUSP10 Gene
mRNA/cDNA for DUSP10 Gene
- 3 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000366899 2589 nts (view in UCSC)
- ENST00000468085 1625 nts (view in UCSC)
- ENST00000477026 1009 nts (view in UCSC)
- ENST00000494642 803 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DUSP10 - Select products 50% OFF >
- * DUSP10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DUSP10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP10
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP10
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP10
- Browse OriGene Inhibitory RNA Products For DUSP10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP10
Clone Products
- Applied Biological Materials (abm): Clones for DUSP10 - Select products 50% OFF >
- * DUSP10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DUSP10
- Addgene plasmids for DUSP10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP10
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||
| SP3: | - | ||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||
| SP5: | - |
Relevant External Links for DUSP10 Gene
- GeneLoc Exon Structure for
- DUSP10
Expression for DUSP10 Gene
mRNA differential expression in normal tissues according to GTEx for DUSP10 Gene
This gene is overexpressed in Liver (x4.4).
This gene is overexpressed in Bone (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP10 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP10
SOURCE GeneReport for Unigene cluster for DUSP10 Gene:
Hs.497822mRNA Expression by UniProt/SwissProt for DUSP10 Gene:
Q9Y6W6-DUS10_HUMAN
Tissue specificity:
Expressed in keratinocytes (at protein level) (PubMed:29043977). Detected in brain (PubMed:16806267).
Evidence on tissue expression from TISSUES for DUSP10 Gene
- Lung(4.4)
- Nervous system(4.4)
- Liver(2.4)
- Kidney(2.2)
Primer Products
-
OriGene qPCR primer pairs for DUSP10
-
OriGene qPCR primer pairs and template standards for DUSP10
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP10 Gene
Orthologs for DUSP10 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DUSP10 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DUSP10 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DUSP10 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | DUSP10 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Dusp10 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dusp10 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DUSP10 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | DUSP10 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DUSP10 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100497288 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-180b22.4 30 |
|
||
| DUSP10 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | puc 31 32 |
|
OneToOne |
- Species where no ortholog for DUSP10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for DUSP10 Gene
- ENSEMBL:
- Gene Tree for DUSP10 (if available)
- TreeFam:
- Gene Tree for DUSP10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DUSP10: view image
Paralogs for DUSP10 Gene
Paralogs for DUSP10 Gene
(11) SIMAP similar genes for DUSP10 Gene using alignment to 2 proteins:
- DUS10_HUMAN
- Q6IAR2_HUMAN
Variants for DUSP10 Gene
Residual Variation Intolerance Score:
17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.12;
22.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DUSP10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DUSP10
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP10 Gene
Disorders for DUSP10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| shwartzman phenomenon |
|
|
Search DUSP10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DUSP10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP10 Gene
Publications for DUSP10 Gene
- Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. (PMID: 10391943) Tanoue T … Nishida E (The Journal of biological chemistry 1999) 2 3 4 23
- Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase. (PMID: 16806267) Jeong DG … Kim SJ (Journal of molecular biology 2006) 3 4 23
- MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. (PMID: 10597297) Theodosiou A … Ashworth A (Oncogene 1999) 2 3 4
- A distinct interaction mode revealed by the crystal structure of the kinase p38α with the MAPK binding domain of the phosphatase MKP5. (PMID: 22375048) Zhang YY … Wang ZX (Science signaling 2011) 3 4
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
ExternalLinks
Products for DUSP10 Gene
- Custom Antibody ServicesOriGene Antibodies for DUSP10
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- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for DUSP10
- Origene Custom Protein Services for DUSP10
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP10
- Browse OriGene Inhibitory RNA Products For DUSP10
- OriGene qPCR primer pairs for DUSP10
- OriGene qPCR primer pairs and template standards for DUSP10
- OriGene CRISPR knockouts for DUSP10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DUSP10
- Sino Biological Human cDNA Clone for DUSP10
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for DUSP10
- Novus Biologicals proteins and lysates for DUSP10
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for DUSP10
- Abcam proteins for DUSP10
- Find your target
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- VectorBuilder Custom and pre-made DNA vectors for DUSP10 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for DUSP10 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for DUSP10 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DUSP10 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DUSP10
- Addgene plasmids for DUSP10
- antibodies-online: Show 30 available DUSP10 Antibodies ranked by validation data
- Compare Top DUSP10 Antibodies
- antibodies-online: Search results for available DUSP10 related products ranked by validation data
- antibodies-online: Show 8 available DUSP10 Proteins ranked by validation data
- Compare Top DUSP10 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for DUSP10
- Search Santa Cruz Biotechnology (SCBT) for DUSP10 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DUSP10
- Horizon Cell Lines for DUSP10
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP10
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DUSP10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP10
- Boster Bio Antibodies for DUSP10
- Browse Boster Bio ELISA Kits
- Signalway Proteins for DUSP10
Sources for DUSP10 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB