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Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
DUSP10 (Dual Specificity Phosphatase 10) is a Protein Coding gene. Diseases associated with DUSP10 include Shwartzman Phenomenon. Among its related pathways are Signaling by GPCR and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is SSH1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004721 | phosphoprotein phosphatase activity | IBA | 21873635 |
GO:0004722 | protein serine/threonine phosphatase activity | IEA | -- |
GO:0004725 | protein tyrosine phosphatase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 16288922 |
GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 10391943 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IBA,IDA | 10391943 |
GO:0005794 | Golgi apparatus | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | MAPK signaling pathway | ||
3 | Developmental Biology |
.51
|
|
4 | Cytokine Signaling in Immune system | ||
5 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000188 | inactivation of MAPK activity | IBA,IDA | 22375048 |
GO:0002819 | regulation of adaptive immune response | IEA | -- |
GO:0006470 | protein dephosphorylation | IDA | 22375048 |
GO:0010033 | response to organic substance | IEA | -- |
GO:0010633 | negative regulation of epithelial cell migration | IEA,ISS | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||
SP3: | - | ||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DUSP10 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DUSP10 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DUSP10 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DUSP10 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dusp10 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dusp10 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | DUSP10 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DUSP10 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DUSP10 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100497288 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-180b22.4 30 |
|
||
DUSP10 31 |
|
OneToOne | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | puc 31 32 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
shwartzman phenomenon |
|
|