Aliases for DUSP10 Gene
External Ids for DUSP10 Gene
Previous GeneCards Identifiers for DUSP10 Gene
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
GeneCards Summary for DUSP10 Gene
DUSP10 (Dual Specificity Phosphatase 10) is a Protein Coding gene. Diseases associated with DUSP10 include Shwartzman Phenomenon. Among its related pathways are Signaling by GPCR and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is SSH1.
UniProtKB/Swiss-Prot Summary for DUSP10 Gene
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.