Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate spe... See more...

Aliases for DUSP10 Gene

Aliases for DUSP10 Gene

  • Dual Specificity Phosphatase 10 2 3 5
  • Mitogen-Activated Protein Kinase Phosphatase 5 3 4
  • Dual Specificity Protein Phosphatase 10 3 4
  • MKP-5 3 4
  • MKP5 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual Specificity Phosphatase MKP-5 3
  • Map Kinase Phosphatase 5 3
  • MAP Kinase Phosphatase 5 4
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for DUSP10 Gene

Previous GeneCards Identifiers for DUSP10 Gene

  • GC01M220468
  • GC01M217790
  • GC01M218406
  • GC01M218931
  • GC01M218263
  • GC01M219941
  • GC01M221874
  • GC01M192550

Summaries for DUSP10 Gene

Entrez Gene Summary for DUSP10 Gene

  • Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for DUSP10 Gene

DUSP10 (Dual Specificity Phosphatase 10) is a Protein Coding gene. Among its related pathways are RET signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP8.

UniProtKB/Swiss-Prot Summary for DUSP10 Gene

  • Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.

Gene Wiki entry for DUSP10 Gene

Additional gene information for DUSP10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP10 Gene

Genomics for DUSP10 Gene

GeneHancer (GH) Regulatory Elements for DUSP10 Gene

Promoters and enhancers for DUSP10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J221739 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 778.1 +0.2 189 5.3 FOXK2 GTF3C2 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF FOXA1 SMARCE1 DUSP10 CICP13 ENSG00000272750 TAF1A LOC105372945
GH01J221706 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 37 +31.7 31726 7.5 SP1 ZBTB40 SMARCE1 ZNF362 MYC ETV6 ELF1 RELA HLF L3MBTL2 LOC105372945 DUSP10 HHIPL2 MARC2
GH01J221687 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 23 +53.3 53273 2.6 ZNF639 IKZF1 ZNF316 NFE2 MAFG MEF2D FOSL1 CUX1 CEBPG EMSY DUSP10 HSALNG0010815 HSALNG0010814
GH01J221986 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 16.5 -249.8 -249789 11.3 SMARCE1 ETV6 RELA HLF DACH1 TEAD4 CTCF CBFA2T2 BACH1 MLLT1 DUSP10 LINC02257 LINC02474 RNU6-403P LINC01705 ENSG00000229399 RF01061-023
GH01J221809 Enhancer 1 FANTOM5 ENCODE dbSUPER 20 -68.1 -68083 2.4 ELF1 RELA MLLT1 IKZF1 GTF2E2 IKZF2 MNT EED ZBTB11 RUNX3 DUSP10 RNU6-403P LINC01655 HSALNG0010821
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUSP10 gene promoter:
  • FOXJ2
  • LUN-1
  • MZF-1
  • PPAR-gamma1
  • PPAR-gamma2
  • RFX1

Genomic Locations for DUSP10 Gene

Genomic Locations for DUSP10 Gene
chr1:221,701,420-221,742,176
(GRCh38/hg38)
Size:
40,757 bases
Orientation:
Minus strand
chr1:221,874,764-221,915,518
(GRCh37/hg19)
Size:
40,755 bases
Orientation:
Minus strand

Genomic View for DUSP10 Gene

Genes around DUSP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP10 Gene

Proteins for DUSP10 Gene

  • Protein details for DUSP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6W6-DUS10_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 10
    Protein Accession:
    Q9Y6W6
    Secondary Accessions:
    • D3DTB4
    • Q6GSI4
    • Q9H9Z5

    Protein attributes for DUSP10 Gene

    Size:
    482 amino acids
    Molecular mass:
    52642 Da
    Quaternary structure:
    • Monomer. Interacts with MAPK14.

    Three dimensional structures from OCA and Proteopedia for DUSP10 Gene

    Alternative splice isoforms for DUSP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP10 Gene

Post-translational modifications for DUSP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP10 Gene

No data available for DME Specific Peptides for DUSP10 Gene

Domains & Families for DUSP10 Gene

Gene Families for DUSP10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DUSP10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52863, highly similar to Dual specificity protein phosphatase 10 (EC 3.1.3.48) (B4DDQ0_HUMAN)
  • Mitogen-activated protein kinase phosphatase 5 (DUS10_HUMAN)
  • DUSP10 protein (Q6IAR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6W6

UniProtKB/Swiss-Prot:

DUS10_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP10: view

Function for DUSP10 Gene

Molecular function for DUSP10 Gene

UniProtKB/Swiss-Prot Function:
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255 PROSITE-ProRule:PRU10044, ECO:0000269 PubMed:16806267, ECO:0000269 PubMed:22375048};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269 PubMed:16806267, ECO:0000269 PubMed:22375048};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269 PubMed:16806267, ECO:0000269 PubMed:22375048};.
GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 10,expressed in various tissues and organs,located evently in nucleus and cytoplasm and inactivating p38 and SAPK/SNK kinases

Enzyme Numbers (IUBMB) for DUSP10 Gene

Phenotypes From GWAS Catalog for DUSP10 Gene

Gene Ontology (GO) - Molecular Function for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 16288922
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA 21873635
GO:0008330 protein tyrosine/threonine phosphatase activity IDA 10391943
genes like me logo Genes that share ontologies with DUSP10: view
genes like me logo Genes that share phenotypes with DUSP10: view

Animal Models for DUSP10 Gene

MGI Knock Outs for DUSP10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP10

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP10 Gene

Localization for DUSP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP10 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 4
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10391943
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA,IDA 10391943
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with DUSP10: view

Pathways & Interactions for DUSP10 Gene

PathCards logo

SuperPathways for DUSP10 Gene

SuperPathway Contained pathways
1 RET signaling
2 MAPK signaling pathway
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 Innate Immune System
genes like me logo Genes that share pathways with DUSP10: view

Pathways by source for DUSP10 Gene

1 Qiagen pathway for DUSP10 Gene
  • JNK Pathway
1 Cell Signaling Technology pathway for DUSP10 Gene

SIGNOR curated interactions for DUSP10 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IDA 22375048
GO:0002819 regulation of adaptive immune response IEA --
GO:0006470 protein dephosphorylation IDA 22375048
GO:0010033 response to organic substance IEA --
GO:0010633 negative regulation of epithelial cell migration ISS,IEA --
genes like me logo Genes that share ontologies with DUSP10: view

Drugs & Compounds for DUSP10 Gene

(4) Drugs for DUSP10 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Calcium Approved Nutra 7773

(2) Additional Compounds for DUSP10 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with DUSP10: view

Transcripts for DUSP10 Gene

mRNA/cDNA for DUSP10 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: -

Relevant External Links for DUSP10 Gene

GeneLoc Exon Structure for
DUSP10
ECgene alternative splicing isoforms for
DUSP10

Expression for DUSP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP10 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP10 Gene

This gene is overexpressed in Liver (x4.4).

Protein differential expression in normal tissues from HIPED for DUSP10 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP10 Gene



Protein tissue co-expression partners for DUSP10 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUSP10 Gene:

DUSP10

SOURCE GeneReport for Unigene cluster for DUSP10 Gene:

Hs.497822

mRNA Expression by UniProt/SwissProt for DUSP10 Gene:

Q9Y6W6-DUS10_HUMAN
Tissue specificity: Expressed in keratinocytes (at protein level) (PubMed:29043977). Detected in brain (PubMed:16806267).

Evidence on tissue expression from TISSUES for DUSP10 Gene

  • Lung(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with DUSP10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP10 Gene

Orthologs for DUSP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP10 33 32
  • 99.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP10 33 32
  • 94.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP10 33 32
  • 94.26 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUSP10 33
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp10 17 33 32
  • 92.25 (n)
rat
(Rattus norvegicus)
Mammalia Dusp10 32
  • 91.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP10 33
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP10 33 32
  • 83.51 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP10 33
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497288 32
  • 80.88 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-180b22.4 32
  • 69.33 (n)
DUSP10 33
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta puc 33 34
  • 22 (a)
OneToOne
Species where no ortholog for DUSP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP10 Gene

ENSEMBL:
Gene Tree for DUSP10 (if available)
TreeFam:
Gene Tree for DUSP10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP10: view image

Paralogs for DUSP10 Gene

(11) SIMAP similar genes for DUSP10 Gene using alignment to 2 proteins:

  • DUS10_HUMAN
  • Q6IAR2_HUMAN
genes like me logo Genes that share paralogs with DUSP10: view

Variants for DUSP10 Gene

Sequence variations from dbSNP and Humsavar for DUSP10 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000072721 -- 221,701,111(-) C/T downstream_transcript_variant
rs1000143619 -- 221,725,413(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000162568 -- 221,712,442(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000229541 -- 221,721,238(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000257611 -- 221,719,006(-) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP10 Gene

Variant ID Type Subtype PubMed ID
esv7152 CNV gain 19470904
nsv469786 CNV loss 16826518

Variation tolerance for DUSP10 Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP10 Gene

Disorders for DUSP10 Gene

Additional Disease Information for DUSP10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DUSP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP10 Gene

Publications for DUSP10 Gene

  1. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. (PMID: 10391943) Tanoue T … Nishida E (The Journal of biological chemistry 1999) 2 3 4 23 56
  2. Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase. (PMID: 16806267) Jeong DG … Kim SJ (Journal of molecular biology 2006) 3 4 23 56
  3. MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. (PMID: 10597297) Theodosiou A … Ashworth A (Oncogene 1999) 2 3 4 56
  4. A distinct interaction mode revealed by the crystal structure of the kinase p38α with the MAPK binding domain of the phosphatase MKP5. (PMID: 22375048) Zhang YY … Wang ZX (Science signaling 2011) 3 4 56
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56

Products for DUSP10 Gene

Sources for DUSP10 Gene