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Aliases for DUSP10 Gene

Aliases for DUSP10 Gene

  • Dual Specificity Phosphatase 10 2 3 5
  • Mitogen-Activated Protein Kinase Phosphatase 5 3 4
  • MKP-5 3 4
  • MKP5 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual Specificity Protein Phosphatase 10 3
  • Dual Specificity Phosphatase MKP-5 3
  • Map Kinase Phosphatase 5 3
  • MAP Kinase Phosphatase 5 4
  • EC 4
  • EC 4

External Ids for DUSP10 Gene

Previous GeneCards Identifiers for DUSP10 Gene

  • GC01M220468
  • GC01M217790
  • GC01M218406
  • GC01M218931
  • GC01M218263
  • GC01M219941
  • GC01M221874
  • GC01M192550

Summaries for DUSP10 Gene

Entrez Gene Summary for DUSP10 Gene

  • Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for DUSP10 Gene

DUSP10 (Dual Specificity Phosphatase 10) is a Protein Coding gene. Among its related pathways are RET signaling and Regulation of p38-alpha and p38-beta. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP7.

UniProtKB/Swiss-Prot for DUSP10 Gene

  • Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.

Gene Wiki entry for DUSP10 Gene

Additional gene information for DUSP10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP10 Gene

Genomics for DUSP10 Gene

GeneHancer (GH) Regulatory Elements for DUSP10 Gene

Promoters and enhancers for DUSP10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J221739 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 678.2 +0.2 189 5.3 FEZF1 DMAP1 IRF4 YY1 ZNF143 ZNF548 SP3 NFYC MEF2D ZNF610 DUSP10 CICP13 TAF1A ENSG00000272750 LOC105372945
GH01J221706 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 37 +31.7 31726 7.5 HDGF FOXA2 PKNOX1 SMAD1 ARNT FEZF1 ZNF2 YY1 ZNF766 CBX5 LOC105372945 DUSP10 CICP13 TAF1A HHIPL2 MARC2 GC01P221677
GH01J221809 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 20 -68.1 -68066 2.4 GTF2E2 JUN RELA EED IKZF2 RUNX3 E2F5 ZBTB11 ELF1 MNT DUSP10 RNU6-403P GC01M221824 PIR32779
GH01J221687 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 23 +53.3 53273 2.6 MEIS2 ZNF639 MAFG CEBPG MEF2D FOSL1 ZNF316 IKZF1 CUX1 NFE2 DUSP10 GC01P221677 LOC105372945
GH01J221776 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.8 -36.1 -36124 3.5 HDGF PKNOX1 ATF1 SMAD1 IRF4 ZNF143 ATF7 RUNX3 JUNB ZNF592 CICP13 DUSP10 RNU6-403P TAF1A ENSG00000272750 PIR32779 GC01M221824
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUSP10 gene promoter:
  • RFX1
  • PPAR-gamma2
  • PPAR-gamma1
  • MZF-1
  • LUN-1
  • FOXJ2

Genomic Locations for DUSP10 Gene

Genomic Locations for DUSP10 Gene
40,757 bases
Minus strand
40,755 bases
Minus strand

Genomic View for DUSP10 Gene

Genes around DUSP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP10 Gene

Proteins for DUSP10 Gene

  • Protein details for DUSP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 10
    Protein Accession:
    Secondary Accessions:
    • D3DTB4
    • Q6GSI4
    • Q9H9Z5

    Protein attributes for DUSP10 Gene

    482 amino acids
    Molecular mass:
    52642 Da
    Quaternary structure:
    • Monomer. Interacts with MAPK14.

    Three dimensional structures from OCA and Proteopedia for DUSP10 Gene

    Alternative splice isoforms for DUSP10 Gene


neXtProt entry for DUSP10 Gene

Post-translational modifications for DUSP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP10 Gene

No data available for DME Specific Peptides for DUSP10 Gene

Domains & Families for DUSP10 Gene

Gene Families for DUSP10 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP10: view

Function for DUSP10 Gene

Molecular function for DUSP10 Gene

UniProtKB/Swiss-Prot Function:
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 10,expressed in various tissues and organs,located evently in nucleus and cytoplasm and inactivating p38 and SAPK/SNK kinases

Enzyme Numbers (IUBMB) for DUSP10 Gene

Phenotypes From GWAS Catalog for DUSP10 Gene

Gene Ontology (GO) - Molecular Function for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA,IEA --
GO:0008330 protein tyrosine/threonine phosphatase activity IDA 10391943
GO:0008432 JUN kinase binding IDA 10391943
genes like me logo Genes that share ontologies with DUSP10: view
genes like me logo Genes that share phenotypes with DUSP10: view

Animal Models for DUSP10 Gene

MGI Knock Outs for DUSP10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP10

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP10 Gene

Localization for DUSP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP10 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10391943
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 10391943
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with DUSP10: view

Pathways & Interactions for DUSP10 Gene

SuperPathways for DUSP10 Gene

SuperPathway Contained pathways
1 RET signaling
2 MAPK signaling pathway
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 Innate Immune System
genes like me logo Genes that share pathways with DUSP10: view

Pathways by source for DUSP10 Gene

1 Qiagen pathway for DUSP10 Gene
1 Cell Signaling Technology pathway for DUSP10 Gene

SIGNOR curated interactions for DUSP10 Gene


Gene Ontology (GO) - Biological Process for DUSP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IDA 22375048
GO:0002819 regulation of adaptive immune response IEA --
GO:0006470 protein dephosphorylation IDA 22375048
GO:0010033 response to organic substance IEA --
GO:0010633 negative regulation of epithelial cell migration IEA,ISS --
genes like me logo Genes that share ontologies with DUSP10: view

Drugs & Compounds for DUSP10 Gene

(4) Drugs for DUSP10 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0

(2) Additional Compounds for DUSP10 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
genes like me logo Genes that share compounds with DUSP10: view

Transcripts for DUSP10 Gene

mRNA/cDNA for DUSP10 Gene

Unigene Clusters for DUSP10 Gene

Dual specificity phosphatase 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP10

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: -

Relevant External Links for DUSP10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP10 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP10 Gene

This gene is overexpressed in Liver (x4.4).

Protein differential expression in normal tissues from HIPED for DUSP10 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUSP10 Gene

Protein tissue co-expression partners for DUSP10 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUSP10 Gene:


SOURCE GeneReport for Unigene cluster for DUSP10 Gene:


mRNA Expression by UniProt/SwissProt for DUSP10 Gene:

Tissue specificity: Detected in brain.

Evidence on tissue expression from TISSUES for DUSP10 Gene

  • Lung(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with DUSP10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP10 Gene

Orthologs for DUSP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DUSP10 34 33
  • 99.65 (n)
(Bos Taurus)
Mammalia DUSP10 34 33
  • 94.4 (n)
(Canis familiaris)
Mammalia DUSP10 34 33
  • 94.26 (n)
(Monodelphis domestica)
Mammalia DUSP10 34
  • 93 (a)
(Mus musculus)
Mammalia Dusp10 16 34 33
  • 92.25 (n)
(Rattus norvegicus)
Mammalia Dusp10 33
  • 91.22 (n)
(Ornithorhynchus anatinus)
Mammalia DUSP10 34
  • 91 (a)
(Gallus gallus)
Aves DUSP10 34 33
  • 83.51 (n)
(Anolis carolinensis)
Reptilia DUSP10 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497288 33
  • 80.88 (n)
(Danio rerio)
Actinopterygii si:ch211-180b22.4 33
  • 69.33 (n)
DUSP10 34
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta puc 34 35
  • 22 (a)
Species where no ortholog for DUSP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP10 Gene

Gene Tree for DUSP10 (if available)
Gene Tree for DUSP10 (if available)
Evolutionary constrained regions (ECRs) for DUSP10: view image

Paralogs for DUSP10 Gene

Paralogs for DUSP10 Gene

(11) SIMAP similar genes for DUSP10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP10: view

Variants for DUSP10 Gene

Sequence variations from dbSNP and Humsavar for DUSP10 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000072721 -- 221,701,111(-) C/T downstream_transcript_variant
rs1000143619 -- 221,725,413(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000162568 -- 221,712,442(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000229541 -- 221,721,238(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000257611 -- 221,719,006(-) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP10 Gene

Variant ID Type Subtype PubMed ID
esv7152 CNV gain 19470904
nsv469786 CNV loss 16826518

Variation tolerance for DUSP10 Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP10 Gene

Disorders for DUSP10 Gene

Additional Disease Information for DUSP10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DUSP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP10 Gene

Publications for DUSP10 Gene

  1. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. (PMID: 10391943) Tanoue T … Nishida E (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase. (PMID: 16806267) Jeong DG … Kim SJ (Journal of molecular biology 2006) 3 4 22 58
  3. MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. (PMID: 10597297) Theodosiou A … Ashworth A (Oncogene 1999) 2 3 4 58
  4. A distinct interaction mode revealed by the crystal structure of the kinase p38α with the MAPK binding domain of the phosphatase MKP5. (PMID: 22375048) Zhang YY … Wang ZX (Science signaling 2011) 3 4 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for DUSP10 Gene

Sources for DUSP10 Gene

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