Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]
DUSP1 (Dual Specificity Phosphatase 1) is a Protein Coding gene. Diseases associated with DUSP1 include Schuurs-Hoeijmakers Syndrome and Variola Major. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004721 | phosphoprotein phosphatase activity | IEA,IBA | 21873635 |
GO:0004722 | protein serine/threonine phosphatase activity | IEA,ISS | -- |
GO:0004725 | protein tyrosine phosphatase activity | IDA | 1406996 |
GO:0005515 | protein binding | IPI | 10617468 |
GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IBA,IDA | 17498703 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA,IDA | 7593328 |
GO:0005737 | cytoplasm | IBA,IDA | 7593328 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | MAPK signaling pathway | ||
3 | Developmental Biology |
.51
|
|
4 | Cytokine Signaling in Immune system | ||
5 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000188 | inactivation of MAPK activity | IBA,ISS | -- |
GO:0001706 | endoderm formation | IBA | 21873635 |
GO:0006470 | protein dephosphorylation | IEA,IBA | 21873635 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007162 | negative regulation of cell adhesion | IMP | 22991462 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Phosphate |
|
14066-19-4, 14265-44-2 |
|
Compound | Action | Cas Number |
---|---|---|
Sanguinarine chloride | Inhibitor of PP2C and MKP-1 | 5578-73-4 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||
SP2: | |||||||||||||||||
SP3: | - | - | |||||||||||||||
SP4: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DUSP1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DUSP1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dusp1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dusp1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | DUSP1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DUSP1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DUSP1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DUSP1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DUSP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dusp1 30 |
|
||
Str.6379 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | dusp1 30 31 |
|
OneToOne | |
Dr.2413 30 |
|
||||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PPS1 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5253 30 |
|
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
728467 | Likely Benign: not provided | 172,769,011(-) | A/G | SYNONYMOUS_VARIANT | |
742343 | Likely Benign: not provided | 172,770,611(-) | G/C | SYNONYMOUS_VARIANT | |
rs34013988 | - | p.Ala56Thr | |||
rs34471628 | - | p.Tyr187His |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759393 | CNV | gain | 17122850 |
nsv600294 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
schuurs-hoeijmakers syndrome |
|
|
variola major |
|
|
ovarian cancer |
|
|
lung squamous cell carcinoma |
|
|
prostate cancer |
|