DUSP1 Gene (Protein Coding)

Dual Specificity Phosphatase 1

GC05M172768
GIFtS:
48
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular p... See more...

Aliases for DUSP1 Gene

Aliases for DUSP1 Gene

  • Dual Specificity Phosphatase 1 2 3 5
  • Mitogen-Activated Protein Kinase Phosphatase 1 3 4
  • Dual Specificity Protein Phosphatase HVH1 3 4
  • Dual Specificity Protein Phosphatase 1 3 4
  • Protein-Tyrosine Phosphatase CL100 3 4
  • MAP Kinase Phosphatase 1 3 4
  • PTPN10 3 4
  • CL100 3 4
  • MKP-1 3 4
  • MKP1 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • CL 100 3
  • HVH1 3
  • VH1 4

External Ids for DUSP1 Gene

Previous HGNC Symbols for DUSP1 Gene

  • PTPN10

Previous GeneCards Identifiers for DUSP1 Gene

  • GC05M172450
  • GC05M172896
  • GC05M172130
  • GC05M172176
  • GC05M172127
  • GC05M167290
  • GC05M172195

Summaries for DUSP1 Gene

Entrez Gene Summary for DUSP1 Gene

  • The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]

GeneCards Summary for DUSP1 Gene

DUSP1 (Dual Specificity Phosphatase 1) is a Protein Coding gene. Diseases associated with DUSP1 include Schuurs-Hoeijmakers Syndrome and Variola Major. Among its related pathways are Direct p53 effectors and RET signaling. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot Summary for DUSP1 Gene

  • Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.

Gene Wiki entry for DUSP1 Gene

Additional gene information for DUSP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP1 Gene

Genomics for DUSP1 Gene

GeneHancer (GH) Regulatory Elements for DUSP1 Gene

Promoters and enhancers for DUSP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUSP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP1

Top Transcription factor binding sites by QIAGEN in the DUSP1 gene promoter:
  • CREB
  • deltaCREB
  • Elk-1
  • Sp1
  • STAT3

Genomic Locations for DUSP1 Gene

Genomic Locations for DUSP1 Gene
chr5:172,768,090-172,771,200
(GRCh38/hg38)
Size:
3,111 bases
Orientation:
Minus strand
chr5:172,195,093-172,198,203
(GRCh37/hg19)
Size:
3,111 bases
Orientation:
Minus strand

Genomic View for DUSP1 Gene

Genes around DUSP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DUSP1 Gene

Proteins for DUSP1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DUSP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28562-DUS1_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 1
    Protein Accession:
    P28562
    Secondary Accessions:
    • D3DQL9
    • Q2V508

    Protein attributes for DUSP1 Gene

    Size:
    367 amino acids
    Molecular mass:
    39298 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP1 Gene

neXtProt entry for DUSP1 Gene

Protein Expression for DUSP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DUSP1 Gene

  • Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.
  • Ubiquitination at Lys280
  • Modification sites at PhosphoSitePlus

Other Protein References for DUSP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP1 Gene

Domains & Families for DUSP1 Gene

Gene Families for DUSP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DUSP1 Gene

Blocks:
  • Dual specificity protein phosphatase
  • Rhodanese-like
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DUSP1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51038, highly similar to Dual specificity protein phosphatase 1 (EC3.1.3.48) (B4DQ64_HUMAN)
  • Protein-tyrosine phosphatase CL100 (DUS1_HUMAN)
  • Dual specificity protein phosphatase (F5H3Z1_HUMAN)
  • VH1 protein (O95978_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P28562

UniProtKB/Swiss-Prot:

DUS1_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP1: view

Function for DUSP1 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for DUSP1 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=. ;.
UniProtKB/Swiss-Prot Induction:
By oxidative stress and heat shock.
GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 1,reversing the activation of mitogen-activated protein (MAP) kinase family,vaccinia virus phosphatase VH1-like 1,induced by EGF,predominantly expressed in lung,placenta,pancreas,involved in signal transduction

Enzyme Numbers (IUBMB) for DUSP1 Gene

Phenotypes From GWAS Catalog for DUSP1 Gene

Gene Ontology (GO) - Molecular Function for DUSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity ISS,IEA --
GO:0004725 protein tyrosine phosphatase activity IDA 1406996
GO:0005515 protein binding IPI 10617468
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA,IDA 17498703
genes like me logo Genes that share ontologies with DUSP1: view
genes like me logo Genes that share phenotypes with DUSP1: view

Animal Models for DUSP1 Gene

MGI Knock Outs for DUSP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP1

Clone Products

  • Addgene plasmids for DUSP1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP1 Gene

Localization for DUSP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP1 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP1 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DUSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 7593328
GO:0005737 cytoplasm IDA,IBA 7593328
genes like me logo Genes that share ontologies with DUSP1: view

Pathways & Interactions for DUSP1 Gene

PathCards logo

SuperPathways for DUSP1 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 MAPK signaling pathway
MAPK signaling pathway
.45
MAPK Signaling Pathway
.45
3 Developmental Biology
Axon guidance
.51
Developmental Biology
.51
4 Cytokine Signaling in Immune system
Cytokine Signaling in Immune system
.69
Signaling by Interleukins
.69
5 Innate Immune System
Immune System
.61
Innate Immune System
.61
genes like me logo Genes that share pathways with DUSP1: view

Pathways by source for DUSP1 Gene

3 GeneGo (Thomson Reuters) pathways for DUSP1 Gene
  • Development EGFR signaling pathway
  • Signal transduction_Erk Interactions- Inhibition of Erk
  • Transcription_P53 signaling pathway
4 Qiagen pathways for DUSP1 Gene
  • Aldosterone Signaling in Epithelial Cells
  • ERK Signaling
  • JNK Pathway
  • NTHi-Induced Signaling
1 Cell Signaling Technology pathway for DUSP1 Gene

SIGNOR curated interactions for DUSP1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DUSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity ISS --
GO:0006470 protein dephosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007162 negative regulation of cell adhesion IMP 22991462
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with DUSP1: view

Drugs & Compounds for DUSP1 Gene

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  1. Drug

(35) Drugs for DUSP1 Gene - From: PharmGKB, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
Salbutamol Approved, Vet_approved Pharma Partial agonist, Agonist 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Sanguinarine chloride Pharma Inhibitor of PP2C and MKP-1 0

(22) Additional Compounds for DUSP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
 14066-19-4, 14265-44-2

(1) ApexBio Compounds for DUSP1 Gene

Compound Action Cas Number
Sanguinarine chloride Inhibitor of PP2C and MKP-1 5578-73-4
genes like me logo Genes that share compounds with DUSP1: view

Drug Products

Transcripts for DUSP1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DUSP1 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for DUSP1

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: - -
SP4:

Relevant External Links for DUSP1 Gene

GeneLoc Exon Structure for
DUSP1

Expression for DUSP1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP1 Gene

mRNA expression in normal human tissues for DUSP1 Gene
mRNA expression by BioGPS for DUSP1 GenemRNA expression by GTEx for DUSP1 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP1 Gene

This gene is overexpressed in Whole Blood (x5.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP1

SOURCE GeneReport for Unigene cluster for DUSP1 Gene:

Hs.171695

mRNA Expression by UniProt/SwissProt for DUSP1 Gene:

P28562-DUS1_HUMAN
Tissue specificity: Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.

Evidence on tissue expression from TISSUES for DUSP1 Gene

  • Nervous system(4.8)
  • Lung(4.3)
  • Eye(3.9)
  • Muscle(3.9)
  • Heart(3.5)
  • Kidney(3.5)
  • Blood(3.4)
  • Liver(3.4)
  • Intestine(3.3)
  • Pancreas(3.3)
  • Bone marrow(3)
  • Skin(3)
  • Adrenal gland(2.9)
  • Spleen(2.9)
  • Thyroid gland(2.7)
  • Lymph node(2.6)
  • Gall bladder(2.5)
  • Stomach(2.5)
  • Bone(2.3)
genes like me logo Genes that share expression patterns with DUSP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP1 Gene

Orthologs for DUSP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUSP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DUSP1 31 30
  • 99.73 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia DUSP1 31 30
  • 92.82 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Dusp1 17 31 30
  • 90.19 (n)
rat
(Rattus norvegicus)
 Mammalia Dusp1 30
  • 89.55 (n)
oppossum
(Monodelphis domestica)
 Mammalia DUSP1 31
  • 88 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia DUSP1 31 30
  • 84.83 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia DUSP1 31
  • 76 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves DUSP1 31 30
  • 80.37 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia DUSP1 31
  • 81 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia dusp1 30
  • 70.59 (n)
Str.6379 30
zebrafish
(Danio rerio)
 Actinopterygii dusp1 31 30
  • 68.53 (n)
 OneToOne
Dr.2413 30
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PPS1 33
sea squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 33 (a)
 OneToMany
Cin.5253 30
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.5253 30
Species where no ortholog for DUSP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP1 Gene

ENSEMBL:
Gene Tree for DUSP1 (if available)
TreeFam:
Gene Tree for DUSP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUSP1: view image

Paralogs for DUSP1 Gene

Paralogs for DUSP1 Gene

(8) SIMAP similar genes for DUSP1 Gene using alignment to 1 proteins:

  • DUS1_HUMAN
genes like me logo Genes that share paralogs with DUSP1: view

Variants for DUSP1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
728467 Likely Benign: not provided 172,769,011(-) A/G SYNONYMOUS_VARIANT
742343 Likely Benign: not provided 172,770,611(-) G/C SYNONYMOUS_VARIANT
rs34013988 - p.Ala56Thr
rs34471628 - p.Tyr187His

Additional dbSNP identifiers (rs#s) for DUSP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DUSP1 Gene

Variant ID Type Subtype PubMed ID
esv2759393 CNV gain 17122850
nsv600294 CNV loss 21841781

Variation tolerance for DUSP1 Gene

Residual Variation Intolerance Score: 34.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUSP1 Gene

Human Gene Mutation Database (HGMD)
DUSP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP1 Gene

Disorders for DUSP1 Gene