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The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular p... See more...
Aliases for DUSP1 Gene
Aliases for DUSP1 Gene
External Ids for DUSP1 Gene
- HGNC: 3064
- NCBI Entrez Gene: 1843
- Ensembl: ENSG00000120129
- OMIM®: 600714
- UniProtKB/Swiss-Prot: P28562
Previous HGNC Symbols for DUSP1 Gene
- PTPN10
Previous GeneCards Identifiers for DUSP1 Gene
- GC05M172450
- GC05M172896
- GC05M172130
- GC05M172176
- GC05M172127
- GC05M167290
- GC05M172195
Summaries for DUSP1 Gene
-
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]
GeneCards Summary for DUSP1 Gene
DUSP1 (Dual Specificity Phosphatase 1) is a Protein Coding gene. Diseases associated with DUSP1 include Intellectual Developmental Disorder, X-Linked 108 and Schuurs-Hoeijmakers Syndrome. Among its related pathways are RET signaling and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP4.
UniProtKB/Swiss-Prot Summary for DUSP1 Gene
-
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
Additional gene information for DUSP1 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUSP1 Gene
Genomics for DUSP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DUSP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DUSP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUSP1
- Top Transcription factor binding sites by QIAGEN in the DUSP1 gene promoter:
-
- CREB
- deltaCREB
- Elk-1
- Sp1
- STAT3
Genomic Locations for DUSP1 Gene
Latest Assembly
- chr5:172,768,096-172,771,195
- (GRCh38/hg38)
- Size:
- 3,100 bases
- Orientation:
- Minus strand
Previous Assembly
- chr5:172,195,099-172,198,198
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 3,100 bases
- Orientation:
- Minus strand
Genomic View for DUSP1 Gene
Genes around DUSP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q35.1 by HGNC
- 5q35.1 by Entrez Gene
- 5q35.1 by Ensembl
DUSP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DUSP1 Gene
Proteins for DUSP1 Gene
-
Protein details for DUSP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P28562-DUS1_HUMAN
- Recommended name:
- Dual specificity protein phosphatase 1
- Protein Accession:
- P28562
- D3DQL9
- Q2V508
Protein attributes for DUSP1 Gene
- Size:
- 367 amino acids
- Molecular mass:
- 39298 Da
- Quaternary structure:
- No Data Available
Protein Expression for DUSP1 Gene
Post-translational modifications for DUSP1 Gene
- Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.
-
Ubiquitination at Lys280
- NX_P28562 (NX_P28562-1)
- Modification sites at PhosphoSitePlus
Other Protein References for DUSP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences DUSP1 / MKP1 Antibody (LS-B2469) and DUSP1 / MKP1 Antibody (LS-B2736)
- G Biosciences Immunotag™ MKP1 Antibody and Immunotag™ DUSP1 Antibody
- NSJ Bioreagents DUSP1 Antibody
- Novus Biologicals Antibodies for DUSP1
- Invitrogen Antibodies for DUSP1 (AFLGC-DUSP1)
-
Boster Bio Antibodies for DUSP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for DUSP1
Protein products for research
-
OriGene Purified Proteins for DUSP1
- Search Origene for MassSpec and Protein Over-expression Lysates for DUSP1
- Origene Custom Protein Services for DUSP1
- Novus Biologicals proteins for DUSP1
- antibodies-online: Show 8 available DUSP1 Proteins ranked by validation data
- Compare Top DUSP1 Proteins
-
Quality Products:
-
Abcam proteins for DUSP1
Assay products for research
No data available for DME Specific Peptides for DUSP1 Gene
Domains & Families for DUSP1 Gene
Gene Families for DUSP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for DUSP1 Gene
- InterPro:
- Blocks:
-
- Rhodanese-like
- Dual specificity protein phosphatase
Suggested Antigen Peptide Sequences for DUSP1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ51038, highly similar to Dual specificity protein phosphatase 1 (EC3.1.3.48) (B4DQ64_HUMAN)
- Protein-tyrosine phosphatase CL100 (DUS1_HUMAN)
- Dual specificity protein phosphatase (F5H3Z1_HUMAN)
- VH1 protein (O95978_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P28562UniProtKB/Swiss-Prot:
DUS1_HUMAN :- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
- Family:
-
- Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Function for DUSP1 Gene
Molecular function for DUSP1 Gene
- UniProtKB/Swiss-Prot Function:
- Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000269|PubMed:1406996};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000250|UniProtKB:P28563};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000250|UniProtKB:P28563};.
- UniProtKB/Swiss-Prot Induction:
- By oxidative stress and heat shock.
- GENATLAS Biochemistry:
- dual specificity (tyr/thr) phosphatase 1,reversing the activation of mitogen-activated protein (MAP) kinase family,vaccinia virus phosphatase VH1-like 1,induced by EGF,predominantly expressed in lung,placenta,pancreas,involved in signal transduction
Enzyme Numbers (IUBMB) for DUSP1 Gene
Phenotypes From GWAS Catalog for DUSP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IBA | 21873635 |
| GO:0004722 | protein serine/threonine phosphatase activity | ISS | -- |
| GO:0004725 | protein tyrosine phosphatase activity | IDA | 1406996 |
| GO:0005515 | protein binding | IPI | 10617468 |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | IDA | 17498703 |
Phenotypes for DUSP1 Gene
- MGI mutant phenotypes for DUSP1:
-
inferred from 3 alleles
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- liver/biliary system phenotype
- hematopoietic system phenotype
- skeleton phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for DUSP1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- Increased IL-8 secretion
- Increased shRNA abundance
- Decreased viability with paclitaxel
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased cell spreading
Animal Models for DUSP1 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for DUSP1
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for DUSP1 - Starting at $85 >
- * DUSP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP1
miRNA for DUSP1 Gene
- miRTarBase miRNAs that target DUSP1
-
- hsa-miR-101-3p (MIRT005876)
- mmu-miR-101a-3p (MIRT005877)
- mmu-let-7b-5p (MIRT012027)
- hsa-miR-26b-5p (MIRT028795)
- hsa-miR-200c-3p (MIRT053465)
- hsa-miR-129-5p (MIRT095977)
- hsa-miR-940 (MIRT437985)
- hsa-miR-146a-5p (MIRT438558)
- hsa-miR-659-3p (MIRT548518)
- hsa-miR-4659b-3p (MIRT548519)
- hsa-miR-4659a-3p (MIRT548520)
- hsa-miR-218-1-3p (MIRT548521)
- hsa-miR-22-5p (MIRT548522)
- hsa-miR-152-5p (MIRT548523)
- hsa-miR-597-3p (MIRT548524)
- hsa-miR-182-3p (MIRT548525)
- hsa-miR-202-3p (MIRT548526)
- hsa-miR-5002-5p (MIRT548527)
- hsa-miR-4678 (MIRT548528)
- hsa-let-7i-5p (MIRT548529)
- hsa-let-7g-5p (MIRT548530)
- hsa-let-7f-5p (MIRT548531)
- hsa-miR-4458 (MIRT548532)
- hsa-miR-98-5p (MIRT548533)
- hsa-let-7e-5p (MIRT548534)
- hsa-let-7d-5p (MIRT548535)
- hsa-let-7c-5p (MIRT548536)
- hsa-let-7b-5p (MIRT548537)
- hsa-let-7a-5p (MIRT548538)
- hsa-miR-4500 (MIRT548539)
- hsa-miR-4776-3p (MIRT616892)
- hsa-miR-192-3p (MIRT616893)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP1
- Browse OriGene Inhibitory RNA Products For DUSP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP1
Clone products for research
- Applied Biological Materials (abm): Clones for DUSP1 - Starting at $45 >
- * DUSP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for DUSP1
- Addgene plasmids for DUSP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP1
Cell Lines for research
-
Horizon Cell Lines for DUSP1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP1 Gene
Localization for DUSP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DUSP1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 3 |
| extracellular | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IDA | 7593328 |
| GO:0005737 | cytoplasm | IBA,IDA | 7593328 |
Pathways & Interactions for DUSP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | MAPK signaling pathway | ||
| 3 | Developmental Biology |
.51
|
|
| 4 | Cytokine Signaling in Immune system | ||
| 5 | Innate Immune System |
.61
|
|
Pathways by source for DUSP1 Gene
6 BioSystems pathways for DUSP1 Gene
48 Reactome pathways for DUSP1 Gene
4 KEGG pathways for DUSP1 Gene
3 GeneGo (Thomson Reuters) pathways for DUSP1 Gene
- Development EGFR signaling pathway
- Signal transduction_Erk Interactions- Inhibition of Erk
- Transcription_P53 signaling pathway
4 Qiagen pathways for DUSP1 Gene
- Aldosterone Signaling in Epithelial Cells
- ERK Signaling
- JNK Pathway
- NTHi-Induced Signaling
1 Cell Signaling Technology pathway for DUSP1 Gene
Interacting Proteins for DUSP1 Gene
Selected Interacting proteins:
P28562-DUS1_HUMAN
ENSP00000239223
for DUSP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for DUSP1
SIGNOR curated interactions for DUSP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000188 | inactivation of MAPK activity | IBA,ISS | -- |
| GO:0001706 | endoderm formation | IBA | 21873635 |
| GO:0006470 | protein dephosphorylation | IBA | 21873635 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007162 | negative regulation of cell adhesion | IMP | 22991462 |
Drugs & Compounds for DUSP1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for DUSP1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Sanguinarine chloride | Inhibitor of PP2C and MKP-1 | 5578-73-4 |
Transcripts for DUSP1 Gene
mRNA/cDNA for DUSP1 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000239223 2013 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for DUSP1 - Starting at $85 >
- * DUSP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUSP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUSP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUSP1
- Browse OriGene Inhibitory RNA Products For DUSP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUSP1
Clone products for research
- Applied Biological Materials (abm): Clones for DUSP1 - Starting at $45 >
- * DUSP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for DUSP1
- Addgene plasmids for DUSP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUSP1
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||
| SP2: | |||||||||||||||||
| SP3: | - | - | |||||||||||||||
| SP4: |
Relevant External Links for DUSP1 Gene
- GeneLoc Exon Structure for
- DUSP1
Expression for DUSP1 Gene
mRNA differential expression in normal tissues according to GTEx for DUSP1 Gene
This gene is overexpressed in Whole Blood (x5.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUSP1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUSP1
SOURCE GeneReport for Unigene cluster for DUSP1 Gene:
Hs.171695mRNA Expression by UniProt/SwissProt for DUSP1 Gene:
P28562-DUS1_HUMAN
Tissue specificity:
Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.
Evidence on tissue expression from TISSUES for DUSP1 Gene
- Nervous system(4.8)
- Lung(4.4)
- Eye(4.1)
- Muscle(4)
- Kidney(3.7)
- Heart(3.7)
- Pancreas(3.7)
- Liver(3.7)
- Intestine(3.6)
- Blood(3.6)
- Skin(3.5)
- Spleen(3.4)
- Bone marrow(3.4)
- Adrenal gland(3.3)
- Lymph node(3.1)
- Thyroid gland(3)
- Stomach(2.9)
- Bone(2.6)
- Gall bladder(2.5)
Primer products for research
-
OriGene qPCR primer pairs for DUSP1
-
OriGene qPCR primer pairs and template standards for DUSP1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP1 Gene
Orthologs for DUSP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DUSP1 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DUSP1 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Dusp1 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dusp1 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | DUSP1 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DUSP1 29 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DUSP1 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | DUSP1 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DUSP1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dusp1 29 |
|
||
| Str.6379 29 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | dusp1 29 30 |
|
OneToOne | |
| Dr.2413 29 |
|
||||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PPS1 32 |
|
|
|
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5253 29 |
|
- Species where no ortholog for DUSP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for DUSP1 Gene
- ENSEMBL:
- Gene Tree for DUSP1 (if available)
- TreeFam:
- Gene Tree for DUSP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DUSP1: view image
- Alliance of Genome Resources:
- Additional Orthologs for DUSP1
Paralogs for DUSP1 Gene
Paralogs for DUSP1 Gene
(8) SIMAP similar genes for DUSP1 Gene using alignment to 1 proteins:
- DUS1_HUMAN
Variants for DUSP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUSP1 Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs149572166 | Likely Benign: not provided | 172,769,011(-) |
A/G NM_004417.4(DUSP1):c.855T>C (p.Phe285=) |
SYNONYMOUS | |
| rs759155703 | Likely Benign: not provided | 172,770,611(-) |
G/C NM_004417.4(DUSP1):c.342C>G (p.Arg114=) |
SYNONYMOUS | |
| rs34013988 | -- |
p.Ala56Thr |
|||
| rs34471628 | -- |
p.Tyr187His |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759393 | CNV | gain | 17122850 |
| nsv600294 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
34.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.19;
52.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DUSP1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP1 Gene
Disorders for DUSP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| intellectual developmental disorder, x-linked 108 |
|
|
| schuurs-hoeijmakers syndrome |
|
|
| variola major |
|
|
| ovarian cancer |
|
|
| lung cancer |
|
|
Search DUSP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DUSP1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP1 Gene
Publications for DUSP1 Gene
- Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene. (PMID: 8106404) Kwak SP … Dixon JE (The Journal of biological chemistry 1994) 3 4 22
- Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. (PMID: 1406996) Keyse SM … Emslie EA (Nature 1992) 2 3 4
- Crystal structure of the human dual specificity phosphatase 1 catalytic domain. (PMID: 29052270) Gumpena R … Waugh DS (Protein science : a publication of the Protein Society 2018) 3 4
- Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. (PMID: 20805296) Coulthard LR … McDermott MF (Annals of the rheumatic diseases 2011) 3 40
- Mitogen-activated protein kinase phosphatase-1 negatively regulates the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in A549 human lung epithelial cells. (PMID: 20089808) Turpeinen T … Korhonen R (The Journal of pharmacology and experimental therapeutics 2010) 3 22
ExternalLinks
Products for DUSP1 Gene
- Custom Antibody ServicesOriGene Antibodies for DUSP1
- Browse OriGene ELISA Kits
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- Taconic Biosciences Mouse Models for DUSP1
- Find your next knockout model in the Taconic Knockout Repository
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- Invitrogen Antibodies for DUSP1 (AFLGC-DUSP1)
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- VectorBuilder Virus packaging for DUSP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
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- Addgene plasmids for DUSP1
- antibodies-online: Show 50 available DUSP1 Antibodies ranked by validation data
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- antibodies-online: Show 30 available DUSP1 Elisa Kits ranked by validation data
- Compare Top DUSP1 Elisa Kits
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- antibodies-online: Show 8 available DUSP1 Proteins ranked by validation data