Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DUS4L Gene

Aliases for DUS4L Gene

  • Dihydrouridine Synthase 4 Like 2 3 5
  • Protein Similar To E.Coli Yhdg And R. Capsulatus NifR3 2 3
  • TRNA-Dihydrouridine(20a/20b) Synthase [NAD(P)+]-Like 3
  • Dihydrouridine Synthase 4-Like (S. Cerevisiae) 2
  • TRNA-Dihydrouridine Synthase 4-Like 4
  • EC 1.3.1.- 4
  • DUS4 3
  • PP35 3
  • Pp35 4

External Ids for DUS4L Gene

Previous GeneCards Identifiers for DUS4L Gene

  • GC07P106799
  • GC07P106991
  • GC07P107203
  • GC07P101565

Summaries for DUS4L Gene

GeneCards Summary for DUS4L Gene

DUS4L (Dihydrouridine Synthase 4 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and FMN binding.

UniProtKB/Swiss-Prot for DUS4L Gene

  • Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Additional gene information for DUS4L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUS4L Gene

Genomics for DUS4L Gene

GeneHancer (GH) Regulatory Elements for DUS4L Gene

Promoters and enhancers for DUS4L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J107559 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 660.6 -0.9 -893 6.8 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B COG5 DUS4L ENSG00000272854 ENSG00000272072 ENSG00000238832 SLC26A4-AS1 SLC26A4 HBP1 GC07M107524
GH07J107742 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 +181.0 181015 4.8 CLOCK DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D GLIS1 LOC101927974 CBLL1 HBP1 SLC26A4-AS1 SLC26A4 COG5 DUS4L
GH07J107594 Enhancer 1 Ensembl ENCODE 10.4 +32.5 32485 3.7 PKNOX1 MZF1 FEZF1 RFX5 ZNF366 ZSCAN5C OVOL3 CEBPB ZNF398 ZEB2 PIR46022 COG5 SLC26A4 SLC26A4-AS1 DUS4L ENSG00000238832 BCAP29
GH07J107591 Enhancer 0.3 ENCODE 10.2 +29.0 28959 1 MNT PIR46022 SLC26A4-AS1 SLC26A4 COG5 DUS4L BCAP29 ENSG00000272854
GH07J107609 Enhancer 0.3 ENCODE 10 +46.4 46410 0.4 CHD2 COG5 SLC26A4-AS1 SLC26A4 DUS4L ENSG00000238832 GC07M107613 BCAP29
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DUS4L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUS4L gene promoter:

Genomic Locations for DUS4L Gene

Genomic Locations for DUS4L Gene
chr7:107,563,484-107,578,523
(GRCh38/hg38)
Size:
15,040 bases
Orientation:
Plus strand
chr7:107,203,929-107,218,968
(GRCh37/hg19)

Genomic View for DUS4L Gene

Genes around DUS4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUS4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUS4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS4L Gene

Proteins for DUS4L Gene

  • Protein details for DUS4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95620-DUS4L_HUMAN
    Recommended name:
    tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like
    Protein Accession:
    O95620
    Secondary Accessions:
    • B4DLX0
    • Q2NKK1

    Protein attributes for DUS4L Gene

    Size:
    317 amino acids
    Molecular mass:
    35816 Da
    Cofactor:
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD00100.1; Type=Frameshift; Positions=14; Evidence={ECO:0000305};

    Alternative splice isoforms for DUS4L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUS4L Gene

Post-translational modifications for DUS4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DUS4L Gene

Domains & Families for DUS4L Gene

Gene Families for DUS4L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DUS4L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95620

UniProtKB/Swiss-Prot:

DUS4L_HUMAN :
  • Belongs to the Dus family. Dus4 subfamily.
Family:
  • Belongs to the Dus family. Dus4 subfamily.
genes like me logo Genes that share domains with DUS4L: view

Function for DUS4L Gene

Molecular function for DUS4L Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Enzyme Numbers (IUBMB) for DUS4L Gene

Phenotypes From GWAS Catalog for DUS4L Gene

Gene Ontology (GO) - Molecular Function for DUS4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0017150 tRNA dihydrouridine synthase activity IBA,IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with DUS4L: view
genes like me logo Genes that share phenotypes with DUS4L: view

Animal Model Products

CRISPR Products

miRNA for DUS4L Gene

miRTarBase miRNAs that target DUS4L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUS4L

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUS4L Gene

Localization for DUS4L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUS4L gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DUS4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with DUS4L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DUS4L Gene

Pathways & Interactions for DUS4L Gene

SuperPathways for DUS4L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUS4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002943 tRNA dihydrouridine synthesis IEA --
GO:0008033 tRNA processing IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DUS4L: view

No data available for Pathways by source and SIGNOR curated interactions for DUS4L Gene

Drugs & Compounds for DUS4L Gene

(1) Drugs for DUS4L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(1) Additional Compounds for DUS4L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5,6-Dihydrouridine
  • 1-beta-D-Ribofuranosylhydrouracil
  • 3,4-Dihydrouridine
  • d
  • 1-b-D-Ribofuranosylhydrouracil
  • 1-β-D-ribofuranosylhydrouracil
5627-05-4
genes like me logo Genes that share compounds with DUS4L: view

Transcripts for DUS4L Gene

Unigene Clusters for DUS4L Gene

Dihydrouridine synthase 4-like (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUS4L

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUS4L Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: -
SP6:
SP7: - -
SP8: - - - - - -
SP9:

Relevant External Links for DUS4L Gene

GeneLoc Exon Structure for
DUS4L
ECgene alternative splicing isoforms for
DUS4L

Expression for DUS4L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUS4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUS4L Gene

This gene is overexpressed in Placenta (52.3) and Fetal Brain (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUS4L Gene



Protein tissue co-expression partners for DUS4L Gene

NURSA nuclear receptor signaling pathways regulating expression of DUS4L Gene:

DUS4L

SOURCE GeneReport for Unigene cluster for DUS4L Gene:

Hs.97627

Evidence on tissue expression from TISSUES for DUS4L Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with DUS4L: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUS4L Gene

Orthologs for DUS4L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUS4L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUS4L 34 33
  • 99.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DUS4L 34 33
  • 93.06 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DUS4L 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dus4l 16 34 33
  • 88.61 (n)
rat
(Rattus norvegicus)
Mammalia Dus4l 33
  • 88.19 (n)
oppossum
(Monodelphis domestica)
Mammalia DUS4L 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUS4L 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUS4L 34 33
  • 78.33 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUS4L 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dus4l 33
  • 75.24 (n)
zebrafish
(Danio rerio)
Actinopterygii dus4l 34 33
  • 69.02 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002791 33
  • 51.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10495 34 33
  • 49.45 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C45G9.2 34 33
  • 54.17 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02959g 33
  • 50.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUS4 36 34 33
  • 50.39 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER075W 33
  • 47.75 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 56 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC777.15 33
  • 52.6 (n)
Species where no ortholog for DUS4L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUS4L Gene

ENSEMBL:
Gene Tree for DUS4L (if available)
TreeFam:
Gene Tree for DUS4L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUS4L: view image

Paralogs for DUS4L Gene

(2) SIMAP similar genes for DUS4L Gene using alignment to 4 proteins:

  • DUS4L_HUMAN
  • F2Z2E4_HUMAN
  • F8WEL2_HUMAN
  • F8WFE3_HUMAN
genes like me logo Genes that share paralogs with DUS4L: view

No data available for Paralogs for DUS4L Gene

Variants for DUS4L Gene

Sequence variations from dbSNP and Humsavar for DUS4L Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs114481539 uncertain-significance, Congenital disorder of glycosylation 107,564,340(+) C/A/G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs115371930 likely-benign, Congenital disorder of glycosylation 107,564,376(+) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs145603444 uncertain-significance, Congenital disorder of glycosylation 107,564,494(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs146391348 uncertain-significance, Congenital disorder of glycosylation 107,563,830(+) C/G upstream_transcript_variant
rs374535796 uncertain-significance, Congenital disorder of glycosylation 107,563,800(+) T/A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DUS4L Gene

Variant ID Type Subtype PubMed ID
esv3614462 CNV gain 21293372
nsv608074 CNV loss 21841781

Variation tolerance for DUS4L Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUS4L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUS4L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUS4L Gene

Disorders for DUS4L Gene

Additional Disease Information for DUS4L

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DUS4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUS4L Gene

Publications for DUS4L Gene

  1. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. (PMID: 21068099) Evangelou E … Translation Research in Europe Applied Technologies for Osteoarthritis (TreatOA) (Annals of the rheumatic diseases 2011) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Recurrent fusion RNA DUS4L-BCAP29 in non-cancer human tissues and cells. (PMID: 28415823) Tang Y … Li H (Oncotarget 2017) 3 58
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S … Seielstad M (Genes and immunity 2010) 3 58

Products for DUS4L Gene

Sources for DUS4L Gene

Content
Loading form....