Aliases for DUS3L Gene

Aliases for DUS3L Gene

  • Dihydrouridine Synthase 3 Like 2 3 5
  • TRNA-Dihydrouridine(47) Synthase [NAD(P)(+)]-Like 3 4
  • DUS3 2 3
  • Dihydrouridine Synthase 3-Like (S. Cerevisiae) 2
  • TRNA-Dihydrouridine Synthase 3-Like 4
  • EC 1.3.1.- 4
  • FLJ13896 2
  • DUS3L 5

External Ids for DUS3L Gene

Previous GeneCards Identifiers for DUS3L Gene

  • GC19M005737
  • GC19M005546

Summaries for DUS3L Gene

GeneCards Summary for DUS3L Gene

DUS3L (Dihydrouridine Synthase 3 Like) is a Protein Coding gene. Diseases associated with DUS3L include Myopathy, Congenital, Compton-North and Cholestasis-Lymphedema Syndrome. Gene Ontology (GO) annotations related to this gene include tRNA dihydrouridine synthase activity. An important paralog of this gene is DUS1L.

UniProtKB/Swiss-Prot Summary for DUS3L Gene

  • Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Additional gene information for DUS3L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUS3L Gene

Genomics for DUS3L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DUS3L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUS3L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUS3L

Top Transcription factor binding sites by QIAGEN in the DUS3L gene promoter:
  • AhR
  • AP-2alpha
  • CUTL1
  • MyoD
  • NF-1
  • NF-1/L
  • SEF-1 (1)
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for DUS3L Gene

Genomic Locations for DUS3L Gene
6,394 bases
Minus strand
6,407 bases
Minus strand

Genomic View for DUS3L Gene

Genes around DUS3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUS3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUS3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS3L Gene

Proteins for DUS3L Gene

  • Protein details for DUS3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
    Protein Accession:
    Secondary Accessions:
    • Q96HM5
    • Q9BSU4
    • Q9H877
    • Q9NPR1

    Protein attributes for DUS3L Gene

    650 amino acids
    Molecular mass:
    72594 Da
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    No Data Available
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for DUS3L Gene


neXtProt entry for DUS3L Gene

Post-translational modifications for DUS3L Gene

  • Ubiquitination at Lys306, Lys134, Lys416, Lys435, and Lys526
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DUS3L Gene

Domains & Families for DUS3L Gene

Gene Families for DUS3L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DUS3L Gene

  • Zn-finger, C-x8-C-x5-C-x3-H type
  • Protein of unknown function UPF0034

Suggested Antigen Peptide Sequences for DUS3L Gene

GenScript: Design optimal peptide antigens:
  • tRNA-dihydrouridine synthase (D6W636_HUMAN)
  • tRNA-dihydrouridine synthase 3-like (DUS3L_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Dus family. Dus3 subfamily.
  • Belongs to the Dus family. Dus3 subfamily.
genes like me logo Genes that share domains with DUS3L: view

Function for DUS3L Gene

Molecular function for DUS3L Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Enzyme Numbers (IUBMB) for DUS3L Gene

Phenotypes From GWAS Catalog for DUS3L Gene

Gene Ontology (GO) - Molecular Function for DUS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003824 catalytic activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0017150 tRNA dihydrouridine synthase activity IEA,IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DUS3L: view
genes like me logo Genes that share phenotypes with DUS3L: view

Animal Model Products

CRISPR Products

miRNA for DUS3L Gene

miRTarBase miRNAs that target DUS3L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUS3L

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUS3L Gene

Localization for DUS3L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUS3L gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 2
extracellular 1
cytoskeleton 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUS3L Gene

Pathways & Interactions for DUS3L Gene

PathCards logo

SuperPathways for DUS3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002943 tRNA dihydrouridine synthesis IEA --
GO:0008033 tRNA processing IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DUS3L: view

No data available for Pathways by source and SIGNOR curated interactions for DUS3L Gene

Drugs & Compounds for DUS3L Gene

(1) Drugs for DUS3L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(1) Additional Compounds for DUS3L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-beta-D-Ribofuranosylhydrouracil
  • 3,4-Dihydrouridine
  • d
  • 1-b-D-Ribofuranosylhydrouracil
  • 1-β-D-ribofuranosylhydrouracil
genes like me logo Genes that share compounds with DUS3L: view

Transcripts for DUS3L Gene

mRNA/cDNA for DUS3L Gene

11 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUS3L

Alternative Splicing Database (ASD) splice patterns (SP) for DUS3L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: -
SP2: - - - - - -
SP3: - - - -
SP4: - - - -
SP5: -

Relevant External Links for DUS3L Gene

GeneLoc Exon Structure for

Expression for DUS3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUS3L Gene

Protein differential expression in normal tissues from HIPED for DUS3L Gene

This gene is overexpressed in Testis (12.5), Peripheral blood mononuclear cells (10.1), Breast (7.6), Blymphocyte (7.1), Pancreas (6.6), and Lung (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUS3L Gene

Protein tissue co-expression partners for DUS3L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUS3L

SOURCE GeneReport for Unigene cluster for DUS3L Gene:


Evidence on tissue expression from TISSUES for DUS3L Gene

  • Pancreas(4.2)
  • Thyroid gland(4.2)
  • Liver(4.2)
  • Nervous system(4)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with DUS3L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUS3L Gene

Orthologs for DUS3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUS3L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DUS3L 30 31
  • 94.44 (n)
(Canis familiaris)
Mammalia DUS3L 30 31
  • 86.35 (n)
(Bos Taurus)
Mammalia DUS3L 30 31
  • 85.35 (n)
(Mus musculus)
Mammalia Dus3l 30 17 31
  • 81.18 (n)
(Rattus norvegicus)
Mammalia Dus3l 30
  • 79.17 (n)
(Ornithorhynchus anatinus)
Mammalia DUS3L 31
  • 65 (a)
(Monodelphis domestica)
Mammalia DUS3L 31
  • 64 (a)
(Gallus gallus)
Aves DUS3L 30 31
  • 68.18 (n)
(Anolis carolinensis)
Reptilia DUS3L 31
  • 45 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dus3l 30
  • 63.55 (n)
MGC76275 30
African clawed frog
(Xenopus laevis)
Amphibia MGC53781 30
(Danio rerio)
Actinopterygii dus3l 30
  • 67.21 (n)
zgc63779 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4216 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009171 30
  • 55.96 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG10463 30 31
  • 54.59 (n)
(Caenorhabditis elegans)
Secernentea Y37E11B.5 30 31
  • 53.79 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AER070C 30
  • 56.59 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUS3 30 31 33
  • 47.53 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03069g 30
  • 45.05 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G38890 30
  • 51.3 (n)
(Oryza sativa)
Liliopsida Os04g0117600 30
  • 52.97 (n)
Os.7618 30
(Triticum aestivum)
Liliopsida Ta.25338 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8801 31
  • 57 (a)
Bread mold
(Neurospora crassa)
Ascomycetes NCU02619 30
  • 56.03 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dus3 30
  • 45.18 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2732 30
Species where no ortholog for DUS3L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DUS3L Gene

Gene Tree for DUS3L (if available)
Gene Tree for DUS3L (if available)
Evolutionary constrained regions (ECRs) for DUS3L: view image

Paralogs for DUS3L Gene

Paralogs for DUS3L Gene

genes like me logo Genes that share paralogs with DUS3L: view

Variants for DUS3L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUS3L Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs12977803 - p.Asp609Asn
rs2436487 - p.Arg185Gly

Additional dbSNP identifiers (rs#s) for DUS3L Gene

Structural Variations from Database of Genomic Variants (DGV) for DUS3L Gene

Variant ID Type Subtype PubMed ID
esv1024134 CNV insertion 17803354
esv1693395 CNV insertion 17803354
esv3393878 CNV duplication 20981092
esv3399820 CNV insertion 20981092
nsv1062851 CNV gain 25217958
nsv470119 CNV loss 18288195
nsv525707 CNV loss 19592680
nsv817812 CNV loss 17921354

Variation tolerance for DUS3L Gene

Residual Variation Intolerance Score: 19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.81; 91.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUS3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUS3L Gene

Disorders for DUS3L Gene

MalaCards: The human disease database

(2) MalaCards diseases for DUS3L Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search DUS3L in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with DUS3L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUS3L Gene

Publications for DUS3L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
  5. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3

Products for DUS3L Gene

Sources for DUS3L Gene