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Aliases for DUS3L Gene

Aliases for DUS3L Gene

  • Dihydrouridine Synthase 3 Like 2 3 5
  • TRNA-Dihydrouridine(47) Synthase [NAD(P)(+)]-Like 3 4
  • Dihydrouridine Synthase 3-Like (S. Cerevisiae) 2
  • TRNA-Dihydrouridine Synthase 3-Like 4
  • EC 1.3.1.- 4
  • DUS3 3

External Ids for DUS3L Gene

Previous GeneCards Identifiers for DUS3L Gene

  • GC19M005737
  • GC19M005546

Summaries for DUS3L Gene

GeneCards Summary for DUS3L Gene

DUS3L (Dihydrouridine Synthase 3 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include tRNA dihydrouridine synthase activity. An important paralog of this gene is DUS2.

UniProtKB/Swiss-Prot for DUS3L Gene

  • Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Additional gene information for DUS3L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUS3L Gene

Genomics for DUS3L Gene

GeneHancer (GH) Regulatory Elements for DUS3L Gene

Promoters and enhancers for DUS3L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J005789 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 671.6 +0.6 616 2.4 MTA3 SP1 ZFX ELF3 MNT SIX5 CBFA2T2 ZNF148 NKRF MLLT1 DUS3L KHSRP SAFB SNRPEP4 ENSG00000267571 VMAC KDM4B PTPRS GPR108 GTF2F1
GH19J005792 Promoter 0.6 Ensembl 607.8 -0.9 -862 0.2 GTF2E2 DUS3L NRTN
GH19J005689 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 147.5 +99.1 99141 5 ZFX SP1 ELF3 CTCF MNT NKRF POLR2A MLLT1 ZNF121 GTF2F1 RPL36 KHSRP DUS3L SAFB SNRPEP4 ENSG00000267571 SAFB2 KDM4B GTF2F1 RANBP3
GH19J006527 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 128.4 -739.6 -739647 6.6 ZNF473 SP1 ELF3 CC2D1A ZFX ZNF148 NKRF POLR2A MLLT1 GTF2F1 TNFSF9 ZNF557 KHSRP DUS3L SAFB SAFB2 SNRPEP4 RANBP3 GTF2F1 ENSG00000267571
GH19J006270 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 99 -484.3 -484275 11 HDGF ZFX SP1 CTCF CC2D1A ELF3 MNT CBFA2T2 ZNF148 MLLT1 MLLT1 DUS3L ZNF557 KHSRP SNRPEP4 SAFB ENSG00000267571 VMAC RANBP3 GPR108
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUS3L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUS3L gene promoter:
  • AhR
  • AP-2alpha
  • CUTL1
  • MyoD
  • NF-1
  • NF-1/L
  • SEF-1 (1)
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for DUS3L Gene

Genomic Locations for DUS3L Gene
6,407 bases
Minus strand
6,407 bases
Minus strand

Genomic View for DUS3L Gene

Genes around DUS3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUS3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUS3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS3L Gene

Proteins for DUS3L Gene

  • Protein details for DUS3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
    Protein Accession:
    Secondary Accessions:
    • Q96HM5
    • Q9BSU4
    • Q9H877
    • Q9NPR1

    Protein attributes for DUS3L Gene

    650 amino acids
    Molecular mass:
    72594 Da
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DUS3L Gene


neXtProt entry for DUS3L Gene

Post-translational modifications for DUS3L Gene

  • Ubiquitination at posLast=306306, isoforms=2, 3435, posLast=134134, posLast=416416, and isoforms=3526
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DUS3L Gene

Domains & Families for DUS3L Gene

Gene Families for DUS3L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DUS3L Gene

GenScript: Design optimal peptide antigens:
  • tRNA-dihydrouridine synthase (D6W636_HUMAN)
  • tRNA-dihydrouridine synthase 3-like (DUS3L_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Dus family. Dus3 subfamily.
  • Belongs to the Dus family. Dus3 subfamily.
genes like me logo Genes that share domains with DUS3L: view

Function for DUS3L Gene

Molecular function for DUS3L Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Enzyme Numbers (IUBMB) for DUS3L Gene

Phenotypes From GWAS Catalog for DUS3L Gene

Gene Ontology (GO) - Molecular Function for DUS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003824 catalytic activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0017150 tRNA dihydrouridine synthase activity IEA,IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DUS3L: view
genes like me logo Genes that share phenotypes with DUS3L: view

Animal Model Products

CRISPR Products

miRNA for DUS3L Gene

miRTarBase miRNAs that target DUS3L

Clone Products

  • Applied Biological Materials (abm): Clones for DUS3L - Now 50% OFF >
  • * DUS3L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DUS3L tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUS3L Gene

Localization for DUS3L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUS3L gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 2
cytoskeleton 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUS3L Gene

Pathways & Interactions for DUS3L Gene

PathCards logo

SuperPathways for DUS3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002943 tRNA dihydrouridine synthesis IEA --
GO:0008033 tRNA processing IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DUS3L: view

No data available for Pathways by source and SIGNOR curated interactions for DUS3L Gene

Drugs & Compounds for DUS3L Gene

(1) Drugs for DUS3L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(1) Additional Compounds for DUS3L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-beta-D-Ribofuranosylhydrouracil
  • 3,4-Dihydrouridine
  • d
  • 1-b-D-Ribofuranosylhydrouracil
  • 1-β-D-ribofuranosylhydrouracil
genes like me logo Genes that share compounds with DUS3L: view

Transcripts for DUS3L Gene

mRNA/cDNA for DUS3L Gene

Unigene Clusters for DUS3L Gene

Dihydrouridine synthase 3-like (S. cerevisiae):
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for DUS3L - Now 50% OFF >
  • * DUS3L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DUS3L tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for DUS3L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: -
SP2: - - - - - -
SP3: - - - -
SP4: - - - -
SP5: -

Relevant External Links for DUS3L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUS3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUS3L Gene

Protein differential expression in normal tissues from HIPED for DUS3L Gene

This gene is overexpressed in Testis (12.5), Peripheral blood mononuclear cells (10.1), Breast (7.6), Blymphocyte (7.1), Pancreas (6.6), and Lung (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUS3L Gene

Protein tissue co-expression partners for DUS3L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DUS3L Gene:


SOURCE GeneReport for Unigene cluster for DUS3L Gene:


Evidence on tissue expression from TISSUES for DUS3L Gene

  • Pancreas(4.2)
  • Thyroid gland(4.2)
  • Liver(4.1)
  • Nervous system(4)
  • Intestine(2)
genes like me logo Genes that share expression patterns with DUS3L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUS3L Gene

Orthologs for DUS3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUS3L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DUS3L 35 34
  • 94.44 (n)
(Canis familiaris)
Mammalia DUS3L 35 34
  • 86.35 (n)
(Bos Taurus)
Mammalia DUS3L 35 34
  • 85.35 (n)
(Mus musculus)
Mammalia Dus3l 17 35 34
  • 81.18 (n)
(Rattus norvegicus)
Mammalia Dus3l 34
  • 79.17 (n)
(Ornithorhynchus anatinus)
Mammalia DUS3L 35
  • 65 (a)
(Monodelphis domestica)
Mammalia DUS3L 35
  • 64 (a)
(Gallus gallus)
Aves DUS3L 35 34
  • 68.18 (n)
(Anolis carolinensis)
Reptilia DUS3L 35
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dus3l 34
  • 63.55 (n)
MGC76275 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53781 34
(Danio rerio)
Actinopterygii dus3l 34
  • 67.21 (n)
zgc63779 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4216 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009171 34
  • 55.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10463 35 34
  • 54.59 (n)
(Caenorhabditis elegans)
Secernentea Y37E11B.5 35 34
  • 53.79 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER070C 34
  • 56.59 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUS3 37 35 34
  • 47.53 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03069g 34
  • 45.05 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G38890 34
  • 51.3 (n)
(Oryza sativa)
Liliopsida Os04g0117600 34
  • 52.97 (n)
Os.7618 34
(Triticum aestivum)
Liliopsida Ta.25338 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8801 35
  • 57 (a)
Cin.2732 34
bread mold
(Neurospora crassa)
Ascomycetes NCU02619 34
  • 56.03 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dus3 34
  • 45.18 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2732 34
Species where no ortholog for DUS3L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DUS3L Gene

Gene Tree for DUS3L (if available)
Gene Tree for DUS3L (if available)
Evolutionary constrained regions (ECRs) for DUS3L: view image

Paralogs for DUS3L Gene

Paralogs for DUS3L Gene

genes like me logo Genes that share paralogs with DUS3L: view

Variants for DUS3L Gene

Sequence variations from dbSNP and Humsavar for DUS3L Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000497507 -- 5,789,957(-) G/A intron_variant
rs1000665292 -- 5,790,805(-) G/A intron_variant
rs1001076536 -- 5,790,960(-) C/T intron_variant
rs1001565377 -- 5,786,289(-) C/G intron_variant, non_coding_transcript_variant
rs1001804489 -- 5,785,683(-) G/A coding_sequence_variant, non_coding_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for DUS3L Gene

Variant ID Type Subtype PubMed ID
esv1024134 CNV insertion 17803354
esv1693395 CNV insertion 17803354
esv3393878 CNV duplication 20981092
esv3399820 CNV insertion 20981092
nsv1062851 CNV gain 25217958
nsv470119 CNV loss 18288195
nsv525707 CNV loss 19592680
nsv817812 CNV loss 17921354

Variation tolerance for DUS3L Gene

Residual Variation Intolerance Score: 19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.81; 91.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUS3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUS3L Gene

Disorders for DUS3L Gene

Additional Disease Information for DUS3L

No disorders were found for DUS3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUS3L Gene

Publications for DUS3L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3 58
  5. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3 58

Products for DUS3L Gene

Sources for DUS3L Gene

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