Aliases for DUS1L Gene

Aliases for DUS1L Gene

  • Dihydrouridine Synthase 1 Like 2 3 5
  • TRNA-Dihydrouridine(16/17) Synthase [NAD(P)(+)]-Like 3 4
  • PP3111 2 3
  • DUS1 2 3
  • Dihydrouridine Synthase 1-Like (S. Cerevisiae) 2
  • TRNA-Dihydrouridine Synthase 1-Like 4
  • EC 1.3.1.- 4
  • DUS1L 5

External Ids for DUS1L Gene

Previous GeneCards Identifiers for DUS1L Gene

  • GC17M077610
  • GC17M080015
  • GC17M075415

Summaries for DUS1L Gene

GeneCards Summary for DUS1L Gene

DUS1L (Dihydrouridine Synthase 1 Like) is a Protein Coding gene. Diseases associated with DUS1L include Robinow Syndrome, Autosomal Dominant 3 and 3-Methylglutaconic Aciduria, Type I. Gene Ontology (GO) annotations related to this gene include flavin adenine dinucleotide binding and tRNA dihydrouridine synthase activity. An important paralog of this gene is DUS4L.

UniProtKB/Swiss-Prot Summary for DUS1L Gene

  • Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Additional gene information for DUS1L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUS1L Gene

Genomics for DUS1L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DUS1L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUS1L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUS1L

Top Transcription factor binding sites by QIAGEN in the DUS1L gene promoter:
  • AP-1
  • HOXA5
  • USF-1
  • USF1

Genomic Locations for DUS1L Gene

Genomic Locations for DUS1L Gene
chr17:82,057,506-82,065,887
(GRCh38/hg38)
Size:
8,382 bases
Orientation:
Minus strand
chr17:80,015,382-80,023,763
(GRCh37/hg19)
Size:
8,382 bases
Orientation:
Minus strand

Genomic View for DUS1L Gene

Genes around DUS1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUS1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUS1L Gene

Proteins for DUS1L Gene

  • Protein details for DUS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1R4-DUS1L_HUMAN
    Recommended name:
    tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
    Protein Accession:
    Q6P1R4
    Secondary Accessions:
    • A6NHV4
    • Q96AI3

    Protein attributes for DUS1L Gene

    Size:
    473 amino acids
    Molecular mass:
    53230 Da
    Cofactor:
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    No Data Available

neXtProt entry for DUS1L Gene

Post-translational modifications for DUS1L Gene

  • Ubiquitination at Lys199
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DUS1L Gene

Domains & Families for DUS1L Gene

Gene Families for DUS1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DUS1L Gene

InterPro:
Blocks:
  • Protein of unknown function UPF0034
ProtoNet:

Suggested Antigen Peptide Sequences for DUS1L Gene

GenScript: Design optimal peptide antigens:
  • tRNA-dihydrouridine synthase 1-like (DUS1L_HUMAN)
  • DUS1L protein (Q9BTJ3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P1R4

UniProtKB/Swiss-Prot:

DUS1L_HUMAN :
  • Belongs to the Dus family. Dus1 subfamily.
Family:
  • Belongs to the Dus family. Dus1 subfamily.
genes like me logo Genes that share domains with DUS1L: view

Function for DUS1L Gene

Molecular function for DUS1L Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Enzyme Numbers (IUBMB) for DUS1L Gene

Phenotypes From GWAS Catalog for DUS1L Gene

Gene Ontology (GO) - Molecular Function for DUS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0017150 tRNA dihydrouridine synthase activity IEA,IBA 21873635
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with DUS1L: view
genes like me logo Genes that share phenotypes with DUS1L: view

Animal Model Products

CRISPR Products

miRNA for DUS1L Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUS1L

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUS1L Gene

Localization for DUS1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUS1L gene
Compartment Confidence
nucleus 3
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUS1L Gene

Pathways & Interactions for DUS1L Gene

PathCards logo

SuperPathways for DUS1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002943 tRNA dihydrouridine synthesis IEA --
GO:0008033 tRNA processing IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DUS1L: view

No data available for Pathways by source and SIGNOR curated interactions for DUS1L Gene

Drugs & Compounds for DUS1L Gene

(1) Drugs for DUS1L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(1) Additional Compounds for DUS1L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5,6-Dihydrouridine
  • 1-beta-D-Ribofuranosylhydrouracil
  • 3,4-Dihydrouridine
  • d
  • 1-b-D-Ribofuranosylhydrouracil
  • 1-β-D-ribofuranosylhydrouracil
5627-05-4
genes like me logo Genes that share compounds with DUS1L: view

Transcripts for DUS1L Gene

mRNA/cDNA for DUS1L Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUS1L

Alternative Splicing Database (ASD) splice patterns (SP) for DUS1L Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a ·
SP1: -
SP2: - -
SP3: - -
SP4:
SP5: - -
SP6: - -
SP7:
SP8: - -
SP9:
SP10:
SP11:

ExUns: 14b · 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for DUS1L Gene

GeneLoc Exon Structure for
DUS1L

Expression for DUS1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUS1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUS1L Gene

This gene is overexpressed in Lung (37.2), Peripheral blood mononuclear cells (12.2), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DUS1L Gene



Protein tissue co-expression partners for DUS1L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUS1L

SOURCE GeneReport for Unigene cluster for DUS1L Gene:

Hs.514599

Evidence on tissue expression from TISSUES for DUS1L Gene

  • Nervous system(4.7)
  • Intestine(4.4)
  • Pancreas(4.3)
  • Skin(2.4)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with DUS1L: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUS1L Gene

Orthologs for DUS1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUS1L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DUS1L 30 31
  • 99.22 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DUS1L 30 31
  • 90.35 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DUS1L 30 31
  • 88.75 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dus1l 30 17 31
  • 85.34 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pp3111 30
  • 84.87 (n)
Oppossum
(Monodelphis domestica)
Mammalia DUS1L 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DUS1L 30
  • 77.11 (n)
Lizard
(Anolis carolinensis)
Reptilia DUS1L 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dus1l 30
  • 74.83 (n)
Str.1993 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24034 30
Zebrafish
(Danio rerio)
Actinopterygii dus1l 30 31
  • 72.71 (n)
OneToOne
-- 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG3645 30 31
  • 60.14 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008484 30
  • 60.03 (n)
Worm
(Caenorhabditis elegans)
Secernentea F36A2.2 30 31
  • 45.88 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUS1 31 33
  • 38 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G67220 30
  • 53.22 (n)
Rice
(Oryza sativa)
Liliopsida Os06g0712900 30
  • 53.64 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6459 31
  • 53 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.8130 30
Species where no ortholog for DUS1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DUS1L Gene

ENSEMBL:
Gene Tree for DUS1L (if available)
TreeFam:
Gene Tree for DUS1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUS1L: view image

Paralogs for DUS1L Gene

Paralogs for DUS1L Gene

(2) SIMAP similar genes for DUS1L Gene using alignment to 10 proteins:

  • DUS1L_HUMAN
  • F5H0Q0_HUMAN
  • H0YGW8_HUMAN
  • J3KSK2_HUMAN
  • J3KT57_HUMAN
  • J3QKP9_HUMAN
  • J3QLE4_HUMAN
  • J3QQL9_HUMAN
  • J3QQZ0_HUMAN
  • Q9BTJ3_HUMAN

Pseudogenes.org Pseudogenes for DUS1L Gene

genes like me logo Genes that share paralogs with DUS1L: view

Variants for DUS1L Gene

Additional dbSNP identifiers (rs#s) for DUS1L Gene

Structural Variations from Database of Genomic Variants (DGV) for DUS1L Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
nsv428351 CNV gain 18775914
nsv457975 CNV loss 19166990
nsv457976 CNV gain 19166990
nsv470620 CNV loss 18288195
nsv470621 CNV gain 18288195
nsv576183 CNV loss 21841781
nsv576187 CNV gain 21841781
nsv576188 CNV loss 21841781
nsv952392 CNV deletion 24416366

Variation tolerance for DUS1L Gene

Residual Variation Intolerance Score: 26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUS1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUS1L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUS1L Gene

Disorders for DUS1L Gene

MalaCards: The human disease database

(3) MalaCards diseases for DUS1L Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search DUS1L in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with DUS1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUS1L Gene

Publications for DUS1L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
  5. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. (PMID: 29513927) Tomkins JE … Manzoni C (Proteomics 2018) 3

Products for DUS1L Gene

Sources for DUS1L Gene