Aliases for DUS1L Gene
Aliases for DUS1L Gene
External Ids for DUS1L Gene
- HGNC: 30086
- Entrez Gene: 64118
- Ensembl: ENSG00000169718
- UniProtKB: Q6P1R4
Previous GeneCards Identifiers for DUS1L Gene
- GC17M077610
- GC17M080015
- GC17M075415
Summaries for DUS1L Gene
GeneCards Summary for DUS1L Gene
DUS1L (Dihydrouridine Synthase 1 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include flavin adenine dinucleotide binding and tRNA dihydrouridine synthase activity.
UniProtKB/Swiss-Prot for DUS1L Gene
-
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUS1L Gene
Genomics for DUS1L Gene
GeneHancer (GH) Regulatory Elements for DUS1L Gene
Promoters and enhancers for DUS1L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DUS1L on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DUS1L gene promoter:
Regulatory Element Products
Genomic Locations for DUS1L Gene
Genomic Locations for DUS1L Gene
- chr17:82,057,506-82,065,887
- (GRCh38/hg38)
- Size:
- 8,382 bases
- Orientation:
- Minus strand
- chr17:80,015,382-80,023,763
- (GRCh37/hg19)
Genomic View for DUS1L Gene
Genes around DUS1L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by Ensembl
- 17q25.3 by Entrez Gene
- 17q25.3 by HGNC
DUS1L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DUS1L Gene
Proteins for DUS1L Gene
-
Protein details for DUS1L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6P1R4-DUS1L_HUMAN
- Recommended name:
- tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
- Protein Accession:
- Q6P1R4
- A6NHV4
- Q96AI3
Protein attributes for DUS1L Gene
- Size:
- 473 amino acids
- Molecular mass:
- 53230 Da
- Cofactor:
- Name=FMN; Xref=ChEBI:CHEBI:58210;
- Quaternary structure:
- No Data Available
Protein Expression for DUS1L Gene
Post-translational modifications for DUS1L Gene
Other Protein References for DUS1L Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DUS1L
- Novus Biologicals Antibodies for DUS1L
- Invitrogen Antibodies for DUS1L
- GeneTex DUS1L antibody for DUS1L
-
Santa Cruz Biotechnology (SCBT) Antibodies for DUS1L
Protein Products
-
OriGene Purified Proteins for DUS1L
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- Search GeneTex for Proteins for DUS1L
-
Abcam proteins for DUS1L
Assay Products
No data available for DME Specific Peptides for DUS1L Gene
Domains & Families for DUS1L Gene
Gene Families for DUS1L Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for DUS1L Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DUS1L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6P1R4- Family:
-
- Belongs to the Dus family. Dus1 subfamily.
Function for DUS1L Gene
Molecular function for DUS1L Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
Enzyme Numbers (IUBMB) for DUS1L Gene
Phenotypes From GWAS Catalog for DUS1L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0017150 | tRNA dihydrouridine synthase activity | IEA,IBA | -- |
| GO:0050660 | flavin adenine dinucleotide binding | IEA | -- |
Phenotypes for DUS1L Gene
- GenomeRNAi human phenotypes for DUS1L:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for DUS1L gene
-
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CRISPR Products
-
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- Applied Biological Materials CRISPR for DUS1L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUS1L
- GenScript: Design CRISPR guide RNA sequences for DUS1L
miRNA for DUS1L Gene
- miRTarBase miRNAs that target DUS1L
miRNA Products
- Search ViGene Biosciences for DUS1L
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DUS1L
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- genomics-online: shRNA clones - Search results for available DUS1L gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DUS1L gene
Clone Products
- Sino Biological Human cDNA Clone for DUS1L
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available DUS1L gene related products
- orf clones - Search results for available DUS1L gene related products
- Applied Biological Materials Clones for DUS1L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DUS1L
-
ViGene Biosciences adenoviral particle packaged cDNA for DUS1L gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DUS1L gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DUS1L gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUS1L Gene
Localization for DUS1L Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
- Plasma membrane (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUS1L Gene
Pathways & Interactions for DUS1L Gene
No Data Available
Interacting Proteins for DUS1L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002943 | tRNA dihydrouridine synthesis | IEA | -- |
| GO:0008033 | tRNA processing | IEA | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for DUS1L Gene
Drugs & Compounds for DUS1L Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| FAD | Approved | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 5,6-Dihydrouridine |
|
5627-05-4 |
|
Transcripts for DUS1L Gene
mRNA/cDNA for DUS1L Gene
- (5) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (528) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DUS1L Gene
CRISPR Products
-
OriGene CRISPR knockouts for DUS1L
- genomics-online: gRNA clones - Search results for available DUS1L gene related products
- Applied Biological Materials CRISPR for DUS1L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUS1L
- GenScript: Design CRISPR guide RNA sequences for DUS1L
miRNA Products
- Search ViGene Biosciences for DUS1L
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DUS1L
- Browse OriGene Inhibitory RNA Products For DUS1L
- genomics-online: shRNA clones - Search results for available DUS1L gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DUS1L gene
Clone Products
- Sino Biological Human cDNA Clone for DUS1L
- VectorBuilder custom plasmid, inducible vectors for DUS1L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DUS1L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available DUS1L gene related products
- orf clones - Search results for available DUS1L gene related products
- Applied Biological Materials Clones for DUS1L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 14b | · | 14c |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: |
Expression for DUS1L Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Lung (37.2), Peripheral blood mononuclear cells (12.2), and CD8 Tcells (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DUS1L Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DUS1L Gene:
DUS1LSOURCE GeneReport for Unigene cluster for DUS1L Gene:
Hs.514599Evidence on tissue expression from TISSUES for DUS1L Gene
- Nervous system(4.7)
- Intestine(4.4)
- Pancreas(4.3)
- Lung(2.2)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs for DUS1L
- genomics-online: primer clones - Search results for available DUS1L gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUS1L Gene
Orthologs for DUS1L Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DUS1L 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | DUS1L 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | DUS1L 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Dus1l 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pp3111 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DUS1L 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DUS1L 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | DUS1L 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dus1l 33 |
|
||
| Str.1993 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24034 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dus1l 33 34 |
|
||
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG3645 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008484 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | F36A2.2 33 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DUS1 34 36 |
|
OneToOne | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G67220 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0712900 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6459 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.8130 33 |
|
- Species where no ortholog for DUS1L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for DUS1L Gene
(2) SIMAP similar genes for DUS1L Gene using alignment to 10 proteins:
Pseudogenes.org Pseudogenes for DUS1L Gene
No data available for Paralogs for DUS1L Gene
Variants for DUS1L Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000871419 | -- | 82,065,975(-) | G/A | upstream_transcript_variant | |
| rs1000903772 | -- | 82,065,025(-) | C/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1001096022 | -- | 82,065,260(-) | C/A/T | intron_variant | |
| rs1001435731 | -- | 82,059,088(-) | T/C | intron_variant | |
| rs1001618553 | -- | 82,059,409(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv21913 | CNV | gain+loss | 19812545 |
| nsv428351 | CNV | gain | 18775914 |
| nsv457975 | CNV | loss | 19166990 |
| nsv457976 | CNV | gain | 19166990 |
| nsv470620 | CNV | loss | 18288195 |
| nsv470621 | CNV | gain | 18288195 |
| nsv576183 | CNV | loss | 21841781 |
| nsv576187 | CNV | gain | 21841781 |
| nsv576188 | CNV | loss | 21841781 |
| nsv952392 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.18;
51.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DUS1L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DUS1L
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUS1L Gene
Disorders for DUS1L Gene
Additional Disease Information for DUS1L
No disorders were found for DUS1L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUS1L Gene
Publications for DUS1L Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
- Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 58
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- VectorBuilder custom plasmid, inducible vectors for DUS1L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DUS1L
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 38 available DUS1L Antibodies ranked by validation data
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- antibodies-online: Search results for available DUS1L related products ranked by validation data
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- ViGene Biosciences adenoviral particle packaged cDNA for DUS1L gene
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Sources for DUS1L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
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