Aliases for DUPD1 Gene

Aliases for DUPD1 Gene

  • Dual Specificity Phosphatase And Pro Isomerase Domain Containing 1 2 3 5
  • Dual Specificity Phosphatase DUPD1 3 4
  • Dual Specificity Phosphatase 27 3 4
  • DUSP27 3 4
  • Atypical Dual-Specific Protein Phosphatase 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • FMDSP 3

External Ids for DUPD1 Gene

Previous GeneCards Identifiers for DUPD1 Gene

  • GC10M076142
  • GC10M076467
  • GC10U900628
  • GC10M076797
  • GC10M070796

Summaries for DUPD1 Gene

GeneCards Summary for DUPD1 Gene

DUPD1 (Dual Specificity Phosphatase And Pro Isomerase Domain Containing 1) is a Protein Coding gene. Diseases associated with DUPD1 include Genitopatellar Syndrome and Variola Major. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP27.

UniProtKB/Swiss-Prot Summary for DUPD1 Gene

  • Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

Additional gene information for DUPD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUPD1 Gene

Genomics for DUPD1 Gene

GeneHancer (GH) Regulatory Elements for DUPD1 Gene

Promoters and enhancers for DUPD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J075058 Promoter/Enhancer 1 EPDnew Ensembl 500.4 +15.1 15078 1.7 SIX5 ZNF263 ZNF341 DEAF1 NFIC CREB3L1 HCFC1 FOS GABPB1 ETS1 DUPD1 DUSP13 ZNF503 lnc-DUSP13-1 LOC101929165
GH10J075073 Promoter 0.3 EPDnew 509.6 0.0 -28 0.1 DUPD1 lnc-SAMD8-2 LOC101929165
GH10J075135 Enhancer 1.2 Ensembl ENCODE dbSUPER 11 -64.0 -63996 3.7 FOS PHB2 ZBTB5 ZBTB11 CTBP1 JUN TAF9B NCOR1 MBD2 WT1 ZNF503-AS1 DUPD1 PPIAP13 RPS26P42 lnc-VDAC2-3 piR-37404 SAMD8 LOC101929165
GH10J075222 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 10 -151.5 -151459 5.3 TEAD4 TEAD1 POLR2A NR2F2 KLF9 FOXA2 ZBTB17 SAP130 NANOG TCF12 ZNF503-AS1 DUPD1 COMTD1 VDAC2 PPIAP13 lnc-COMTD1-6
GH10J074921 Enhancer 1.1 Ensembl ENCODE 10.1 +148.1 148131 9.8 ZNF217 ZSCAN5C TCF12 JUND PHB2 FOS ZNF639 ZNF10 ZIC2 TRIM28 RF00017-708 KAT6B ENSG00000227186 ENSG00000234149 DUPD1 ADK LOC101929165
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUPD1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUPD1

Top Transcription factor binding sites by QIAGEN in the DUPD1 gene promoter:
  • AML1a
  • c-Myb
  • C/EBPalpha
  • En-1
  • MZF-1
  • Pax-2
  • Pax-2a
  • Pax-2b
  • Pax-6

Genomic Locations for DUPD1 Gene

Genomic Locations for DUPD1 Gene
chr10:75,037,472-75,073,632
(GRCh38/hg38)
Size:
36,161 bases
Orientation:
Minus strand
chr10:76,797,594-76,818,272
(GRCh37/hg19)
Size:
20,679 bases
Orientation:
Minus strand

Genomic View for DUPD1 Gene

Genes around DUPD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUPD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUPD1 Gene

Proteins for DUPD1 Gene

  • Protein details for DUPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68J44-DUPD1_HUMAN
    Recommended name:
    Dual specificity phosphatase DUPD1
    Protein Accession:
    Q68J44
    Secondary Accessions:
    • B2RP93

    Protein attributes for DUPD1 Gene

    Size:
    220 amino acids
    Molecular mass:
    25336 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DUPD1 Gene

neXtProt entry for DUPD1 Gene

Post-translational modifications for DUPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUPD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUPD1 Gene

Domains & Families for DUPD1 Gene

Gene Families for DUPD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DUPD1 Gene

Suggested Antigen Peptide Sequences for DUPD1 Gene

GenScript: Design optimal peptide antigens:
  • Dual specificity phosphatase 27 (DUPD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q68J44

UniProtKB/Swiss-Prot:

DUPD1_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUPD1: view

Function for DUPD1 Gene

Molecular function for DUPD1 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.02 mM for para-nitrophenylphosphate (at pH 5.5) {ECO:0000269 PubMed:17498703}; Note=kcat is 0.330 sec(-1) for para-nitrophenylphosphate. {ECO:0000269 PubMed:17498703};

Enzyme Numbers (IUBMB) for DUPD1 Gene

Phenotypes From GWAS Catalog for DUPD1 Gene

Gene Ontology (GO) - Molecular Function for DUPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IDA 17498703
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
GO:0042803 protein homodimerization activity IDA 21543850
genes like me logo Genes that share ontologies with DUPD1: view
genes like me logo Genes that share phenotypes with DUPD1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUPD1 Gene

Localization for DUPD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUPD1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUPD1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DUPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0032991 protein-containing complex IDA 21543850
genes like me logo Genes that share ontologies with DUPD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DUPD1 Gene

Pathways & Interactions for DUPD1 Gene

PathCards logo

SuperPathways for DUPD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IDA 17498703
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUPD1: view

No data available for Pathways by source and SIGNOR curated interactions for DUPD1 Gene

Drugs & Compounds for DUPD1 Gene

(2) Drugs for DUPD1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with DUPD1: view

Transcripts for DUPD1 Gene

mRNA/cDNA for DUPD1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUPD1 Gene

No ASD Table

Relevant External Links for DUPD1 Gene

GeneLoc Exon Structure for
DUPD1

Expression for DUPD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUPD1 Gene

mRNA differential expression in normal tissues according to GTEx for DUPD1 Gene

This gene is overexpressed in Muscle - Skeletal (x50.5).

Protein differential expression in normal tissues from HIPED for DUPD1 Gene

This gene is overexpressed in Bone (58.1) and Heart (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUPD1 Gene



Protein tissue co-expression partners for DUPD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUPD1

SOURCE GeneReport for Unigene cluster for DUPD1 Gene:

Hs.535090
genes like me logo Genes that share expression patterns with DUPD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUPD1 Gene

Orthologs for DUPD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUPD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUPD1 31 30
  • 99.09 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dupd1 17 31 30
  • 86.33 (n)
rat
(Rattus norvegicus)
Mammalia Dupd1 30
  • 85.69 (n)
cow
(Bos Taurus)
Mammalia DUPD1 31
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUPD1 31
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUPD1 31
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUPD1 31 30
  • 71.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUPD1 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dupd1 30
  • 68.06 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:136906 30
  • 67.06 (n)
DUPD1 (5 of 12) 31
  • 55 (a)
OneToMany
DUPD1 (10 of 12) 31
  • 40 (a)
OneToMany
DUPD1 (7 of 12) 31
  • 36 (a)
OneToMany
DUPD1 (2 of 12) 31
  • 35 (a)
OneToMany
DUPD1 (6 of 12) 31
  • 31 (a)
OneToMany
DUPD1 (4 of 12) 31
  • 26 (a)
OneToMany
DUPD1 (9 of 12) 31
  • 22 (a)
OneToMany
DUPD1 (11 of 12) 31
  • 22 (a)
OneToMany
DUPD1 (8 of 12) 31
  • 20 (a)
OneToMany
DUPD1 (12 of 12) 31
  • 20 (a)
OneToMany
DUPD1 (1 of 12) 31
  • 19 (a)
OneToMany
DUPD1 (3 of 12) 31
  • 16 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7378 31
  • 37 (a)
OneToMany
Species where no ortholog for DUPD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUPD1 Gene

ENSEMBL:
Gene Tree for DUPD1 (if available)
TreeFam:
Gene Tree for DUPD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUPD1: view image

Paralogs for DUPD1 Gene

(4) SIMAP similar genes for DUPD1 Gene using alignment to 1 proteins:

  • DUPD1_HUMAN
genes like me logo Genes that share paralogs with DUPD1: view

Variants for DUPD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUPD1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
637031 Pathogenic: Young Simpson syndrome 75,029,988(-) A/AC FRAMESHIFT_VARIANT
642582 Uncertain Significance: Genitopatellar syndrome 75,028,786(-) A/T MISSENSE_VARIANT
647581 Pathogenic: Genitopatellar syndrome 75,030,325(-) AC/A NONSENSE
802590 Likely Pathogenic: Genitopatellar syndrome 75,028,896(-) G/T NONSENSE
802591 Pathogenic: Genitopatellar syndrome 75,029,684(-) TG/T FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for DUPD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DUPD1 Gene

Variant ID Type Subtype PubMed ID
dgv926n100 CNV gain 25217958
dgv927n100 CNV gain 25217958
nsv7188 CNV insertion 18451855

Variation tolerance for DUPD1 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.71; 78.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUPD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUPD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUPD1 Gene

Disorders for DUPD1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DUPD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
genitopatellar syndrome
  • gps
variola major
  • smallpox
- elite association - COSMIC cancer census association via MalaCards
Search DUPD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DUPD1

genes like me logo Genes that share disorders with DUPD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUPD1 Gene

Publications for DUPD1 Gene

  1. Identification and characterization of DUSP27, a novel dual-specific protein phosphatase. (PMID: 17498703) Friedberg I … Mustelin T (FEBS letters 2007) 3 4 23 54
  2. Structure of human dual-specificity phosphatase 27 at 2.38 Å resolution. (PMID: 21543850) Lountos GT … Waugh DS (Acta crystallographica. Section D, Biological crystallography 2011) 3 4 54
  3. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. (PMID: 19851299) Johansson A … EUROSPAN Consortium (Obesity (Silver Spring, Md.) 2010) 3 41 54
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 54
  5. De Novo 1.77-Mb Microdeletion of 10q22.2q22.3 in a Girl With Developmental Delay, Speech Delay, Congenital Cleft Palate, and Bilateral Hearing Impairment. (PMID: 27031267) Lei TY … Liao C (The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2017) 3 54

Products for DUPD1 Gene

Sources for DUPD1 Gene