Aliases for DUOX2 Gene
External Ids for DUOX2 Gene
Previous GeneCards Identifiers for DUOX2 Gene
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]
GeneCards Summary for DUOX2 Gene
DUOX2 (Dual Oxidase 2) is a Protein Coding gene. Diseases associated with DUOX2 include Thyroid Dyshormonogenesis 6 and Familial Thyroid Dyshormonogenesis. Among its related pathways are Nucleotide-binding Oligomerization Domain (NOD) pathway and Metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heme binding. An important paralog of this gene is DUOX1.
UniProtKB/Swiss-Prot Summary for DUOX2 Gene
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.