DUOX1 Gene (Protein Coding)

Dual Oxidase 1

GC15P045129
GIFtS:
42
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2... See more...

Aliases for DUOX1 Gene

Aliases for DUOX1 Gene

  • Dual Oxidase 1 2 3 4 5
  • NADPH Thyroid Oxidase 1 2 3 4
  • LNOX1 2 3 4
  • THOX1 2 3 4
  • Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 3
  • Flavoprotein NADPH Oxidase 2 3
  • Thyroid Oxidase 1 3 4
  • Large NOX 1 3 4
  • Long NOX 1 3 4
  • NOXEF1 2 3
  • EC 1.11.1.- 4
  • EC 1.6.3.1 4
  • DUOX1 5
  • DUOX 4

External Ids for DUOX1 Gene

Previous GeneCards Identifiers for DUOX1 Gene

  • GC15P040980
  • GC15P038469
  • GC15P043001
  • GC15P043138
  • GC15P043209
  • GC15P045422
  • GC15P022246

Summaries for DUOX1 Gene

Entrez Gene Summary for DUOX1 Gene

  • The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for DUOX1 Gene

DUOX1 (Dual Oxidase 1) is a Protein Coding gene. Diseases associated with DUOX1 include Congenital Hypothyroidism and Granulomatous Disease, Chronic, Autosomal Recessive, 4. Among its related pathways are Aldosterone synthesis and secretion and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heme binding. An important paralog of this gene is DUOX2.

UniProtKB/Swiss-Prot Summary for DUOX1 Gene

  • Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.

Gene Wiki entry for DUOX1 Gene

Additional gene information for DUOX1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DUOX1 Gene

Genomics for DUOX1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for DUOX1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DUOX1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DUOX1

Top Transcription factor binding sites by QIAGEN in the DUOX1 gene promoter:
  • AP-1
  • C/EBPalpha
  • ER-alpha
  • GR
  • GR-alpha
  • GR-beta
  • HEN1
  • IRF-1
  • p53
  • PPAR-gamma1

Genomic Locations for DUOX1 Gene

Latest Assembly
chr15:45,129,933-45,165,578
(GRCh38/hg38)
Size:
35,646 bases
Orientation:
Plus strand

Previous Assembly
chr15:45,422,192-45,457,772
(GRCh37/hg19 by Entrez Gene)
Size:
35,581 bases
Orientation:
Plus strand

chr15:45,422,131-45,457,774
(GRCh37/hg19 by Ensembl)
Size:
35,644 bases
Orientation:
Plus strand

Genomic View for DUOX1 Gene

Genes around DUOX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUOX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUOX1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DUOX1 Gene

Proteins for DUOX1 Gene

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  • Protein details for DUOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRD9-DUOX1_HUMAN
    Recommended name:
    Dual oxidase 1
    Protein Accession:
    Q9NRD9
    Secondary Accessions:
    • A6NH28
    • Q14C94
    • Q6ZMB3
    • Q6ZR09
    • Q9NZC1

    Protein attributes for DUOX1 Gene

    Size:
    1551 amino acids
    Molecular mass:
    177235 Da
    Quaternary structure:
    • Interacts with TXNDC11, TPO and CYBA.
    SequenceCaution:
    • Sequence=AK128591; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=BAD18816.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DUOX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUOX1 Gene

Protein Expression for DUOX1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DUOX1 Gene

Other Protein References for DUOX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for DUOX1
  • Santa Cruz Biotechnology (SCBT) Antibodies for DUOX1

No data available for DME Specific Peptides for DUOX1 Gene

Domains & Families for DUOX1 Gene

Gene Families for DUOX1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for DUOX1 Gene

InterPro:
Blocks:
  • Ferric reductase-like transmembrane component, N-terminal
  • Haem peroxidase
ProtoNet:

Suggested Antigen Peptide Sequences for DUOX1 Gene

GenScript: Design optimal peptide antigens:
  • Thyroid oxidase 1 (DUOX1_HUMAN)
  • Dual oxidase 1 (Q14C85_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NRD9

UniProtKB/Swiss-Prot:

DUOX1_HUMAN :
  • In the N-terminal section; belongs to the peroxidase family.
Family:
  • In the N-terminal section; belongs to the peroxidase family.
genes like me logo Genes that share domains with DUOX1: view

Function for DUOX1 Gene

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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for DUOX1 Gene

UniProtKB/Swiss-Prot Function:
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + NADH + O2 = H2O2 + NAD(+); Xref=Rhea:RHEA:11264, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.3.1; Evidence={ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:15972824};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + NADPH + O2 = H2O2 + NADP(+); Xref=Rhea:RHEA:11260, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.6.3.1; Evidence={ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:15972824};.
UniProtKB/Swiss-Prot Induction:
By forskolin (at protein level). By thyrotropin and the Th2-specific cytokines IL-4 and IL-13.
UniProtKB/Swiss-Prot EnzymeRegulation:
The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide.

Enzyme Numbers (IUBMB) for DUOX1 Gene

Phenotypes From GWAS Catalog for DUOX1 Gene

Gene Ontology (GO) - Molecular Function for DUOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 19339556
GO:0016174 NAD(P)H oxidase activity NAS 10806195
GO:0016175 superoxide-generating NADPH oxidase activity IBA 21873635
genes like me logo Genes that share ontologies with DUOX1: view
genes like me logo Genes that share phenotypes with DUOX1: view

Animal Models for research

  • Taconic Biosciences Mouse Models for DUOX1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUOX1

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUOX1 Gene

Localization for DUOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUOX1 Gene

Apical cell membrane. Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUOX1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
extracellular 3
mitochondrion 3
cytosol 3
cytoskeleton 2
peroxisome 2
nucleus 2
endosome 2
lysosome 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DUOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 19339556
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IGI 22814254
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DUOX1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DUOX1 Gene

Pathways & Interactions for DUOX1 Gene

genes like me logo Genes that share pathways with DUOX1: view

Pathways by source for DUOX1 Gene

1 KEGG pathway for DUOX1 Gene

UniProtKB/Swiss-Prot Q9NRD9-DUOX1_HUMAN

  • Pathway: Hormone biosynthesis; thyroid hormone biosynthesis.

SIGNOR curated interactions for DUOX1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DUOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006590 thyroid hormone generation TAS --
GO:0006952 defense response IBA 21873635
GO:0006979 response to oxidative stress IEA --
GO:0019221 cytokine-mediated signaling pathway IDA 16111680
GO:0042335 cuticle development IMP 11514595
genes like me logo Genes that share ontologies with DUOX1: view

Drugs & Compounds for DUOX1 Gene

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(7) Drugs for DUOX1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
FAD Approved Pharma 0
Hydrogen peroxide Approved, Vet_approved Pharma 140
NADPH Experimental Pharma 0
NAD Experimental Pharma 0

(3) Additional Compounds for DUOX1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DUOX1: view

Transcripts for DUOX1 Gene

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mRNA/cDNA for DUOX1 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUOX1

Alternative Splicing Database (ASD) splice patterns (SP) for DUOX1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1:
SP2:
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9: -
SP10:

ExUns: 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for DUOX1 Gene

GeneLoc Exon Structure for
DUOX1

Expression for DUOX1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUOX1 Gene

mRNA expression in normal human tissues for DUOX1 Gene
mRNA expression by BioGPS for DUOX1 GenemRNA expression by GTEx for DUOX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUOX1 Gene

This gene is overexpressed in Esophagus - Mucosa (x8.8), Lung (x7.4), Thyroid (x6.3), Skin - Not Sun Exposed (Suprapubic) (x4.7), Stomach (x4.6), and Skin - Sun Exposed (Lower leg) (x4.5).

Protein differential expression in normal tissues from HIPED for DUOX1 Gene

This gene is overexpressed in Nasal epithelium (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUOX1 Gene



Protein tissue co-expression partners for DUOX1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DUOX1

SOURCE GeneReport for Unigene cluster for DUOX1 Gene:

Hs.272813

mRNA Expression by UniProt/SwissProt for DUOX1 Gene:

Q9NRD9-DUOX1_HUMAN
Tissue specificity: Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.

Evidence on tissue expression from TISSUES for DUOX1 Gene

  • Thyroid gland(4.6)
  • Lung(4.6)
  • Skin(2.9)
  • Blood(2.7)
  • Heart(2.7)
  • Intestine(2.5)
  • Stomach(2.4)
  • Nervous system(2.4)
  • Kidney(2.4)
  • Liver(2.3)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with DUOX1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DUOX1 Gene

Orthologs for DUOX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUOX1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia DUOX1 30 31
  • 99.42 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia DUOX1 30 31
  • 89.64 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia DUOX1 30 31
  • 89.58 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Duox1 30 17 31
  • 87.28 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Duox1 30
  • 86.76 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 86 (a)
 ManyToMany
-- 31
  • 74 (a)
 ManyToMany
Oppossum
(Monodelphis domestica)
 Mammalia DUOX1 31
  • 82 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves DUOX2 30
  • 70.46 (n)
-- 31
  • 66 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 56 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia duox1 30
  • 62.36 (n)
Zebrafish
(Danio rerio)
 Actinopterygii duox 30 31
  • 60.61 (n)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta Duox 31
  • 39 (a)
 OneToMany
CG3131 32
  • 39 (a)
Worm
(Caenorhabditis elegans)
 Secernentea bli-3 31
  • 35 (a)
 ManyToMany
duox-2 31
  • 34 (a)
 ManyToMany
F56C11.1 32
  • 34 (a)
F53G12.3 32
  • 33 (a)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons RBOHA 30
  • 45.96 (n)
Rice
(Oryza sativa)
 Liliopsida Os01g0360200 30
  • 45.13 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 44 (a)
 OneToMany
Species where no ortholog for DUOX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DUOX1 Gene

ENSEMBL:
Gene Tree for DUOX1 (if available)
TreeFam:
Gene Tree for DUOX1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DUOX1: view image

Paralogs for DUOX1 Gene

Paralogs for DUOX1 Gene

(6) SIMAP similar genes for DUOX1 Gene using alignment to 5 proteins:

  • DUOX1_HUMAN
  • H0YK19_HUMAN
  • H0YNR5_HUMAN
  • L8ECP1_HUMAN
  • Q14C85_HUMAN

Pseudogenes.org Pseudogenes for DUOX1 Gene

genes like me logo Genes that share paralogs with DUOX1: view

Variants for DUOX1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DUOX1 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs113761790 Likely Benign: not provided 45,164,770(+) C/T
NM_175940.3(DUOX1):c.4534-9C>T 		INTRON
rs114272662 Benign: not provided 45,152,374(+) T/C
NM_175940.3(DUOX1):c.3282T>C (p.Ser1094=) 		SYNONYMOUS
rs140249290 Benign: not provided 45,142,087(+) C/T
NM_175940.3(DUOX1):c.1797C>T (p.Ile599=) 		SYNONYMOUS
rs141582627 Benign: not provided 45,153,993(+) C/T
NM_175940.3(DUOX1):c.3567C>T (p.Thr1189=) 		SYNONYMOUS
rs142271080 Benign: not provided 45,139,607(+) G/A
NM_175940.3(DUOX1):c.1389+8G>A 		INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DUOX1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DUOX1 Gene

Variant ID Type Subtype PubMed ID
esv1002924 CNV deletion 20482838
esv2760029 CNV gain+loss 17122850
esv3406380 CNV insertion 20981092
esv3414549 CNV insertion 20981092
nsv457125 CNV loss 19166990
nsv518213 CNV gain 19592680
nsv520580 CNV loss 19592680
nsv569312 CNV loss 21841781
nsv569313 CNV gain 21841781
nsv569314 CNV loss 21841781
nsv569315 CNV gain 21841781

Variation tolerance for DUOX1 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.65; 93.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUOX1 Gene

Human Gene Mutation Database (HGMD)
DUOX1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUOX1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUOX1 Gene

Disorders for DUOX1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for DUOX1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
congenital hypothyroidism
  • neonatal hypothyroidism
granulomatous disease, chronic, autosomal recessive, 4
  • cgd4
phagocyte bactericidal dysfunction
  • phagocytic dysfunction
cardiomyopathy, familial hypertrophic, 2
  • cmh2
allergic disease
  • allergic hypersensitivity disease
- elite association - COSMIC cancer census association via MalaCards
Search DUOX1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DUOX1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DUOX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUOX1 Gene

Publications for DUOX1 Gene

  1. Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. (PMID: 10806195) De Deken X … Miot F (The Journal of biological chemistry 2000) 2 3 4 23
  2. Genetic polymorphisms and susceptibility to lung disease. (PMID: 16608528) Lee PL … Wang L (Journal of negative results in biomedicine 2006) 3 23 41
  3. Identification of a novel partner of duox: EFP1, a thioredoxin-related protein. (PMID: 15561711) Wang D … Miot F (The Journal of biological chemistry 2005) 3 4 23
  4. Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity. (PMID: 15972824) Ameziane-El-Hassani R … Dupuy C (The Journal of biological chemistry 2005) 3 4 23
  5. Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. (PMID: 16111680) Harper RW … Wu R (FEBS letters 2005) 3 4 23

ExternalLinks

View latest publications for DUOX1 gene in Mastermind

Products for DUOX1 Gene

Sources for DUOX1 Gene