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DUOX1 Gene(Protein Coding)

Dual Oxidase 1

GCID:
GC15P045129
GIFtS:
49
Genes Participants
UDN Logo

Aliases for DUOX1 Gene

Aliases for DUOX1 Gene

  • Dual Oxidase 1 2 3 5
  • NADPH Thyroid Oxidase 1 2 3 4
  • Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 3
  • Flavoprotein NADPH Oxidase 2 3
  • Thyroid Oxidase 1 3 4
  • Large NOX 1 3 4
  • Long NOX 1 3 4
  • LNOX1 3 4
  • THOX1 3 4
  • EC 1.11.1.- 4
  • EC 1.6.3.1 4
  • NOXEF1 3
  • DUOX 4

External Ids for DUOX1 Gene

Previous GeneCards Identifiers for DUOX1 Gene

  • GC15P040980
  • GC15P038469
  • GC15P043001
  • GC15P043138
  • GC15P043209
  • GC15P045422
  • GC15P022246

Summaries for DUOX1 Gene

Entrez Gene Summary for DUOX1 Gene

  • The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for DUOX1 Gene

DUOX1 (Dual Oxidase 1) is a Protein Coding gene. Diseases associated with DUOX1 include Congenital Hypothyroidism and Phagocyte Bactericidal Dysfunction. Among its related pathways are Viral mRNA Translation and Amine-derived hormones. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heme binding. An important paralog of this gene is DUOX2.

UniProtKB/Swiss-Prot for DUOX1 Gene

  • Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.

Gene Wiki entry for DUOX1 Gene

Additional gene information for DUOX1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUOX1 Gene

Genomics for DUOX1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for DUOX1 Gene

Promoters and enhancers for DUOX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH15I045130 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 558.5 +0.6 575 1.3 ATF2 ZFX EZH2 DUOX1 DUOXA1 PIR49799 ENSG00000259539
GH15I045129 Promoter/Enhancer 0.9 EPDnew dbSUPER 550.8 -0.1 -107 0.1 ZFX EZH2 DUOX1 DUOXA1 PIR49799 PIR50334
GH15I045197 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.6 +70.0 69993 4.3 MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 NFYC MEF2D SHF ENSG00000259932 TRH-GTG1-9 TRH-GTG1-8 TRH-GTG1-7 CTDSPL2 SPATA5L1 SPG11 ENSG00000259563 DUOX1
GH15I045185 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 10.9 +57.5 57531 3.1 HDGF PKNOX1 ARID4B SIN3A IRF4 ZNF48 ATF7 RUNX3 RXRA REST SHF DUOX1 DUOXA1 LOC101928414 TRH-GTG1-7 ENSG00000259519
GH15I045165 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 11.3 +37.9 37919 4.7 HDGF PKNOX1 ATF1 SIN3A FEZF1 YY1 TCF12 POLR2B ZNF766 ZNF207 ENSG00000259539 DUOXA1 CTDSPL2 SPG11 SHF ENSG00000259563 DUOX1 SPATA5L1 SLC28A2 DUOX2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DUOX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DUOX1 gene promoter:

Genomic Locations for DUOX1 Gene

Genomic Locations for DUOX1 Gene
chr15:45,129,933-45,165,578
(GRCh38/hg38)
Size:
35,646 bases
Orientation:
Plus strand
chr15:45,422,131-45,457,774
(GRCh37/hg19)

Genomic View for DUOX1 Gene

Genes around DUOX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUOX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUOX1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DUOX1 Gene

Proteins for DUOX1 Gene

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  1. Antibody
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  • Protein details for DUOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRD9-DUOX1_HUMAN
    Recommended name:
    Dual oxidase 1
    Protein Accession:
    Q9NRD9
    Secondary Accessions:
    • A6NH28
    • Q14C94
    • Q6ZMB3
    • Q6ZR09
    • Q9NZC1

    Protein attributes for DUOX1 Gene

    Size:
    1551 amino acids
    Molecular mass:
    177235 Da
    Quaternary structure:
    • Interacts with TXNDC11, TPO and CYBA.
    SequenceCaution:
    • Sequence=AK128591; Type=Erroneous termination; Positions=967; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=BAD18816.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DUOX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUOX1 Gene

Protein Expression for DUOX1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DUOX1 Gene

  • N-glycosylated.
  • Glycosylation at posLast=9494, Asn342, Asn354, posLast=461461, and Asn534
  • Modification sites at PhosphoSitePlus

Other Protein References for DUOX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUOX1 Gene

Domains & Families for DUOX1 Gene

Gene Families for DUOX1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for DUOX1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DUOX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRD9

UniProtKB/Swiss-Prot:

DUOX1_HUMAN :
  • In the N-terminal section; belongs to the peroxidase family.
Family:
  • In the N-terminal section; belongs to the peroxidase family.
genes like me logo Genes that share domains with DUOX1: view

Function for DUOX1 Gene

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  2. CRISPR
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  6. Cell Line

Molecular function for DUOX1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).
UniProtKB/Swiss-Prot EnzymeRegulation:
The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide.
UniProtKB/Swiss-Prot Function:
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
UniProtKB/Swiss-Prot Induction:
By forskolin (at protein level). By thyrotropin and the Th2-specific cytokines IL-4 and IL-13.

Enzyme Numbers (IUBMB) for DUOX1 Gene

Gene Ontology (GO) - Molecular Function for DUOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0016174 NAD(P)H oxidase activity TAS --
GO:0016491 oxidoreductase activity IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with DUOX1: view

Phenotypes for DUOX1 Gene

GenomeRNAi human phenotypes for DUOX1:
genes like me logo Genes that share phenotypes with DUOX1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUOX1

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUOX1 Gene

Localization for DUOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUOX1 Gene

Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUOX1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for DUOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane NAS 10806195
genes like me logo Genes that share ontologies with DUOX1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DUOX1 Gene

Pathways & Interactions for DUOX1 Gene

genes like me logo Genes that share pathways with DUOX1: view

Pathways by source for DUOX1 Gene

UniProtKB/Swiss-Prot Q9NRD9-DUOX1_HUMAN

  • Pathway: Hormone biosynthesis; thyroid hormone biosynthesis.

Gene Ontology (GO) - Biological Process for DUOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006590 thyroid hormone generation TAS --
GO:0006979 response to oxidative stress IEA --
GO:0019221 cytokine-mediated signaling pathway IDA 16111680
GO:0042335 cuticle development IMP 11514595
GO:0042446 hormone biosynthetic process IEA --
genes like me logo Genes that share ontologies with DUOX1: view

No data available for SIGNOR curated interactions for DUOX1 Gene

Drugs & Compounds for DUOX1 Gene

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  1. Drug

(6) Drugs for DUOX1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
FAD Approved Pharma 0
Hydrogen peroxide Approved, Vet_approved Pharma 73
calcium Approved Nutra 0
NAD Pharma Full agonist, Agonist 0

(4) Additional Compounds for DUOX1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
 53-57-6
genes like me logo Genes that share compounds with DUOX1: view

Transcripts for DUOX1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DUOX1 Gene

(4) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(59) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUOX1 Gene

Dual oxidase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUOX1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1:
SP2:
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9: -
SP10:

ExUns: 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for DUOX1 Gene

GeneLoc Exon Structure for
DUOX1
ECgene alternative splicing isoforms for
DUOX1

Expression for DUOX1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUOX1 Gene

mRNA expression in normal human tissues for DUOX1 Gene
mRNA expression by BioGPS for DUOX1 GenemRNA expression by GTEx for DUOX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUOX1 Gene

This gene is overexpressed in Esophagus - Mucosa (x8.8), Lung (x7.4), Thyroid (x6.3), Skin - Not Sun Exposed (Suprapubic) (x4.7), Stomach (x4.6), and Skin - Sun Exposed (Lower leg) (x4.5).

Protein differential expression in normal tissues from HIPED for DUOX1 Gene

This gene is overexpressed in Nasal epithelium (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUOX1 Gene



Protein tissue co-expression partners for DUOX1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUOX1 Gene:

DUOX1

SOURCE GeneReport for Unigene cluster for DUOX1 Gene:

Hs.272813

mRNA Expression by UniProt/SwissProt for DUOX1 Gene:

Q9NRD9-DUOX1_HUMAN
Tissue specificity: Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.

Evidence on tissue expression from TISSUES for DUOX1 Gene

  • Thyroid gland(4.6)
  • Lung(4.5)
  • Blood(2.4)
  • Skin(2.3)
  • Heart(2.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with DUOX1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DUOX1 Gene

Orthologs for DUOX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUOX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DUOX1 33 34
  • 99.42 (n)
cow
(Bos Taurus)
 Mammalia DUOX1 33 34
  • 89.64 (n)
dog
(Canis familiaris)
 Mammalia DUOX1 33 34
  • 89.58 (n)
mouse
(Mus musculus)
 Mammalia Duox1 33 16 34
  • 87.28 (n)
rat
(Rattus norvegicus)
 Mammalia Duox1 33
  • 86.76 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 86 (a)
 ManyToMany
-- 34
  • 74 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia DUOX1 34
  • 82 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves DUOX2 33
  • 70.46 (n)
-- 34
  • 66 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 56 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia duox1 33
  • 62.36 (n)
zebrafish
(Danio rerio)
 Actinopterygii duox 33 34
  • 60.61 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG3131 35
  • 39 (a)
Duox 34
  • 39 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea bli-3 34
  • 35 (a)
 ManyToMany
F56C11.1 35
  • 34 (a)
duox-2 34
  • 34 (a)
 ManyToMany
F53G12.3 35
  • 33 (a)
thale cress
(Arabidopsis thaliana)
 eudicotyledons RBOHA 33
  • 45.96 (n)
rice
(Oryza sativa)
 Liliopsida Os01g0360200 33
  • 45.13 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 44 (a)
 OneToMany
Species where no ortholog for DUOX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUOX1 Gene

ENSEMBL:
Gene Tree for DUOX1 (if available)
TreeFam:
Gene Tree for DUOX1 (if available)

Paralogs for DUOX1 Gene

Paralogs for DUOX1 Gene

(6) SIMAP similar genes for DUOX1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for DUOX1 Gene

genes like me logo Genes that share paralogs with DUOX1: view

Variants for DUOX1 Gene

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Sequence variations from dbSNP and Humsavar for DUOX1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs760297837 benign, not specified 45,153,494(+) AT/ intron_variant
rs1000072131 -- 45,145,431(+) T/C intron_variant
rs1000090683 -- 45,152,863(+) A/C intron_variant
rs1000173854 -- 45,163,449(+) A/G intron_variant
rs1000210494 -- 45,128,723(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DUOX1 Gene

Variant ID Type Subtype PubMed ID
esv1002924 CNV deletion 20482838
esv2760029 CNV gain+loss 17122850
esv3406380 CNV insertion 20981092
esv3414549 CNV insertion 20981092
nsv457125 CNV loss 19166990
nsv518213 CNV gain 19592680
nsv520580 CNV loss 19592680
nsv569312 CNV loss 21841781
nsv569313 CNV gain 21841781
nsv569314 CNV loss 21841781
nsv569315 CNV gain 21841781

Variation tolerance for DUOX1 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.65; 93.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DUOX1 Gene

Human Gene Mutation Database (HGMD)
DUOX1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUOX1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUOX1 Gene

Disorders for DUOX1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DUOX1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
congenital hypothyroidism
  • cretinism
phagocyte bactericidal dysfunction
  • phagocytic dysfunction
adrenal rest tumor
  • adrenal rest neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search DUOX1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DUOX1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DUOX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUOX1 Gene

Publications for DUOX1 Gene

  1. Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. (PMID: 10806195) De Deken X … Miot F (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. Genetic polymorphisms and susceptibility to lung disease. (PMID: 16608528) Lee PL … Wang L (Journal of negative results in biomedicine 2006) 3 22 44 58
  3. Identification of a novel partner of duox: EFP1, a thioredoxin-related protein. (PMID: 15561711) Wang D … Miot F (The Journal of biological chemistry 2005) 3 4 22 58
  4. Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity. (PMID: 15972824) Ameziane-El-Hassani R … Dupuy C (The Journal of biological chemistry 2005) 3 4 22 58
  5. Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. (PMID: 16111680) Harper RW … Wu R (FEBS letters 2005) 3 4 22 58

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