Aliases for DUOX1 Gene
Aliases for DUOX1 Gene
External Ids for DUOX1 Gene
- HGNC: 3062
- Entrez Gene: 53905
- Ensembl: ENSG00000137857
- OMIM: 606758
- UniProtKB: Q9NRD9
Previous GeneCards Identifiers for DUOX1 Gene
- GC15P040980
- GC15P038469
- GC15P043001
- GC15P043138
- GC15P043209
- GC15P045422
- GC15P022246
Summaries for DUOX1 Gene
-
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for DUOX1 Gene
DUOX1 (Dual Oxidase 1) is a Protein Coding gene. Diseases associated with DUOX1 include Congenital Hypothyroidism and Phagocyte Bactericidal Dysfunction. Among its related pathways are Metabolism and Amine-derived hormones. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heme binding. An important paralog of this gene is DUOX2.
UniProtKB/Swiss-Prot for DUOX1 Gene
-
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUOX1 Gene
Genomics for DUOX1 Gene
GeneHancer (GH) Regulatory Elements for DUOX1 Gene
Promoters and enhancers for DUOX1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH15J045130 | Promoter/Enhancer | 1.1 | EPDnew ENCODE dbSUPER | 658.4 | +0.6 | 575 | 1.3 | ATF2 ZFX EZH2 | DUOX1 PIR49799 DUOXA1 DUOX2 ENSG00000259539 | |
| GH15J045131 | Promoter/Enhancer | 0.9 | EPDnew dbSUPER | 658.5 | -0.5 | -482 | 0.1 | SUZ12 EZH2 | DUOX1 PIR49799 DUOXA1 PIR50334 | |
| GH15J045129 | Promoter/Enhancer | 0.9 | EPDnew dbSUPER | 650.7 | -0.3 | -263 | 0.1 | SUZ12 EZH2 | PIR49799 DUOXA1 DUOX1 PIR50334 | |
| GH15J045197 | Promoter/Enhancer | 1.8 | Ensembl ENCODE dbSUPER | 12.6 | +70.0 | 69993 | 4.3 | MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 NFYC MEF2D | SHF TRH-GTG1-9 TRH-GTG1-8 TRH-GTG1-7 ENSG00000259932 CTDSPL2 ENSG00000259563 SPG11 SPATA5L1 DUOX1 | |
| GH15J045165 | Promoter/Enhancer | 1.7 | Ensembl ENCODE dbSUPER | 11.3 | +37.9 | 37919 | 4.7 | HDGF PKNOX1 ATF1 SIN3A FEZF1 YY1 TCF12 POLR2B ZNF766 ZNF207 | ENSG00000259539 DUOXA1 CTDSPL2 SPG11 SHF ENSG00000259563 DUOX1 SPATA5L1 SLC28A2 DUOX2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DUOX1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DUOX1 gene promoter:
Regulatory Element Products
Genomic Locations for DUOX1 Gene
Genomic Locations for DUOX1 Gene
- chr15:45,129,933-45,165,578
- (GRCh38/hg38)
- Size:
- 35,646 bases
- Orientation:
- Plus strand
- chr15:45,422,131-45,457,774
- (GRCh37/hg19)
Genomic View for DUOX1 Gene
Genes around DUOX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q21.1 by Entrez Gene
- 15q21.1 by HGNC
- 15q21.1 by Ensembl
DUOX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DUOX1 Gene
Proteins for DUOX1 Gene
-
Protein details for DUOX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NRD9-DUOX1_HUMAN
- Recommended name:
- Dual oxidase 1
- Protein Accession:
- Q9NRD9
- A6NH28
- Q14C94
- Q6ZMB3
- Q6ZR09
- Q9NZC1
Protein attributes for DUOX1 Gene
- Size:
- 1551 amino acids
- Molecular mass:
- 177235 Da
- Quaternary structure:
-
- Interacts with TXNDC11, TPO and CYBA.
- SequenceCaution:
-
- Sequence=AK128591; Type=Erroneous termination; Positions=967; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=BAD18816.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for DUOX1 Gene
Post-translational modifications for DUOX1 Gene
- N-glycosylated.
- Glycosylation at posLast=534534, Asn461, Asn354, posLast=342342, and posLast=9494
- Modification sites at PhosphoSitePlus
Other Protein References for DUOX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for DUOX1
- Invitrogen Antibodies for DUOX1
- GeneTex DUOX1 Antibody for DUOX1
-
Santa Cruz Biotechnology (SCBT) Antibodies for DUOX1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for DUOX1
- Origene Custom Protein Services for DUOX1
- Novus Biologicals proteins for DUOX1
- antibodies-online: Search results for 7 available DUOX1 Proteins ranked by validation data
- Compare Top DUOX1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for DUOX1
Assay Products
- antibodies-online: Search results for 5 available DUOX1 Elisa Kits ranked by validation data
- Compare Top DUOX1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for DUOX1 Gene
Domains & Families for DUOX1 Gene
Gene Families for DUOX1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
- Predicted secreted proteins
- Transporters
Protein Domains for DUOX1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DUOX1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NRD9- Family:
-
- In the N-terminal section; belongs to the peroxidase family.
Function for DUOX1 Gene
Molecular function for DUOX1 Gene
- UniProtKB/Swiss-Prot Function:
- Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
- UniProtKB/Swiss-Prot CatalyticActivity:
- NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide.
- UniProtKB/Swiss-Prot Induction:
- By forskolin (at protein level). By thyrotropin and the Th2-specific cytokines IL-4 and IL-13.
Enzyme Numbers (IUBMB) for DUOX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004601 | peroxidase activity | IEA | -- |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0016174 | NAD(P)H oxidase activity | TAS | -- |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0020037 | heme binding | IEA | -- |
Phenotypes for DUOX1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for DUOX1
- Cyagen custom Knockout/knockin (KOKI) mouse models for DUOX1
-
CRISPR Products
-
OriGene CRISPR knockouts for DUOX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUOX1
- genomics-online: gRNA clones - Search results for 79 available DUOX1 gene related products
- Overview of 79 available DUOX1 gene related products
- Applied Biological Materials CRISPR for DUOX1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUOX1
- GenScript: Design CRISPR guide RNA sequences for DUOX1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUOX1
- Browse OriGene Inhibitory RNA Products For DUOX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUOX1
- genomics-online: shRNA clones - Search results for 79 available DUOX1 gene related products
- Overview of 79 available DUOX1 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DUOX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DUOX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUOX1
- Applied Biological Materials Clones for DUOX1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DUOX1
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUOX1 Gene
Localization for DUOX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DUOX1 Gene
- Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0016324 | apical plasma membrane | NAS | 10806195 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for DUOX1 Gene
Pathways & Interactions for DUOX1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Amine-derived hormones | ||
| 2 | Metabolism |
.37
|
|
| 3 | Viral mRNA Translation | ||
Pathways by source for DUOX1 Gene
4 Reactome pathways for DUOX1 Gene
UniProtKB/Swiss-Prot Q9NRD9-DUOX1_HUMAN
- Pathway: Hormone biosynthesis; thyroid hormone biosynthesis.
Interacting Proteins for DUOX1 Gene
GPS-Prot Interaction Network for DUOX1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006590 | thyroid hormone generation | TAS | -- |
| GO:0006979 | response to oxidative stress | IEA | -- |
| GO:0019221 | cytokine-mediated signaling pathway | IDA | 16111680 |
| GO:0042335 | cuticle development | IMP | 11514595 |
| GO:0042446 | hormone biosynthetic process | IEA | -- |
No data available for SIGNOR curated interactions for DUOX1 Gene
Drugs & Compounds for DUOX1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| nadph |
|
53-57-6 |
Transcripts for DUOX1 Gene
mRNA/cDNA for DUOX1 Gene
- (59) Selected AceView cDNA sequences:
- (10) Additional mRNA sequences :
- (4) REFSEQ mRNAs :
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000321429 5738 bps (uc001zus.3)
- ENST00000389037 5483 bps (uc001zut.3)
- ENST00000557893 1548 bps (uc059iso.1)
- ENST00000558322 436 bps (uc059isj.1)
- ENST00000558446 536 bps (uc059isp.1)
CRISPR Products
-
OriGene CRISPR knockouts for DUOX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUOX1
- genomics-online: gRNA clones - Search results for 79 available DUOX1 gene related products
- Overview of 79 available DUOX1 gene related products
- Applied Biological Materials CRISPR for DUOX1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DUOX1
- GenScript: Design CRISPR guide RNA sequences for DUOX1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUOX1
- Browse OriGene Inhibitory RNA Products For DUOX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUOX1
- genomics-online: shRNA clones - Search results for 79 available DUOX1 gene related products
- Overview of 79 available DUOX1 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DUOX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DUOX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUOX1
- Applied Biological Materials Clones for DUOX1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||
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| SP9: | |||||||||||||||||||||||||
| SP10: |
Expression for DUOX1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Basal Cells Trachea
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Esophagus (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for DUOX1 Gene
This gene is overexpressed in Esophagus - Mucosa (x8.8), Lung (x7.4), Thyroid (x6.3), Skin - Not Sun Exposed (Suprapubic) (x4.7), Stomach (x4.6), and Skin - Sun Exposed (Lower leg) (x4.5).
This gene is overexpressed in Nasal epithelium (63.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DUOX1 Gene
NURSA nuclear receptor signaling pathways regulating expression of DUOX1 Gene:
DUOX1SOURCE GeneReport for Unigene cluster for DUOX1 Gene:
Hs.272813mRNA Expression by UniProt/SwissProt for DUOX1 Gene:
Q9NRD9-DUOX1_HUMAN
Tissue specificity:
Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.
Evidence on tissue expression from TISSUES for DUOX1 Gene
- Thyroid gland(4.6)
- Lung(4.5)
- Blood(2.4)
- Skin(2.3)
- Heart(2.2)
- Intestine(2)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for DUOX1
- genomics-online: primer clones - Search results for 79 available DUOX1 gene related products
- Overview of 79 available DUOX1 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DUOX1 Gene
Orthologs for DUOX1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DUOX1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DUOX1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DUOX1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Duox1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Duox1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | DUOX1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DUOX2 33 |
|
||
| -- 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | duox1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | duox 34 33 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | Duox 34 |
|
OneToMany | |
| CG3131 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | bli-3 34 |
|
ManyToMany | |
| duox-2 34 |
|
ManyToMany | |||
| F56C11.1 35 |
|
|
|||
| F53G12.3 35 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | RBOHA 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0360200 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for DUOX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for DUOX1 Gene
- ENSEMBL:
- Gene Tree for DUOX1 (if available)
- TreeFam:
- Gene Tree for DUOX1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DUOX1: view image
Paralogs for DUOX1 Gene
(6) SIMAP similar genes for DUOX1 Gene using alignment to 5 proteins:
- DUOX1_HUMAN
- H0YK19_HUMAN
- H0YNR5_HUMAN
- L8ECP1_HUMAN
- Q14C85_HUMAN
Pseudogenes.org Pseudogenes for DUOX1 Gene
Variants for DUOX1 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs760297837 | benign, not specified | 45,153,494(+) | AT/ | intron_variant | |
| rs1000072131 | -- | 45,145,431(+) | T/C | intron_variant | |
| rs1000090683 | -- | 45,152,863(+) | A/C | intron_variant | |
| rs1000173854 | -- | 45,163,449(+) | A/G | intron_variant | |
| rs1000210494 | -- | 45,128,723(+) | T/C | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1002924 | CNV | deletion | 20482838 |
| esv2760029 | CNV | gain+loss | 17122850 |
| esv3406380 | CNV | insertion | 20981092 |
| esv3414549 | CNV | insertion | 20981092 |
| nsv457125 | CNV | loss | 19166990 |
| nsv518213 | CNV | gain | 19592680 |
| nsv520580 | CNV | loss | 19592680 |
| nsv569312 | CNV | loss | 21841781 |
| nsv569313 | CNV | gain | 21841781 |
| nsv569314 | CNV | loss | 21841781 |
| nsv569315 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.65;
93.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DUOX1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUOX1 Gene
Disorders for DUOX1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| congenital hypothyroidism |
|
|
| phagocyte bactericidal dysfunction |
|
|
| adrenal rest tumor |
|
|
| thyroid cancer |
|
Search DUOX1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DUOX1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for DUOX1 Gene
Publications for DUOX1 Gene
- Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. (PMID: 10806195) De Deken X … Miot F (The Journal of biological chemistry 2000) 2 3 4 22 58
- Genetic polymorphisms and susceptibility to lung disease. (PMID: 16608528) Lee PL … Wang L (Journal of negative results in biomedicine 2006) 3 22 44 58
- Identification of a novel partner of duox: EFP1, a thioredoxin-related protein. (PMID: 15561711) Wang D … Miot F (The Journal of biological chemistry 2005) 3 4 22 58
- Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. (PMID: 16111680) Harper RW … Wu R (FEBS letters 2005) 3 4 22 58
- Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity. (PMID: 15972824) Ameziane-El-Hassani R … Dupuy C (The Journal of biological chemistry 2005) 3 4 22 58
Products for DUOX1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
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- Search Origene for MassSpec and Protein Over-expression Lysates for DUOX1
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for DUOX1
- Browse OriGene Inhibitory RNA Products For DUOX1
- OriGene qPCR primer pairs for DUOX1
- OriGene CRISPR knockouts for DUOX1
- OriGene ORF clones in human for DUOX1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DUOX1
- GenScript: Next-day shipping of latest version cDNA ORF clones for DUOX1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for DUOX1
- GenScript Custom Assay Services for DUOX1
- GenScript Custom overexpressing Cell Line Services for DUOX1
- GenScript: Design CRISPR guide RNA sequences for DUOX1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DUOX1
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- Sino Biological Transfection Reagent
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- Novus Biologicals Antibodies for DUOX1
- Novus Biologicals proteins for DUOX1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Taconic Biosciences Mouse Models for DUOX1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- VectorBuilder custom plasmid, inducible vectors for DUOX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DUOX1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 35 available DUOX1 Antibodies ranked by validation data
- Compare Top DUOX1 Antibodies
- antibodies-online: Search results for 5 available DUOX1 Elisa Kits ranked by validation data
- Compare Top DUOX1 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 7 available DUOX1 Proteins ranked by validation data
- Compare Top DUOX1 Proteins
- Quality Products:
- GeneTex DUOX1 Antibody for DUOX1
- Search GeneTex for Proteins for DUOX1
- Santa Cruz Biotechnology (SCBT) Antibodies for DUOX1
- Search Santa Cruz Biotechnology (SCBT) for DUOX1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DUOX1
- Horizon Cell Lines for DUOX1
- genomics-online: cdna clones - Search results for 79 available DUOX1 gene related products
- Overview of 79 available DUOX1 gene related products
- orf clones - Search results for 79 available DUOX1 gene related products
- Overview of 79 available DUOX1 gene related products
- genomics-online: gRNA clones - Search results for 79 available DUOX1 gene related products
- Overview of 79 available DUOX1 gene related products
- genomics-online: primer clones - Search results for 79 available DUOX1 gene related products
- Overview of 79 available DUOX1 gene related products
- genomics-online: shRNA clones - Search results for 79 available DUOX1 gene related products
- Overview of 79 available DUOX1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DUOX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DUOX1
- GeneCopoeia miRNA 3'UTR Target clone products for DUOX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DUOX1
Sources for DUOX1 Gene
- (1) GeneCards
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- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (14) ProtoNet
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
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- (114) diseasecard
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
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- (147) Gene ORGANizer
- (148) abm
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- (150) Human Protein Atlas
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- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio