Aliases for DUOX1 Gene
External Ids for DUOX1 Gene
Previous GeneCards Identifiers for DUOX1 Gene
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for DUOX1 Gene
DUOX1 (Dual Oxidase 1) is a Protein Coding gene. Diseases associated with DUOX1 include Congenital Hypothyroidism and Granulomatous Disease, Chronic, Autosomal Dominant Type. Among its related pathways are Aldosterone synthesis and secretion and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heme binding. An important paralog of this gene is DUOX2.
UniProtKB/Swiss-Prot Summary for DUOX1 Gene
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.