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DTYMK (Deoxythymidylate Kinase) is a Protein Coding gene. Diseases associated with DTYMK include Mitochondrial Dna Depletion Syndrome and Submandibular Adenitis. Among its related pathways are Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis. Gene Ontology (GO) annotations related to this gene include kinase activity and thymidylate kinase activity. An important paralog of this gene is CMPK2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004550 | nucleoside diphosphate kinase activity | IBA | 21873635 |
GO:0004798 | thymidylate kinase activity | IEA,IDA | 8845311 |
GO:0005524 | ATP binding | IEA | -- |
GO:0009041 | uridylate kinase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005739 | mitochondrion | IEA,IBA | 21873635 |
GO:0005758 | mitochondrial intermembrane space | IEA | -- |
GO:0005759 | mitochondrial matrix | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006165 | nucleoside diphosphate phosphorylation | IEA | -- |
GO:0006227 | dUDP biosynthetic process | IBA | 21873635 |
GO:0006233 | dTDP biosynthetic process | IEA,IBA | 21873635 |
GO:0006235 | dTTP biosynthetic process | IBA,IEA | -- |
GO:0009165 | nucleotide biosynthetic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
5-Thymidylic acid | Experimental | Pharma | Target | 0 | ||
2',3'-Dideoxythymidine-5'-Monophosphate | Experimental | Pharma | Target | 0 | ||
3'-deoxy-3'-aminothymidine monophosphate | Experimental | Pharma | Target | 0 | ||
3'-Fluoro-3'-deoxythymidine 5'-monophosphate | Experimental | Pharma | Target | 0 | ||
P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 | |||
dTDP |
|
491-97-4 |
|
|||
dudp |
|
4208-67-7 |
|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DTYMK 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dtymk 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dtymk 30 |
|
||
Cow (Bos Taurus) |
Mammalia | DTYMK 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | DTYMK 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DTYMK 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DTYMK 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DTYMK 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dtymk 30 |
|
||
Str.7637 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.19382 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dtymk 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005260 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5757 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | R53.2 30 31 32 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR369W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC8 30 31 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B06556g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | ZEU1 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os07g0639900 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU07773 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tmp1 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
730030 | Benign: not provided | 241,686,681(-) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
mitochondrial dna depletion syndrome |
|
|
submandibular adenitis |
|
|
mycobacterium tuberculosis 1 |
|