DTYMK Gene (Protein Coding)

Deoxythymidylate Kinase

GC02M241675
GIFtS:
43
See more...

Aliases for DTYMK Gene

Aliases for DTYMK Gene

  • Deoxythymidylate Kinase 2 3 5
  • DTMP Kinase 2 3 4
  • CDC8 2 3 4
  • TMPK 2 3 4
  • TYMK 2 3 4
  • Deoxythymidylate Kinase (Thymidylate Kinase) 2 3
  • Thymidylate Kinase 3 4
  • Thymidylate (DTMP) Kinase 2
  • EC 2.7.4.9 4
  • PP3731 3
  • DTYMK 5

External Ids for DTYMK Gene

Previous GeneCards Identifiers for DTYMK Gene

  • GC02U990022
  • GC02P239574
  • GC02M242634
  • GC02M242935
  • GC02M242335
  • GC02M242263
  • GC02M234370
  • GC02M242615

Summaries for DTYMK Gene

GeneCards Summary for DTYMK Gene

DTYMK (Deoxythymidylate Kinase) is a Protein Coding gene. Diseases associated with DTYMK include Mitochondrial Dna Depletion Syndrome and Submandibular Adenitis. Among its related pathways are Metabolism of nucleotides and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis. Gene Ontology (GO) annotations related to this gene include kinase activity and thymidylate kinase activity. An important paralog of this gene is CMPK2.

UniProtKB/Swiss-Prot Summary for DTYMK Gene

Gene Wiki entry for DTYMK Gene

Additional gene information for DTYMK Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DTYMK Gene

Genomics for DTYMK Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for DTYMK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DTYMK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DTYMK

Top Transcription factor binding sites by QIAGEN in the DTYMK gene promoter:
  • AREB6
  • c-Rel
  • CBF(2)
  • GATA-1
  • GATA-3
  • Ik-3
  • NF-1
  • NF-1/L
  • Nkx2-5
  • Pax-4a

Genomic Locations for DTYMK Gene

Latest Assembly
chr2:241,675,747-241,686,944
(GRCh38/hg38)
Size:
11,198 bases
Orientation:
Minus strand

Previous Assembly
chr2:242,615,162-242,626,230
(GRCh37/hg19 by Entrez Gene)
Size:
11,069 bases
Orientation:
Minus strand

chr2:242,615,157-242,626,406
(GRCh37/hg19 by Ensembl)
Size:
11,250 bases
Orientation:
Minus strand

Genomic View for DTYMK Gene

Genes around DTYMK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTYMK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTYMK Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DTYMK Gene

Proteins for DTYMK Gene

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  3. Assay products for research

  • Protein details for DTYMK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23919-KTHY_HUMAN
    Recommended name:
    Thymidylate kinase
    Protein Accession:
    P23919
    Secondary Accessions:
    • B7ZW70
    • Q6FGX1
    • Q9BUX4

    Protein attributes for DTYMK Gene

    Size:
    212 amino acids
    Molecular mass:
    23819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DTYMK Gene

    Alternative splice isoforms for DTYMK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTYMK Gene

Protein Expression for DTYMK Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DTYMK Gene

  • Ubiquitination at Lys51
  • Modification sites at PhosphoSitePlus

Other Protein References for DTYMK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DTYMK Gene

Domains & Families for DTYMK Gene

Gene Families for DTYMK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DTYMK Gene

InterPro:
Blocks:
  • Thymidylate kinase
ProtoNet:

Suggested Antigen Peptide Sequences for DTYMK Gene

GenScript: Design optimal peptide antigens:
  • dTMP kinase (KTHY_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P23919

UniProtKB/Swiss-Prot:

KTHY_HUMAN :
  • Belongs to the thymidylate kinase family.
Family:
  • Belongs to the thymidylate kinase family.
genes like me logo Genes that share domains with DTYMK: view

Function for DTYMK Gene

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  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for DTYMK Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of dTMP to dTDP.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517, ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.4.9;.
GENATLAS Biochemistry:
deoxythymidylate kinase

Enzyme Numbers (IUBMB) for DTYMK Gene

Phenotypes From GWAS Catalog for DTYMK Gene

Gene Ontology (GO) - Molecular Function for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004550 nucleoside diphosphate kinase activity IBA 21873635
GO:0004798 thymidylate kinase activity IEA,IDA 8845311
GO:0005524 ATP binding IEA --
GO:0009041 uridylate kinase activity IBA 21873635
genes like me logo Genes that share ontologies with DTYMK: view
genes like me logo Genes that share phenotypes with DTYMK: view

Animal Models for research

miRNA for DTYMK Gene

miRTarBase miRNAs that target DTYMK

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTYMK

Clone products for research

  • Addgene plasmids for DTYMK

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTYMK Gene

Localization for DTYMK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DTYMK gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IEA,IBA 21873635
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with DTYMK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DTYMK Gene

Pathways & Interactions for DTYMK Gene

genes like me logo Genes that share pathways with DTYMK: view

UniProtKB/Swiss-Prot P23919-KTHY_HUMAN

  • Pathway: Pyrimidine metabolism; dTTP biosynthesis.

Gene Ontology (GO) - Biological Process for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006227 dUDP biosynthetic process IBA 21873635
GO:0006233 dTDP biosynthetic process IEA,IBA 21873635
GO:0006235 dTTP biosynthetic process IBA,IEA --
GO:0009165 nucleotide biosynthetic process IEA --
genes like me logo Genes that share ontologies with DTYMK: view

No data available for SIGNOR curated interactions for DTYMK Gene

Drugs & Compounds for DTYMK Gene

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(16) Drugs for DTYMK Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
5-Thymidylic acid Experimental Pharma Target 0
2',3'-Dideoxythymidine-5'-Monophosphate Experimental Pharma Target 0
3'-deoxy-3'-aminothymidine monophosphate Experimental Pharma Target 0
3'-Fluoro-3'-deoxythymidine 5'-monophosphate Experimental Pharma Target 0
P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate Experimental Pharma Target 0

(18) Additional Compounds for DTYMK Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0
dTDP
  • 2'-Deoxyribosylthymine 5'-(trihydrogen diphosphate)
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • Thymidine 5'-diphosphate
  • Thymidine 5'-pyrophosphate
 491-97-4
dudp
  • 2'-Deoxyuridine 5'-diphosphate
  • 2'-Deoxyuridine 5'-diphosphoric acid
  • 2'-Deoxyuridine-5'-diphosphate
  • Deoxyuridine-diphosphate
  • 2'-Deoxyuridine 5'-(trihydrogen diphosphate)
 4208-67-7
genes like me logo Genes that share compounds with DTYMK: view

Transcripts for DTYMK Gene

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mRNA/cDNA for DTYMK Gene

6 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTYMK

Clone products for research

  • Addgene plasmids for DTYMK

Alternative Splicing Database (ASD) splice patterns (SP) for DTYMK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - -
SP7:
SP8:

Relevant External Links for DTYMK Gene

GeneLoc Exon Structure for
DTYMK

Expression for DTYMK Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DTYMK Gene

mRNA expression in normal human tissues for DTYMK Gene
mRNA expression by BioGPS for DTYMK GenemRNA expression by GTEx for DTYMK Gene

Protein differential expression in normal tissues from HIPED for DTYMK Gene

This gene is overexpressed in Bone (14.2) and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DTYMK Gene



Protein tissue co-expression partners for DTYMK Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DTYMK

SOURCE GeneReport for Unigene cluster for DTYMK Gene:

Hs.471873

Evidence on tissue expression from TISSUES for DTYMK Gene

  • Nervous system(4.6)
  • Liver(4.4)
  • Muscle(4.3)
  • Skin(2.2)
  • Intestine(2.1)
  • Blood(2.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with DTYMK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTYMK Gene

Orthologs for DTYMK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DTYMK Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia DTYMK 30 31
  • 99.84 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Dtymk 30 17 31
  • 82.55 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Dtymk 30
  • 82.23 (n)
Cow
(Bos Taurus)
 Mammalia DTYMK 30 31
  • 82.15 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 80 (a)
 OneToMany
-- 31
  • 76 (a)
 OneToMany
Dog
(Canis familiaris)
 Mammalia DTYMK 31
  • 78 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia DTYMK 31
  • 72 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves DTYMK 31
  • 29 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia DTYMK 31
  • 75 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia dtymk 30
  • 64.94 (n)
Str.7637 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.19382 30
Zebrafish
(Danio rerio)
 Actinopterygii dtymk 30 31
  • 62.74 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP005260 30
  • 54.84 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta CG5757 30 31 32
  • 49.68 (n)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea R53.2 30 31 32
  • 47.29 (n)
 OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_AFR369W 30
  • 52.9 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CDC8 30 31 33
  • 51.76 (n)
 OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0B06556g 30
  • 50.6 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons ZEU1 30
  • 50.9 (n)
Rice
(Oryza sativa)
 Liliopsida Os07g0639900 30
  • 53.78 (n)
Bread mold
(Neurospora crassa)
 Ascomycetes NCU07773 30
  • 52.92 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes tmp1 30
  • 52.33 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 49 (a)
 OneToOne
Species where no ortholog for DTYMK was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DTYMK Gene

ENSEMBL:
Gene Tree for DTYMK (if available)
TreeFam:
Gene Tree for DTYMK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DTYMK: view image

Paralogs for DTYMK Gene

Paralogs for DTYMK Gene

(11) SIMAP similar genes for DTYMK Gene using alignment to 6 proteins:

  • KTHY_HUMAN
  • G5E9E9_HUMAN
  • H7BZ20_HUMAN
  • H7C312_HUMAN
  • H7C3A4_HUMAN
  • Q6FGU2_HUMAN
genes like me logo Genes that share paralogs with DTYMK: view

Variants for DTYMK Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DTYMK Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs11555213 Benign: not provided 241,686,681(-) G/A
NM_012145.4(DTYMK):c.103C>T (p.His35Tyr) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DTYMK Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DTYMK Gene

Variant ID Type Subtype PubMed ID
dgv165e55 CNV loss 17911159
nsv508901 CNV insertion 20534489
nsv584974 CNV gain 21841781

Variation tolerance for DTYMK Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DTYMK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DTYMK

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTYMK Gene

Disorders for DTYMK Gene

MalaCards: The human disease database

(4) MalaCards diseases for DTYMK Gene - From: COP and GCD

Disorder Aliases PubMed IDs
mitochondrial dna depletion syndrome
  • mtdna depletion syndrome
submandibular adenitis
  • submandibular lymphadenitis
mycobacterium tuberculosis 1
  • mycobacterium tuberculosis, susceptibility to, 1
disease by infectious agent
  • infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search DTYMK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DTYMK

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DTYMK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DTYMK Gene

Publications for DTYMK Gene

  1. Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth. (PMID: 8024690) Huang SH … Jong A (DNA and cell biology 1994) 2 3 4 23
  2. Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast. (PMID: 2017365) Su JY … Sclafani RA (Nucleic acids research 1991) 2 3 4 23
  3. Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. (PMID: 12614151) Ostermann N … Lavie A (Biochemistry 2003) 3 4 23
  4. Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status. (PMID: 18413751) Hu CM … Chang ZF (Cancer research 2008) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

ExternalLinks

View latest publications for DTYMK gene in Mastermind

Products for DTYMK Gene

  • Addgene plasmids for DTYMK

Sources for DTYMK Gene