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Aliases for DTYMK Gene

Aliases for DTYMK Gene

  • Deoxythymidylate Kinase 2 3 5
  • DTMP Kinase 2 3 4
  • Deoxythymidylate Kinase (Thymidylate Kinase) 2 3
  • CDC8 3 4
  • TMPK 3 4
  • TYMK 3 4
  • Thymidylate (DTMP) Kinase 2
  • Thymidylate Kinase 3
  • EC 2.7.4.9 4
  • PP3731 3

External Ids for DTYMK Gene

Previous GeneCards Identifiers for DTYMK Gene

  • GC02U990022
  • GC02P239574
  • GC02M242634
  • GC02M242935
  • GC02M242335
  • GC02M242263
  • GC02M234370
  • GC02M242615

Summaries for DTYMK Gene

GeneCards Summary for DTYMK Gene

DTYMK (Deoxythymidylate Kinase) is a Protein Coding gene. Diseases associated with DTYMK include Mycobacterium Tuberculosis 1. Among its related pathways are Metabolism and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis. Gene Ontology (GO) annotations related to this gene include kinase activity and thymidylate kinase activity.

UniProtKB/Swiss-Prot for DTYMK Gene

  • Catalyzes the conversion of dTMP to dTDP.

Gene Wiki entry for DTYMK Gene

Additional gene information for DTYMK Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTYMK Gene

Genomics for DTYMK Gene

GeneHancer (GH) Regulatory Elements for DTYMK Gene

Promoters and enhancers for DTYMK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J241685 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.2 -177 3.1 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 ING5 GC02M241683 DTYMK ENSG00000235351 ENSG00000223374 D2HGDH ENSG00000215692 RTP5 ENSG00000234793 ATG4B
GH02J241700 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.4 -15.0 -15032 3 HDGF CLOCK ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF207 ZNF143 ING5 DTYMK ENSG00000235351 ATG4B MTERF4 ENSG00000223374 GC02M241683 PIR47998
GH02J241313 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 23.6 +370.9 370938 4.9 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC SEPT2 HDLBP ANKMY1 FARP2 ATG4B ENSG00000235351 DTYMK MTERF4 ING5 CAPN10
GH02J241616 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 20 +68.0 67984 4.1 HDGF PKNOX1 ARNT GLI4 YY1 ETS1 ZNF143 FOS KLF13 SP3 THAP4 ING5 ENSG00000223374 SNED1 ENSG00000235351 MTERF4 FARP2 BOK D2HGDH DTYMK
GH02J241100 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 +584.6 584611 3.1 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MTERF4 ENSG00000223374 SNED1 PASK D2HGDH FARP2 ENSG00000235351 LINC01881 ING5 DTYMK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DTYMK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DTYMK gene promoter:

Genomic Locations for DTYMK Gene

Genomic Locations for DTYMK Gene
chr2:241,675,742-241,686,991
(GRCh38/hg38)
Size:
11,250 bases
Orientation:
Minus strand
chr2:242,615,157-242,626,406
(GRCh37/hg19)

Genomic View for DTYMK Gene

Genes around DTYMK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTYMK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTYMK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTYMK Gene

Proteins for DTYMK Gene

  • Protein details for DTYMK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23919-KTHY_HUMAN
    Recommended name:
    Thymidylate kinase
    Protein Accession:
    P23919
    Secondary Accessions:
    • B7ZW70
    • Q6FGX1
    • Q9BUX4

    Protein attributes for DTYMK Gene

    Size:
    212 amino acids
    Molecular mass:
    23819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DTYMK Gene

    Alternative splice isoforms for DTYMK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTYMK Gene

Post-translational modifications for DTYMK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DTYMK Gene

Domains & Families for DTYMK Gene

Gene Families for DTYMK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DTYMK Gene

Suggested Antigen Peptide Sequences for DTYMK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23919

UniProtKB/Swiss-Prot:

KTHY_HUMAN :
  • Belongs to the thymidylate kinase family.
Family:
  • Belongs to the thymidylate kinase family.
genes like me logo Genes that share domains with DTYMK: view

Function for DTYMK Gene

Molecular function for DTYMK Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of dTMP to dTDP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + dTMP = ADP + dTDP.
GENATLAS Biochemistry:
deoxythymidylate kinase

Enzyme Numbers (IUBMB) for DTYMK Gene

Phenotypes From GWAS Catalog for DTYMK Gene

Gene Ontology (GO) - Molecular Function for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004798 thymidylate kinase activity IEA,IDA 8845311
GO:0005524 ATP binding IEA --
GO:0009041 uridylate kinase activity IBA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with DTYMK: view
genes like me logo Genes that share phenotypes with DTYMK: view

Animal Model Products

miRNA for DTYMK Gene

miRTarBase miRNAs that target DTYMK

Clone Products

  • Addgene plasmids for DTYMK

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTYMK Gene

Localization for DTYMK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DTYMK gene
Compartment Confidence
cytosol 5
mitochondrion 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA,IBA --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with DTYMK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DTYMK Gene

Pathways & Interactions for DTYMK Gene

genes like me logo Genes that share pathways with DTYMK: view

UniProtKB/Swiss-Prot P23919-KTHY_HUMAN

  • Pathway: Pyrimidine metabolism; dTTP biosynthesis.

Gene Ontology (GO) - Biological Process for DTYMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006227 dUDP biosynthetic process IBA --
GO:0006233 dTDP biosynthetic process IEA,IBA --
GO:0006235 dTTP biosynthetic process IBA,IEA --
GO:0008283 cell proliferation TAS 8024690
GO:0009165 nucleotide biosynthetic process IEA --
genes like me logo Genes that share ontologies with DTYMK: view

No data available for SIGNOR curated interactions for DTYMK Gene

Drugs & Compounds for DTYMK Gene

(14) Drugs for DTYMK Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
5-Thymidylic acid Experimental Pharma Target 0
2',3'-Dideoxythymidine-5'-Monophosphate Experimental Pharma Target 0
3'-Azido-3'-Deoxythymidine-5'-Monophosphate Experimental Pharma Target 0
P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate Experimental Pharma Target 0
P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate Experimental Pharma Target 0

(20) Additional Compounds for DTYMK Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
dTDP
  • 2'-Deoxyribosylthymine 5'-(trihydrogen diphosphate)
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • Thymidine 5'-diphosphate
  • Thymidine 5'-pyrophosphate
491-97-4
dudp
  • 2'-Deoxyuridine 5'-diphosphate
  • 2'-Deoxyuridine 5'-diphosphoric acid
  • 2'-Deoxyuridine-5'-diphosphate
  • Deoxyuridine-diphosphate
4208-67-7
dUMP
  • 2'-Deoxyuridine 5'-monophosphate
  • 2'-Deoxyuridine 5'-phosphate
  • Deoxyuridine 5'-phosphate
  • Deoxyuridine monophosphate
  • Deoxyuridylate
964-26-1
Thymidine 3',5'-cyclic monophosphate
  • 3',5'-Cyclic thymidine monophosphate
  • 3',5'-Cyclic TMP
  • 4H-furo[3,2-D]-1,3,2-Dioxaphosphorin thymidine deriv.
  • CTMP
  • Cyclic 3',5'-dTMP
6453-60-7
genes like me logo Genes that share compounds with DTYMK: view

Transcripts for DTYMK Gene

Unigene Clusters for DTYMK Gene

Deoxythymidylate kinase (thymidylate kinase):
Representative Sequences:

Clone Products

  • Addgene plasmids for DTYMK

Alternative Splicing Database (ASD) splice patterns (SP) for DTYMK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - -
SP7:
SP8:

Relevant External Links for DTYMK Gene

GeneLoc Exon Structure for
DTYMK
ECgene alternative splicing isoforms for
DTYMK

Expression for DTYMK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DTYMK Gene

Protein differential expression in normal tissues from HIPED for DTYMK Gene

This gene is overexpressed in Bone (14.2) and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DTYMK Gene



Protein tissue co-expression partners for DTYMK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DTYMK Gene:

DTYMK

SOURCE GeneReport for Unigene cluster for DTYMK Gene:

Hs.471873

Evidence on tissue expression from TISSUES for DTYMK Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with DTYMK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTYMK Gene

Orthologs for DTYMK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DTYMK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTYMK 34 33
  • 99.84 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dtymk 16 34 33
  • 82.55 (n)
rat
(Rattus norvegicus)
Mammalia Dtymk 33
  • 82.23 (n)
cow
(Bos Taurus)
Mammalia DTYMK 34 33
  • 82.15 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 80 (a)
OneToMany
-- 34
  • 76 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DTYMK 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTYMK 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves DTYMK 34
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTYMK 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dtymk 33
  • 64.94 (n)
Str.7637 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19382 33
zebrafish
(Danio rerio)
Actinopterygii dtymk 34 33
  • 62.74 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005260 33
  • 54.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5757 34 35 33
  • 49.68 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R53.2 34 35 33
  • 47.29 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR369W 33
  • 52.9 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC8 36 34 33
  • 51.76 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06556g 33
  • 50.6 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ZEU1 33
  • 50.9 (n)
rice
(Oryza sativa)
Liliopsida Os07g0639900 33
  • 53.78 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07773 33
  • 52.92 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tmp1 33
  • 52.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToOne
Species where no ortholog for DTYMK was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DTYMK Gene

ENSEMBL:
Gene Tree for DTYMK (if available)
TreeFam:
Gene Tree for DTYMK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DTYMK: view image

Paralogs for DTYMK Gene

(11) SIMAP similar genes for DTYMK Gene using alignment to 6 proteins:

  • KTHY_HUMAN
  • G5E9E9_HUMAN
  • H7BZ20_HUMAN
  • H7C312_HUMAN
  • H7C3A4_HUMAN
  • Q6FGU2_HUMAN
genes like me logo Genes that share paralogs with DTYMK: view

No data available for Paralogs for DTYMK Gene

Variants for DTYMK Gene

Sequence variations from dbSNP and Humsavar for DTYMK Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000242398 -- 241,688,233(-) T/C upstream_transcript_variant
rs1000405985 -- 241,677,678(-) C/T intron_variant
rs1000472141 -- 241,686,872(-) G/A 5_prime_UTR_variant, non_coding_transcript_variant
rs1000588761 -- 241,682,832(-) G/A coding_sequence_variant, intron_variant, missense_variant
rs1000672993 -- 241,682,166(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DTYMK Gene

Variant ID Type Subtype PubMed ID
dgv165e55 CNV loss 17911159
nsv508901 CNV insertion 20534489
nsv584974 CNV gain 21841781

Variation tolerance for DTYMK Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DTYMK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DTYMK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTYMK Gene

Disorders for DTYMK Gene

MalaCards: The human disease database

(1) MalaCards diseases for DTYMK Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
mycobacterium tuberculosis 1
  • mycobacterium tuberculosis, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search DTYMK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DTYMK

genes like me logo Genes that share disorders with DTYMK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DTYMK Gene

Publications for DTYMK Gene

  1. Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth. (PMID: 8024690) Huang SH … Jong A (DNA and cell biology 1994) 2 3 4 22 58
  2. Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast. (PMID: 2017365) Su JY … Sclafani RA (Nucleic acids research 1991) 2 3 4 22 58
  3. Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. (PMID: 12614151) Ostermann N … Lavie A (Biochemistry 2003) 3 4 22 58
  4. Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status. (PMID: 18413751) Hu CM … Chang ZF (Cancer research 2008) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DTYMK Gene

Sources for DTYMK Gene

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