Aliases for DTX4 Gene
External Ids for DTX4 Gene
Previous GeneCards Identifiers for DTX4 Gene
GeneCards Summary for DTX4 Gene
DTX4 (Deltex E3 Ubiquitin Ligase 4) is a Protein Coding gene. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Cytosolic sensors of pathogen-associated DNA. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is DTX1.
UniProtKB/Swiss-Prot Summary for DTX4 Gene
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.