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DTX4 (Deltex E3 Ubiquitin Ligase 4) is a Protein Coding gene. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Cytosolic sensors of pathogen-associated DNA. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is DTX1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytosolic sensors of pathogen-associated DNA | ||
2 | Notch Signaling Pathway (WikiPathways) | ||
3 | Innate Immune System |
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|
|
4 | Signaling by NOTCH1 | ||
5 | NOTCH2 Activation and Transmission of Signal to the Nucleus |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007219 | Notch signaling pathway | IEA | -- |
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0032479 | regulation of type I interferon production | TAS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | DTX4 33 32 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | DTX4 33 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | DTX4 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Dtx4 32 |
|
||
cow (Bos Taurus) |
Mammalia | DTX4 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Dtx4 17 33 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | DTX4 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | DTX4 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | DTX4 33 |
|
OneToOne | |
zebrafish (Danio rerio) |
Actinopterygii | dtx1 32 |
|
||
DTX4 (1 of 2) 33 |
|
OneToMany | |||
DTX4 (2 of 2) 33 |
|
OneToMany | |||
fruit fly (Drosophila melanogaster) |
Insecta | dx 33 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7641 33 |
|
OneToMany |
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000184692 | -- | 59,198,910(+) | G/A | intron_variant | |
rs1000341302 | -- | 59,195,793(+) | G/A | intron_variant | |
rs1000419492 | -- | 59,207,272(+) | G/A/T | 3_prime_UTR_variant | |
rs1000426645 | -- | 59,183,125(+) | T/C | intron_variant | |
rs1000525654 | -- | 59,199,168(+) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759830 | CNV | gain | 17122850 |
nsv1050013 | CNV | gain | 25217958 |
No disorders were found for DTX4 Gene.