Aliases for DTX3L Gene
Aliases for DTX3L Gene
External Ids for DTX3L Gene
- HGNC: 30323
- Entrez Gene: 151636
- Ensembl: ENSG00000163840
- OMIM: 613143
- UniProtKB: Q8TDB6
Previous GeneCards Identifiers for DTX3L Gene
- GC03P123766
- GC03P122284
- GC03P119656
Summaries for DTX3L Gene
-
DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
GeneCards Summary for DTX3L Gene
DTX3L (Deltex E3 Ubiquitin Ligase 3L) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (KEGG) and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and histone binding. An important paralog of this gene is DTX2.
UniProtKB/Swiss-Prot for DTX3L Gene
-
E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of Lys-91 of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-20 methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B HIST1H2BH/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating Lys-48-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteosomal-mediated degradation (PubMed:26479788).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTX3L Gene
Genomics for DTX3L Gene
GeneHancer (GH) Regulatory Elements for DTX3L Gene
Promoters and enhancers for DTX3L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DTX3L on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DTX3L gene promoter:
-
- Nkx2-5
- C/EBPalpha
- AML1a
- MZF-1
- IRF-7A
- FOXO1
- FOXO1a
- Bach1
- CP2
- GCNF-1
Regulatory Element Products
Genomic Locations for DTX3L Gene
Genomic Locations for DTX3L Gene
- chr3:122,564,238-122,575,203
- (GRCh38/hg38)
- Size:
- 10,966 bases
- Orientation:
- Plus strand
- chr3:122,283,085-122,294,050
- (GRCh37/hg19)
- Size:
- 10,966 bases
- Orientation:
- Plus strand
Genomic View for DTX3L Gene
Genes around DTX3L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q21.1 by Entrez Gene
- 3q21.1 by HGNC
- 3q21.1 by Ensembl
DTX3L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DTX3L Gene
Proteins for DTX3L Gene
-
Protein details for DTX3L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TDB6-DTX3L_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase DTX3L
- Protein Accession:
- Q8TDB6
- B3KWH6
- Q53ZZ3
- Q5MJP7
Protein attributes for DTX3L Gene
- Size:
- 740 amino acids
- Molecular mass:
- 83554 Da
- Quaternary structure:
-
- Homodimer and heterodimer (PubMed:12670957, PubMed:28525742). Can heterodimerize with DTX1, enhancing its ubiquitin ligase activity in vitro (PubMed:12670957). Interacts (via N-terminus) with ADP ribosyltransferase PARP9/BAL1 (via PARP catalytic domain) forming a stable complex; the interaction is required to activate PARP9 but is dispensable for DTX3L catalytic activity (PubMed:12670957, PubMed:23230272, PubMed:26479788, PubMed:28525742). Forms a complex with STAT1 and PARP9 independently of IFNB1 or IFNG-mediated STAT1 Tyr-701 phosphorylation (PubMed:26479788). Found in a complex with PARP9, STAT1 and HIST1H2BH (PubMed:26479788). Found in a complex with E3 ligase ITCH and ESCRT-0 components HGS and STAM (PubMed:24790097). Interacts (via C-terminus) with ITCH; the interaction is increased upon CXCL12 stimulation and inhibits ITCH catalytic activity; the interaction is direct (PubMed:24790097). Interacts with HGS and STAM; the interaction brings together HGS and STAM and promotes their recruitment to early endosomes (PubMed:24790097).
- (Microbial infection) Interacts with encephalomyocarditis virus (EMCV) C3 protease; the interaction results in C3 protease Lys-48-linked ubiquitination.
- (Microbial infection) Interacts with human rhinovirus (HRV) C3 protease; the interaction results in C3 protease Lys-48-linked ubiquitination.
Protein Expression for DTX3L Gene
Post-translational modifications for DTX3L Gene
- Autoubiquitinated.
- Ubiquitination at posLast=728728, posLast=709709, posLast=675675, posLast=653653, posLast=593593, Lys401, Lys337, Lys316, Lys259, Lys232, and Lys198
- Modification sites at PhosphoSitePlus
Other Protein References for DTX3L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DTX3L
- Novus Biologicals Antibodies for DTX3L
- Invitrogen Antibodies for DTX3L
- GeneTex DTX3L Antibody for DTX3L
-
Santa Cruz Biotechnology (SCBT) Antibodies for DTX3L
Protein Products
-
OriGene Purified Proteins for DTX3L
- Search Origene for MassSpec and Protein Over-expression Lysates for DTX3L
- Origene Custom Protein Services for DTX3L
- Search GeneTex for Proteins for DTX3L
Assay Products
No data available for DME Specific Peptides for DTX3L Gene
Domains & Families for DTX3L Gene
Gene Families for DTX3L Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for DTX3L Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DTX3L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TDB6- Family:
-
- Belongs to the Deltex family.
Function for DTX3L Gene
Molecular function for DTX3L Gene
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of Lys-91 of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-20 methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B HIST1H2BH/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating Lys-48-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteosomal-mediated degradation (PubMed:26479788).
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Binding to PARP9 enhances DTX3L catalytic activity.
- UniProtKB/Swiss-Prot Induction:
- Induced by IFNG (PubMed:16809771, PubMed:26479788). Induced by IFNB1 (PubMed:26479788).
Enzyme Numbers (IUBMB) for DTX3L Gene
Phenotypes From GWAS Catalog for DTX3L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0004857 | enzyme inhibitor activity | IMP | 24790097 |
| GO:0005515 | protein binding | IPI | 16809771 |
| GO:0008047 | enzyme activator activity | IDA | 28525742 |
Phenotypes for DTX3L Gene
- GenomeRNAi human phenotypes for DTX3L:
-
- Increased shRNA abundance (Z-score > 2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased Hepatitis C virus replication
- Increased cell death HMECs cells
- Reduced mammosphere formation
- Decreased ionizing radiation sensitivity
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased shRNA abundance (Z-score < -2)
- Increased viability
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DTX3L
-
CRISPR Products
-
OriGene CRISPR knockouts for DTX3L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DTX3L
- genomics-online: gRNA clones - Search results for 100 available DTX3L gene related products
- Overview of 100 available DTX3L gene related products
-
Recommended
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- Applied Biological Materials CRISPR for DTX3L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DTX3L
- GenScript: Design CRISPR guide RNA sequences for DTX3L
miRNA for DTX3L Gene
- miRTarBase miRNAs that target DTX3L
-
- hsa-mir-21-5p (MIRT030687)
- hsa-mir-6516-5p (MIRT460010)
- hsa-mir-455-3p (MIRT460011)
- hsa-mir-6807-5p (MIRT460012)
- hsa-mir-7847-3p (MIRT460013)
- hsa-mir-6851-5p (MIRT460014)
- hsa-mir-3689d (MIRT460015)
- hsa-mir-6499-3p (MIRT460016)
- hsa-mir-6086 (MIRT460017)
- hsa-mir-377-5p (MIRT460018)
- hsa-mir-4795-5p (MIRT460019)
- hsa-mir-1247-3p (MIRT460020)
- hsa-mir-129-5p (MIRT497788)
- hsa-mir-510-3p (MIRT497789)
- hsa-mir-488-3p (MIRT497790)
- hsa-mir-5009-3p (MIRT497791)
- hsa-mir-1277-5p (MIRT497792)
- hsa-mir-7703 (MIRT635661)
- hsa-mir-4252 (MIRT635662)
- hsa-mir-4793-3p (MIRT635663)
- hsa-mir-766-3p (MIRT635664)
- hsa-mir-4738-5p (MIRT635665)
- hsa-mir-1273g-3p (MIRT635666)
- hsa-mir-607 (MIRT658854)
- hsa-mir-520h (MIRT658855)
- hsa-mir-520g-3p (MIRT658856)
- hsa-mir-3973 (MIRT658857)
- hsa-mir-3606-3p (MIRT658858)
- hsa-mir-6507-3p (MIRT658859)
- hsa-mir-4282 (MIRT658860)
- hsa-mir-665 (MIRT681648)
- hsa-mir-6771-5p (MIRT681649)
- hsa-mir-3622b-5p (MIRT681650)
- hsa-mir-202-3p (MIRT681651)
- hsa-mir-98-5p (MIRT681652)
- hsa-mir-4500 (MIRT681653)
- hsa-mir-4458 (MIRT681654)
- hsa-let-7i-5p (MIRT681655)
- hsa-let-7g-5p (MIRT681656)
- hsa-let-7f-5p (MIRT681657)
- hsa-let-7e-5p (MIRT681658)
- hsa-let-7d-5p (MIRT681659)
- hsa-let-7c-5p (MIRT681660)
- hsa-let-7b-5p (MIRT681661)
- hsa-let-7a-5p (MIRT681662)
- hsa-mir-6884-5p (MIRT681663)
- hsa-mir-485-5p (MIRT681664)
- hsa-mir-7162-3p (MIRT681665)
- hsa-mir-6746-5p (MIRT681666)
- hsa-mir-6888-5p (MIRT681667)
- hsa-mir-5197-5p (MIRT681668)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DTX3L
- Browse OriGene Inhibitory RNA Products For DTX3L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTX3L
- genomics-online: shRNA clones - Search results for 100 available DTX3L gene related products
- Overview of 100 available DTX3L gene related products
-
Recommended
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
Clone Products
- Sino Biological Human cDNA Clone for DTX3L
- VectorBuilder custom plasmid, inducible vectors for DTX3L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DTX3L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DTX3L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DTX3L
- genomics-online: cdna clones - Search results for 100 available DTX3L gene related products
- Overview of 100 available DTX3L gene related products
-
Recommended
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- orf clones - Search results for 100 available DTX3L gene related products
- Overview of 100 available DTX3L gene related products
-
Recommended
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- Applied Biological Materials Clones for DTX3L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DTX3L
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTX3L Gene
Localization for DTX3L Gene
Subcellular locations from UniProtKB/Swiss-Prot for DTX3L Gene
- Cytoplasm. Nucleus. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocates to the nucleus in response to IFNG or IFNB1 stimulation (PubMed:26479788). Localizes at sites of DNA damage in a PARP1-dependent manner (PubMed:23230272). Localization to early endosomes is increased upon CXCL12 stimulation where it co-localizes with ITCH, CXCL4, HGS and STAM (PubMed:24790097). A minor proportion localizes to lysosomes (PubMed:24790097). {ECO:0000269 PubMed:23230272, ECO:0000269 PubMed:24790097, ECO:0000269 PubMed:26479788}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| lysosome | 5 |
| endosome | 3 |
| mitochondrion | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | colocalizes_with nucleus | IDA,IEA | 26479788 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 16809771 |
| GO:0005764 | lysosome | IDA,IEA | 24790097 |
| GO:0005765 | lysosomal membrane | IEA | -- |
Pathways & Interactions for DTX3L Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Notch signaling pathway (KEGG) | ||
| 3 | Chromatin Regulation / Acetylation | ||
| 4 | DNA Damage | ||
| 5 | Innate Immune System |
.61
|
|
Pathways by source for DTX3L Gene
1 GeneTex pathway for DTX3L Gene
1 BioSystems pathway for DTX3L Gene
4 Reactome pathways for DTX3L Gene
1 KEGG pathway for DTX3L Gene
2 Cell Signaling Technology pathways for DTX3L Gene
UniProtKB/Swiss-Prot Q8TDB6-DTX3L_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for DTX3L Gene
Selected Interacting proteins:
Q8TDB6-DTX3L_HUMAN
ENSP00000296161
for DTX3L Gene via
IID
STRING
UniProtKB
GPS-Prot Interaction Network for DTX3L
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002230 | positive regulation of defense response to virus by host | IGI | 26479788 |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006302 | double-strand break repair | IMP | 23230272 |
No data available for SIGNOR curated interactions for DTX3L Gene
Transcripts for DTX3L Gene
mRNA/cDNA for DTX3L Gene
- (1) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (195) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000296161 5868 bps (uc003efk.4)
- ENST00000383661 687 bps (uc010hrj.4)
Unigene Clusters for DTX3L Gene
CRISPR Products
-
OriGene CRISPR knockouts for DTX3L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DTX3L
- genomics-online: gRNA clones - Search results for 100 available DTX3L gene related products
- Overview of 100 available DTX3L gene related products
-
Recommended
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- Applied Biological Materials CRISPR for DTX3L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DTX3L
- GenScript: Design CRISPR guide RNA sequences for DTX3L
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DTX3L
- Browse OriGene Inhibitory RNA Products For DTX3L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTX3L
- genomics-online: shRNA clones - Search results for 100 available DTX3L gene related products
- Overview of 100 available DTX3L gene related products
-
Recommended
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
Clone Products
- Sino Biological Human cDNA Clone for DTX3L
- VectorBuilder custom plasmid, inducible vectors for DTX3L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DTX3L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DTX3L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DTX3L
- genomics-online: cdna clones - Search results for 100 available DTX3L gene related products
- Overview of 100 available DTX3L gene related products
-
Recommended
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- orf clones - Search results for 100 available DTX3L gene related products
- Overview of 100 available DTX3L gene related products
-
Recommended
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- Applied Biological Materials Clones for DTX3L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for DTX3L Gene
This gene is overexpressed in Peripheral blood mononuclear cells (21.8), Lymph node (13.8), and Pancreas (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DTX3L Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DTX3L Gene:
DTX3LSOURCE GeneReport for Unigene cluster for DTX3L Gene:
Hs.518201Evidence on tissue expression from TISSUES for DTX3L Gene
- Liver(4.4)
Primer Products
-
OriGene qPCR primer pairs for DTX3L
- genomics-online: primer clones - Search results for 100 available DTX3L gene related products
- Overview of 100 available DTX3L gene related products
-
Recommended
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTX3L Gene
Orthologs for DTX3L Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DTX3L 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DTX3L 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DTX3L 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Dtx3l 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Dtx3l 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DTX3L 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DTX3L 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DTX3L 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DTX3L 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | DTX3L 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | dx 34 |
|
OneToMany |
- Species where no ortholog for DTX3L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for DTX3L Gene
- ENSEMBL:
- Gene Tree for DTX3L (if available)
- TreeFam:
- Gene Tree for DTX3L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DTX3L: view image
Paralogs for DTX3L Gene
Variants for DTX3L Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036098 | A breast cancer sample | p.Lys209Asn | |||
| rs1000455364 | -- | 122,571,256(+) | C/A | intron_variant | |
| rs1000724738 | -- | 122,572,651(+) | C/T | 3_prime_UTR_variant | |
| rs1000819033 | -- | 122,566,193(+) | A/G | intron_variant | |
| rs1001535967 | -- | 122,563,304(+) | C/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3597613 | CNV | loss | 21293372 |
| esv2672720 | CNV | deletion | 23128226 |
Residual Variation Intolerance Score:
51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.50;
55.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DTX3L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DTX3L
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTX3L Gene
Disorders for DTX3L Gene
Additional Disease Information for DTX3L
No disorders were found for DTX3L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTX3L Gene
Publications for DTX3L Gene
- The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K … Shipp MA (The Journal of biological chemistry 2003) 2 3 4 22 58
- Fold of the conserved DTC domain in Deltex proteins. (PMID: 22411408) Obiero J … Dhe-Paganon S (Proteins 2012) 2 3 4 58
- Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9. (PMID: 28525742) Yang CS … Paschal BM (Molecular cell 2017) 3 4 58
- PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection. (PMID: 26479788) Zhang Y … Holtzman MJ (Nature immunology 2015) 3 4 58
- The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. (PMID: 24790097) Holleman J … Marchese A (Molecular biology of the cell 2014) 3 4 58
Products for DTX3L Gene
- Browse R&D Systems for Antibodies
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- Novus Biologicals Tissue Microarrays
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- VectorBuilder custom plasmid, inducible vectors for DTX3L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DTX3L
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DTX3L
- antibodies-online: Search results for 50 available DTX3L Antibodies ranked by validation data
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- antibodies-online: Search results for available DTX3L related products ranked by validation data
- antibodies-online: Search results for 4 available DTX3L Proteins ranked by validation data
- Compare Top DTX3L Proteins
- GeneTex DTX3L Antibody for DTX3L
- Search GeneTex for Proteins for DTX3L
- Santa Cruz Biotechnology (SCBT) Antibodies for DTX3L
- Search Santa Cruz Biotechnology (SCBT) for DTX3L siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DTX3L
- Horizon Cell Lines for DTX3L
- genomics-online: cdna clones - Search results for 100 available DTX3L gene related products
- Overview of 100 available DTX3L gene related products
- Recommended
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- orf clones - Search results for 100 available DTX3L gene related products
- Overview of 100 available DTX3L gene related products
- Recommended
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- genomics-online: gRNA clones - Search results for 100 available DTX3L gene related products
- Overview of 100 available DTX3L gene related products
- Recommended
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- genomics-online: primer clones - Search results for 100 available DTX3L gene related products
- Overview of 100 available DTX3L gene related products
- Recommended
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- genomics-online: shRNA clones - Search results for 100 available DTX3L gene related products
- Overview of 100 available DTX3L gene related products
- Recommended
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-N-His
- pPB-C-His
- Browse GeneCopoeia Cell Lines
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- GeneCopoeia miRNA 3'UTR Target clone products for DTX3L
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Sources for DTX3L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
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- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt