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DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009] See more...
Aliases for DTX3 Gene
Aliases for DTX3 Gene
External Ids for DTX3 Gene
- HGNC: 24457
- Entrez Gene: 196403
- Ensembl: ENSG00000178498
- OMIM: 613142
- UniProtKB: Q8N9I9
Previous GeneCards Identifiers for DTX3 Gene
- GC12P056284
- GC12P057998
- GC12P055036
Summaries for DTX3 Gene
-
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
GeneCards Summary for DTX3 Gene
DTX3 (Deltex E3 Ubiquitin Ligase 3) is a Protein Coding gene. Among its related pathways are Notch Signaling Pathway (sino) and Notch Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is DTX3L.
UniProtKB/Swiss-Prot Summary for DTX3 Gene
-
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Additional gene information for DTX3 Gene
- HGNC(24457)
- Entrez Gene(196403)
- Ensembl(ENSG00000178498)
- OMIM(613142)
- UniProtKB(Q8N9I9)
- Open Targets Platform(ENSG00000178498)
- Search for DTX3 at DataMed
- Search for DTX3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DTX3 Gene
Genomics for DTX3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DTX3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DTX3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DTX3
- Top Transcription factor binding sites by QIAGEN in the DTX3 gene promoter:
-
- AP-4
- E47
- IRF-1
- ITF-2
- NF-kappaB
- NF-kappaB1
- Pax-3
- RORalpha1
- Tal-1
- Tal-1beta
Genomic Locations for DTX3 Gene
Genomic Locations for DTX3 Gene
- chr12:57,604,327-57,609,804
- (GRCh38/hg38)
- Size:
- 5,478 bases
- Orientation:
- Plus strand
- chr12:57,998,405-58,003,587
- (GRCh37/hg19)
- Size:
- 5,183 bases
- Orientation:
- Plus strand
Genomic View for DTX3 Gene
Genes around DTX3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.3 by HGNC
- 12q13.3 by Entrez Gene
- 12q13.3 by Ensembl
DTX3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DTX3 Gene
Proteins for DTX3 Gene
-
Protein details for DTX3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N9I9-DTX3_HUMAN
- Recommended name:
- Probable E3 ubiquitin-protein ligase DTX3
- Protein Accession:
- Q8N9I9
- Q53ZZ2
- Q8NAU6
- Q8NDS8
Protein attributes for DTX3 Gene
- Size:
- 347 amino acids
- Molecular mass:
- 37988 Da
- Quaternary structure:
-
- Homodimer. May form a heterodimers with other members of the Deltex family. Interacts with NOTCH1.
- SequenceCaution:
-
- Sequence=CAD38593.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
Protein Expression for DTX3 Gene
Post-translational modifications for DTX3 Gene
Other Protein References for DTX3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences DTX3 Antibody
- Novus Biologicals Antibodies for DTX3
-
Abcam antibodies for DTX3
- Invitrogen Antibodies for DTX3 (AFLGC-DTX3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for DTX3
Protein Products
-
OriGene Purified Proteins for DTX3
- Search Origene for MassSpec and Protein Over-expression Lysates for DTX3
- Origene Custom Protein Services for DTX3
-
Signalway Proteins for DTX3
-
Abcam proteins for DTX3
No data available for DME Specific Peptides for DTX3 Gene
Domains & Families for DTX3 Gene
Gene Families for DTX3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for DTX3 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- ProtoNet:
Suggested Antigen Peptide Sequences for DTX3 Gene
- GenScript: Design optimal peptide antigens:
-
- RING finger protein 154 (DTX3_HUMAN)
- cDNA FLJ44795 fis, clone BRACE3040239, highly similar to Protein deltex-3 (Q53ZZ2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8N9I9- Family:
-
- Belongs to the Deltex family.
Function for DTX3 Gene
Molecular function for DTX3 Gene
- UniProtKB/Swiss-Prot Function:
- Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000250|UniProtKB:Q61010};.
Enzyme Numbers (IUBMB) for DTX3 Gene
Phenotypes From GWAS Catalog for DTX3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 19549727 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0061630 | ubiquitin protein ligase activity | IBA | 21873635 |
Phenotypes for DTX3 Gene
- MGI mutant phenotypes for DTX3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DTX3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DTX3 - Select products 50% OFF >
- * DTX3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DTX3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DTX3
-
Santa Cruz Biotechnology (SCBT) CRISPR for DTX3
miRNA for DTX3 Gene
- miRTarBase miRNAs that target DTX3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DTX3
- Browse OriGene Inhibitory RNA Products For DTX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTX3
Clone Products
- Applied Biological Materials (abm): Clones for DTX3 - Select products 50% OFF >
- * DTX3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DTX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DTX3
Cell Line Products
-
Horizon Cell Lines for DTX3
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTX3 Gene
Localization for DTX3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DTX3 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 2 |
| golgi apparatus | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| lysosome | 1 |
- Golgi apparatus (2)
- Nucleoli (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IBA | 21873635 |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for DTX3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Notch Signaling Pathway (WikiPathways) | ||
| 2 | Notch Signaling Pathway (sino) | ||
Pathways by source for DTX3 Gene
1 Sino Biological pathway for DTX3 Gene
1 BioSystems pathway for DTX3 Gene
1 KEGG pathway for DTX3 Gene
1 GeneTex pathway for DTX3 Gene
UniProtKB/Swiss-Prot Q8N9I9-DTX3_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for DTX3 Gene
Selected Interacting proteins:
Q8N9I9-DTX3_HUMAN
ENSP00000448696
for DTX3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for DTX3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007219 | Notch signaling pathway | IEA,IBA | 21873635 |
| GO:0016567 | protein ubiquitination | IEA | -- |
No data available for SIGNOR curated interactions for DTX3 Gene
Transcripts for DTX3 Gene
mRNA/cDNA for DTX3 Gene
- 3 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000548804 2067 nts (view in UCSC)
- ENST00000550596 569 nts (view in UCSC)
- ENST00000551835 561 nts (view in UCSC)
- ENST00000549583 1331 nts (view in UCSC)
- ENST00000337737 2028 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DTX3 - Select products 50% OFF >
- * DTX3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DTX3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DTX3
-
Santa Cruz Biotechnology (SCBT) CRISPR for DTX3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DTX3
- Browse OriGene Inhibitory RNA Products For DTX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTX3
Clone Products
- Applied Biological Materials (abm): Clones for DTX3 - Select products 50% OFF >
- * DTX3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DTX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DTX3
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||
| SP12: |
Relevant External Links for DTX3 Gene
- GeneLoc Exon Structure for
- DTX3
Expression for DTX3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Retina (12.8), Rectum (11.2), Fetal Brain (8.6), and Stomach (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DTX3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DTX3
SOURCE GeneReport for Unigene cluster for DTX3 Gene:
Hs.32374Evidence on tissue expression from TISSUES for DTX3 Gene
- Nervous system(4.8)
- Pancreas(2.3)
Primer Products
-
OriGene qPCR primer pairs for DTX3
-
OriGene qPCR primer pairs and template standards for DTX3
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTX3 Gene
Orthologs for DTX3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DTX3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DTX3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DTX3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dtx3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Dtx3 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DTX3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | DTX3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dtx3 30 |
|
||
| Str.17194 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:66440 30 |
|
||
| DTX3 31 |
|
OneToOne | |||
| zgc66440 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | dx 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for DTX3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for DTX3 Gene
- ENSEMBL:
- Gene Tree for DTX3 (if available)
- TreeFam:
- Gene Tree for DTX3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DTX3: view image
Paralogs for DTX3 Gene
Variants for DTX3 Gene
Residual Variation Intolerance Score:
30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.44;
9.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DTX3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DTX3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DTX3 Gene
Disorders for DTX3 Gene
Additional Disease Information for DTX3
No disorders were found for DTX3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTX3 Gene
Publications for DTX3 Gene
- The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K … Shipp MA (The Journal of biological chemistry 2003) 2 3 4 23
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma. (PMID: 31854042) Ding XY … Qin X (Cancer science 2020) 3
- Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. (PMID: 29643511) Pao KC … Virdee S (Nature 2018) 3
ExternalLinks
Products for DTX3 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for DTX3
- Search Origene for MassSpec and Protein Over-expression Lysates for DTX3
- Origene Custom Protein Services for DTX3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DTX3
- Browse OriGene Inhibitory RNA Products For DTX3
- OriGene qPCR primer pairs for DTX3
- OriGene qPCR primer pairs and template standards for DTX3
- OriGene CRISPR knockouts for DTX3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DTX3
- Sino Biological Human cDNA Clone for DTX3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for DTX3
- Novus Biologicals proteins and lysates for DTX3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for DTX3
- Abcam proteins for DTX3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for DTX3 (AFLGC-DTX3)
- VectorBuilder Custom and pre-made DNA vectors for DTX3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for DTX3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for DTX3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DTX3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DTX3
- antibodies-online: Show 13 available Deltex Homolog 3 Antibodies ranked by validation data
- Compare Top Deltex Homolog 3 Antibodies
- antibodies-online: Search results for available Deltex Homolog 3 related products ranked by validation data
- antibodies-online: Show 4 available Deltex Homolog 3 Proteins ranked by validation data
- Compare Top Deltex Homolog 3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for DTX3
- Search Santa Cruz Biotechnology (SCBT) for DTX3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DTX3
- Horizon Cell Lines for DTX3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DTX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DTX3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DTX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTX3
- Signalway Proteins for DTX3
Sources for DTX3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB