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Aliases for DTX3 Gene

Aliases for DTX3 Gene

  • Deltex E3 Ubiquitin Ligase 3 2 3 5
  • RING-Type E3 Ubiquitin Transferase DTX3 3 4
  • RING Finger Protein 154 3 4
  • Protein Deltex-3 3 4
  • Deltex3 3 4
  • RNF154 3 4
  • Probable E3 Ubiquitin-Protein Ligase DTX3 3
  • Deltex 3, E3 Ubiquitin Ligase 3
  • Deltex 3 Homolog (Drosophila) 2
  • Deltex Homolog 3 (Drosophila) 2
  • Deltex Homolog 3 3
  • EC 2.3.2.27 4

External Ids for DTX3 Gene

Previous GeneCards Identifiers for DTX3 Gene

  • GC12P056284
  • GC12P057998
  • GC12P055036

Summaries for DTX3 Gene

Entrez Gene Summary for DTX3 Gene

  • DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

GeneCards Summary for DTX3 Gene

DTX3 (Deltex E3 Ubiquitin Ligase 3) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (KEGG) and Notch Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is DTX3L.

UniProtKB/Swiss-Prot for DTX3 Gene

  • Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Additional gene information for DTX3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTX3 Gene

Genomics for DTX3 Gene

GeneHancer (GH) Regulatory Elements for DTX3 Gene

Promoters and enhancers for DTX3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J057603 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.4 449 3.2 SIN3A FEZF1 ZNF2 RFX5 YY1 ZNF335 POLR2B SCRT2 EGR2 YY2 DTX3 ENSG00000224713 ARHGEF25 PIP4K2C
GH12J057109 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 91 -493.1 -493073 3.8 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 MCM3 STAT6 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 CDK4 ANKRD52 DTX3
GH12J057516 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 26.1 -83.2 -83238 8.8 CLOCK FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MBD6 DDIT3 ENSG00000285133 MIR616 NEMP1 BAZ2A RN7SL809P ZBTB39 EEF1AKMT3 DTX3
GH12J057245 Enhancer 1.1 ENCODE dbSUPER 36.2 -359.1 -359094 0.2 PKNOX1 ZNF2 YY1 ZNF213 ATF7 KLF13 YY2 ZNF662 REST ZNF491 ENSG00000257740 DTX3 PAN2 LOC283387 ANKRD52 NAB2 NEMP1 EEF1AKMT3 ENSG00000224713 ZBTB39
GH12J056631 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.8 -969.4 -969408 6.9 MLX ZFP64 FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC BAZ2A IKZF4 ENSG00000257740 SMARCC2 SLC26A10 ANKRD52 ENSG00000224713 DTX3 ARHGEF25 PAN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DTX3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DTX3 gene promoter:
  • RORalpha1
  • Tal-1beta
  • ITF-2
  • Pax-3
  • E47
  • AP-4
  • IRF-1
  • Tal-1
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for DTX3 Gene

Genomic Locations for DTX3 Gene
chr12:57,604,327-57,609,804
(GRCh38/hg38)
Size:
5,478 bases
Orientation:
Plus strand
chr12:57,998,405-58,003,587
(GRCh37/hg19)
Size:
5,183 bases
Orientation:
Plus strand

Genomic View for DTX3 Gene

Genes around DTX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTX3 Gene

Proteins for DTX3 Gene

  • Protein details for DTX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9I9-DTX3_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase DTX3
    Protein Accession:
    Q8N9I9
    Secondary Accessions:
    • Q53ZZ2
    • Q8NAU6
    • Q8NDS8

    Protein attributes for DTX3 Gene

    Size:
    347 amino acids
    Molecular mass:
    37988 Da
    Quaternary structure:
    • Homodimer. May form a heterodimers with other members of the Deltex family. Interacts with NOTCH1.
    SequenceCaution:
    • Sequence=CAD38593.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for DTX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTX3 Gene

Post-translational modifications for DTX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DTX3 Gene

Domains & Families for DTX3 Gene

Gene Families for DTX3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DTX3 Gene

Suggested Antigen Peptide Sequences for DTX3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N9I9

UniProtKB/Swiss-Prot:

DTX3_HUMAN :
  • Belongs to the Deltex family.
Family:
  • Belongs to the Deltex family.
genes like me logo Genes that share domains with DTX3: view

Function for DTX3 Gene

Molecular function for DTX3 Gene

UniProtKB/Swiss-Prot Function:
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme Numbers (IUBMB) for DTX3 Gene

Phenotypes From GWAS Catalog for DTX3 Gene

Gene Ontology (GO) - Molecular Function for DTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19549727
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DTX3: view
genes like me logo Genes that share phenotypes with DTX3: view

Animal Model Products

miRNA for DTX3 Gene

miRTarBase miRNAs that target DTX3

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTX3 Gene

Localization for DTX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTX3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DTX3 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DTX3: view

Pathways & Interactions for DTX3 Gene

genes like me logo Genes that share pathways with DTX3: view

Pathways by source for DTX3 Gene

1 Sino Biological pathway for DTX3 Gene
1 GeneTex pathway for DTX3 Gene
1 BioSystems pathway for DTX3 Gene
1 KEGG pathway for DTX3 Gene

UniProtKB/Swiss-Prot Q8N9I9-DTX3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DTX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DTX3: view

No data available for SIGNOR curated interactions for DTX3 Gene

Drugs & Compounds for DTX3 Gene

No Compound Related Data Available

Transcripts for DTX3 Gene

Unigene Clusters for DTX3 Gene

Deltex homolog 3 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTX3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7a · 7b ^ 8 ^ 9
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - - -
SP7: - -
SP8: - -
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for DTX3 Gene

GeneLoc Exon Structure for
DTX3
ECgene alternative splicing isoforms for
DTX3

Expression for DTX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DTX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DTX3 Gene

This gene is overexpressed in Retina (12.8), Rectum (11.2), Fetal Brain (8.6), and Stomach (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DTX3 Gene



Protein tissue co-expression partners for DTX3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DTX3 Gene:

DTX3

SOURCE GeneReport for Unigene cluster for DTX3 Gene:

Hs.32374

Evidence on tissue expression from TISSUES for DTX3 Gene

  • Nervous system(4.7)
  • Pancreas(2.3)
genes like me logo Genes that share expression patterns with DTX3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTX3 Gene

Orthologs for DTX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DTX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTX3 34 33
  • 97.08 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DTX3 34 33
  • 92.32 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DTX3 34 33
  • 91.24 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dtx3 33
  • 90.97 (n)
mouse
(Mus musculus)
Mammalia Dtx3 16 34 33
  • 90.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DTX3 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia DTX3 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dtx3 33
  • 68.43 (n)
Str.17194 33
zebrafish
(Danio rerio)
Actinopterygii zgc:66440 33
  • 59.18 (n)
DTX3 34
  • 42 (a)
OneToOne
zgc66440 33
fruit fly
(Drosophila melanogaster)
Insecta dx 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToOne
Species where no ortholog for DTX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTX3 Gene

ENSEMBL:
Gene Tree for DTX3 (if available)
TreeFam:
Gene Tree for DTX3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DTX3: view image

Paralogs for DTX3 Gene

Paralogs for DTX3 Gene

(3) SIMAP similar genes for DTX3 Gene using alignment to 4 proteins:

  • DTX3_HUMAN
  • F8VUZ4_HUMAN
  • F8VV96_HUMAN
  • H0YHF9_HUMAN
genes like me logo Genes that share paralogs with DTX3: view

Variants for DTX3 Gene

Sequence variations from dbSNP and Humsavar for DTX3 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000700275 -- 57,607,160(+) G/C coding_sequence_variant, missense_variant
rs1001378807 -- 57,610,282(+) G/A downstream_transcript_variant
rs1001638897 -- 57,603,538(+) A/C upstream_transcript_variant
rs1001900918 -- 57,605,200(+) A/G 5_prime_UTR_variant, intron_variant
rs1002192094 -- 57,606,510(+) A/G 5_prime_UTR_variant, coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for DTX3 Gene

Variant ID Type Subtype PubMed ID
esv2759901 CNV gain 17122850
nsv428283 CNV gain 18775914
nsv482992 CNV gain+loss 15286789
nsv559034 CNV loss 21841781

Variation tolerance for DTX3 Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DTX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DTX3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTX3 Gene

Disorders for DTX3 Gene

Additional Disease Information for DTX3

No disorders were found for DTX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTX3 Gene

Publications for DTX3 Gene

  1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K … Shipp MA (The Journal of biological chemistry 2003) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland SL … Hayden MR (Human molecular genetics 2014) 3 58

Products for DTX3 Gene

Sources for DTX3 Gene

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