Aliases for DTX3 Gene
External Ids for DTX3 Gene
Previous GeneCards Identifiers for DTX3 Gene
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
GeneCards Summary for DTX3 Gene
DTX3 (Deltex E3 Ubiquitin Ligase 3) is a Protein Coding gene. Among its related pathways are Notch Signaling Pathway (sino) and Notch signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is DTX3L.
UniProtKB/Swiss-Prot for DTX3 Gene
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.