DTX2 Gene (Protein Coding)

Deltex E3 Ubiquitin Ligase 2

GC07P076461
GIFtS:
41
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009] See more...

Aliases for DTX2 Gene

Aliases for DTX2 Gene

  • Deltex E3 Ubiquitin Ligase 2 2 3 5
  • RNF58 2 3 4
  • Probable E3 Ubiquitin-Protein Ligase DTX2 3 4
  • RING-Type E3 Ubiquitin Transferase DTX2 3 4
  • Deltex 2, E3 Ubiquitin Ligase 2 3
  • Protein Deltex-2 3 4
  • KIAA1528 2 4
  • Deltex2 3 4
  • HDTX2 3 4
  • Deltex (Drosophila) Homolog 2 2
  • Deltex Homolog 2 (Drosophila) 2
  • Zinc Ion Binding Protein 3
  • Ring Finger Protein 58 3
  • RING Finger Protein 58 4
  • Deltex Homolog 2 3
  • EC 2.3.2.27 4
  • DTX2 5

External Ids for DTX2 Gene

Previous GeneCards Identifiers for DTX2 Gene

  • GC07P074626
  • GC07P075689
  • GC07P075703
  • GC07P075735
  • GC07P075928
  • GC07P076090
  • GC07P071168

Summaries for DTX2 Gene

Entrez Gene Summary for DTX2 Gene

  • DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

GeneCards Summary for DTX2 Gene

DTX2 (Deltex E3 Ubiquitin Ligase 2) is a Protein Coding gene. Diseases associated with DTX2 include Ependymoblastoma and Pthirus Pubis Infestation. Among its related pathways are Signaling by GPCR and NOTCH2 Activation and Transmission of Signal to the Nucleus. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is DTX4.

UniProtKB/Swiss-Prot Summary for DTX2 Gene

  • Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Gene Wiki entry for DTX2 Gene

Additional gene information for DTX2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DTX2 Gene

Genomics for DTX2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for DTX2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J076461 Promoter/Enhancer 1 EPDnew Ensembl dbSUPER 250.7 +1.1 1125 3.6 GABPB1 MLLT1 DTX2 lnc-ZP3-4 FDPSP2 UPK3B RF00017-6395
GH07J076462 Promoter 0.3 Ensembl 250.7 -1.2 -1175 0.2 DTX2 lnc-ZP3-4 piR-61288-018 SSC4D RF00017-6395
GH07J076281 Promoter/Enhancer 1.6 EPDnew Ensembl dbSUPER 14.3 -179.3 -179275 2.4 MNT IKZF1 ZEB1 NONO MCM3 ZIC2 ARNT SIN3A NFATC3 ZNF639 SRRM3 HSALNG0059056 STAG3L1 PMS2P3 FAM185BP SPDYE18 NSUN5P1 DTX2P1 SPDYE5 ENSG00000225726
GH07J076290 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 -167.1 -167121 8.9 TBP ZBTB10 CEBPA MNT DEK IKZF1 HES1 MBD2 ZNF217 CTCF STAG3L1 PMS2P3 FAM185BP POMZP3 PMS2P9 NSUN5P1 DTX2P1 SRRM3 DTX2 SPDYE18
GH07J076372 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 14.3 -88.3 -88333 1.2 TBP IKZF1 SMAD5 MCM7 NONO ARNT ZNF395 NFATC3 SIN3B VEZF1 SPDYE5 DTX2P1 PMS2P9 PMS2P3 DTX2 SPDYE17 SPDYE18 NSUN5P1 CCDC146 FAM185BP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DTX2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DTX2

Top Transcription factor binding sites by QIAGEN in the DTX2 gene promoter:
  • AP-4
  • Evi-1
  • GATA-1
  • GATA-2
  • GATA-3
  • HOXA5
  • Max1

Genomic Locations for DTX2 Gene

Latest Assembly
chr7:76,461,676-76,505,995
(GRCh38/hg38)
Size:
44,320 bases
Orientation:
Plus strand

Previous Assembly
chr7:76,090,972-76,135,308
(GRCh37/hg19 by Entrez Gene)
Size:
44,337 bases
Orientation:
Plus strand

chr7:76,090,993-76,135,312
(GRCh37/hg19 by Ensembl)
Size:
44,320 bases
Orientation:
Plus strand

Genomic View for DTX2 Gene

Genes around DTX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTX2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DTX2 Gene

Proteins for DTX2 Gene

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  • Protein details for DTX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UW9-DTX2_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase DTX2
    Protein Accession:
    Q86UW9
    Secondary Accessions:
    • Q4ZH49
    • Q6XM87
    • Q6XM88
    • Q96H69
    • Q9H890
    • Q9P200

    Protein attributes for DTX2 Gene

    Size:
    622 amino acids
    Molecular mass:
    67246 Da
    Quaternary structure:
    • Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1.
    SequenceCaution:
    • Sequence=BAA96052.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DTX2 Gene

    Alternative splice isoforms for DTX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTX2 Gene

Protein Expression for DTX2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DTX2 Gene

  • Ubiquitination at Lys249 and Lys553
  • Modification sites at PhosphoSitePlus

Other Protein References for DTX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DTX2 Gene

Domains & Families for DTX2 Gene

Gene Families for DTX2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DTX2 Gene

InterPro:
Blocks:
  • Zn-finger, RING
ProtoNet:

Suggested Antigen Peptide Sequences for DTX2 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 58 (DTX2_HUMAN)
  • Deltex 2 transcript I (Q4FEB2_HUMAN)
  • Deltex 2 transcript E (Q4FEB4_HUMAN)
  • Zinc ion binding protein (Q4ZH49_HUMAN)
  • DTX2 protein (Q6P2H0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86UW9

UniProtKB/Swiss-Prot:

DTX2_HUMAN :
  • The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
  • Belongs to the Deltex family.
Domain:
  • The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
Family:
  • Belongs to the Deltex family.
genes like me logo Genes that share domains with DTX2: view

Function for DTX2 Gene

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  6. Cell Lines for research

Molecular function for DTX2 Gene

UniProtKB/Swiss-Prot Function:
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000250|UniProtKB:Q61010};.

Enzyme Numbers (IUBMB) for DTX2 Gene

Phenotypes From GWAS Catalog for DTX2 Gene

Gene Ontology (GO) - Molecular Function for DTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with DTX2: view
genes like me logo Genes that share phenotypes with DTX2: view

Animal Models for DTX2 Gene

MGI Knock Outs for DTX2:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTX2

Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DTX2 Gene

Localization for DTX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTX2 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000269 PubMed:11564735}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DTX2 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA,IDA --
GO:0005737 cytoplasm IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with DTX2: view

Pathways & Interactions for DTX2 Gene

genes like me logo Genes that share pathways with DTX2: view

Pathways by source for DTX2 Gene

1 BioSystems pathway for DTX2 Gene
1 KEGG pathway for DTX2 Gene
1 GeneTex pathway for DTX2 Gene

UniProtKB/Swiss-Prot Q86UW9-DTX2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IBA 21873635
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DTX2: view

No data available for SIGNOR curated interactions for DTX2 Gene

Drugs & Compounds for DTX2 Gene

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No Compound Related Data Available

Transcripts for DTX2 Gene

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mRNA/cDNA for DTX2 Gene

4 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTX2

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for DTX2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a ·
SP1: -
SP2: - - - - - - - -
SP3: - - - - - -
SP4:
SP5: -
SP6: - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - -
SP11: - - - -
SP12: - - - - - - - - -
SP13: - -
SP14:
SP15: - - - - - -
SP16: - - - - - - -
SP17:

ExUns: 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -

Relevant External Links for DTX2 Gene

GeneLoc Exon Structure for
DTX2

Expression for DTX2 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DTX2 Gene

mRNA expression in normal human tissues for DTX2 Gene
mRNA expression by GTEx for DTX2 GenemRNA expression by BioGPS for DTX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DTX2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.7) and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for DTX2 Gene

This gene is overexpressed in Cervix (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DTX2 Gene



Protein tissue co-expression partners for DTX2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DTX2

SOURCE GeneReport for Unigene cluster for DTX2 Gene:

Hs.187058

Evidence on tissue expression from TISSUES for DTX2 Gene

  • Nervous system(4.6)
  • Muscle(4.2)
  • Thyroid gland(4)
genes like me logo Genes that share expression patterns with DTX2: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTX2 Gene

Orthologs for DTX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DTX2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia DTX2 30 31
  • 98.87 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia DTX2 30 31
  • 88.3 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia DTX2 30 31
  • 87.65 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Dtx2 30
  • 83.87 (n)
Mouse
(Mus musculus)
 Mammalia Dtx2 30 17 31
  • 83.76 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia DTX2 31
  • 74 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia DTX2 31
  • 66 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves DTX2 30 31
  • 66.98 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia DTX2 31
  • 56 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia dtx2 30
  • 60.09 (n)
Str.4864 30
African clawed frog
(Xenopus laevis)
 Amphibia MGC53737 30
Zebrafish
(Danio rerio)
 Actinopterygii dtx2 30 31
  • 65.83 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta dx 31
  • 23 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.7641 31
  • 30 (a)
 OneToMany
Species where no ortholog for DTX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DTX2 Gene

ENSEMBL:
Gene Tree for DTX2 (if available)
TreeFam:
Gene Tree for DTX2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DTX2: view image

Paralogs for DTX2 Gene

Paralogs for DTX2 Gene

(3) SIMAP similar genes for DTX2 Gene using alignment to 16 proteins:

  • DTX2_HUMAN
  • C9IYX1_HUMAN
  • C9JEH4_HUMAN
  • C9JF39_HUMAN
  • C9JII1_HUMAN
  • C9JLU8_HUMAN
  • C9JS11_HUMAN
  • C9JVC8_HUMAN
  • C9JY61_HUMAN
  • E7ET89_HUMAN
  • H7C3B8_HUMAN
  • Q4FEB2_HUMAN
  • Q4FEB4_HUMAN
  • Q4ZH49_HUMAN
  • Q6P2H0_HUMAN
  • Q75MM6_HUMAN

Pseudogenes.org Pseudogenes for DTX2 Gene

genes like me logo Genes that share paralogs with DTX2: view

Variants for DTX2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DTX2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs17855260 Likely Benign: not provided 76,503,581(+) T/C
NM_001102594.1(DTX2):c.1545T>C (p.Gly515=) 		SYNONYMOUS
rs368597411 Benign: not provided 76,503,421(+) G/C
NM_001102594.1(DTX2):c.1390-5G>C 		INTRON
rs6958774 Likely Benign: not provided 76,502,333(+) G/A
NM_001102594.1(DTX2):c.1266G>A (p.Ala422=) 		SYNONYMOUS
rs73703182 Benign: not provided 76,503,488(+) C/G
NM_001102594.1(DTX2):c.1452C>G (p.Pro484=) 		SYNONYMOUS
rs1638152 - p.Gly384Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DTX2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DTX2 Gene

Variant ID Type Subtype PubMed ID
dgv11464n54 CNV gain 21841781
dgv11465n54 CNV loss 21841781
dgv11466n54 CNV loss 21841781
dgv120n16 CNV deletion 17901297
dgv1218e199 CNV deletion 23128226
dgv121n16 CNV insertion 17901297
dgv21n31 CNV gain 19718026
dgv232e55 CNV gain 17911159
dgv233e55 CNV loss 17911159
dgv234e55 CNV gain 17911159
dgv235e55 CNV loss 17911159
dgv6470n100 CNV loss 25217958
dgv6471n100 CNV gain 25217958
dgv6472n100 CNV loss 25217958
dgv6473n100 CNV gain 25217958
dgv6474n100 CNV loss 25217958
dgv6475n100 CNV gain 25217958
dgv6476n100 CNV gain 25217958
dgv6477n100 CNV loss 25217958
esv23516 CNV gain 19812545
esv2422494 CNV duplication 17116639
esv2734687 CNV deletion 23290073
esv2761124 CNV gain 21179565
esv2764008 CNV gain+loss 21179565
esv33074 CNV gain 17666407
esv3613764 CNV loss 21293372
esv3613765 CNV gain 21293372
esv3613766 CNV loss 21293372
esv3891147 CNV gain+loss 25118596
nsv1034692 CNV gain+loss 25217958
nsv1074521 CNV deletion 25765185
nsv1144183 CNV deletion 24896259
nsv1145148 CNV deletion 24896259
nsv428174 CNV gain 18775914
nsv471446 CNV gain 19718026
nsv482106 CNV gain 20164927
nsv509211 CNV insertion 20534489
nsv510964 OTHER complex 20534489
nsv517634 CNV gain+loss 19592680
nsv528969 CNV gain 19592680
nsv5797 CNV deletion 18451855
nsv607585 CNV gain 21841781
nsv607593 CNV gain 21841781
nsv7403 OTHER inversion 18451855
nsv8159 CNV loss 18304495
nsv951360 CNV deletion 24416366
nsv970893 CNV duplication 23825009
nsv970894 CNV duplication 23825009
nsv981537 CNV duplication 23825009

Variation tolerance for DTX2 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DTX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DTX2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTX2 Gene

Disorders for DTX2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DTX2 Gene - From: COP

Disorder Aliases PubMed IDs
ependymoblastoma
  • embryonal tumor with multilayered rosettes
pthirus pubis infestation
  • crabs
lice infestation
  • infestation by pediculus
- elite association - COSMIC cancer census association via MalaCards
Search DTX2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DTX2

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DTX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DTX2 Gene

Publications for DTX2 Gene

  1. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K … Shipp MA (The Journal of biological chemistry 2003) 2 3 4 23
  2. cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos. (PMID: 17286044) Yi Z … Wu Z (DNA sequence : the journal of DNA sequencing and mapping 2006) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4

ExternalLinks

View latest publications for DTX2 gene in Mastermind

Products for DTX2 Gene

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