Aliases for DTX2 Gene
Aliases for DTX2 Gene
External Ids for DTX2 Gene
- HGNC: 15973
- Entrez Gene: 113878
- Ensembl: ENSG00000091073
- OMIM: 613141
- UniProtKB: Q86UW9
Previous GeneCards Identifiers for DTX2 Gene
- GC07P074626
- GC07P075689
- GC07P075703
- GC07P075735
- GC07P075928
- GC07P076090
- GC07P071168
Summaries for DTX2 Gene
-
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
GeneCards Summary for DTX2 Gene
DTX2 (Deltex E3 Ubiquitin Ligase 2) is a Protein Coding gene. Among its related pathways are Signaling by NOTCH1 and Notch signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is DTX1.
UniProtKB/Swiss-Prot for DTX2 Gene
-
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Additional gene information for DTX2 Gene
- Monarch Initiative
- Search for DTX2 at DataMed
- Search for DTX2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTX2 Gene
Genomics for DTX2 Gene
GeneHancer (GH) Regulatory Elements for DTX2 Gene
Promoters and enhancers for DTX2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07I076461 | Promoter/Enhancer | 1.3 | EPDnew Ensembl dbSUPER | 550.8 | +0.4 | 446 | 1.4 | GABPB1 | DTX2 FDPSP2 | |
| GH07I076459 | Enhancer | 0.2 | dbSUPER | 550.8 | -1.8 | -1772 | 0.9 | DTX2 SSC4D | ||
| GH07I076372 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 14.3 | -88.3 | -88312 | 1.2 | HDGF PKNOX1 ARNT ZNF280A POLR2B ZNF766 ARID2 FOS ATF7 ZNF263 | SPDYE5 DTX2P1 PMS2P9 PMS2P3 DTX2 SPDYE17 SPDYE18 NSUN5P1 CCDC146 FAM185BP | |
| GH07I076290 | Enhancer | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 10.2 | -167.1 | -167100 | 8.9 | HNRNPUL1 PKNOX1 CLOCK FOXA2 ARNT ARID4B NEUROD1 SIN3A DMAP1 IRF4 | STAG3L1 PMS2P3 FAM185BP POMZP3 PMS2P9 NSUN5P1 DTX2P1 SRRM3 DTX2 SPDYE18 | |
| GH07I075637 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 9.7 | -822.3 | -822276 | 3.6 | ARNT SIN3A ZNF2 ZBTB7B ZNF766 REST SMARCA4 GLIS1 NBN KDM1A | SPDYE5 HIP1 STAG3L1 PMS2P3 NSUN5P1 GTF2IRD2B GTF2IRD2 LOC101926943 TRIM73 DTX2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DTX2 on UCSC Golden Path with GeneCards custom track
Genomic Locations for DTX2 Gene
Genomic Locations for DTX2 Gene
- chr7:76,461,655-76,505,998
- (GRCh38/hg38)
- Size:
- 44,344 bases
- Orientation:
- Plus strand
- chr7:76,090,972-76,135,312
- (GRCh37/hg19)
Genomic View for DTX2 Gene
Genes around DTX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q11.23 by Ensembl
- 7q11.23 by Entrez Gene
- 7q11.23 by HGNC
DTX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DTX2 Gene
Proteins for DTX2 Gene
-
Protein details for DTX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86UW9-DTX2_HUMAN
- Recommended name:
- Probable E3 ubiquitin-protein ligase DTX2
- Protein Accession:
- Q86UW9
- Q4ZH49
- Q6XM87
- Q6XM88
- Q96H69
- Q9H890
- Q9P200
Protein attributes for DTX2 Gene
- Size:
- 622 amino acids
- Molecular mass:
- 67246 Da
- Quaternary structure:
-
- Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1.
- SequenceCaution:
-
- Sequence=BAA96052.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for DTX2 Gene
Post-translational modifications for DTX2 Gene
Other Protein References for DTX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for DTX2
-
Abcam antibodies for DTX2
- Invitrogen Antibodies for DTX2
- Search GeneTex for Antibodies for DTX2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for DTX2
- Origene Custom Protein Services for DTX2
- Search GeneTex for Proteins for DTX2
Assay Products
- antibodies-online: Search results for available DTX2 related products ranked by validation data
No data available for DME Specific Peptides for DTX2 Gene
Domains & Families for DTX2 Gene
Gene Families for DTX2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for DTX2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DTX2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86UW9UniProtKB/Swiss-Prot:
DTX2_HUMAN :- The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
- Belongs to the Deltex family.
- Domain:
-
- The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
- Family:
-
- Belongs to the Deltex family.
Function for DTX2 Gene
Molecular function for DTX2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
- UniProtKB/Swiss-Prot Function:
- Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Enzyme Numbers (IUBMB) for DTX2 Gene
Phenotypes From GWAS Catalog for DTX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for DTX2 Gene
- MGI mutant phenotypes for DTX2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DTX2:
-
- Increased vaccinia virus (VACV) infection
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased Salmonella enterica Typhimurium invasion
- Decreased homologous recombination repair frequency
- Increased cell death HMECs cells
- Downregulation of Wnt pathway after Wnt3A stimulation
Animal Models for DTX2 Gene
- MGI Knock Outs for DTX2:
-
- Dtx2 tm1Mjb
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DTX2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for DTX2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DTX2 gene
- Search ViGene Biosciences for DTX2
CRISPR Products
-
OriGene CRISPR knockouts for DTX2
- genomics-online: gRNA clones - Search results for 147 available DTX2 gene related products
- Overview of 147 available DTX2 gene related products
-
Recommended
- Applied Biological Materials CRISPR for DTX2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DTX2
- GenScript: Design CRISPR guide RNA sequences for DTX2
miRNA for DTX2 Gene
- miRTarBase miRNAs that target DTX2
-
- hsa-mir-20a-5p (MIRT050508)
- hsa-mir-7111-5p (MIRT486927)
- hsa-mir-6870-5p (MIRT486928)
- hsa-mir-4723-5p (MIRT486929)
- hsa-mir-5698 (MIRT486930)
- hsa-mir-939-5p (MIRT486931)
- hsa-mir-1343-5p (MIRT486932)
- hsa-mir-6827-5p (MIRT486933)
- hsa-mir-4763-3p (MIRT486934)
- hsa-mir-1207-5p (MIRT486935)
- hsa-mir-6722-3p (MIRT486936)
- hsa-mir-1909-3p (MIRT486937)
- hsa-mir-4707-5p (MIRT486938)
- hsa-mir-1225-3p (MIRT486939)
- hsa-mir-6798-5p (MIRT486940)
- hsa-mir-4692 (MIRT486941)
- hsa-mir-4514 (MIRT486942)
- hsa-mir-6794-5p (MIRT486943)
- hsa-mir-940 (MIRT486944)
- hsa-mir-4716-3p (MIRT486945)
- hsa-mir-6893-5p (MIRT486946)
- hsa-mir-6808-5p (MIRT486947)
miRNA Products
- Search ViGene Biosciences for DTX2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DTX2
- Browse OriGene Inhibitory RNA Products For DTX2
- genomics-online: shRNA clones - Search results for 147 available DTX2 gene related products
- Overview of 147 available DTX2 gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for DTX2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DTX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DTX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 147 available DTX2 gene related products
- Overview of 147 available DTX2 gene related products
-
Recommended
- orf clones - Search results for 147 available DTX2 gene related products
- Overview of 147 available DTX2 gene related products
-
Recommended
- Applied Biological Materials Clones for DTX2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DTX2
-
ViGene Biosciences adenoviral particle packaged cDNA for DTX2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DTX2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DTX2 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DTX2 Gene
Localization for DTX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DTX2 Gene
- Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000269 PubMed:11564735}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nuclear membrane (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0031965 | nuclear membrane | IDA | -- |
Pathways & Interactions for DTX2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Notch signaling pathway (KEGG) | ||
| 2 | Signaling by NOTCH1 | ||
| 3 | NOTCH2 Activation and Transmission of Signal to the Nucleus | ||
| 4 | Signaling by GPCR | ||
Pathways by source for DTX2 Gene
1 GeneTex pathway for DTX2 Gene
1 BioSystems pathway for DTX2 Gene
4 Reactome pathways for DTX2 Gene
1 KEGG pathway for DTX2 Gene
UniProtKB/Swiss-Prot Q86UW9-DTX2_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for DTX2 Gene
Selected Interacting proteins:
ENSP00000322885
Q86UW9-DTX2_HUMAN
for DTX2 Gene via
STRING
IID
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007219 | Notch signaling pathway | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
No data available for SIGNOR curated interactions for DTX2 Gene
Transcripts for DTX2 Gene
mRNA/cDNA for DTX2 Gene
- (18) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (195) Selected AceView cDNA sequences:
- (21) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DTX2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DTX2
- genomics-online: gRNA clones - Search results for 147 available DTX2 gene related products
- Overview of 147 available DTX2 gene related products
-
Recommended
- Applied Biological Materials CRISPR for DTX2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DTX2
- GenScript: Design CRISPR guide RNA sequences for DTX2
miRNA Products
- Search ViGene Biosciences for DTX2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DTX2
- Browse OriGene Inhibitory RNA Products For DTX2
- genomics-online: shRNA clones - Search results for 147 available DTX2 gene related products
- Overview of 147 available DTX2 gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for DTX2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DTX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DTX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 147 available DTX2 gene related products
- Overview of 147 available DTX2 gene related products
-
Recommended
- orf clones - Search results for 147 available DTX2 gene related products
- Overview of 147 available DTX2 gene related products
-
Recommended
- Applied Biological Materials Clones for DTX2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP17: |
| ExUns: | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: | |||||||||||||
| SP5: | - | ||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: | |||||||||||||
| SP13: | |||||||||||||
| SP14: | |||||||||||||
| SP15: | |||||||||||||
| SP16: | |||||||||||||
| SP17: | - |
Expression for DTX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Ovary (Reproductive System)
- Secondary Oocyte Antral Follicle
-
Gonad
- Secondary Oocyte Antral Follicle
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for DTX2 Gene
This gene is overexpressed in Esophagus - Mucosa (x4.7) and Whole Blood (x4.3).
This gene is overexpressed in Cervix (64.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DTX2 Gene
NURSA nuclear receptor signaling pathways regulating expression of DTX2 Gene:
DTX2SOURCE GeneReport for Unigene cluster for DTX2 Gene:
Hs.187058Evidence on tissue expression from TISSUES for DTX2 Gene
- Nervous system(4.5)
- Muscle(4.1)
- Thyroid gland(4)
Primer Products
-
OriGene qPCR primer pairs for DTX2
-
OriGene qPCR primer pairs and template standards for DTX2
- genomics-online: primer clones - Search results for 147 available DTX2 gene related products
- Overview of 147 available DTX2 gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTX2 Gene
Orthologs for DTX2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DTX2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | DTX2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | DTX2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dtx2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Dtx2 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DTX2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DTX2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DTX2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | DTX2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dtx2 33 |
|
||
| Str.4864 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53737 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dtx2 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | dx 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7641 34 |
|
OneToMany |
- Species where no ortholog for DTX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for DTX2 Gene
(3) SIMAP similar genes for DTX2 Gene using alignment to 16 proteins:
Pseudogenes.org Pseudogenes for DTX2 Gene
Variants for DTX2 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000130029 | -- | 76,483,793(+) | C/T | intron_variant | |
| rs1000325454 | -- | 76,465,079(+) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000603294 | -- | 76,483,583(+) | G/C | intron_variant | |
| rs1000930599 | -- | 76,469,032(+) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000978791 | -- | 76,479,403(+) | A/C | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
Residual Variation Intolerance Score:
46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.55;
44.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DTX2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DTX2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTX2 Gene
Disorders for DTX2 Gene
Additional Disease Information for DTX2
No disorders were found for DTX2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTX2 Gene
Publications for DTX2 Gene
- The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K … Shipp MA (The Journal of biological chemistry 2003) 2 3 4 22 58
- cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos. (PMID: 17286044) Yi Z … Wu Z (DNA sequence : the journal of DNA sequencing and mapping 2006) 3 22 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
Products for DTX2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
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- Browse Immunoprecipitation Assays
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for DTX2
- Origene Custom Protein Services for DTX2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DTX2
- Browse OriGene Inhibitory RNA Products For DTX2
- OriGene qPCR primer pairs and template standards for DTX2
- OriGene qPCR primer pairs for DTX2
- OriGene CRISPR knockouts for DTX2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DTX2
- GenScript: Next-day shipping of latest version cDNA ORF clones for DTX2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for DTX2
- GenScript Custom Assay Services for DTX2
- GenScript Custom overexpressing Cell Line Services for DTX2
- GenScript: Design CRISPR guide RNA sequences for DTX2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DTX2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for DTX2
- Novus Biologicals lysates and proteins for DTX2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for DTX2
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- Search Knockout (KO) Validated Antibodies
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- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for DTX2
- VectorBuilder custom plasmid, inducible vectors for DTX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DTX2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 57 available DTX2 Antibodies ranked by validation data
- Compare Top DTX2 Antibodies
- antibodies-online: Search results for available DTX2 related products ranked by validation data
- antibodies-online: Search results for 5 available DTX2 Proteins ranked by validation data
- Compare Top DTX2 Proteins
- Search GeneTex for Antibodies for DTX2
- Search GeneTex for Proteins for DTX2
- ViGene Biosciences adenoviral particle packaged cDNA for DTX2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for DTX2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for DTX2 gene
- Search ViGene Biosciences for DTX2
- Horizon Cell Lines for DTX2
- genomics-online: cdna clones - Search results for 147 available DTX2 gene related products
- Overview of 147 available DTX2 gene related products
- Recommended
- orf clones - Search results for 147 available DTX2 gene related products
- Overview of 147 available DTX2 gene related products
- Recommended
- genomics-online: gRNA clones - Search results for 147 available DTX2 gene related products
- Overview of 147 available DTX2 gene related products
- Recommended
- genomics-online: primer clones - Search results for 147 available DTX2 gene related products
- Overview of 147 available DTX2 gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 147 available DTX2 gene related products
- Overview of 147 available DTX2 gene related products
- Recommended
Sources for DTX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (119) Disease Ontology
- (120) Genetics Home Reference
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- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
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- (128) ViGene Biosciences
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
