Aliases for DTX2 Gene
External Ids for DTX2 Gene
Previous GeneCards Identifiers for DTX2 Gene
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
GeneCards Summary for DTX2 Gene
DTX2 (Deltex E3 Ubiquitin Ligase 2) is a Protein Coding gene. Diseases associated with DTX2 include Ependymoblastoma and Pthirus Pubis Infestation. Among its related pathways are Signaling by GPCR and NOTCH2 Activation and Transmission of Signal to the Nucleus. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is DTX1.
UniProtKB/Swiss-Prot Summary for DTX2 Gene
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.