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DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009] See more...
Aliases for DTX2 Gene
Aliases for DTX2 Gene
External Ids for DTX2 Gene
- HGNC: 15973
- Entrez Gene: 113878
- Ensembl: ENSG00000091073
- OMIM: 613141
- UniProtKB: Q86UW9
Previous GeneCards Identifiers for DTX2 Gene
- GC07P074626
- GC07P075689
- GC07P075703
- GC07P075735
- GC07P075928
- GC07P076090
- GC07P071168
Summaries for DTX2 Gene
-
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
GeneCards Summary for DTX2 Gene
DTX2 (Deltex E3 Ubiquitin Ligase 2) is a Protein Coding gene. Diseases associated with DTX2 include Ependymoblastoma and Pthirus Pubis Infestation. Among its related pathways are Signaling by GPCR and NOTCH2 Activation and Transmission of Signal to the Nucleus. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is DTX1.
UniProtKB/Swiss-Prot Summary for DTX2 Gene
-
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Additional gene information for DTX2 Gene
- HGNC(15973)
- Entrez Gene(113878)
- Ensembl(ENSG00000091073)
- OMIM(613141)
- UniProtKB(Q86UW9)
- Open Targets Platform(ENSG00000091073)
- Monarch Initiative
- Search for DTX2 at DataMed
- Search for DTX2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DTX2 Gene
Genomics for DTX2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DTX2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07J076461 | Promoter/Enhancer | 0.9 | EPDnew Ensembl dbSUPER | 600.7 | +0.8 | 846 | 2.6 | GABPB1 | DTX2 lnc-ZP3-4 FDPSP2 UPK3B RF00017-6397 | |
| GH07J076462 | Promoter | 0.3 | Ensembl | 600.7 | -1.2 | -1154 | 0.2 | DTX2 lnc-ZP3-4 piR-61288-018 SSC4D RF00017-6397 | ||
| GH07J076459 | Enhancer | 0.2 | dbSUPER | 600.7 | -1.8 | -1772 | 0.9 | DTX2 lnc-ZP3-4 piR-61288-018 SSC4D RF00017-6397 | ||
| GH07J076281 | Promoter/Enhancer | 1.6 | EPDnew Ensembl dbSUPER | 14.3 | -179.2 | -179155 | 2.6 | RNF2 ARHGAP35 ZNF512 IKZF1 KDM1A ZNF300 DDX20 PRDM1 MTA2 PHF21A | SRRM3 STAG3L1 PMS2P3 FAM185BP SPDYE18 NSUN5P1 ENSG00000225726 ENSG00000205485 DTX2P1 SPDYE5 | |
| GH07J076290 | Promoter/Enhancer | 2 | FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 10.2 | -167.1 | -167100 | 8.9 | ARHGAP35 CEBPG HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 ZNF629 LEF1 | STAG3L1 PMS2P3 FAM185BP POMZP3 PMS2P9 NSUN5P1 DTX2P1 SRRM3 DTX2 SPDYE18 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DTX2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DTX2
- Top Transcription factor binding sites by QIAGEN in the DTX2 gene promoter:
-
- AP-4
- Evi-1
- GATA-1
- GATA-2
- GATA-3
- HOXA5
- Max1
Genomic Locations for DTX2 Gene
Genomic Locations for DTX2 Gene
- chr7:76,461,655-76,505,995
- (GRCh38/hg38)
- Size:
- 44,341 bases
- Orientation:
- Plus strand
- chr7:76,090,972-76,135,312
- (GRCh37/hg19)
- Size:
- 44,341 bases
- Orientation:
- Plus strand
Genomic View for DTX2 Gene
Genes around DTX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q11.23 by HGNC
- 7q11.23 by Entrez Gene
- 7q11.23 by Ensembl
DTX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DTX2 Gene
Proteins for DTX2 Gene
-
Protein details for DTX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86UW9-DTX2_HUMAN
- Recommended name:
- Probable E3 ubiquitin-protein ligase DTX2
- Protein Accession:
- Q86UW9
- Q4ZH49
- Q6XM87
- Q6XM88
- Q96H69
- Q9H890
- Q9P200
Protein attributes for DTX2 Gene
- Size:
- 622 amino acids
- Molecular mass:
- 67246 Da
- Quaternary structure:
-
- Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1.
- SequenceCaution:
-
- Sequence=BAA96052.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for DTX2 Gene
Post-translational modifications for DTX2 Gene
Other Protein References for DTX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences DTX2 Antibody
- Novus Biologicals Antibodies for DTX2
-
Abcam antibodies for DTX2
- Invitrogen Antibodies for DTX2 (AFLGC-DTX2)
- antibodies-online: Show 9 available DTX2 Antibodies ranked by validation data
- Compare Top DTX2 Antibodies
-
Recommended
- 27 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 11 WB Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-mouse)
- 11 WB Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
-
Boster Bio Antibodies for DTX2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for DTX2
- Origene Custom Protein Services for DTX2
-
Signalway Proteins for DTX2
No data available for DME Specific Peptides for DTX2 Gene
Domains & Families for DTX2 Gene
Gene Families for DTX2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for DTX2 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- ProtoNet:
Suggested Antigen Peptide Sequences for DTX2 Gene
- GenScript: Design optimal peptide antigens:
-
- RING finger protein 58 (DTX2_HUMAN)
- Deltex 2 transcript I (Q4FEB2_HUMAN)
- Deltex 2 transcript E (Q4FEB4_HUMAN)
- Zinc ion binding protein (Q4ZH49_HUMAN)
- DTX2 protein (Q6P2H0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q86UW9UniProtKB/Swiss-Prot:
DTX2_HUMAN :- The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
- Belongs to the Deltex family.
- Domain:
-
- The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
- Family:
-
- Belongs to the Deltex family.
Function for DTX2 Gene
Molecular function for DTX2 Gene
- UniProtKB/Swiss-Prot Function:
- Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000250|UniProtKB:Q61010};.
Enzyme Numbers (IUBMB) for DTX2 Gene
Phenotypes From GWAS Catalog for DTX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0061630 | ubiquitin protein ligase activity | IBA | 21873635 |
Phenotypes for DTX2 Gene
- MGI mutant phenotypes for DTX2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DTX2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Increased cell death HMECs cells
- Decreased vaccinia virus (VACV) infection
- Decreased viability
- Downregulation of Wnt pathway after Wnt3A stimulation
- Increased Salmonella enterica Typhimurium invasion
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased homologous recombination repair frequency
Animal Models for DTX2 Gene
- MGI Knock Outs for DTX2:
-
- Dtx2 Dtx2<tm1Mjb>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DTX2 - Select products 50% OFF >
- * DTX2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DTX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DTX2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DTX2
miRNA for DTX2 Gene
- miRTarBase miRNAs that target DTX2
-
- mmu-miR-124-3p (MIRT015693)
- hsa-miR-20a-5p (MIRT050508)
- hsa-miR-7111-5p (MIRT486927)
- hsa-miR-6870-5p (MIRT486928)
- hsa-miR-4723-5p (MIRT486929)
- hsa-miR-5698 (MIRT486930)
- hsa-miR-939-5p (MIRT486931)
- hsa-miR-1343-5p (MIRT486932)
- hsa-miR-6827-5p (MIRT486933)
- hsa-miR-4763-3p (MIRT486934)
- hsa-miR-1207-5p (MIRT486935)
- hsa-miR-6722-3p (MIRT486936)
- hsa-miR-1909-3p (MIRT486937)
- hsa-miR-4707-5p (MIRT486938)
- hsa-miR-1225-3p (MIRT486939)
- hsa-miR-6798-5p (MIRT486940)
- hsa-miR-4692 (MIRT486941)
- hsa-miR-4514 (MIRT486942)
- hsa-miR-6794-5p (MIRT486943)
- hsa-miR-940 (MIRT486944)
- hsa-miR-4716-3p (MIRT486945)
- hsa-miR-6893-5p (MIRT486946)
- hsa-miR-6808-5p (MIRT486947)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DTX2
- Browse OriGene Inhibitory RNA Products For DTX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTX2
Clone Products
- Applied Biological Materials (abm): Clones for DTX2 - Select products 50% OFF >
- * DTX2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG205461
- MG218205
- MR205461
- MR205461L3
- MR205461L4
- MR218205
- MR218205L3
- MR218205L4
- MR230553
- MR230554
- MR230698
- RC203717
- RC203717L3
- RC203717L4
- RC212997
- RC212997L3
- RC212997L4
- RC213418
- RC213418L3
- RC213418L4
- RC214817
- RC214817L3
- RC214817L4
- RG203717
- RG212997
- RG213418
- RG214817
- RR205250
- RR205250L3
- RR205250L4
- MR205461L3V
- MR205461L4V
- MR218205L3V
- MR218205L4V
- RC203717L3V
- RC203717L4V
- RC212997L3V
- RC212997L4V
- RC213418L3V
- RC213418L4V
- RC214817L3V
- RC214817L4V
- RR205250L3V
- RR205250L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DTX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DTX2
Cell Line Products
-
Horizon Cell Lines for DTX2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DTX2 Gene
Localization for DTX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DTX2 Gene
- Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000269 PubMed:11564735}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Nuclear membrane (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IBA,IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0031965 | nuclear membrane | IDA | -- |
Pathways & Interactions for DTX2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Notch Signaling Pathway (WikiPathways) | ||
| 2 | Signaling by NOTCH1 | ||
| 3 | NOTCH2 Activation and Transmission of Signal to the Nucleus | ||
| 4 | Signaling by GPCR | ||
Pathways by source for DTX2 Gene
1 BioSystems pathway for DTX2 Gene
4 Reactome pathways for DTX2 Gene
1 KEGG pathway for DTX2 Gene
1 GeneTex pathway for DTX2 Gene
UniProtKB/Swiss-Prot Q86UW9-DTX2_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for DTX2 Gene
Selected Interacting proteins:
Q86UW9-DTX2_HUMAN
ENSP00000322885
for DTX2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for DTX2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007219 | Notch signaling pathway | IEA,IBA | 21873635 |
| GO:0016567 | protein ubiquitination | IEA | -- |
No data available for SIGNOR curated interactions for DTX2 Gene
Transcripts for DTX2 Gene
mRNA/cDNA for DTX2 Gene
- 4 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000425780 566 nts (view in UCSC)
- ENST00000456590 569 nts (view in UCSC)
- ENST00000451769 550 nts (view in UCSC)
- ENST00000324432 2769 nts (view in UCSC)
- ENST00000492339 556 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DTX2 - Select products 50% OFF >
- * DTX2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DTX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DTX2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DTX2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DTX2
- Browse OriGene Inhibitory RNA Products For DTX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTX2
Clone Products
- Applied Biological Materials (abm): Clones for DTX2 - Select products 50% OFF >
- * DTX2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG205461
- MG218205
- MR205461
- MR205461L3
- MR205461L4
- MR218205
- MR218205L3
- MR218205L4
- MR230553
- MR230554
- MR230698
- RC203717
- RC203717L3
- RC203717L4
- RC212997
- RC212997L3
- RC212997L4
- RC213418
- RC213418L3
- RC213418L4
- RC214817
- RC214817L3
- RC214817L4
- RG203717
- RG212997
- RG213418
- RG214817
- RR205250
- RR205250L3
- RR205250L4
- MR205461L3V
- MR205461L4V
- MR218205L3V
- MR218205L4V
- RC203717L3V
- RC203717L4V
- RC212997L3V
- RC212997L4V
- RC213418L3V
- RC213418L4V
- RC214817L3V
- RC214817L4V
- RR205250L3V
- RR205250L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DTX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DTX2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP17: |
| ExUns: | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: | |||||||||||||
| SP5: | - | ||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: | |||||||||||||
| SP13: | |||||||||||||
| SP14: | |||||||||||||
| SP15: | |||||||||||||
| SP16: | |||||||||||||
| SP17: | - |
Relevant External Links for DTX2 Gene
- GeneLoc Exon Structure for
- DTX2
Expression for DTX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Ovary (Reproductive System)
- Secondary Oocyte Antral Follicle
-
Gonad
- Secondary Oocyte Antral Follicle
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for DTX2 Gene
This gene is overexpressed in Esophagus - Mucosa (x4.7) and Whole Blood (x4.3).
This gene is overexpressed in Cervix (64.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DTX2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DTX2
SOURCE GeneReport for Unigene cluster for DTX2 Gene:
Hs.187058Evidence on tissue expression from TISSUES for DTX2 Gene
- Nervous system(4.6)
- Muscle(4.3)
- Thyroid gland(4)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for DTX2
-
OriGene qPCR primer pairs and template standards for DTX2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTX2 Gene
Orthologs for DTX2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DTX2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DTX2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DTX2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dtx2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Dtx2 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | DTX2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DTX2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | DTX2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DTX2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dtx2 30 |
|
||
| Str.4864 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53737 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | dtx2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | dx 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7641 31 |
|
OneToMany |
- Species where no ortholog for DTX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for DTX2 Gene
- ENSEMBL:
- Gene Tree for DTX2 (if available)
- TreeFam:
- Gene Tree for DTX2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DTX2: view image
Paralogs for DTX2 Gene
(3) SIMAP similar genes for DTX2 Gene using alignment to 16 proteins:
- DTX2_HUMAN
- C9IYX1_HUMAN
- C9JEH4_HUMAN
- C9JF39_HUMAN
- C9JII1_HUMAN
- C9JLU8_HUMAN
- C9JS11_HUMAN
- C9JVC8_HUMAN
- C9JY61_HUMAN
- E7ET89_HUMAN
- H7C3B8_HUMAN
- Q4FEB2_HUMAN
- Q4FEB4_HUMAN
- Q4ZH49_HUMAN
- Q6P2H0_HUMAN
- Q75MM6_HUMAN
Pseudogenes.org Pseudogenes for DTX2 Gene
Variants for DTX2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DTX2 Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 734656 | Benign: not provided | 76,503,421(+) | G/C | INTRON_VARIANT | |
| 768164 | Likely Benign: not provided | 76,502,333(+) | G/A | SYNONYMOUS_VARIANT | |
| 768165 | Likely Benign: not provided | 76,503,581(+) | T/C | SYNONYMOUS_VARIANT | |
| 776233 | Benign: not provided | 76,503,488(+) | C/G | SYNONYMOUS_VARIANT | |
| rs1638152 | - | p.Gly384Glu |
Residual Variation Intolerance Score:
46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.55;
44.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DTX2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DTX2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTX2 Gene
Disorders for DTX2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ependymoblastoma |
|
|
| pthirus pubis infestation |
|
|
| lice infestation |
|
|
Search DTX2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DTX2
No data available for UniProtKB/Swiss-Prot and Genatlas for DTX2 Gene
Publications for DTX2 Gene
- The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. (PMID: 12670957) Takeyama K … Shipp MA (The Journal of biological chemistry 2003) 2 3 4 23
- cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos. (PMID: 17286044) Yi Z … Wu Z (DNA sequence : the journal of DNA sequencing and mapping 2006) 3 23
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
ExternalLinks
Products for DTX2 Gene
- Custom Antibody Services
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- MG205461
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- RR205250L3V
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DTX2
- Sino Biological Human cDNA Clone for DTX2
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- Novus Biologicals proteins and lysates for DTX2
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- VectorBuilder CRISPR vectors for DTX2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DTX2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DTX2
- antibodies-online: Show 9 available DTX2 Antibodies ranked by validation data
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- Recommended
- 27 WB Antibodies (anti-human)
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- 1 IHC (p) Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 11 WB Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-mouse)
- 11 WB Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- antibodies-online: Search results for available DTX2 related products ranked by validation data
- antibodies-online: Show 5 available DTX2 Proteins ranked by validation data
- Compare Top DTX2 Proteins
- Horizon Cell Lines for DTX2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DTX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DTX2
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTX2
- Boster Bio Antibodies for DTX2
- Browse Boster Bio ELISA Kits
- Signalway Proteins for DTX2
Sources for DTX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
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- (110) Genetics Home Reference
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- (112) MedlinePlus
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- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
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- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB