Aliases for DTX1 Gene
External Ids for DTX1 Gene
Previous GeneCards Identifiers for DTX1 Gene
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for DTX1 Gene
DTX1 (Deltex E3 Ubiquitin Ligase 1) is a Protein Coding gene. Diseases associated with DTX1 include Familial Pityriasis Rubra Pilaris and Pityriasis Rubra Pilaris. Among its related pathways are Signaling by GPCR and Presenilin action in Notch and Wnt signaling. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is DTX4.
UniProtKB/Swiss-Prot Summary for DTX1 Gene
Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.