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Aliases for DTWD2 Gene

Aliases for DTWD2 Gene

  • DTW Domain Containing 2 2 3 5

External Ids for DTWD2 Gene

Previous GeneCards Identifiers for DTWD2 Gene

  • GC05M118205
  • GC05M113359

Summaries for DTWD2 Gene

GeneCards Summary for DTWD2 Gene

DTWD2 (DTW Domain Containing 2) is a Protein Coding gene.

Additional gene information for DTWD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTWD2 Gene

Genomics for DTWD2 Gene

GeneHancer (GH) Regulatory Elements for DTWD2 Gene

Promoters and enhancers for DTWD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I118987 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.4 +0.2 165 1.9 HDGF ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 POLR2B ZNF213 DTWD2 PTMAP2 MIR1244-2
GH05I118989 Enhancer 0.4 ENCODE 550.8 -1.4 -1436 0.2 ZNF335 L3MBTL2 TEAD4 DTWD2 DMXL1 LOC105379143 GC05P119008
GH05I119267 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -285.1 -285089 12.3 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 TNFAIP8 DTWD2 DMXL1 GC05P119298
GH05I119030 Enhancer 1.3 FANTOM5 Ensembl ENCODE 18.8 -43.4 -43445 3.3 HDGF PKNOX1 BATF IRF4 CHAMP1 ATF7 ETV6 FOS BCLAF1 IKZF2 TNFAIP8 LOC105379143 DTWD2 DMXL1 ENSG00000250928
GH05I119410 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -423.2 -423223 2.1 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF213 ARID2 ZNF143 TNFAIP8 DTWD2 ENSG00000250678 RNU6-373P HSD17B4 FAM170A DMXL1 GC05P119446 LOC102723444
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DTWD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DTWD2 gene promoter:

Genomic Locations for DTWD2 Gene

Genomic Locations for DTWD2 Gene
152,472 bases
Minus strand

Genomic View for DTWD2 Gene

Genes around DTWD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTWD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTWD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTWD2 Gene

Proteins for DTWD2 Gene

  • Protein details for DTWD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DTW domain-containing protein 2
    Protein Accession:

    Protein attributes for DTWD2 Gene

    298 amino acids
    Molecular mass:
    33416 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DTWD2 Gene

Post-translational modifications for DTWD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DTWD2 Gene

No data available for DME Specific Peptides for DTWD2 Gene

Domains & Families for DTWD2 Gene

Gene Families for DTWD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DTWD2 Gene


Suggested Antigen Peptide Sequences for DTWD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DXTW motif.
  • Belongs to the DTW family.
  • Contains 1 DXTW motif.
  • Belongs to the DTW family.
genes like me logo Genes that share domains with DTWD2: view

Function for DTWD2 Gene

Phenotypes From GWAS Catalog for DTWD2 Gene

genes like me logo Genes that share phenotypes with DTWD2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTWD2 Gene

Localization for DTWD2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DTWD2 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DTWD2 Gene

Pathways & Interactions for DTWD2 Gene

SuperPathways for DTWD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DTWD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with DTWD2: view

No data available for Pathways by source and SIGNOR curated interactions for DTWD2 Gene

Drugs & Compounds for DTWD2 Gene

No Compound Related Data Available

Transcripts for DTWD2 Gene

Unigene Clusters for DTWD2 Gene

DTW domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTWD2 Gene

No ASD Table

Relevant External Links for DTWD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DTWD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DTWD2 Gene

Protein differential expression in normal tissues from HIPED for DTWD2 Gene

This gene is overexpressed in Lung (46.5) and Pancreas (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DTWD2 Gene

Protein tissue co-expression partners for DTWD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DTWD2 Gene:


SOURCE GeneReport for Unigene cluster for DTWD2 Gene:


Evidence on tissue expression from TISSUES for DTWD2 Gene

  • Skin(4.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with DTWD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTWD2 Gene

Orthologs for DTWD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DTWD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DTWD2 33 34
  • 99.66 (n)
(Canis familiaris)
Mammalia DTWD2 33
  • 93.22 (n)
-- 34
  • 83 (a)
-- 34
  • 81 (a)
(Bos Taurus)
Mammalia DTWD2 33 34
  • 88.81 (n)
(Mus musculus)
Mammalia Dtwd2 33 16 34
  • 85.46 (n)
(Rattus norvegicus)
Mammalia Dtwd2 33
  • 84.45 (n)
(Monodelphis domestica)
Mammalia DTWD2 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia DTWD2 34
  • 71 (a)
(Gallus gallus)
Aves DTWD2 33 34
  • 76.5 (n)
(Anolis carolinensis)
Reptilia DTWD2 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dtwd2 33
  • 70.48 (n)
Str.17704 33
(Danio rerio)
Actinopterygii si:zfos-1462c8.5 33
  • 59.97 (n)
DTWD2 34
  • 57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3789 33
fruit fly
(Drosophila melanogaster)
Insecta CG10050 33 34
  • 48.28 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001801 33
  • 45.31 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G41750 33
  • 44.5 (n)
(Oryza sativa)
Liliopsida Os12g0142600 33
  • 47.22 (n)
Species where no ortholog for DTWD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTWD2 Gene

Gene Tree for DTWD2 (if available)
Gene Tree for DTWD2 (if available)

Paralogs for DTWD2 Gene Pseudogenes for DTWD2 Gene

genes like me logo Genes that share paralogs with DTWD2: view

No data available for Paralogs for DTWD2 Gene

Variants for DTWD2 Gene

Sequence variations from dbSNP and Humsavar for DTWD2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000002862 -- 118,840,502(-) C/T 3_prime_UTR_variant
rs1000029029 -- 118,870,794(-) G/A intron_variant
rs1000042596 -- 118,914,522(-) G/A intron_variant
rs1000053137 -- 118,950,159(-) G/A intron_variant
rs1000062637 -- 118,836,245(-) T/A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for DTWD2 Gene

Variant ID Type Subtype PubMed ID
esv2557297 CNV deletion 19546169
esv2666628 CNV deletion 23128226
esv3606473 CNV gain 21293372
esv3606474 CNV gain 21293372
esv3606475 CNV loss 21293372
nsv1017548 CNV loss 25217958
nsv526318 CNV loss 19592680
nsv599562 CNV gain 21841781
nsv599563 CNV loss 21841781
nsv823191 CNV loss 20364138
nsv950120 CNV duplication 24416366
nsv964930 CNV duplication 23825009

Variation tolerance for DTWD2 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DTWD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTWD2 Gene

Disorders for DTWD2 Gene

Additional Disease Information for DTWD2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DTWD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTWD2 Gene

Publications for DTWD2 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for DTWD2 Gene

Sources for DTWD2 Gene

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