Aliases for DTWD1 Gene

Aliases for DTWD1 Gene

  • DTW Domain Containing 1 2 3 5
  • DTW Domain-Containing Protein 1 3 4
  • X 009 Protein 3
  • MDS009 3

External Ids for DTWD1 Gene

Previous GeneCards Identifiers for DTWD1 Gene

  • GC15P047701
  • GC15P049913
  • GC15P026744

Summaries for DTWD1 Gene

GeneCards Summary for DTWD1 Gene

DTWD1 (DTW Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is YIPF3.

Gene Wiki entry for DTWD1 Gene

Additional gene information for DTWD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DTWD1 Gene

Genomics for DTWD1 Gene

GeneHancer (GH) Regulatory Elements for DTWD1 Gene

Promoters and enhancers for DTWD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DTWD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DTWD1 gene promoter:
  • AML1a
  • c-Myb
  • c-Rel
  • MRF-2
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • RORalpha2
  • Sox9

Genomic Locations for DTWD1 Gene

Genomic Locations for DTWD1 Gene
35,253 bases
Plus strand
24,157 bases
Plus strand

Genomic View for DTWD1 Gene

Genes around DTWD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTWD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTWD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTWD1 Gene

Proteins for DTWD1 Gene

  • Protein details for DTWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DTW domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q567Q3
    • Q8WVG9
    • Q9NRU6

    Protein attributes for DTWD1 Gene

    304 amino acids
    Molecular mass:
    35248 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF87319.1; Type=Frameshift; Positions=132, 182, 187, 188, 192, 194, 196, 199, 204, 207, 209; Evidence={ECO:0000305};

    Alternative splice isoforms for DTWD1 Gene


neXtProt entry for DTWD1 Gene

Post-translational modifications for DTWD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DTWD1 Gene

Domains & Families for DTWD1 Gene

Gene Families for DTWD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DTWD1 Gene


Suggested Antigen Peptide Sequences for DTWD1 Gene

GenScript: Design optimal peptide antigens:
  • DTW domain-containing protein 1 (DTWD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DXTW motif.
  • Belongs to the DTW family.
  • Contains 1 DXTW motif.
  • Belongs to the DTW family.
genes like me logo Genes that share domains with DTWD1: view

Function for DTWD1 Gene

Phenotypes From GWAS Catalog for DTWD1 Gene

genes like me logo Genes that share phenotypes with DTWD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTWD1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTWD1 Gene

Localization for DTWD1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DTWD1 gene
Compartment Confidence
nucleus 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DTWD1 Gene

Pathways & Interactions for DTWD1 Gene

PathCards logo

SuperPathways for DTWD1 Gene

No Data Available

Interacting Proteins for DTWD1 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000251250 Q8N5C7-DTWD1_HUMAN for DTWD1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for DTWD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for DTWD1 Gene

Drugs & Compounds for DTWD1 Gene

No Compound Related Data Available

Transcripts for DTWD1 Gene

mRNA/cDNA for DTWD1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTWD1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTWD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: -
SP8: - - - - - - -

Relevant External Links for DTWD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DTWD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DTWD1 Gene

Protein differential expression in normal tissues from HIPED for DTWD1 Gene

This gene is overexpressed in Ovary (54.1) and Adrenal (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DTWD1 Gene

Protein tissue co-expression partners for DTWD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DTWD1 Gene:


SOURCE GeneReport for Unigene cluster for DTWD1 Gene:


Evidence on tissue expression from TISSUES for DTWD1 Gene

  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with DTWD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTWD1 Gene

Orthologs for DTWD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DTWD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DTWD1 33 32
  • 99.67 (n)
(Canis familiaris)
Mammalia DTWD1 33 32
  • 93.31 (n)
(Bos Taurus)
Mammalia DTWD1 33
  • 86 (a)
(Rattus norvegicus)
Mammalia Dtwd1 32
  • 79.39 (n)
(Mus musculus)
Mammalia Dtwd1 17 33 32
  • 78.84 (n)
(Monodelphis domestica)
Mammalia DTWD1 33
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia DTWD1 33
  • 61 (a)
(Gallus gallus)
Aves LOC770318 32
  • 71.28 (n)
DTWD1 33
  • 60 (a)
(Anolis carolinensis)
Reptilia DTWD1 33
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dtwd1 32
  • 68.24 (n)
Str.17345 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.23765 32
(Danio rerio)
Actinopterygii dtwd1 33 32
  • 56.65 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004295 32
  • 51.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2006 33 32
  • 49.26 (n)
(Caenorhabditis elegans)
Secernentea Y53C12A.10 33 32
  • 51.45 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3444 33
  • 43 (a)
Species where no ortholog for DTWD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DTWD1 Gene

Gene Tree for DTWD1 (if available)
Gene Tree for DTWD1 (if available)
Evolutionary constrained regions (ECRs) for DTWD1: view image

Paralogs for DTWD1 Gene

Paralogs for DTWD1 Gene Pseudogenes for DTWD1 Gene

genes like me logo Genes that share paralogs with DTWD1: view

Variants for DTWD1 Gene

Sequence variations from dbSNP and Humsavar for DTWD1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000056121 -- 49,625,915(+) A/G intron_variant
rs1000269723 -- 49,653,355(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000279160 -- 49,620,598(+) A/T upstream_transcript_variant
rs1000325724 -- 49,653,168(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000361883 -- 49,647,749(+) G/A/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DTWD1 Gene

Variant ID Type Subtype PubMed ID
nsv569392 CNV loss 21841781

Variation tolerance for DTWD1 Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DTWD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTWD1 Gene

Disorders for DTWD1 Gene

Additional Disease Information for DTWD1

No disorders were found for DTWD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTWD1 Gene

Publications for DTWD1 Gene

  1. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PMID: 22041458) Clark SL … van den Oord EJ (Psychological medicine 2012) 3 43 56
  2. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. (PMID: 29513927) Tomkins JE … Manzoni C (Proteomics 2018) 3 56
  3. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. (PMID: 29656893) Gupta R … Choudhary C (Cell 2018) 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56

Products for DTWD1 Gene

Sources for DTWD1 Gene