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Aliases for DTWD1 Gene

Aliases for DTWD1 Gene

  • DTW Domain Containing 1 2 3 5
  • DTW Domain-Containing Protein 1 3
  • X 009 Protein 3
  • MDS009 3

External Ids for DTWD1 Gene

Previous GeneCards Identifiers for DTWD1 Gene

  • GC15P047701
  • GC15P049913
  • GC15P026744

Summaries for DTWD1 Gene

GeneCards Summary for DTWD1 Gene

DTWD1 (DTW Domain Containing 1) is a Protein Coding gene.

Gene Wiki entry for DTWD1 Gene

Additional gene information for DTWD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTWD1 Gene

Genomics for DTWD1 Gene

GeneHancer (GH) Regulatory Elements for DTWD1 Gene

Promoters and enhancers for DTWD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J049618 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 660.9 +1.0 991 6.1 CLOCK MLX ZFP64 YBX1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 FAM227B DTWD1 GABPB1-AS1 USP8 ENSG00000259298 ENSG00000259715 GABPB1 CEP152 ENSG00000259618 FGF7
GH15J049154 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 27.5 -465.3 -465312 3.1 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 COPS2 SECISBP2L NDUFAF4P1 GALK2 DTWD1 CEP152 DUT FGF7 FAM227B
GH15J049421 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 16.6 -196.7 -196707 4.7 RB1 ARNT ZSCAN4 ZNF2 DNMT3B RAD21 CHAMP1 E2F8 ZNF366 ARID2 FGF7 DTWD1 COPS2 ENSG00000259715 SECISBP2L GALK2 LOC105370811 FAM227B
GH15J050423 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.2 +803.6 803564 2.5 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B USP8 ENSG00000259298 GABPB1 ENSG00000259618 DTWD1 TRPM7 ENSG00000259715 DCAF13P3 GABPB1-AS1 AP4E1
GH15J049044 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.8 -575.2 -575167 2.8 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 SECISBP2L DTWD1 CEP152 DUT SHC4 ENSG00000259488 RN7SL577P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DTWD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DTWD1 gene promoter:
  • AML1a
  • NF-kappaB2
  • NF-kappaB1
  • NF-kappaB
  • c-Rel
  • RORalpha2
  • MRF-2
  • Sox9
  • c-Myb

Genomic Locations for DTWD1 Gene

Genomic Locations for DTWD1 Gene
chr15:49,620,980-49,656,232
(GRCh38/hg38)
Size:
35,253 bases
Orientation:
Plus strand
chr15:49,913,177-49,937,333
(GRCh37/hg19)
Size:
24,157 bases
Orientation:
Plus strand

Genomic View for DTWD1 Gene

Genes around DTWD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTWD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTWD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTWD1 Gene

Proteins for DTWD1 Gene

  • Protein details for DTWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5C7-DTWD1_HUMAN
    Recommended name:
    DTW domain-containing protein 1
    Protein Accession:
    Q8N5C7
    Secondary Accessions:
    • Q567Q3
    • Q8WVG9
    • Q9NRU6

    Protein attributes for DTWD1 Gene

    Size:
    304 amino acids
    Molecular mass:
    35248 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF87319.1; Type=Frameshift; Positions=132, 182, 187, 188, 192, 194, 196, 199, 204, 207, 209; Evidence={ECO:0000305};

    Alternative splice isoforms for DTWD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DTWD1 Gene

Post-translational modifications for DTWD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Boster Bio Antibodies for DTWD1
  • Santa Cruz Biotechnology (SCBT) Antibodies for DTWD1

No data available for DME Specific Peptides for DTWD1 Gene

Domains & Families for DTWD1 Gene

Gene Families for DTWD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DTWD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DTWD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5C7

UniProtKB/Swiss-Prot:

DTWD1_HUMAN :
  • Contains 1 DXTW motif.
  • Belongs to the DTW family.
Domain:
  • Contains 1 DXTW motif.
Family:
  • Belongs to the DTW family.
genes like me logo Genes that share domains with DTWD1: view

Function for DTWD1 Gene

Phenotypes From GWAS Catalog for DTWD1 Gene

genes like me logo Genes that share phenotypes with DTWD1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTWD1 Gene

Localization for DTWD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DTWD1 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DTWD1 Gene

Pathways & Interactions for DTWD1 Gene

SuperPathways for DTWD1 Gene

No Data Available

Interacting Proteins for DTWD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000251250%0d%0a9606.ENSP00000237201%0d%0a
Selected Interacting proteins: Q8N5C7-DTWD1_HUMAN ENSP00000251250 for DTWD1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for DTWD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DTWD1 Gene

Drugs & Compounds for DTWD1 Gene

No Compound Related Data Available

Transcripts for DTWD1 Gene

Unigene Clusters for DTWD1 Gene

DTW domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTWD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: -
SP8: - - - - - - -

Relevant External Links for DTWD1 Gene

GeneLoc Exon Structure for
DTWD1
ECgene alternative splicing isoforms for
DTWD1

Expression for DTWD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DTWD1 Gene

Protein differential expression in normal tissues from HIPED for DTWD1 Gene

This gene is overexpressed in Ovary (54.1) and Adrenal (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DTWD1 Gene



Protein tissue co-expression partners for DTWD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DTWD1 Gene:

DTWD1

SOURCE GeneReport for Unigene cluster for DTWD1 Gene:

Hs.127432

Evidence on tissue expression from TISSUES for DTWD1 Gene

  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with DTWD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTWD1 Gene

Orthologs for DTWD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DTWD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DTWD1 34 33
  • 99.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DTWD1 34 33
  • 93.31 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DTWD1 34
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dtwd1 33
  • 79.39 (n)
mouse
(Mus musculus)
Mammalia Dtwd1 16 34 33
  • 78.84 (n)
oppossum
(Monodelphis domestica)
Mammalia DTWD1 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DTWD1 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC770318 33
  • 71.28 (n)
DTWD1 34
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DTWD1 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dtwd1 33
  • 68.24 (n)
Str.17345 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23765 33
zebrafish
(Danio rerio)
Actinopterygii dtwd1 34 33
  • 56.65 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004295 33
  • 51.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2006 34 33
  • 49.26 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y53C12A.10 34 33
  • 51.45 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3444 34
  • 43 (a)
OneToOne
Species where no ortholog for DTWD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DTWD1 Gene

ENSEMBL:
Gene Tree for DTWD1 (if available)
TreeFam:
Gene Tree for DTWD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DTWD1: view image

Paralogs for DTWD1 Gene

Pseudogenes.org Pseudogenes for DTWD1 Gene

genes like me logo Genes that share paralogs with DTWD1: view

No data available for Paralogs for DTWD1 Gene

Variants for DTWD1 Gene

Sequence variations from dbSNP and Humsavar for DTWD1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000056121 -- 49,625,915(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000269723 -- 49,653,355(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000279160 -- 49,620,598(+) A/T upstream_transcript_variant
rs1000325724 -- 49,653,168(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000361883 -- 49,647,749(+) G/A/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DTWD1 Gene

Variant ID Type Subtype PubMed ID
nsv569392 CNV loss 21841781

Variation tolerance for DTWD1 Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DTWD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DTWD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTWD1 Gene

Disorders for DTWD1 Gene

Additional Disease Information for DTWD1

No disorders were found for DTWD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTWD1 Gene

Publications for DTWD1 Gene

  1. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PMID: 22041458) Clark SL … van den Oord EJ (Psychological medicine 2012) 3 44 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 58
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58

Products for DTWD1 Gene

Sources for DTWD1 Gene

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