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Aliases for DTD2 Gene

Aliases for DTD2 Gene

  • D-Tyrosyl-TRNA Deacylase 2 (Putative) 2 3 5
  • Putative D-Tyrosyl-TRNA Deacylase 2 3 4
  • C14orf126 3 4
  • Probable D-Tyrosyl-TRNA(Tyr) Deacylase 2 3
  • Putative D-Tyrosyl-TRNA(Tyr) Deacylase 2 3
  • Chromosome 14 Open Reading Frame 126 2
  • EC 3.1.-.- 4

External Ids for DTD2 Gene

Previous HGNC Symbols for DTD2 Gene

  • C14orf126

Previous GeneCards Identifiers for DTD2 Gene

  • GC14M031917

Summaries for DTD2 Gene

GeneCards Summary for DTD2 Gene

DTD2 (D-Tyrosyl-TRNA Deacylase 2 (Putative)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and D-tyrosyl-tRNA(Tyr) deacylase activity. An important paralog of this gene is ENSG00000203546.

UniProtKB/Swiss-Prot for DTD2 Gene

  • May D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential).

Additional gene information for DTD2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DTD2 Gene

Genomics for DTD2 Gene

GeneHancer (GH) Regulatory Elements for DTD2 Gene

Promoters and enhancers for DTD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I031456 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 559.6 +0.3 347 2.3 HDGF PKNOX1 CLOCK FOXA2 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 DTD2 ENSG00000203546 LOC101927124 HEATR5A HECTD1 GC14P031438
GH14I031458 Enhancer 0.9 ENCODE 550.8 -1.0 -980 0.2 FOXA2 ZFP64 ARID4B ETS1 YY1 TCF12 ATF7 SP5 MXD4 REST DTD2 ENSG00000203546 LOC101927124 HEATR5A GC14M031463
GH14I031418 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.4 +37.0 37039 3.9 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SLC30A9 LOC101927124 HEATR5A LOC644295 HECTD1 DTD2 ENSG00000203546
GH14I032134 Enhancer 1 ENCODE 10.6 -677.4 -677350 0.1 PKNOX1 CLOCK ARNT NEUROD1 FEZF1 ZNF2 FOS SP3 REST ZNF662 ARHGAP5 RNU6-8 LOC101927124 NPAS3 RNU6-7 HECTD1 DTD2 GC14P032154 ARHGAP5-AS1
GH14I031204 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.4 +250.2 250219 5.1 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 HECTD1 G2E3 RPL21P5 SCFD1 ARHGAP5 HEATR5A DTD2 RNU6-541P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DTD2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DTD2 Gene

Genomic Locations for DTD2 Gene
11,475 bases
Minus strand

Genomic View for DTD2 Gene

Genes around DTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTD2 Gene

Proteins for DTD2 Gene

  • Protein details for DTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative D-tyrosyl-tRNA(Tyr) deacylase 2
    Protein Accession:
    Secondary Accessions:
    • D3DS87

    Protein attributes for DTD2 Gene

    168 amino acids
    Molecular mass:
    18660 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DTD2 Gene

Post-translational modifications for DTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DTD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DTD2 Gene

Domains & Families for DTD2 Gene

Gene Families for DTD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DTD2 Gene

Suggested Antigen Peptide Sequences for DTD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DTD family.
  • Belongs to the DTD family.
genes like me logo Genes that share domains with DTD2: view

Function for DTD2 Gene

Molecular function for DTD2 Gene

UniProtKB/Swiss-Prot Function:
May D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential).

Enzyme Numbers (IUBMB) for DTD2 Gene

Gene Ontology (GO) - Molecular Function for DTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002161 aminoacyl-tRNA editing activity IBA --
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 22939629
GO:0016787 hydrolase activity IEA --
GO:0051499 D-aminoacyl-tRNA deacylase activity IEA --
genes like me logo Genes that share ontologies with DTD2: view
genes like me logo Genes that share phenotypes with DTD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTD2 Gene

Localization for DTD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTD2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DTD2 gene
Compartment Confidence
mitochondrion 2
extracellular 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DTD2: view

Pathways & Interactions for DTD2 Gene

No Data Available

Interacting Proteins for DTD2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)
Selected Interacting proteins: Q96FN9-DTD2_HUMAN ENSP00000312224 for DTD2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for DTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006399 tRNA metabolic process IBA --
GO:0006450 regulation of translational fidelity IEA --
GO:0008150 biological_process ND --
GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity IEA --
genes like me logo Genes that share ontologies with DTD2: view

No data available for Pathways by source and SIGNOR curated interactions for DTD2 Gene

Drugs & Compounds for DTD2 Gene

No Compound Related Data Available

Transcripts for DTD2 Gene

mRNA/cDNA for DTD2 Gene

Unigene Clusters for DTD2 Gene

D-tyrosyl-tRNA deacylase 2 (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DTD2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for DTD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DTD2 Gene

Protein differential expression in normal tissues from HIPED for DTD2 Gene

This gene is overexpressed in Bone marrow stromal cell (20.9) and Salivary gland (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DTD2 Gene:


SOURCE GeneReport for Unigene cluster for DTD2 Gene:


Evidence on tissue expression from TISSUES for DTD2 Gene

  • Eye(4.1)
genes like me logo Genes that share expression patterns with DTD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTD2 Gene

Orthologs for DTD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DTD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DTD2 33
  • 99.6 (n)
-- 34
  • 99 (a)
(Canis familiaris)
Mammalia -- 34
  • 90 (a)
DTD2 33
  • 89.29 (n)
(Bos Taurus)
Mammalia C21H14orf126 33
  • 89.88 (n)
-- 34
  • 89 (a)
-- 34
  • 89 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 80 (a)
(Mus musculus)
Mammalia Dtd2 33 16 34
  • 79.56 (n)
(Rattus norvegicus)
Mammalia Dtd2 33
  • 78.97 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
(Gallus gallus)
Aves C14ORF126 33
  • 73.58 (n)
-- 34
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dtd2 33
  • 61.11 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12995 33
(Danio rerio)
Actinopterygii dtd2 33 34
  • 64.78 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12205 33
Species where no ortholog for DTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DTD2 Gene

Gene Tree for DTD2 (if available)
Gene Tree for DTD2 (if available)

Paralogs for DTD2 Gene

Paralogs for DTD2 Gene

genes like me logo Genes that share paralogs with DTD2: view

Variants for DTD2 Gene

Sequence variations from dbSNP and Humsavar for DTD2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000332163 -- 31,454,871(-) G/T intron_variant
rs1000620550 -- 31,454,997(-) A/C intron_variant
rs1000933653 -- 31,448,008(-) C/T 3_prime_UTR_variant
rs1001344961 -- 31,449,041(-) G/A intron_variant
rs1002191878 -- 31,457,957(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DTD2 Gene

Variant ID Type Subtype PubMed ID
nsv456198 CNV loss 19166990
nsv564179 CNV loss 21841781

Variation tolerance for DTD2 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DTD2 Gene

Disorders for DTD2 Gene

Additional Disease Information for DTD2

No disorders were found for DTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DTD2 Gene

Publications for DTD2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 58
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for DTD2 Gene

Sources for DTD2 Gene

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