The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec ... See more...

Aliases for DTD1 Gene

Aliases for DTD1 Gene

  • D-Aminoacyl-TRNA Deacylase 1 2 3 4 5
  • DNA-Unwinding Element-Binding Protein B 2 3 4
  • DUEB 2 3 4
  • Histidyl-TRNA Synthase-Related 3 4
  • Gly-TRNA(Ala) Deacylase 3 4
  • C20orf88 3 4
  • Pqn-68 2 3
  • DUE-B 3 4
  • HARS2 3 4
  • DTD 3 4
  • D-Tyrosyl-TRNA Deacylase 1 Homolog (S. Cerevisiae) 2
  • Chromosome 20 Open Reading Frame 88 2
  • D-Tyrosyl-TRNA Deacylase 1 Homolog 3
  • D-Tyrosyl-TRNA(Tyr) Deacylase 1 3
  • D-Tyrosyl-TRNA Deacylase 1 2
  • Histidyl-TRNA Synthetase 2 3
  • EC 3.1.1.96 4
  • BA555E18.1 2
  • MGC119131 2
  • BA379J5.3 2
  • MGC41905 2
  • DTD1 5

External Ids for DTD1 Gene

Previous HGNC Symbols for DTD1 Gene

  • C20orf88
  • HARS2

Previous GeneCards Identifiers for DTD1 Gene

  • GC20P018517
  • GC20P018530
  • GC20P018568

Summaries for DTD1 Gene

Entrez Gene Summary for DTD1 Gene

  • The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

GeneCards Summary for DTD1 Gene

DTD1 (D-Aminoacyl-TRNA Deacylase 1) is a Protein Coding gene. Diseases associated with DTD1 include Spinocerebellar Ataxia 10 and Enamel Erosion. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and D-tyrosyl-tRNA(Tyr) deacylase activity. An important paralog of this gene is ENSG00000284776.

UniProtKB/Swiss-Prot Summary for DTD1 Gene

  • Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034).
  • An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DTD1 Gene

Genomics for DTD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DTD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J018587 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 261.8 +0.7 659 2.8 CHD2 ZBTB10 MXD4 SP1 NR2C1 MNT SMAD5 ETS1 MBD2 POLR2A DTD1 HSALNG0128971 lnc-RBBP9-1 LINC00653 SMIM26 ZNF133 ENSG00000230495 RNU6ATAC34P SEC23B DZANK1
GH20J018593 Promoter 0.3 EPDnew 250.4 +5.8 5803 0.1 RF00017-3531 RN7SL638P lnc-SMIM26-4 DTD1 piR-57176-380 ENSG00000284776 SCP2D1
GH20J018627 Promoter 0.3 EPDnew 250.3 +40.0 39982 0.1 DTD1 piR-38629 lnc-RBBP9-2 ENSG00000284776 SCP2D1
GH20J018566 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 23.7 -20.3 -20263 2.6 ZSCAN16 CHD2 TBP ZBTB10 SP1 MXD4 NR2C1 MNT SMAD5 ETS1 SMIM26 ENSG00000284776 HSALNG0141639 lnc-RBBP9-3 DTD1 SEC23B RBBP9 ZNF133 DZANK1 POLR3F
GH20J018506 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.2 -80.2 -80241 3.4 CHD2 TBP SP1 BCL11A MXD4 MNT BRCA1 SMAD5 ETS1 MBD2 SEC23B HSALNG0128965 RBBP9 ZNF133 LINC00653 ENSG00000230495 SMIM26 DTD1 POLR3F DZANK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DTD1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DTD1

Top Transcription factor binding sites by QIAGEN in the DTD1 gene promoter:
  • Cart-1
  • FOXL1
  • GATA-1
  • Gfi-1
  • Pax-5
  • PPAR-alpha
  • RelA
  • SRY
  • TGIF

Genomic Locations for DTD1 Gene

Latest Assembly
chr20:18,587,942-18,766,644
(GRCh38/hg38)
Size:
178,703 bases
Orientation:
Plus strand

Previous Assembly
chr20:18,568,698-18,747,288
(GRCh37/hg19 by Entrez Gene)
Size:
178,591 bases
Orientation:
Plus strand

chr20:18,568,537-18,744,561
(GRCh37/hg19 by Ensembl)
Size:
176,025 bases
Orientation:
Plus strand

Genomic View for DTD1 Gene

Genes around DTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DTD1 Gene

Proteins for DTD1 Gene

  • Protein details for DTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEA8-DTD1_HUMAN
    Recommended name:
    D-aminoacyl-tRNA deacylase 1
    Protein Accession:
    Q8TEA8
    Secondary Accessions:
    • A8K5X5
    • D3DW37
    • Q496D1
    • Q5W184
    • Q8WXU8
    • Q9BW67
    • Q9H464
    • Q9H474

    Protein attributes for DTD1 Gene

    Size:
    209 amino acids
    Molecular mass:
    23424 Da
    Quaternary structure:
    • Homodimer (PubMed15653697). Interacts with CDC45 and TOPBP1 (PubMed:20065034).
    SequenceCaution:
    • Sequence=BAB85044.1; Type=Miscellaneous discrepancy; Note=Presence of Alu-repeat DNA.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DTD1 Gene

neXtProt entry for DTD1 Gene

Post-translational modifications for DTD1 Gene

  • Preferentially phosphorylated in cells arrested early in S phase (PubMed:15653697). Phosphorylation in the C-terminus weakens the interaction with CDC45 (PubMed:20065034).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DTD1 Gene

No data available for DME Specific Peptides for DTD1 Gene

Domains & Families for DTD1 Gene

Gene Families for DTD1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DTD1 Gene

InterPro:
Blocks:
  • D-tyrosyl-tRNA(Tyr) deacylase
ProtoNet:

Suggested Antigen Peptide Sequences for DTD1 Gene

GenScript: Design optimal peptide antigens:
  • Histidyl-tRNA synthase-related (DTD1_HUMAN)
  • D-tyrosyl-tRNA(Tyr) deacylase (Q496C9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TEA8

UniProtKB/Swiss-Prot:

DTD1_HUMAN :
  • A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
  • Belongs to the DTD family.
Domain:
  • A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
Family:
  • Belongs to the DTD family.
genes like me logo Genes that share domains with DTD1: view

Function for DTD1 Gene

Molecular function for DTD1 Gene

UniProtKB/Swiss-Prot Function:
Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034).
UniProtKB/Swiss-Prot Function:
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala); Xref=Rhea:RHEA:53744, Rhea:RHEA-COMP:9657, Rhea:RHEA-COMP:13640, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305, ChEBI:CHEBI:78442, ChEBI:CHEBI:78522; EC=3.1.1.96; Evidence={ECO:0000250|UniProtKB:Q8IIS0};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + H(+) + tRNA; Xref=Rhea:RHEA:13953, Rhea:RHEA-COMP:10123, Rhea:RHEA-COMP:10124, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:59871, ChEBI:CHEBI:78442, ChEBI:CHEBI:79333; EC=3.1.1.96; Evidence={ECO:0000250|UniProtKB:Q8IIS0};.

Enzyme Numbers (IUBMB) for DTD1 Gene

Phenotypes From GWAS Catalog for DTD1 Gene

Gene Ontology (GO) - Molecular Function for DTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0002161 aminoacyl-tRNA editing activity IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DTD1: view
genes like me logo Genes that share phenotypes with DTD1: view

Animal Models for research

  • Taconic Biosciences Mouse Models for DTD1

miRNA for DTD1 Gene

miRTarBase miRNAs that target DTD1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTD1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DTD1 Gene

Localization for DTD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DTD1 Gene

Nucleus. Cytoplasm. Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements (PubMed:20065034).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DTD1 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoli (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IBA 21873635
genes like me logo Genes that share ontologies with DTD1: view

Pathways & Interactions for DTD1 Gene

PathCards logo

SuperPathways for DTD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006399 tRNA metabolic process IEA,IBA 21873635
GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity IEA --
genes like me logo Genes that share ontologies with DTD1: view

No data available for Pathways by source and SIGNOR curated interactions for DTD1 Gene

Drugs & Compounds for DTD1 Gene

No Compound Related Data Available

Transcripts for DTD1 Gene

mRNA/cDNA for DTD1 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DTD1

Alternative Splicing Database (ASD) splice patterns (SP) for DTD1 Gene

No ASD Table

Relevant External Links for DTD1 Gene

GeneLoc Exon Structure for
DTD1

Expression for DTD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DTD1 Gene

Protein differential expression in normal tissues from HIPED for DTD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.6), Fetal Brain (6.6), and Frontal cortex (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DTD1 Gene



Protein tissue co-expression partners for DTD1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DTD1

SOURCE GeneReport for Unigene cluster for DTD1 Gene:

Hs.659442

mRNA Expression by UniProt/SwissProt for DTD1 Gene:

Q8TEA8-DTD1_HUMAN
Tissue specificity: Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain.

Evidence on tissue expression from TISSUES for DTD1 Gene

  • Nervous system(4.7)
  • Skin(4.3)
  • Blood(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with DTD1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DTD1 Gene

Orthologs for DTD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DTD1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DTD1 30 31
  • 99.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DTD1 30 31
  • 91.07 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dtd1 30 17 31
  • 88.36 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DTD1 30 31
  • 88.04 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DTD1 31
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dtd1 30
  • 87.63 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia DTD1 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DTD1 30 31
  • 79.77 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DTD1 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dtd1 30
  • 74.76 (n)
Str.17396 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.4690 30
Zebrafish
(Danio rerio)
Actinopterygii dtd1 30 31
  • 71.52 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9158 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001371 30
  • 59.56 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG18643 30 31
  • 58.96 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea pqn-68 30 31
  • 54.65 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ABL152W 30
  • 49.65 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D08690g 30
  • 48.55 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DTD1 30 31 33
  • 46.94 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G18460 30
  • 54.73 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0242500 30
  • 58.5 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 67 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU03854 30
  • 50.11 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC8C9.05 30
  • 48.59 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2652 30
Species where no ortholog for DTD1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DTD1 Gene

ENSEMBL:
Gene Tree for DTD1 (if available)
TreeFam:
Gene Tree for DTD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DTD1: view image

Paralogs for DTD1 Gene

Paralogs for DTD1 Gene

genes like me logo Genes that share paralogs with DTD1: view

Variants for DTD1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DTD1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DTD1 Gene

Variant ID Type Subtype PubMed ID
dgv4283n100 CNV loss 25217958
esv1401622 CNV insertion 17803354
esv1476050 CNV insertion 17803354
esv1522771 CNV deletion 17803354
esv1653693 CNV insertion 17803354
esv2468883 CNV insertion 19546169
esv2658051 CNV deletion 23128226
esv3556909 CNV deletion 23714750
esv3645442 CNV loss 21293372
esv3645443 CNV gain 21293372
nsv1078315 OTHER inversion 25765185
nsv1123460 CNV deletion 24896259
nsv1142306 CNV tandem duplication 24896259
nsv178568 CNV deletion 16902084
nsv178936 CNV deletion 16902084
nsv473794 CNV novel sequence insertion 20440878
nsv954259 CNV insertion 24416366

Variation tolerance for DTD1 Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DTD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DTD1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DTD1 Gene

Disorders for DTD1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DTD1 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search DTD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DTD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DTD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DTD1 Gene

Publications for DTD1 Gene

  1. The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation. (PMID: 20065034) Chowdhury A … Leffak M (Molecular and cellular biology 2010) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Structure and function of the c-myc DNA-unwinding element-binding protein DUE-B. (PMID: 17264083) Kemp M … Nair SK (The Journal of biological chemistry 2007) 3 4
  4. The c-myc DNA-unwinding element-binding protein modulates the assembly of DNA replication complexes in vitro. (PMID: 15653697) Casper JM … Leffak M (The Journal of biological chemistry 2005) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for DTD1 Gene

Sources for DTD1 Gene