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The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
DTD1 (D-Aminoacyl-TRNA Deacylase 1) is a Protein Coding gene. Diseases associated with DTD1 include Spinocerebellar Ataxia 10 and Fetal Akinesia Deformation Sequence 1. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and D-tyrosyl-tRNA(Tyr) deacylase activity. An important paralog of this gene is ENSG00000284776.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000049 | tRNA binding | IEA | -- |
GO:0002161 | aminoacyl-tRNA editing activity | IEA,IBA | 21873635 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003723 | RNA binding | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006260 | DNA replication | IEA | -- |
GO:0006399 | tRNA metabolic process | IEA,IBA | 21873635 |
GO:0106074 | aminoacyl-tRNA metabolism involved in translational fidelity | IEA | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DTD1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DTD1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dtd1 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DTD1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DTD1 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dtd1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | DTD1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DTD1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DTD1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dtd1 30 |
|
||
Str.17396 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.4690 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dtd1 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9158 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001371 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG18643 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | pqn-68 30 31 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ABL152W 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D08690g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DTD1 30 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G18460 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0242500 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU03854 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC8C9.05 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2652 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4283n100 | CNV | loss | 25217958 |
esv1401622 | CNV | insertion | 17803354 |
esv1476050 | CNV | insertion | 17803354 |
esv1522771 | CNV | deletion | 17803354 |
esv1653693 | CNV | insertion | 17803354 |
esv2468883 | CNV | insertion | 19546169 |
esv2658051 | CNV | deletion | 23128226 |
esv3556909 | CNV | deletion | 23714750 |
esv3645442 | CNV | loss | 21293372 |
esv3645443 | CNV | gain | 21293372 |
nsv1078315 | OTHER | inversion | 25765185 |
nsv1123460 | CNV | deletion | 24896259 |
nsv1142306 | CNV | tandem duplication | 24896259 |
nsv178568 | CNV | deletion | 16902084 |
nsv178936 | CNV | deletion | 16902084 |
nsv473794 | CNV | novel sequence insertion | 20440878 |
nsv954259 | CNV | insertion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
spinocerebellar ataxia 10 |
|
|
fetal akinesia deformation sequence 1 |
|
|