Aliases for DTD1 Gene
External Ids for DTD1 Gene
Previous HGNC Symbols for DTD1 Gene
Previous GeneCards Identifiers for DTD1 Gene
The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
GeneCards Summary for DTD1 Gene
DTD1 (D-Aminoacyl-TRNA Deacylase 1) is a Protein Coding gene. Diseases associated with DTD1 include Spinocerebellar Ataxia 10 and Fetal Akinesia Deformation Sequence 1. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and D-tyrosyl-tRNA(Tyr) deacylase activity. An important paralog of this gene is ENSG00000284776.
UniProtKB/Swiss-Prot Summary for DTD1 Gene
Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034).
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.